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公开(公告)号：WO2017219339A1
公开(公告)日：2017-12-28
申请号：PCT/CN2016/086994
申请日：2016-06-24
Applicant: COLGATE-PALMOLIVE COMPANY
Inventor： PRENCIPE, Michael , RUSSO, Amy , STETTLER, Hansruedi , WON, Betty , MANUS, Lisa , STRANICK, Michael A. , YAN, Peng , TAN, Chengkang , PATEL, Vyoma , MORGAN, Andre Michelle , POTANIN, Andrei , HUANG, Xiaoyi
Abstract: An oral care composition comprises (a) arginine or lysine; (b) zinc citrate and zinc oxide; (c) fluoride source; and (d) a silica abrasive which exhibits an acid pH when measured as an aqueous slurry. The composition is used in the manufacture of a product for application to the oral cavity of a subject in need thereof to improve oral health.
Abstract translation: 口腔护理组合物包含（a）精氨酸或赖氨酸; （b）柠檬酸锌和氧化锌; （c）氟化物源; 和（d）当以含水浆液测量时呈现酸性pH的二氧化硅研磨剂。 该组合物用于制造用于需要其的受试者的口腔以改善口腔健康的产品。
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公开(公告)号：WO2017000837A1
公开(公告)日：2017-01-05
申请号：PCT/CN2016/086995
申请日：2016-06-24
Applicant: COLGATE-PALMOLIVE COMPANY , HUANG, Xiaoyi
Inventor： HUANG, Xiaoyi , PRENCIPE, Michael , RUSSO, Amy , STETTLER, Hansruedi , PATEL, Vyoma , WON, Betty , YAN, Peng , MORGAN, Andre Michelle
CPC classification number: A61K8/44 , A61K8/21 , A61K8/25 , A61K8/27 , A61K8/345 , A61K8/362 , A61K8/365 , A61K2800/28 , A61K2800/92 , A61Q11/00
Abstract: An oral care composition comprises arginine or lysine, zinc citrate and zinc oxide, a fluoride source, and glycerin, as well as to methods of using and of making the composition.
Abstract translation: 口腔护理组合物包含精氨酸或赖氨酸，柠檬酸锌和氧化锌，氟化物源和甘油，以及使用和制备组合物的方法。
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公开(公告)号：WO2016076842A1
公开(公告)日：2016-05-19
申请号：PCT/US2014/065094
申请日：2014-11-11
Applicant: COLGATE-PALMOLIVE COMPANY
Inventor： STETTLER, Hans , RUSSO, Amy
CPC classification number: G01N33/56955 , C12M1/12 , C12Q1/18
Abstract: Disclosed is an in vitro oral biofilm model of interdental spaces including: a support, and a plurality of substratum pairs attached to the support, wherein an oral biofilm is capable of forming on the substratum pairs, wherein the substratum pairs each include a first member and a second member, and wherein the first member and the second member of each substratum pair are arranged to form a space interval between the first member and second member. Methods for assessing the formation of oral biofilms using the in vitro oral biofilm model and methods for testing agents, such as oral compositions, on biofilm reduction using the present model are also provided.
Abstract translation: 公开了一种齿间空间的体外口腔生物膜模型，其包括：支持体和连接到支持体上的多个底物对，其中口腔生物膜能够在基底对上形成，其中基底对各自包括第一构件和 第二构件，并且其中每个基底对的第一构件和第二构件被布置成在第一构件和第二构件之间形成间隔。 还提供了使用体外口腔生物膜模型来评估口腔生物膜形成的方法和用于测试试剂如口服组合物的方法对使用本发明模型的生物膜还原的方法。
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公开(公告)号：WO2017223497A1
公开(公告)日：2017-12-28
申请号：PCT/US2017/039084
申请日：2017-06-23
Applicant: COLGATE-PALMOLIVE COMPANY
Inventor： POTH, Tilo , POTANIN, Andrei , BLANVALET, Claude , WON, Betty , MANUS, Lisa , STRANICK, Michael A. , HUANG, Xiaoyi , PRENCIPE, Michael , RUSSO, Amy , STETTLER, Hansruedi , YAN, Peng , TAN, Chengkang , PATEL, Vyoma , MORGAN, Andre Michelle
Abstract: Described herein are oral care compositions comprising an amino acid; a combination of zinc ion sources; and a thickening system comprising a nonionic cellulose ether having a molecular weight of from about 300,000 to about 350,000; and a polysaccharide gum; along with methods of making and using same.
Abstract translation: 本文描述了包含氨基酸的口腔护理组合物; 锌离子源的组合; 和增稠体系，其包含分子量为约300,000至约350,000的非离子纤维素醚; 和多糖胶; 以及制作和使用它们的方法。
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公开(公告)号：WO2017003856A1
公开(公告)日：2017-01-05
申请号：PCT/US2016/039226
申请日：2016-06-24
Applicant: COLGATE-PALMOLIVE COMPANY
Inventor： THOMSON, Paul , DOGU, Nihal , PRENCIPE, Michael , RUSSO, Amy , STETTLER, Hans , MORGAN, Andre Michelle
CPC classification number: A61K8/44 , A61K8/21 , A61K8/25 , A61K8/27 , A61K8/345 , A61K8/362 , A61K8/365 , A61K2800/28 , A61K2800/92 , A61Q11/00
Abstract: This invention relates to oral care compositions comprising a basic amino acid in free or salt from (e.g., free form arginine); zinc oxide and zinc citrate; and a fluoride source comprising stannous fluoride.
