公开(公告)号：WO2011009084A2

公开(公告)日：2011-01-20

申请号：PCT/US2010042340

申请日：2010-07-16

Applicant: VERTEX PHARMA ,  HENDERSON JAMES A ,  MAXWELL JOHN ,  VAILLANCOURT LOUIS ,  MORRIS MARK ,  GREY JR RONALD ,  GIROUX SIMON ,  KONG LAVAL CHAN CHUN ,  DAS SANJOY KUMAR ,  LIU BINGCAN ,  POISSON CARL ,  CADILHAC CAROLINE ,  BUBENIK MONICA ,  REDDY T JAGADEESWAR ,  FALARDEAU GUY ,  YANNOPOULOS CONSTANTIN ,  WANG JIAN ,  PEREIRA OSWY Z ,  BENNANI YOUSSEF L ,  PIERCE ALBERT C ,  BHISETTI GOVINDA RAO ,  COTTRELL KEVIN M ,  MARONE VALERIE

Inventor： HENDERSON JAMES A ,  MAXWELL JOHN ,  VAILLANCOURT LOUIS ,  MORRIS MARK ,  GREY JR RONALD ,  GIROUX SIMON ,  KONG LAVAL CHAN CHUN ,  DAS SANJOY KUMAR ,  LIU BINGCAN ,  POISSON CARL ,  CADILHAC CAROLINE ,  BUBENIK MONICA ,  REDDY T JAGADEESWAR ,  FALARDEAU GUY ,  YANNOPOULOS CONSTANTIN ,  WANG JIAN ,  PEREIRA OSWY Z ,  BENNANI YOUSSEF L ,  PIERCE ALBERT C ,  BHISETTI GOVINDA RAO ,  COTTRELL KEVIN M ,  MARONE VALERIE

IPC: C07D403/14 ,  A61K31/506

CPC classification number: C07K5/06052 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D407/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D495/04

Abstract: Compounds represented by formula (I) or pharmaceutically acceptable salts and solvates thereof, wherein A, B, B', X, Y, R1, R1 ', R2, R2', R3, R3', R5, R5', R6, m, n, or p are as defined herein, are useful for treating flaviviridae viral infections.

Abstract translation: 其中A，B，B'，X，Y，R1，R1'，R2，R2'，R3，R3'，R5，R5'，R6，m ，n或p如本文所定义，可用于治疗黄病毒科病毒感染。

公开(公告)号：NZ588700A

公开(公告)日：2012-07-27

申请号：NZ58870009

申请日：2009-04-14

Applicant: VERTEX PHARMA

Inventor： WANG TIANSHENG ,  ARONOV ALEXANDER ,  CORNEBISE MARK ,  MALTAIS FRANCOIS ,  LEDOBOER MARK ,  LE TIRAN ARNAUD ,  MARONE VALERIE ,  MESSERSMITH DAVID ,  COTTRELL KEVIN ,  COME JON H

IPC: C07D417/04 ,  A61K31/428 ,  A61K31/4365 ,  A61P37/00 ,  C07D513/04

Abstract: Provided are inhibitors of phosphatidylinositol 3-kinases with formula (I) as depicted, with defined substituents. The compounds are useful for lessening the severity of a disease or condition selected from an autoimmune disease or an inflammatory disease of the brain or spinal cord.

公开(公告)号：CA2767887A1

公开(公告)日：2011-01-20

申请号：CA2767887

申请日：2010-07-16

Applicant: VERTEX PHARMA

Inventor： HENDERSON JAMES A ,  MAXWELL JOHN ,  VAILLANCOURT LOUIS ,  MORRIS MARK ,  GREY RONALD JR ,  GIROUX SIMON ,  KONG LAVAL CHAN CHUN ,  DAS SANJOY KUMAR ,  LIU BINGCAN ,  POISSON CARL ,  CADILHAC CAROLINE ,  BUBENIK MONICA ,  REDDY T JAGADEESWAR ,  FALARDEAU GUY ,  YANNOPOULOS CONSTANTIN ,  WANG JIAN ,  PEREIRA OSWY Z ,  BENNANI YOUSSEF L ,  PIERCE ALBERT C ,  BHISETTI GOVINDA RAO ,  COTTRELL KEVIN M ,  MARONE VALERIE

IPC: C07D403/14 ,  A61K31/4184 ,  A61K31/506 ,  A61P3/00 ,  C07D407/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D495/04

Abstract: Compounds represented by formula (I) or pharmaceutically acceptable salts and solvates thereof, wherein A, B, B', X, Y, R1, R1 ', R2, R2', R3, R3', R5, R5', R6, m, n, or p are as defined herein, are useful for treating flaviviridae viral infections.

公开(公告)号：CA2753560A1

公开(公告)日：2010-11-25

申请号：CA2753560

申请日：2010-02-25

Applicant: VERTEX PHARMA

Inventor： ARONOV ALEX ,  COME JON ,  COTTRELL KEVIN ,  GREY RONALD ,  LE TIRAN AMAUD ,  MARONE VALERIE ,  MARTINEZ-BOTELLA GABRIEL ,  MESSERSMITH DAVID ,  HUCK EMILIE PORTER

IPC: C07D417/04 ,  A61K31/4427 ,  A61K31/4965 ,  A61K31/501 ,  A61K31/506 ,  A61P29/00 ,  A61P37/00 ,  C07D417/14 ,  C07D513/04

Abstract: The present invention relates to compounds useful as inhibitors of P13K, particularly of P13Kgamma. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of several diseases, such as cancer and autoimmune diseases.

