公开(公告)号：WO2013119894A1

公开(公告)日：2013-08-15

申请号：PCT/US2013/025259

申请日：2013-02-08

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： KJUS, Nini ,  FONNUM, Geir ,  BRANCHAUD, Bruce ,  YING, Lai-Qiang ,  MENCHEN, Steven ,  GREMYACHINSKIY, Dmitriy ,  KANG, Hee Chol

IPC: C07F7/18 ,  C08F222/38

CPC classification number: C08F230/08 ,  C07F7/10 ,  C07F7/1804 ,  C07F7/1852 ,  C08F220/58 ,  C08F222/385 ,  C08F236/20 ,  C08K3/20

Abstract: A silyl protected diacrylamide compound is described. A method of forming such a compound includes mixing a silylation reagent with a hydroxylated diamine compound under first reactive conditions to form a product in a first solution, separating the product from the first solution, and mixing the product with acryloyl chloride under second reactive conditions in a second solution to form a silyl protected diacrylamide compound.

Abstract translation: 描述了甲硅烷基保护的二丙烯酰胺化合物。 形成这种化合物的方法包括在第一反应条件下将甲硅烷基化试剂与羟基化二胺化合物混合以在第一溶液中形成产物，将产物与第一溶液分离，并在第二反应条件下将产物与丙烯酰氯混合 形成甲硅烷基保护的二丙烯酰胺化合物的第二溶液。

公开(公告)号：WO2013119936A2

公开(公告)日：2013-08-15

申请号：PCT/US2013/025328

申请日：2013-02-08

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： FONNUM, Geir ,  MODAHL, Grete ,  KJUS, Nini ,  MOLTEBERG, Astrid Evenroed ,  TRAN, Diem ,  AASERUD, Jo ,  GOKMEN, M. Talha ,  MENCHEN, Steven ,  FULLER, Carl ,  ANDRUZZI, Luisa ,  HINZ, Wolfgang ,  GREMYACHINSKIY, Dmitriy ,  LIGHT, David ,  MASTROIANNI, Alexander ,  ROSENBLUM, Barnett ,  KHAN, Shaheer ,  STOLARCZYK, Craig ,  SOKOLSKY, Tanya

IPC: C08F2/16 ,  C08F230/08

CPC classification number: C08F130/08 ,  C07F7/1852 ,  C07F7/188 ,  C08F2/20 ,  C08F2/26 ,  C08F6/24 ,  C08F8/12 ,  C08F8/32 ,  C08F8/34 ,  C08F220/58 ,  C08F222/385 ,  C08F230/08 ,  C08F2800/20 ,  C08J9/20 ,  C08J2343/04 ,  C12P19/34 ,  C12Q1/686 ,  C12Q1/6874 ,  G01N27/4145 ,  Y10T428/2982 ,  C08F257/02 ,  C08F2222/1013 ,  C08F212/36 ,  C08F220/60 ,  C12Q2563/149 ,  C12Q2563/159 ,  C12Q2565/543

Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.

Abstract translation: 形成颗粒的方法包括在水性悬浮液中的分散相中聚合具有疏水保护基团的亲水性单体的多个聚合单元，从而形成包含多个疏水保护基团的聚合物颗粒。 该方法还包括将聚合物颗粒转化为亲水性颗粒。

公开(公告)号：EP2812339A1

公开(公告)日：2014-12-17

申请号：EP13705888.9

申请日：2013-02-08

Applicant: Life Technologies Corporation

Inventor： KJUS, Nini ,  FONNUM, Geir ,  BRANCHAUD, Bruce ,  YING, Lai-Qiang ,  MENCHEN, Steven ,  GREMYACHINSKIY, Dmitriy ,  KANG, Hee Chol

IPC: C07F7/18 ,  C08F222/38

Abstract: A silyl protected diacrylamide compound is described. A method of forming such a compound includes mixing a silylation reagent with a hydroxylated diamine compound under first reactive conditions to form a product in a first solution, separating the product from the first solution, and mixing the product with acryloyl chloride under second reactive conditions in a second solution to form a silyl protected diacrylamide compound.

