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    FLAT-FIELD IMAGING SYSTEM AND METHODS OF USE
    1.
    发明申请
    FLAT-FIELD IMAGING SYSTEM AND METHODS OF USE 审中-公开
    平面成像系统及其使用方法

    公开(公告)号：WO2012174142A1

    公开(公告)日：2012-12-20

    申请号：PCT/US2012/042290

    申请日：2012-06-13

    Applicant: LIFE TECHNOLOGIES CORPORATION ,  ANDERSEN, Mark ,  PALLAS, Michael ,  WANG, Haopeng

    Inventor： ANDERSEN, Mark ,  PALLAS, Michael ,  WANG, Haopeng

    IPC: C12Q1/68

    CPC classification number: G01N15/04 ,  C12Q1/6816 ,  C12Q2563/107 ,  C12Q2563/159 ,  C12Q2565/607 ,  C12Q2565/629

    Abstract: A method of aligning a plurality of targets is provided. The method includes generating a plurality of targets. A third phase includes the plurality of targets. The method further includes combining a first phase, a second phase, and the third phase in a volume. The first phase, the second phase, and the third phase are substantially immiscible, and the third phase is in fluid communication with the first phase and the second phase, and the first phase, the second phase, and the third phase are operable to be in a configuration of the third phase between the first phase and the second phase in the volume.

    Abstract translation: 提供了一种对齐多个目标的方法。 该方法包括生成多个目标。 第三阶段包括多个目标。 该方法还包括组合体积中的第一阶段，第二阶段和第三阶段。 第一相，第二相和第三相基本上是不混溶的，第三相与第一相和第二相流体连通，第一相，第二相和第三相可操作为 在体积中的第一相和第二相之间的第三相的配置。

    SYSTEMS AND METHODS FOR CONTAINING BIOLOGICAL SAMPLES
    2.
    发明申请
    SYSTEMS AND METHODS FOR CONTAINING BIOLOGICAL SAMPLES 审中-公开
    包含生物样品的系统和方法

    公开(公告)号：WO2013138706A2

    公开(公告)日：2013-09-19

    申请号：PCT/US2013/032002

    申请日：2013-03-15

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： PALLAS, Michael ,  NURSE, James C. ,  MAHER, Kevin ,  FONSECA, Jorge ,  GHENCIU, Eliodor ,  FOSTER, Evan

    IPC: B01L3/00

    CPC classification number: B01L3/50857 ,  B01L3/50 ,  B01L3/50851 ,  B01L2200/141 ,  B01L2300/0893 ,  B01L2300/0896 ,  B01L2300/161 ,  C12Q1/6806 ,  C12Q1/686 ,  G03F7/2002

    Abstract: An article for holding a plurality of biological samples includes a substrate a substrate comprising a first surface and an opposing second surface and a plurality of reaction sites in the substrate. Each of the reaction sites extends from an opening in the first surface to an opening in the second surface. The reaction sites comprise a hexagonal shape and are configured to provide sufficient surface tension by capillary action to hold respective biological samples. The reaction sites have a density over at least a portion of the surfaces that is at least 170 holes per square millimeter. At least one of the surfaces may have a surface roughness characterized by an arithmetic average roughness (Ra) that is less than or equal to 5 nanometers.

    Abstract translation: 用于保持多个生物样品的制品包括基底，该基底包括基底中的第一表面和相对的第二表面和多个反应位点。 每个反应位置从第一表面中的开口延伸到第二表面中的开口。 反应位点包括六边形形状，并且构造成通过毛细作用提供足够的表面张力以保持各自的生物样品。 反应位点的表面密度至少在每平方毫米170个孔以上。 至少一个表面可以具有由小于或等于5纳米的算术平均粗糙度（Ra）表征的表面粗糙度。

    CASE AND CASE HOLDER FOR BIOLOGICAL SAMPLES AND CORRESPONDING METHOD OF USE
    3.
    发明申请
    CASE AND CASE HOLDER FOR BIOLOGICAL SAMPLES AND CORRESPONDING METHOD OF USE 审中-公开
    用于生物样本的案例和案例持有人和相应的使用方法

    公开(公告)号：WO2014190357A1

    公开(公告)日：2014-11-27

    申请号：PCT/US2014/039623

    申请日：2014-05-27

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： PALLAS, Michael ,  FOSTER, Evan ,  FONSECA, Jorge ,  NURSE, James ,  STRAUB, Theodore