Abstract translation: 本发明涉及包含游离或盐的碱性氨基酸（例如游离形式的精氨酸）的口腔护理组合物; 氧化锌和柠檬酸锌; 和含氟化亚锡的氟化物源。
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Patent Agency Ranking
公开(公告)号：WO2017223496A1
公开(公告)日：2017-12-28
申请号：PCT/US2017/039080
申请日：2017-06-23
Applicant: COLGATE-PALMOLIVE COMPANY
Inventor： HUANG, Xiaoyi , JOSIAS, Wilbens , PRENCIPE, Michael , STRANICK, Michael, A. , WON, Betty , MAURAO, Marcella , RUSSO, Amy , MANUS, Lisa , STETTLER, Hansruedi , PATEL, Vyoma , MORGAN, Andre, Michelle , POTANIN, Andrei , TAN, Chengkang , YAN, Peng
Abstract: Described herein are oral care compositions comprising a basic amino acid; a combination of zinc ion sources; and from about 0.75 wt.% to about 2 wt.% of a chelating system; along with methods of making and using same.
Abstract translation: 本文描述了包含碱性氨基酸的口腔护理组合物; 锌离子源的组合; 和约0.75重量％至约2重量％的螯合体系; 以及制作和使用它们的方法。
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公开(公告)号：WO2017223493A1
公开(公告)日：2017-12-28
申请号：PCT/US2017/039074
申请日：2017-06-23
Applicant: COLGATE-PALMOLIVE COMPANY
Inventor： PONTANIN, Andrei , POTH, Tilo , AHUJA, Amit , BLANVALET, Claude , WON, Betty , MANUS, Lisa , STRANICK, Michael, A. , HUANG, Xiaoyi , PRENCIPE, Michael , RUSSO, Amy , STETTLER, Hansruedi , YAN, Peng , TAN, Chengkang , PATEL, Vyoma , MORGAN, Andre, Michelle
Abstract: Described herein are oral care compositions comprising a basic amino acid; a combination of zinc ion sources; and a thickening system comprising a nonionic cellulose ether having a viscosity, measured at 2% in water at 25 °C, of 4500 to 7500 cps; and a polysaccharide gum; along with methods of making and using same.
Abstract translation: 本文描述了包含碱性氨基酸的口腔护理组合物; 锌离子源的组合; 和包含非离子纤维素醚的增稠体系，所述非离子纤维素醚的粘度在25℃在水中2％时测量为4500-7500cps; 和多糖胶; 以及制作和使用它们的方法。
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公开(公告)号：WO2017003844A1
公开(公告)日：2017-01-05
申请号：PCT/US2016/039194
申请日：2016-06-24
Applicant: COLGATE-PALMOLIVE COMPANY
Inventor： PRENCIPE, Michael , RUSSO, Amy , STETTLER, Hans , MORGAN, Andre Michelle
CPC classification number: A61K8/44 , A61K8/21 , A61K8/25 , A61K8/27 , A61K8/345 , A61K8/362 , A61K8/365 , A61K2800/28 , A61K2800/92 , A61Q11/00
Abstract: This invention relates to oral care compositions comprising arginine or lysine, zinc citrate and zinc oxide, and a fluoride source, as well as to methods of using and of making these compositions.
Abstract translation: 本发明涉及包含精氨酸或赖氨酸，柠檬酸锌和氧化锌以及氟化物源的口腔护理组合物，以及使用和制备这些组合物的方法。
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公开(公告)号：EP3244872A1
公开(公告)日：2017-11-22
申请号：EP16741429.1
申请日：2016-06-24
Applicant: Colgate-Palmolive Company
Inventor： THOMSON, Paul , DOGU, Nihal , PRENCIPE, Michael , RUSSO, Amy , STETTLER, Hansruedi , MORGAN, Andre Michelle
CPC classification number: A61K8/44 , A61K8/21 , A61K8/25 , A61K8/27 , A61K8/345 , A61K8/362 , A61K8/365 , A61K2800/28 , A61K2800/92 , A61Q11/00
Abstract: This invention relates to oral care compositions comprising arginine or lysine, zinc citrate and zinc oxide, and a fluoride source, as well as to methods of using and of making these compositions.
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公开(公告)号：EP3344219A1
公开(公告)日：2018-07-11
申请号：EP17737129.1
申请日：2017-06-23
Applicant: Colgate-Palmolive Company
Inventor： POTANIN, Andrei , POTH, Tilo , AHUJA, Amit , BLANVALET, Claude , WON, Betty , MANUS, Lisa , STRANICK, Michael, A. , HUANG, Xiaoyi , PRENCIPE, Michael , RUSSO, Amy , STETTLER, Hansruedi , YAN, Peng , TAN, Chengkang , PATEL, Vyoma , MORGAN, Andre, Michelle
CPC classification number: A61K8/44 , A61K8/042 , A61K8/21 , A61K8/24 , A61K8/25 , A61K8/27 , A61K8/34 , A61K8/365 , A61K8/37 , A61K8/442 , A61K8/73 , A61K8/731 , A61K2800/28 , A61K2800/48 , A61K2800/52 , A61Q11/00
Abstract: Described herein are oral care compositions comprising a basic amino acid; a combination of zinc ion sources; and a thickening system comprising a nonionic cellulose ether having a viscosity, measured at 2% in water at 25° C., of 4500 to 7500 cps; and a polysaccharide gum; along with methods of making and using same.
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