Abstract translation: 描述了甲硅烷基保护的二丙烯酰胺化合物。 形成这种化合物的方法包括在第一反应条件下将甲硅烷基化试剂与羟基化二胺化合物混合以在第一溶液中形成产物，从第一溶液中分离产物，并将产物与丙烯酰氯在第二反应条件下在 第二种形成甲硅烷基保护的二丙烯酰胺化合物的溶液。

公开(公告)号：EP3640254A1

公开(公告)日：2020-04-22

申请号：EP19201582.4

申请日：2013-02-08

Applicant: Life Technologies Corporation

Inventor： KJUS, Nini ,  FONNUM, Geir ,  BRANCHAUD, Bruce ,  YING, Lai-Qiang ,  MENCHEN, Steven ,  GREMYACHINSKIY, Dmitriy ,  KANG, Hee Chol

IPC: C07F7/18 ,  C08F222/38 ,  C08F220/58

Abstract: A silyl protected diacrylamide compound is described. A method of forming such a compound includes mixing a silylation reagent with a hydroxylated diamine compound under first reactive conditions to form a product in a first solution, separating the product from the first solution, and mixing the product with acryloyl chloride under second reactive conditions in a second solution to form a silyl protected diacrylamide compound.

公开(公告)号：EP4116338A1

公开(公告)日：2023-01-11

申请号：EP22192503.5

申请日：2013-02-08

Applicant: Life Technologies Corporation

Inventor： FONNUM, Geir ,  MODAHL, Grete ,  KJUS, Nini ,  MOLTEBERG, Astrid Evenroed ,  TRAN, Diem ,  AASERUD, Jo ,  GOKMEN, M. Talha ,  MENCHEN, Steven ,  FULLER, Carl ,  ANDRUZZI, Luisa ,  HINZ, Wolfgang ,  GREMYACHINSKIY, Dmitriy ,  LIGHT, David ,  MASTROIANNI, Alexander ,  ROSENBLUM, Barnett ,  KHAN, Shaheer ,  STOLARCZYK, Craig ,  SOKOLSKY, Tanya

IPC: C08F2/16 ,  C08F220/54 ,  C08F8/12 ,  C08F222/38 ,  C12Q1/68 ,  C09D5/00 ,  C08F2/20 ,  C08F2/26 ,  C08F230/08 ,  C08F257/02 ,  C08F220/58 ,  C08F220/60 ,  C08F8/34 ,  C08F130/08 ,  C07F7/18

Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.

公开(公告)号：EP2812339B1

公开(公告)日：2019-11-06

申请号：EP13705888.9

申请日：2013-02-08

Applicant: Life Technologies Corporation

Inventor： KJUS, Nini ,  FONNUM, Geir ,  BRANCHAUD, Bruce ,  YING, Lai-Qiang ,  MENCHEN, Steven ,  GREMYACHINSKIY, Dmitriy ,  KANG, Hee Chol

IPC: C08F220/58 ,  C08F230/08 ,  C08F236/20 ,  C08K3/20 ,  C07F7/18 ,  C08F222/38

公开(公告)号：EP2812360A2

公开(公告)日：2014-12-17

申请号：EP13706818.5

申请日：2013-02-08

Applicant: Life Technologies Corporation

Inventor： FONNUM, Geir ,  MODAHL, Grete ,  KJUS, Nini ,  MOLTEBERG, Astrid Evenroed ,  TRAN, Diem ,  AASERUD, Jo ,  GOKMEN, M. Talha ,  MENCHEN, Steven ,  FULLER, Carl ,  ANDRUZZI, Luisa ,  HINZ, Wolfgang ,  GREMYACHINSKIY, Dmitriy ,  LIGHT, David ,  MASTROIANNI, Alexander ,  ROSENBLUM, Barnett ,  KHAN, Shaheer ,  STOLARCZYK, Craig ,  SOKOLSKY, Tanya

IPC: C08F2/16 ,  C08F220/54 ,  C08F8/12 ,  C08F222/38 ,  C12Q1/68 ,  C08F2/20 ,  C08F2/26 ,  C08F230/08 ,  C08F257/02 ,  C08F220/58 ,  C08F220/60 ,  C08F8/34 ,  C08F130/08 ,  C07F7/18

CPC classification number: C08F130/08 ,  C07F7/1852 ,  C07F7/188 ,  C08F2/20 ,  C08F2/26 ,  C08F6/24 ,  C08F8/12 ,  C08F8/32 ,  C08F8/34 ,  C08F220/58 ,  C08F222/385 ,  C08F230/08 ,  C08F2800/20 ,  C08J9/20 ,  C08J2343/04 ,  C12P19/34 ,  C12Q1/686 ,  C12Q1/6874 ,  G01N27/4145 ,  Y10T428/2982 ,  C08F257/02 ,  C08F2222/1013 ,  C08F212/36 ,  C08F220/60 ,  C12Q2563/149 ,  C12Q2563/159 ,  C12Q2565/543

Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.