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公开(公告)号：PL3203840T3
公开(公告)日：2021-01-11
申请号：PL15849396
申请日：2015-10-06
Applicant: VERTEX PHARMA
Inventor： MILLER MARK THOMAS , ANDERSON COREY , ARUMUGAM VIJAYALAKSMI , BEAR BRIAN RICHARD , BINCH HAYLEY MARIE , CLEMENS JEREMY J , CLEVELAND THOMAS , CONROY ERICA , COON TIMOTHY RICHARD , FRIEMAN BRYAN A , GROOTENHUIS PETER DIEDERIK JAN , GROSS RAYMOND STANLEY , HADIDA-RUAH SARA SABINA , KHATUYA HARIPADA , JOSHI PRAMOD VIRUPAX , KRENITSKY PAUL JOHN , LIN CHUN-CHIEH , MARELIUS GULIN ERDOGAN , MELILLO VITO , MCCARTNEY JASON , NICHOLLS GEORGIA MCGAUGHEY , PIERRE FABRICE JEAN DENIS , SILINA ALINA , TERMIN ANDREAS P , UY JOHNNY , ZHOU JINGLAN
IPC: A01N41/06 , A61K31/18 , C07D209/18 , C07D209/49 , C07D213/64 , C07D213/73 , C07D231/20 , C07D235/24 , C07D239/34 , C07D401/04 , C07D403/10 , C07D403/12 , C07D407/12 , C07D413/14
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公开(公告)号：RS60906B1
公开(公告)日：2020-11-30
申请号：RSP20201210
申请日：2015-10-06
Applicant: VERTEX PHARMA
Inventor： MILLER MARK THOMAS , ANDERSON COREY , ARUMUGAM VIJAYALAKSMI , BEAR BRIAN RICHARD , BINCH HAYLEY MARIE , CLEMENS JEREMY J , CLEVELAND THOMAS , CONROY ERICA , COON TIMOTHY RICHARD , FRIEMAN BRYAN A , GROOTENHUIS PETER DIEDERIK JAN , GROSS RAYMOND STANLEY , HADIDA-RUAH SARA SABINA , KHATUYA HARIPADA , JOSHI PRAMOD VIRUPAX , KRENITSKY PAUL JOHN , LIN CHUN-CHIEH , MARELIUS GULIN ERDOGAN , MELILLO VITO , MCCARTNEY JASON , NICHOLLS GEORGIA MCGAUGHEY , PIERRE FABRICE JEAN DENIS , SILINA ALINA , TERMIN ANDREAS P , UY JOHNNY , ZHOU JINGLAN
IPC: A01N41/06 , A61K31/18 , C07D209/18 , C07D209/49 , C07D213/64 , C07D213/73 , C07D231/20 , C07D235/24 , C07D239/34 , C07D401/04 , C07D403/10 , C07D403/12 , C07D407/12 , C07D413/14
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公开(公告)号：AU2020220185A1
公开(公告)日：2020-09-10
申请号：AU2020220185
申请日：2020-08-21
Applicant: VERTEX PHARMA
Inventor： MILLER MARK THOMAS , ANDERSON COREY , ARUMUGAM VIJAYALAKSMI , BEAR BRIAN RICHARD , BINCH HAYLEY MARIE , CLEMENS JEREMY J , CLEVELAND THOMAS , CONROY ERICA , COON TIMOTHY RICHARD , FRIEMAN BRYAN A , GROOTENHUIS PETER DIEDERIK JAN , GROSS RAYMOND STANLEY , HADIDA-RUAH SARA SABINA , KHATUYA HARIPADA , JOSHI PRAMOD VIRUPAX , KRENITSKY PAUL JOHN , LIN CHUN-CHIEH , MARELIUS GULIN ERDOGAN , MELILLO VITO , MCCARTNEY JASON , NICHOLLS GEORGIA MCGAUGHEY , PIERRE FABRICE JEAN DENIS , SILINA ALINA , TERMIN ANDREAS P , UY JOHNNY , ZHOU JINGLAN
IPC: C07D209/18 , A01N41/06 , A61K31/18
Abstract: The present invention features a compound of formula (I): W OZ, x z' (R1)n A B (R2)p (Y)0 C (R3)q (1) or a pharmaceutically acceptable salt thereof, where R 1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.
