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公开(公告)号：WO2012006084A3
公开(公告)日：2012-01-12
申请号：PCT/US2011/042176
申请日：2011-06-28
Applicant: LIFE TECHNOLOGIES CORPORATION , DANEHY, Ronald , FONSECA, Jorge , PRASAD, Jayanthi
Inventor： DANEHY, Ronald , FONSECA, Jorge , PRASAD, Jayanthi
Abstract: A system for preparing biological sample contains a body including a proximal side and a distal side, a plurality of mandrels, a plurality of resilient elements, a plurality of fluid dispensers, and one or more samples. The mandrels are moveably positioned within the body, where each resilient element engages a respective one of the mandrels. Each of the fluid dispensers is configured to engage a distal end of a corresponding one of the mandrels. Each sample comprises a solution containing one or more nucleic acid sequences contained within at least one of the fluid dispensers.
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2.发明申请
公开(公告)号：WO2014074740A1
公开(公告)日：2014-05-15
申请号：PCT/US2013/068995
申请日：2013-11-07
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： FONSECA, Jorge
CPC classification number: B01L3/50853 , B01L3/50857 , B01L9/52 , B01L2200/142 , B01L2300/0819 , B01L2300/0822 , B01L2300/0851 , B01L2300/0858 , B01L2300/0864 , B01L2300/161
Abstract: A case for containing biological samples includes a base, a substrate, and a cover. The substrate includes a plurality of reaction regions disposed along a surface of the substrate and configured to receive one or more biological samples. The cover includes a downward facing surface, is configured to be attached to the base to provide a cavity containing the substrate, and is configured so that the downward facing surface of the cover is parallel or approximately parallel to the substrate surface. The cover may comprise a fill port disposed along the inner surface and is configured for at least partially filling the cavity when the cover is attached to the base. The base may comprise a plurality of tabs located on an upward facing surface thereof, wherein the substrate is attached to the base by physical contact between at least some of the tabs and the substrate.
Abstract translation: 用于容纳生物样品的情况包括基底，基底和盖。 衬底包括沿着衬底的表面设置并被配置为接收一个或多个生物样品的多个反应区域。 盖子包括面向下的表面，被配置为附接到基座以提供容纳基底的空腔，并且被构造成使得盖的朝下的表面平行或大致平行于基底表面。 盖可以包括沿着内表面设置的填充口，并且构造成当盖附接到基座时至少部分地填充空腔。 底座可以包括位于其向上表面上的多个突片，其中通过至少一些突片和基底之间的物理接触将基底附接到基底。
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公开(公告)号：WO2019094973A1
公开(公告)日：2019-05-16
申请号：PCT/US2018/060840
申请日：2018-11-13
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： LI, Kelly , PAGANI, Ioanna , LI, Jisheng , PATEL, Sunali , VARMA, Kamini , FONSECA, Jorge , PURI, Nitin , DIAMOND, Evan
IPC: C12Q1/689
CPC classification number: C12Q1/689 , C12Q2600/16
Abstract: Various methods are disclosed for amplifying nucleic acid sequences in a nucleic acid sample. The methods involve forming at least five amplification reaction mixes each including an aliquot from a sample source that includes nucleic acid sequences, using at least five different assays each including a pair of amplification primers, the assays selected from the group of assays in Table 1and/or targeting the sequences specified in Table 1.
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公开(公告)号：WO2013138706A2
公开(公告)日：2013-09-19
申请号：PCT/US2013/032002
申请日：2013-03-15
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： PALLAS, Michael , NURSE, James C. , MAHER, Kevin , FONSECA, Jorge , GHENCIU, Eliodor , FOSTER, Evan
IPC: B01L3/00
CPC classification number: B01L3/50857 , B01L3/50 , B01L3/50851 , B01L2200/141 , B01L2300/0893 , B01L2300/0896 , B01L2300/161 , C12Q1/6806 , C12Q1/686 , G03F7/2002
Abstract: An article for holding a plurality of biological samples includes a substrate a substrate comprising a first surface and an opposing second surface and a plurality of reaction sites in the substrate. Each of the reaction sites extends from an opening in the first surface to an opening in the second surface. The reaction sites comprise a hexagonal shape and are configured to provide sufficient surface tension by capillary action to hold respective biological samples. The reaction sites have a density over at least a portion of the surfaces that is at least 170 holes per square millimeter. At least one of the surfaces may have a surface roughness characterized by an arithmetic average roughness (Ra) that is less than or equal to 5 nanometers.
