公开(公告)号：WO2005042497A3

公开(公告)日：2005-07-21

申请号：PCT/US2004036297

申请日：2004-10-28

Applicant: VERTEX PHARMA ,  WILSON DEAN M ,  TERMIN ANDREAS P ,  GONZALEZ JESUS E III ,  ZIMMERMANN NICOLE ,  ZHANG YULIAN ,  FANNING LEV T D

Inventor： WILSON DEAN M ,  TERMIN ANDREAS P ,  GONZALEZ JESUS E III ,  ZIMMERMANN NICOLE ,  ZHANG YULIAN ,  FANNING LEV T D

IPC: A61K31/33 ,  A61K31/415 ,  A61K31/4184 ,  A61K31/454 ,  C07D209/14 ,  C07D209/42 ,  C07D235/06 ,  C07D235/10 ,  C07D235/14 ,  C07D235/18 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12

CPC classification number: C07D405/12 ,  C04B35/632 ,  C07D209/42 ,  C07D235/14 ,  C07D235/18 ,  C07D401/04 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D409/12 ,  C07D413/12

Abstract: The present invention relates to compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein the , Z, Y, R , and W groups of formula I are as defined herein. The invention also provides pharmaceutically acceptable compositions and methods of suing the compositions in the treatment of various disorders.

Abstract translation: 本发明涉及式I的化合物：或其药学上可接受的盐，其中式I的R 1，Z，Y，R A和W基团如本文所定义。 本发明还提供了用于治疗各种病症的药学上可接受的组合物和方法。

公开(公告)号：WO2007146284A3

公开(公告)日：2008-04-03

申请号：PCT/US2007013776

申请日：2007-06-12

Applicant: VERTEX PHARMA ,  FANNING LEV T D ,  JOSHI PRAMOD ,  KRENITSKY PAUL ,  TERMIN ANDREAS ,  WILSON DEAN ,  ZHANG YULIAN

Inventor： FANNING LEV T D ,  JOSHI PRAMOD ,  KRENITSKY PAUL ,  TERMIN ANDREAS ,  WILSON DEAN ,  ZHANG YULIAN

IPC: A61K31/519 ,  A61P25/00

CPC classification number: C07D495/14 ,  C07D333/20 ,  C07D495/04

Abstract: The present invention relates to compounds of formula (I) useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

Abstract translation: 本发明涉及可用作离子通道抑制剂的式（I）化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。

公开(公告)号：NZ542664A

公开(公告)日：2009-03-31

申请号：NZ54266404

申请日：2004-03-03

Applicant: VERTEX PHARMA

Inventor： GONZALES JESUS E ,  WILSON DEAN MITCHELL ,  TERMIN ANDREAS PETER ,  GROOTENHUIS PETER DIEDERIK JAN ,  ZHANG YULIAN ,  PETZOLDT BENJAMIN JOHN ,  FANNING LEV TYLER DEWEY ,  NEUBERT TIMOTHY DONALD ,  TUNG ROGER D ,  MARTINBOROUGH ESTHER ,  ZIMMERMANN NICOLE

IPC: A61K31/517 ,  A61K31/5377 ,  A61K31/541 ,  C07D20060101 ,  C07D239/91 ,  C07D239/94 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/02 ,  C07D413/12 ,  C07D417/02 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04

Abstract: The disclosure relates to quinazoline compounds of formula (IA-ii) useful as inhibitors of voltage-gated sodium channels and calcium channels, wherein the variables are as defined in the specification. Also described are pharmaceutically acceptable compositions comprising the compounds of formula (I) and their use for the manufacture of a medicament for treating or lessening the severity of a disease, disorder, or condition selected from acute, chronic, neuropathic, or inflammatory pain, arthritis, migraine, cluster headaches, trigeminal neuralgia, herpetic neuralgia, general neuralgias, epilepsy or an epilepsy condition, a neurodegenerative disorder, a psychiatric disorders such as anxiety and depression, myotonia, arrhythmia, a movement disorder, a neuroendocrine disorder, ataxia, multiple sclerosis, irritable bowel syndrome, or incontinence.

公开(公告)号：MX2008015908A

公开(公告)日：2009-01-28

申请号：MX2008015908

申请日：2007-06-12

Applicant: VERTEX PHARMA

Inventor： JOSHI PRAMOD ,  KRENITSKY PAUL ,  WILSON DEAN ,  TERMIN ANDREAS ,  FANNING LEV T D ,  ZHANG YULIAN

IPC: A61K31/519 ,  A61P25/00

Abstract: La presente invención se refiere a compuestos de utilidad como inhibidores de canales iónicos. La invención también provee composiciones farmacéuticamente aceptables que comprenden los compuestos de la invención y métodos de uso de las composiciones en el tratamiento de diversos trastornos.

