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    SYSTEMS AND METHODS FOR CONTAINING BIOLOGICAL SAMPLES
    1.
    发明申请
    SYSTEMS AND METHODS FOR CONTAINING BIOLOGICAL SAMPLES 审中-公开
    包含生物样品的系统和方法

    公开(公告)号：WO2013138706A2

    公开(公告)日：2013-09-19

    申请号：PCT/US2013/032002

    申请日：2013-03-15

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： PALLAS, Michael ,  NURSE, James C. ,  MAHER, Kevin ,  FONSECA, Jorge ,  GHENCIU, Eliodor ,  FOSTER, Evan

    IPC: B01L3/00

    CPC classification number: B01L3/50857 ,  B01L3/50 ,  B01L3/50851 ,  B01L2200/141 ,  B01L2300/0893 ,  B01L2300/0896 ,  B01L2300/161 ,  C12Q1/6806 ,  C12Q1/686 ,  G03F7/2002

    Abstract: An article for holding a plurality of biological samples includes a substrate a substrate comprising a first surface and an opposing second surface and a plurality of reaction sites in the substrate. Each of the reaction sites extends from an opening in the first surface to an opening in the second surface. The reaction sites comprise a hexagonal shape and are configured to provide sufficient surface tension by capillary action to hold respective biological samples. The reaction sites have a density over at least a portion of the surfaces that is at least 170 holes per square millimeter. At least one of the surfaces may have a surface roughness characterized by an arithmetic average roughness (Ra) that is less than or equal to 5 nanometers.

    Abstract translation: 用于保持多个生物样品的制品包括基底，该基底包括基底中的第一表面和相对的第二表面和多个反应位点。 每个反应位置从第一表面中的开口延伸到第二表面中的开口。 反应位点包括六边形形状，并且构造成通过毛细作用提供足够的表面张力以保持各自的生物样品。 反应位点的表面密度至少在每平方毫米170个孔以上。 至少一个表面可以具有由小于或等于5纳米的算术平均粗糙度（Ra）表征的表面粗糙度。

    SYSTEMS AND METHODS FOR BIOLOGICAL ANALYSIS
    2.
    发明申请
    SYSTEMS AND METHODS FOR BIOLOGICAL ANALYSIS 审中-公开
    生物分析系统与方法

    公开(公告)号：WO2013138767A1

    公开(公告)日：2013-09-19

    申请号：PCT/US2013/032420

    申请日：2013-03-15

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： PALLAS, Michael, C. ,  NURSE, James ,  LIM, Gary ,  STRAUB, Theodore ,  GHENCIU, Eliodor ,  FOSTER, Evan ,  FONSECA, Jorge ,  MAHER, Kevin

    IPC: B01L7/00 ,  C12Q1/68 ,  B01L3/00

    CPC classification number: B01L3/50857 ,  B01L3/50 ,  B01L3/50851 ,  B01L2200/141 ,  B01L2300/0893 ,  B01L2300/0896 ,  B01L2300/161 ,  C12Q1/6806 ,  C12Q1/686 ,  G03F7/2002

    Abstract: A system for performing biological reactions is provided. The system includes a chip including a substrate and a plurality of reaction sites. The plurality of reaction sites are each configured to include a liquid sample of at most one nanoliter. Further, the system includes a control system configured to initiate biological reactions within the liquid samples. The system further includes a detection system configured to detect biological reactions on the chip. According to various embodiments, the chip includes at least 20000 reaction sites. In other embodiments, the chip includes at least 30000 reaction sites.

    Abstract translation: 提供了用于进行生物反应的系统。 该系统包括包括基底和多个反应位点的芯片。 多个反应位点各自被配置为包括至多一个纳升级的液体样品。 此外，该系统包括被配置为启动液体样品内的生物反应的控制系统。 该系统还包括被配置为检测芯片上的生物反应的检测系统。 根据各种实施方案，该芯片包括至少20000个反应位点。 在其它实施方案中，芯片包括至少30000个反应位点。

    COATED SUBSTRATE FOR BIOLOGICAL REACTION SYSTEMS
    6.
    发明公开
    COATED SUBSTRATE FOR BIOLOGICAL REACTION SYSTEMS 审中-公开
    涂布底材对生物反应系统

    公开(公告)号：EP2825311A1

    公开(公告)日：2015-01-21

    申请号：EP13716895.1

    申请日：2013-03-15

    Applicant: Life Technologies Corporation

    Inventor： GHENCIU, Eliodor ,  FOSTER, Evan ,  STRAUB, Theodore ,  PALLAS, Michael C.

    IPC: B01L3/00 ,  C40B60/14 ,  B01L3/02

    Abstract: A sample loader for loading a liquid sample into a plurality of reaction sites within a substrate is provided. The sample loader includes a first blade, and a second blade coupled to the first blade. The sample loader further comprises a flow path between the first blade and second blade configured to dispense a liquid sample to a substrate including a plurality of reaction sites. Further, in various embodiments the liquid sample has an advancing contact angle of 85+/−15 degrees with the first and second blade. Furthermore, loading of the liquid sample dispensed from the flow path to the plurality of reaction sites may be based on capillary action.

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