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1.发明申请
公开(公告)号：WO2004046120A3
公开(公告)日：2004-08-12
申请号：PCT/US0336849
申请日：2003-11-17
Applicant: VERTEX PHARMA , PIERCE ALBERT C , ARNOST MICHAEL , DAVIES ROBERT J , FORSTER CORNELIA J , GALULLO VINCENT , GREY RONALD , LEDEBOER MARK , TIAN SHI-KAI , XU JINWANG , BINCH HAYLEY , LEDFORD BRIAN , MESSERSMITH DAVID , NANTHAKUMAR SUGANTHI , JAYARAJ ANDREW
Inventor： PIERCE ALBERT C , ARNOST MICHAEL , DAVIES ROBERT J , FORSTER CORNELIA J , GALULLO VINCENT , GREY RONALD , LEDEBOER MARK , TIAN SHI-KAI , XU JINWANG , BINCH HAYLEY , LEDFORD BRIAN , MESSERSMITH DAVID , NANTHAKUMAR SUGANTHI , JAYARAJ ANDREW
IPC: A61K31/4196 , A61K31/5377 , A61K31/541 , A61K31/55 , C07D249/10 , C07D249/14 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/02 , C07D417/02 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/14 , C07D487/04 , C07D495/04 , A61K31/41 , C07D498/04 , C07D513/04
CPC classification number: C07D401/04 , C07D249/10 , C07D249/14 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/14 , C07D487/04 , C07D495/04
Abstract: The present invention relates to inhibitors of protein kinases of formula I. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
Abstract translation: 本发明涉及式I的蛋白激酶抑制剂。本发明还提供包含本发明化合物的药物组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：WO2011041634A8
公开(公告)日：2011-12-29
申请号：PCT/US2010051053
申请日：2010-10-01
Applicant: VERTEX PHARMA , MESSERSMITH DAVID , ARONOV ALEX , LAUFFER DAVID J , GRILLOT ANNE-LAURE , DAVIES ROBERT J
Inventor： MESSERSMITH DAVID , ARONOV ALEX , LAUFFER DAVID J , GRILLOT ANNE-LAURE , DAVIES ROBERT J
IPC: C07D401/08 , A61K31/4439 , A61K31/4965 , A61P25/28 , A61P37/00 , C07D401/14 , C07D403/08
CPC classification number: C07D401/08 , C07D401/14 , C07D403/08
Abstract: The present invention relates to compounds useful as inhibitors of P13K, particularly of P13K?. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
Abstract translation: 本发明涉及可用作P13K抑制剂，特别是P13Kα的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：SG181917A1
公开(公告)日：2012-08-30
申请号：SG2012046884
申请日：2010-12-21
Applicant: VERTEX PHARMA
Inventor： ARONOV ALEX , COME JON H , DAVIES ROBERT J , PIERCE ALBERT C , WANG JIAN , NANTHAKUMAR SUGANTHINI , CAO JINGRONG , BANDARAGE UPUL K , KRUEGER ELAINE , TIRAN AMAUD LE , LIAO YUSHENG , MESSERSMITH DAVID , COLLIER PHILIP N , GREY RONALD , O'DOWD HARDWIN , HENDERSON JAMES A , GRILLOT ANNE-LAURE
Abstract: The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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公开(公告)号：NZ588700A
公开(公告)日：2012-07-27
申请号：NZ58870009
申请日：2009-04-14
Applicant: VERTEX PHARMA
Inventor： WANG TIANSHENG , ARONOV ALEXANDER , CORNEBISE MARK , MALTAIS FRANCOIS , LEDOBOER MARK , LE TIRAN ARNAUD , MARONE VALERIE , MESSERSMITH DAVID , COTTRELL KEVIN , COME JON H
IPC: C07D417/04 , A61K31/428 , A61K31/4365 , A61P37/00 , C07D513/04
Abstract: Provided are inhibitors of phosphatidylinositol 3-kinases with formula (I) as depicted, with defined substituents. The compounds are useful for lessening the severity of a disease or condition selected from an autoimmune disease or an inflammatory disease of the brain or spinal cord.