公开(公告)号：NO20061080L

公开(公告)日：2006-04-19

申请号：NO20061080

申请日：2006-03-06

Applicant: VERTEX PHARMA

Inventor： GONZALES III JESUS E ,  WILSON DEAN MIRCHELL ,  ZHANG YULIAN ,  NEUBERT TIMOTHY DONALD ,  MARTINBOROUGH ESTHER ,  ZIMMERMANN NICOLE ,  TERMIN ANDREAS PETER ,  WANG JIAN

IPC: C07D239/94 ,  A61K31/517 ,  A61K31/5377 ,  A61P25/00 ,  A61P29/00 ,  C07D239/70 ,  C07D239/91 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D405/12 ,  C07D413/02 ,  C07D471/04 ,  C07D495/04

Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

公开(公告)号：AU2004217891A1

公开(公告)日：2004-09-16

申请号：AU2004217891

申请日：2004-03-03

Applicant: VERTEX PHARMA

Inventor： FANNING LEV TYLER DEWEY ,  TUNG ROGER D ,  ZHANG YULIAN ,  GONZALES JESUS E III ,  TERMIN ANDREAS PETER ,  NEUBERT TIMOTHY DONALD ,  MARTINBOROUGH ESTHER ,  PETZOLDT BENJAMIN JOHN ,  GROOTENHUIS PETER DIEDERIK JAN ,  WILSON DEAN MITCHELL ,  ZIMMERMANN NICOLE

IPC: A61K31/517 ,  A61K31/5377 ,  A61K31/541 ,  C07D20060101 ,  C07D239/91 ,  C07D239/94 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/02 ,  C07D413/12 ,  C07D417/02 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04

Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

公开(公告)号：DE602004024873D1

公开(公告)日：2010-02-11

申请号：DE602004024873

申请日：2004-03-03

Applicant: VERTEX PHARMA

Inventor： GONZALES JESUS E ,  WILSON DEAN MITCHELL ,  TERMIN ANDREAS PETER ,  GROOTENHUIS PETER DIEDERIK ,  ZHANG YULIAN ,  PETZOLDT BENJAMIN JOHN ,  FANNING LEV TYLER ,  NEUBERT TIMOTHY DONALD ,  TUNG ROGER D ,  MARTINBOROUGH ESTHER ,  ZIMMERMANN NICOLE

IPC: C07D239/94 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/541 ,  C07D20060101 ,  C07D239/91 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/02 ,  C07D413/12 ,  C07D417/02 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04

Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

公开(公告)号：AU2007258313A1

公开(公告)日：2007-12-21

申请号：AU2007258313

申请日：2007-06-12

Applicant: VERTEX PHARMA

Inventor： JOSHI PRAMOD ,  KRENITSKY PAUL ,  ZHANG YULIAN ,  FANNING LEV T D ,  WILSON DEAN ,  TERMIN ANDREAS

IPC: A61K31/519 ,  A61P25/00

Abstract: The present invention relates to compounds of formula IA-i useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

公开(公告)号：BRPI0408026A

公开(公告)日：2006-02-07

申请号：BRPI0408026

申请日：2004-03-03

Applicant: VERTEX PHARMA

Inventor： GONZALES JESUS E III ,  WILSON DEAN MITCHELL ,  TERMIN ANDREAS PETER ,  GROOTENHUIS PETER DIEDERIK JAN ,  ZHANG YULIAN ,  PETZOLDT BENJAMIN JOHN ,  FANNING LEV TYLER DEWEY ,  NEUBERT TIMOTHY DONALD ,  TUNG ROGER D ,  MARTINBOROUGH ESTHER ,  ZIMMERMANN NICOLE

IPC: A61K31/517 ,  A61K31/5377 ,  A61K31/541 ,  C07D20060101 ,  C07D239/91 ,  C07D239/94 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/02 ,  C07D413/12 ,  C07D417/02 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04

Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

公开(公告)号：CA2543918A1

公开(公告)日：2005-05-12

申请号：CA2543918

申请日：2004-10-28

Applicant: VERTEX PHARMA

Inventor： WILSON DEAN M ,  TERMIN ANDREAS P ,  ZHANG YULIAN ,  FANNING LEV T D ,  ZIMMERMANN NICOLE ,  GONZALEZ JESUS E III

IPC: C07D235/06 ,  A61K31/33 ,  A61K31/415 ,  A61K31/4184 ,  A61K31/454 ,  C07D209/14 ,  C07D209/42 ,  C07D235/10 ,  C07D235/14 ,  C07D235/18 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12

Abstract: The present invention relates to compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein the R1, Z, Y, RA, and W groups of formula I are as defined herein. The invention also provides pharmaceutically acceptable compositions and methods of using the compositions in the treatment of various disorders.