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    MASS CYTOMETRY REAGENTS AND METHODS FOR SIGNAL AMPLIFICATION
    1.
    发明申请
    MASS CYTOMETRY REAGENTS AND METHODS FOR SIGNAL AMPLIFICATION 审中-公开

    公开(公告)号：WO2021127435A1

    公开(公告)日：2021-06-24

    申请号：PCT/US2020/066012

    申请日：2020-12-18

    Applicant: FLUIDIGM CANADA INC.

    Inventor： ALLO, Bedilu ,  LOU, Xudong ,  LIU, Peng ,  MAJONIS, Daniel ,  MAVROPOULOS, Anastasia ,  GHEIRATMAND, Ladan

    IPC: C08F20/10 ,  C08F20/56 ,  C08F220/36 ,  C08F220/54 ,  C08F220/56

    Abstract: Described herein are reagents and methods for improving signal in imaging mass cytometry. Aspects include mass tags with a large number of labeling atoms, chemical modifications to mass tags and additional reagents to reduce background and/or maintain target binding of mass tagged specific binding partners (SBPs), and schemes for associating a plurality of mass tags with a single SBP. As such, embodiments include any combination of one or more reagents and their use. The reagents, kits and methods herein may be used for mass cytometry, including imaging mass cytometry. In some aspects, reagents, kits or methods may be used for delivery of a large number of radioisotopes to a target analyte, for example for therapeutic use or radiometric detection. In certain aspects, only non-radioactive isotopes may be used for mass cytometry.

    ADDITIONAL MASS TAG POLYMERS FOR MASS CYTOMETRY
    3.
    发明申请
    ADDITIONAL MASS TAG POLYMERS FOR MASS CYTOMETRY 审中-公开

    公开(公告)号：WO2021026483A1

    公开(公告)日：2021-02-11

    申请号：PCT/US2020/045470

    申请日：2020-08-07

    Applicant: FLUIDIGM CANADA INC.

    Inventor： LIU, Peng ,  MAJONIS, Daniel ,  BARANOV, Vladimir

    IPC: A61K51/04 ,  A61K51/00 ,  A61K51/02

    Abstract: A new class of mass-tag polymers is provided, which include enriched metal isotopes such as zirconium and hafnium mass tags. The chemistry of these new mass tags are different from that of lanthanide mass tags, and opens up new mass channels that can be used in mass cytometry. These polymers may be used for mass cytometry, therapeutic delivery of a radioactive isotope, or screening of a therapeutic isotope. Aspects include a kit, method of making, and method of using a polymer, isotopic composition, or both. A kit may include a polymer. The polymer may include pendant groups that chelate an enriched isotope, such as zirconium and/or hafnium. The kit may include an isotopic composition comprising an enriched zirconium or hafnium isotope. Polymers may be conjugated to a biologically active material. Aspects may also include making a kit. Aspects include use of a kit, such as for mass cytometry.

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