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公开(公告)号：AU2010341573A1
公开(公告)日：2012-07-19
申请号：AU2010341573
申请日：2010-12-21
Applicant: VERTEX PHARMA
Inventor： ARONOV ALEX , COME JON H , DAVIES ROBERT J , PIERCE ALBERT C , WANG JIAN , NANTHAKUMAR SUGANTHINI , CAO JINGRONG , BANDARAGE UPUL K , KRUEGER ELAINE , TIRAN AMAUD LE , LIAO YUSHENG , MESSERSMITH DAVID , COLLIER PHILIP N , GREY RONALD , O'DOWD HARDWIN , HENDERSON JAMES A , GRILLOT ANNE-LAURE
IPC: C07D401/04 , A61K31/352 , A61K31/424 , A61K31/429 , A61P9/00 , A61P29/00 , A61P37/00 , C07D401/14 , C07D405/14 , C07D417/14 , C07D471/04 , C07D471/20 , C07D491/20
Abstract: The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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Patent Agency Ranking
公开(公告)号：MX2011013032A
公开(公告)日：2012-02-08
申请号：MX2011013032
申请日：2010-06-09
Applicant: VERTEX PHARMA
Inventor： CAO JINGRONG , DAVIES ROBERT J , MESSERSMITH DAVID , BANDARAGE UPUL K , COME JON H , ARONOV ALEX , COTTRELL KEVIN MICHAEL , XU JINGWANG
IPC: C07D417/06 , A61K31/427 , A61P25/00
Abstract: La presente invención se refiere a compuestos útiles como inhibidores de PBK, particularmente de PBKy. La invención también proporciona composiciones farmacéuticamente aceptables que comprenden los compuestos y métodos para usar las composiciones en el tratamiento de varias enfermedades, afecciones, o trastornos.
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公开(公告)号：MX2011008645A
公开(公告)日：2011-09-30
申请号：MX2011008645
申请日：2010-02-16
Applicant: VERTEX PHARMA
Inventor： DAVIES ROBERT , LEDEBOER MARK , LIAO YUSHENG , XU JINWANG , LEDFORD BRIAN , MESSERSMITH DAVID , TIRAN ARNAUD LE , WANG TIANSHENG , COTTRELL KEVIN , ARONOV ALEX , BANDARAGE UPUL KEERTHI , KRUEGER ELAINE
IPC: C07D513/04 , A61K31/4365 , A61P25/00
Abstract: La presente invención se refiere a los compuestos (I) útiles como inhibidores de PI3K, particularmente de PI3KY. La invención también proporciona composiciones farmacéuticamente aceptables que comprenden los compuestos y métodos para el uso de las composiciones en el tratamiento de diversas enfermedades, afecciones o trastornos.
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公开(公告)号：CA2752596A1
公开(公告)日：2010-08-26
申请号：CA2752596
申请日：2010-02-16
Applicant: VERTEX PHARMA
Inventor： ARONOV ALEX , BANDARAGE UPUL KEERTHI , COTTRELL KEVIN , DAVIES ROBERT , KRUEGER ELAINE , LEDEBOER MARK , LEDFORD BRIAN , LE TIRAN ARNAUD , LIAO YUSHENG , MESSERSMITH DAVID , WANG TIANSHENG , XU JINWANG
IPC: C07D513/04 , A61K31/4365 , A61P25/00
Abstract: The present invention relates to compounds (I) useful as inhibitors of PBK, particularly of PI3K?. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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公开(公告)号：AU2003294329B2
公开(公告)日：2010-04-29
申请号：AU2003294329
申请日：2003-11-17
Applicant: VERTEX PHARMA
Inventor： FORSTER CORNELIA J , JAYARAJ ANDREW , LEDEBOER MARK , PIERCE ALBERT C , DAVIES ROBERT J , BINCH HAYLEY , LEDFORD BRIAN , GREY RONALD , ARNOST MICHAEL , XU JINWANG , MESSERSMITH DAVID , GALULLO VINCENT , NANTHAKUMAR SUGANTHI , TIAN SHI-KAI
IPC: C07D249/14 , A61K31/4196 , A61K31/5377 , A61K31/541 , A61K31/55 , C07D249/10 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/02 , C07D417/02 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/14 , C07D487/04 , C07D495/04
Abstract: The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
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公开(公告)号：AT425160T
公开(公告)日：2009-03-15
申请号：AT03814019
申请日：2003-12-17
Applicant: VERTEX PHARMA
Inventor： LEDEBOER MARK , DAVIES ROBERT , MESSERSMITH DAVID , MOON YOUNG-CHOON , MULLICAN MICHAEL
IPC: C07D413/14 , A61K31/4745 , A61K31/506 , A61K31/519 , C07D413/02 , C07D413/04 , C07D417/14 , C07D491/02
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