公开(公告)号：CA2721434A1

公开(公告)日：2009-10-22

申请号：CA2721434

申请日：2009-04-14

Applicant: VERTEX PHARMA

Inventor： WANG TIANSHANG ,  ARONOV ALEXANDER ,  CORNEBISE MARK ,  MALTAIS FRANCOIS ,  LEDOBOER MARK ,  LE TIRAN ARNAUD ,  MARONE VALERIE ,  MESSERSMITH DAVID ,  COTTRELL KEVIN ,  COME JON H ,  BOTELA GABRIEL MARTINEZ

IPC: C07D417/04 ,  A61K31/428 ,  A61K31/4365 ,  A61P37/00 ,  C07D513/04

Abstract: The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3K ggr;. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

公开(公告)号：NO20084652A

公开(公告)日：2008-12-03

申请号：NO20084652

申请日：2008-11-05

Applicant: VERTEX PHARMA

Inventor： FORSTER CORNELIA J ,  CAO JINGRONG ,  PIERCE ALBERT ,  MALTAIS FRANCOIS ,  LEDEBOER MARK ,  MESSERSMITH DAVID ,  WANG TIANSHENG ,  GAO HUAI ,  MARTINEZ-BOTELLA GABRIEL ,  SALITURO FRANCESCO ,  FARMER LUC ,  WANNAMAKER MARION ,  DUFFY JOHN ,  MARONE VALERIE

IPC: C07D487/04

CPC classification number: C07D487/04

公开(公告)号：IN999DEN2012A

公开(公告)日：2015-04-10

申请号：IN999DEN2012

申请日：2012-02-03

Applicant: VERTEX PHARMA

Inventor： HENDERSON JAMES A ,  MAXWELL JOHN ,  VAILLANCOURT LOUIS ,  MORRIS MARK ,  GREY JR RONALD ,  GIROUX SIMON ,  KONG LAVAL CHAN CHUN ,  DAS SANJOY KUMAR ,  LIU BINGCAN ,  POISSON CARL ,  CADILHAC CAROLINE ,  BUBENIK MONICA ,  REDDY T JAGADEESWAR ,  FALARDEAU GUY ,  YANNOPOULOS CONSTANTIN ,  WANG JIAN ,  PEREIRA OSWY Z ,  BENNANI YOUSSEF L ,  PIERCE ALBERT C ,  BHISETTI GOVINDA RAO ,  COTTRELL KEVIN M ,  MARONE VALERIE

IPC: C07D401/14

Abstract: Compounds represented by formula (I) or pharmaceutically acceptable salts and solvates thereof, where A, B, B', X, Y, Rl', R2', R3', R5, R5', R6, m, n, or p are as defined herein, are useful for treating flaviviridae viral infections.

公开(公告)号：AU2009236380A1

公开(公告)日：2009-10-22

申请号：AU2009236380

申请日：2009-04-14

Applicant: VERTEX PHARMA

Inventor： TIRAN ARNAUD LE ,  LEDOBOER MARK ,  WANG TIANSHANG ,  MESSERSMITH DAVID ,  COTTRELL KEVIN ,  ARONOV ALEXANDER ,  MARONE VALERIE ,  MALTAIS FRANCOIS ,  CORNEBISE MARK ,  COME JON H ,  BOTELA GABRIEL MARTINEZ

IPC: C07D417/04 ,  A61K31/428 ,  A61K31/4365 ,  A61P37/00 ,  C07D513/04

Abstract: The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

公开(公告)号：CA2709710A1

公开(公告)日：2009-07-09

申请号：CA2709710

申请日：2008-12-18

Applicant: VERTEX PHARMA

Inventor： LEDEBOER MARK ,  STEWART MICHELLE ,  MESSERSMITH DAVID ,  DUFFY JOHN ,  MARTINEZ-BOTELLA GABRIEL ,  COME JON ,  GAO HUAI ,  SALITURO FRANCESCO ,  MARONE VALERIE ,  PIERCE ALBERT

IPC: C07D487/04 ,  A61K31/519 ,  A61P35/00

Abstract: The present invention relates to compounds of formula (I) useful as selective inhibitors of JAK2 kinase. The invention also provides pharmaceutical acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various diseases, conditions or disorders. The invention also provides processes for preparing the compounds of the invention.

公开(公告)号：AU2007235487A1

公开(公告)日：2007-10-18

申请号：AU2007235487

申请日：2007-04-05

Applicant: VERTEX PHARMA

Inventor： MESSERSMITH DAVID ,  FORSTER CORNELIA ,  MARTINEZ-BOTELLA GABRIEL ,  WANG TIANSHENG ,  MALTAIS FRANCOIS ,  SALITURO FRANCESCO ,  GAO HUAI ,  LEDEBOER MARK ,  FARMER LUC ,  DUFFY JOHN ,  WANNAMAKER MARION ,  CAO JINGRONG ,  PIERCE ALBERT ,  MARONE VALERIE

IPC: C07D487/04

Abstract: The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.