    IPC: B01L3/00

    CPC classification number: B01L3/50851 ,  B01L3/50857 ,  B01L7/52 ,  B01L9/523 ,  B01L2200/0673 ,  B01L2200/0684 ,  B01L2200/141 ,  B01L2300/0609 ,  B01L2300/0819 ,  B01L2300/0822 ,  B01L2300/0829 ,  B01L2300/0893 ,  B01L2300/18 ,  C12Q1/686 ,  G01N21/6452

    Abstract: A system for processing a plurality of biological samples contains a support and a temperature controller. The support is configured to hold a case that includes an inner chamber and a substrate located within the inner chamber, the substrate containing a plurality of isolated reaction sites containing one or more biological samples. The temperature controller is configured to maintain or control a temperature of at least one of the support, the case, or the one or more biological samples during an assay or reaction on the one or more biological samples. The support is also configured to maintain at least one of the surfaces of substrate at a positive angle relative to a horizontal plane during the assay or reaction.

    Abstract translation: 用于处理多个生物样品的系统包含支架和温度控制器。 支撑件被构造成保持壳体，该壳体包括位于内室内的内室和基板，所述基板包含多个包含一个或多个生物样品的分离的反应位点。 温度控制器被配置为在一个或多个生物样品的测定或反应过程中维持或控制至少一种载体，壳体或一种或多种生物样品的温度。 支撑体还被配置为在测定或反应期间相对于水平面保持基板的至少一个表面为正角度。

    CASE AND CASE HOLDER FOR BIOLOGICAL SAMPLES AND CORRESPONDING METHOD OF USE
    5.
    发明公开
    CASE AND CASE HOLDER FOR BIOLOGICAL SAMPLES AND CORRESPONDING METHOD OF USE 审中-公开
    住房和住房支持的生物样品和使用相关方法

    公开(公告)号：EP3003558A1

    公开(公告)日：2016-04-13

    申请号：EP14733021.1

    申请日：2014-05-27

    Applicant: Life Technologies Corporation

    Inventor： PALLAS, Michael ,  FOSTER, Evan ,  FONSECA, Jorge ,  NURSE, James ,  STRAUB, Theodore

    IPC: B01L3/00

    CPC classification number: B01L3/50851 ,  B01L3/50857 ,  B01L7/52 ,  B01L9/523 ,  B01L2200/0673 ,  B01L2200/0684 ,  B01L2200/141 ,  B01L2300/0609 ,  B01L2300/0819 ,  B01L2300/0822 ,  B01L2300/0829 ,  B01L2300/0893 ,  B01L2300/18 ,  C12Q1/686 ,  G01N21/6452

    Abstract: A system for processing a plurality of biological samples contains a support and a temperature controller. The support is configured to hold a case that includes an inner chamber and a substrate located within the inner chamber, the substrate containing a plurality of isolated reaction sites containing one or more biological samples. The temperature controller is configured to maintain or control a temperature of at least one of the support, the case, or the one or more biological samples during an assay or reaction on the one or more biological samples. The support is also configured to maintain at least one of the surfaces of substrate at a positive angle relative to a horizontal plane during the assay or reaction.

    Abstract translation: 一种用于处理生物样品的所述多个系统包含一个支撑和一个温度控制器。 支撑被构造为保持确实包括位于内部腔室的情况下，以及位于所述内室中的基质，包含含有一种或多种生物样品中分离的反应位点的多个基板。 温度控制器被配置为维持或上的一个或多个生物样品的测定或反应过程中控制支撑中的至少一个的情况下，或所述一种或多种生物样品的温度。 因此，该支撑件被配置以保持衬底的表面中的至少一个在正向相对水平面的测定或反应过程中的角度。

    FLAT-FIELD IMAGING SYSTEM AND METHODS OF USE
    7.
    发明公开
    FLAT-FIELD IMAGING SYSTEM AND METHODS OF USE 有权
    平板成像系统及其使用方法

    公开(公告)号：EP2721177A1

    公开(公告)日：2014-04-23

    申请号：EP12731806.1

    申请日：2012-06-13

    Applicant: Life Technologies Corporation

    Inventor： ANDERSEN, Mark ,  PALLAS, Michael ,  WANG, Haopeng

    IPC: C12Q1/68

    CPC classification number: G01N15/04 ,  C12Q1/6816 ,  C12Q2563/107 ,  C12Q2563/159 ,  C12Q2565/607 ,  C12Q2565/629

    Abstract: A method of aligning a plurality of targets is provided. The method includes generating a plurality of targets. A third phase includes the plurality of targets. The method further includes combining a first phase, a second phase, and the third phase in a volume. The first phase, the second phase, and the third phase are substantially immiscible, and the third phase is in fluid communication with the first phase and the second phase, and the first phase, the second phase, and the third phase are operable to be in a configuration of the third phase between the first phase and the second phase in the volume.

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