Abstract translation: 用于保持多个生物样品的制品包括基底，该基底包括基底中的第一表面和相对的第二表面和多个反应位点。 每个反应位置从第一表面中的开口延伸到第二表面中的开口。 反应位点包括六边形形状，并且构造成通过毛细作用提供足够的表面张力以保持各自的生物样品。 反应位点的表面密度至少在每平方毫米170个孔以上。 至少一个表面可以具有由小于或等于5纳米的算术平均粗糙度（Ra）表征的表面粗糙度。
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公开(公告)号：WO2013049702A9
公开(公告)日：2013-04-04
申请号：PCT/US2012/058096
申请日：2012-09-28
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： FREUDENTHAL, Jacob K. , DAHLHOFF, Geoffrey , MAHER, Kevin , CHEN, Mingsong , LIM, Gary , DANEHY, Ronald , FORTESCUE, David , SHEN, Ming , SOH, Woon Liang Terence , CHENG, Francis , WU, Ruoyun , LEE, Thiam Chye , CHAPPELL, Gary , LIM, Chee Kiong , DERE, Jeff , STRAUB, Ted , FONSECA, Jorge , BOO, Kuan Moon , LAU, Soo Yong
Abstract: A biological analysis system is provided. The system comprises an interchangeable assembly configured to accommodate any one of a plurality of sample holders, each respective sample holder configured to receive a plurality of samples. The system also includes a control system configured to cycle the plurality of samples through a series of temperatures. The system further includes an optical system configured to detect fluorescent signals emitted from the plurality of samples. The optical system, in particular, can comprise a single field lens, an excitation source, an optical sensor, and a plurality of filter components. The excitation source can be one or more light emitting diodes. The field lens can be a bi-convex lens.
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Patent Agency Ranking6.发明申请CASE AND CASE HOLDER FOR BIOLOGICAL SAMPLES AND CORRESPONDING METHOD OF USE 审中-公开用于生物样本的案例和案例持有人和相应的使用方法
公开(公告)号：WO2014190357A1
公开(公告)日：2014-11-27
申请号：PCT/US2014/039623
申请日：2014-05-27
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： PALLAS, Michael , FOSTER, Evan , FONSECA, Jorge , NURSE, James , STRAUB, Theodore
IPC: B01L3/00
CPC classification number: B01L3/50851 , B01L3/50857 , B01L7/52 , B01L9/523 , B01L2200/0673 , B01L2200/0684 , B01L2200/141 , B01L2300/0609 , B01L2300/0819 , B01L2300/0822 , B01L2300/0829 , B01L2300/0893 , B01L2300/18 , C12Q1/686 , G01N21/6452
Abstract: A system for processing a plurality of biological samples contains a support and a temperature controller. The support is configured to hold a case that includes an inner chamber and a substrate located within the inner chamber, the substrate containing a plurality of isolated reaction sites containing one or more biological samples. The temperature controller is configured to maintain or control a temperature of at least one of the support, the case, or the one or more biological samples during an assay or reaction on the one or more biological samples. The support is also configured to maintain at least one of the surfaces of substrate at a positive angle relative to a horizontal plane during the assay or reaction.
Abstract translation: 用于处理多个生物样品的系统包含支架和温度控制器。 支撑件被构造成保持壳体，该壳体包括位于内室内的内室和基板，所述基板包含多个包含一个或多个生物样品的分离的反应位点。 温度控制器被配置为在一个或多个生物样品的测定或反应过程中维持或控制至少一种载体，壳体或一种或多种生物样品的温度。 支撑体还被配置为在测定或反应期间相对于水平面保持基板的至少一个表面为正角度。
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公开(公告)号：WO2013138767A1
公开(公告)日：2013-09-19
申请号：PCT/US2013/032420
申请日：2013-03-15
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： PALLAS, Michael, C. , NURSE, James , LIM, Gary , STRAUB, Theodore , GHENCIU, Eliodor , FOSTER, Evan , FONSECA, Jorge , MAHER, Kevin
CPC classification number: B01L3/50857 , B01L3/50 , B01L3/50851 , B01L2200/141 , B01L2300/0893 , B01L2300/0896 , B01L2300/161 , C12Q1/6806 , C12Q1/686 , G03F7/2002
Abstract: A system for performing biological reactions is provided. The system includes a chip including a substrate and a plurality of reaction sites. The plurality of reaction sites are each configured to include a liquid sample of at most one nanoliter. Further, the system includes a control system configured to initiate biological reactions within the liquid samples. The system further includes a detection system configured to detect biological reactions on the chip. According to various embodiments, the chip includes at least 20000 reaction sites. In other embodiments, the chip includes at least 30000 reaction sites.
