公开(公告)号：CA2721434A1

公开(公告)日：2009-10-22

申请号：CA2721434

申请日：2009-04-14

Applicant: VERTEX PHARMA

Inventor： WANG TIANSHANG ,  ARONOV ALEXANDER ,  CORNEBISE MARK ,  MALTAIS FRANCOIS ,  LEDOBOER MARK ,  LE TIRAN ARNAUD ,  MARONE VALERIE ,  MESSERSMITH DAVID ,  COTTRELL KEVIN ,  COME JON H ,  BOTELA GABRIEL MARTINEZ

IPC: C07D417/04 ,  A61K31/428 ,  A61K31/4365 ,  A61P37/00 ,  C07D513/04

Abstract: The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3K ggr;. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

公开(公告)号：AU2009236380A1

公开(公告)日：2009-10-22

申请号：AU2009236380

申请日：2009-04-14

Applicant: VERTEX PHARMA

Inventor： TIRAN ARNAUD LE ,  LEDOBOER MARK ,  WANG TIANSHANG ,  MESSERSMITH DAVID ,  COTTRELL KEVIN ,  ARONOV ALEXANDER ,  MARONE VALERIE ,  MALTAIS FRANCOIS ,  CORNEBISE MARK ,  COME JON H ,  BOTELA GABRIEL MARTINEZ

IPC: C07D417/04 ,  A61K31/428 ,  A61K31/4365 ,  A61P37/00 ,  C07D513/04

Abstract: The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

公开(公告)号：MX2010011370A

公开(公告)日：2010-12-15

申请号：MX2010011370

申请日：2009-04-14

Applicant: VERTEX PHARMA

Inventor： MESSERSMITH DAVID ,  CORNEBISE MARK ,  TIRAN ARNAUD LE ,  ARONOV ALEXANDER ,  WANG TIANSHENG ,  MARONE VALERIE ,  COTTRELL KEVIN ,  MALTAIS FRANCOIS ,  LEDOBOER MARK ,  COME JON H ,  BOTELA GABRIEL MARTINEZ

IPC: C07D417/04 ,  A61K31/428 ,  A61K31/4365 ,  A61P37/00 ,  C07D513/04

Abstract: La presente invención se refiere a compuestos útiles como inhibidores de PI3K, particularmente de PI3K ggr. La invención también proporciona composiciones farmacéuticamente aceptables que comprenden los compuestos y métodos para usar las composiciones en el tratamiento de varias enfermedades, afecciones, o trastornos.

公开(公告)号：NZ588700A

公开(公告)日：2012-07-27

申请号：NZ58870009

申请日：2009-04-14

Applicant: VERTEX PHARMA

Inventor： WANG TIANSHENG ,  ARONOV ALEXANDER ,  CORNEBISE MARK ,  MALTAIS FRANCOIS ,  LEDOBOER MARK ,  LE TIRAN ARNAUD ,  MARONE VALERIE ,  MESSERSMITH DAVID ,  COTTRELL KEVIN ,  COME JON H

IPC: C07D417/04 ,  A61K31/428 ,  A61K31/4365 ,  A61P37/00 ,  C07D513/04

Abstract: Provided are inhibitors of phosphatidylinositol 3-kinases with formula (I) as depicted, with defined substituents. The compounds are useful for lessening the severity of a disease or condition selected from an autoimmune disease or an inflammatory disease of the brain or spinal cord.