Abstract translation: 提供了用于进行生物反应的系统。 该系统包括包括基底和多个反应位点的芯片。 多个反应位点各自被配置为包括至多一个纳升级的液体样品。 此外，该系统包括被配置为启动液体样品内的生物反应的控制系统。 该系统还包括被配置为检测芯片上的生物反应的检测系统。 根据各种实施方案，该芯片包括至少20000个反应位点。 在其它实施方案中，芯片包括至少30000个反应位点。
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公开(公告)号：EP2585834A2
公开(公告)日：2013-05-01
申请号：EP11804124.3
申请日：2011-06-28
Applicant: Life Technologies Corporation
Inventor： DANEHY, Ronald , FONSECA, Jorge , PRASAD, Jayanthi
CPC classification number: B01L3/56 , B01L3/0275 , B01L3/0293 , B01L2200/025 , B01L2300/161 , G01N35/1011 , G01N35/1074 , G01N2035/103
Abstract: A system for preparing biological sample contains a body including a proximal side and a distal side, a plurality of mandrels, a plurality of resilient elements, a plurality of fluid dispensers, and one or more samples. The mandrels are moveably positioned within the body, where each resilient element engages a respective one of the mandrels. Each of the fluid dispensers is configured to engage a distal end of a corresponding one of the mandrels. Each sample comprises a solution containing one or more nucleic acid sequences contained within at least one of the fluid dispensers.
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9.发明公开CASE AND CASE HOLDER FOR BIOLOGICAL SAMPLES AND CORRESPONDING METHOD OF USE 审中-公开住房和住房支持的生物样品和使用相关方法
公开(公告)号：EP3003558A1
公开(公告)日：2016-04-13
申请号：EP14733021.1
申请日：2014-05-27
Applicant: Life Technologies Corporation
Inventor： PALLAS, Michael , FOSTER, Evan , FONSECA, Jorge , NURSE, James , STRAUB, Theodore
IPC: B01L3/00
CPC classification number: B01L3/50851 , B01L3/50857 , B01L7/52 , B01L9/523 , B01L2200/0673 , B01L2200/0684 , B01L2200/141 , B01L2300/0609 , B01L2300/0819 , B01L2300/0822 , B01L2300/0829 , B01L2300/0893 , B01L2300/18 , C12Q1/686 , G01N21/6452
Abstract: A system for processing a plurality of biological samples contains a support and a temperature controller. The support is configured to hold a case that includes an inner chamber and a substrate located within the inner chamber, the substrate containing a plurality of isolated reaction sites containing one or more biological samples. The temperature controller is configured to maintain or control a temperature of at least one of the support, the case, or the one or more biological samples during an assay or reaction on the one or more biological samples. The support is also configured to maintain at least one of the surfaces of substrate at a positive angle relative to a horizontal plane during the assay or reaction.
Abstract translation: 一种用于处理生物样品的所述多个系统包含一个支撑和一个温度控制器。 支撑被构造为保持确实包括位于内部腔室的情况下，以及位于所述内室中的基质，包含含有一种或多种生物样品中分离的反应位点的多个基板。 温度控制器被配置为维持或上的一个或多个生物样品的测定或反应过程中控制支撑中的至少一个的情况下，或所述一种或多种生物样品的温度。 因此，该支撑件被配置以保持衬底的表面中的至少一个在正向相对水平面的测定或反应过程中的角度。
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公开(公告)号：EP2825314A1
公开(公告)日：2015-01-21
申请号：EP13713049.8
申请日：2013-03-15
Applicant: Life Technologies Corporation
Inventor： PALLAS, Michael, C. , NURSE, James , LIM,Gary , STRAUB, Theodore , GHENCIU, Eliodor , FOSTER, Evan , FONSECA, Jorge , MAHER, Kevin
CPC classification number: B01L3/50857 , B01L3/50 , B01L3/50851 , B01L2200/141 , B01L2300/0893 , B01L2300/0896 , B01L2300/161 , C12Q1/6806 , C12Q1/686 , G03F7/2002
Abstract: A system for performing biological reactions is provided. The system includes a chip including a substrate and a plurality of reaction sites. The plurality of reaction sites are each configured to include a liquid sample of at most one nanoliter. Further, the system includes a control system configured to initiate biological reactions within the liquid samples. The system further includes a detection system configured to detect biological reactions on the chip. According to various embodiments, the chip includes at least 20000 reaction sites. In other embodiments, the chip includes at least 30000 reaction sites.
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