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公开(公告)号：HRP20201603T1
公开(公告)日：2021-02-19
申请号：HRP20201603
申请日：2020-10-07
Applicant: VERTEX PHARMA
Inventor： MILLER MARK THOMAS , ANDERSON COREY , ARUMUGAM VIJAYALAKSMI , BEAR BRIAN RICHARD , BINCH HAYLEY MARIE , CLEMENS JEREMY J , CLEVELAND THOMAS , CONROY ERICA , COON TIMOTHY RICHARD , FRIEMAN BRYAN A , GROOTENHUIS PETER DIEDERIK JAN , GROSS RAYMOND STANLEY , HADIDA-RUAH SARA SABINA , KHATUYA HARIPADA , JOSHI PRAMOD VIRUPAX , KRENITSKY PAUL JOHN , LIN CHUN-CHIEH , MARELIUS GULIN ERDOGAN , MELILLO VITO , MCCARTNEY JASON , NICHOLLS GEORGIA MCGAUGHEY , PIERRE FABRICE JEAN DENIS , SILINA ALINA , TERMIN ANDREAS P , UY JOHNNY , ZHOU JINGLAN
IPC: A01N41/06 , A61K31/18 , C07D209/18 , C07D209/49 , C07D213/64 , C07D213/73 , C07D231/20 , C07D235/24 , C07D239/34 , C07D401/04 , C07D403/10 , C07D403/12 , C07D407/12 , C07D413/14
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公开(公告)号：MA41051B1
公开(公告)日：2020-11-30
申请号：MA41051
申请日：2015-10-06
Applicant: VERTEX PHARMA
Inventor： MILLER MARK THOMAS , ANDERSON COREY , ARUMUGAM VIJAYALAKSMI , BEAR BRIAN RICHARD , BINCH HAYLEY MARIE , CLEMENS JEREMY J , CLEVELAND THOMAS , CONROY ERICA , COON TIMOTHY RICHARD , FRIEMAN BRYAN A , GROOTENHUIS PETER DIEDERIK JAN , GROSS RAYMOND STANLEY , HADIDA-RUAH SARA SABINA , KHATUYA HARIPADA , JOSHI PRAMOD VIRUPAX , KRENITSKY PAUL JOHN , LIN CHUN-CHIEH , MARELIUS GULIN ERDOGAN , MELILLO VITO , MCCARTNEY JASON , NICHOLLS GEORGIA MCGAUGHEY , PIERRE FABRICE JEAN DENIS , SILINA ALINA , TERMIN ANDREAS P , UY JOHNNY , ZHOU JINGLAN
IPC: A01N41/06 , A61K31/18 , C07D209/18 , C07D209/49 , C07D213/64 , C07D213/73 , C07D231/20 , C07D235/24 , C07D239/34 , C07D401/04 , C07D403/10 , C07D403/12 , C07D407/12 , C07D413/14
Abstract: La présente invention concerne un composé de formule (i): (i) ou un sel pharmaceutiquement acceptable de celui-ci, où r1, r2, r3, w, x, y, z, n, o, p et q sont tels que définis dans la description, lequel composé est utile pour le traitement de maladies médiées par le cftr, telles que la mucoviscidose. La présente invention concerne également des compositions pharmaceutiques, une méthode de traitement et des kits correspondants.
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Patent Agency Ranking
公开(公告)号：SI3203840T1
公开(公告)日：2020-10-30
申请号：SI201531355
申请日：2015-10-06
Applicant: VERTEX PHARMA
Inventor： MILLER MARK THOMAS , ANDERSON COREY , ARUMUGAM VIJAYALAKSMI , BEAR BRIAN RICHARD , BINCH HAYLEY MARIE , CLEMENS JEREMY J , CLEVELAND THOMAS , CONROY ERICA , COON TIMOTHY RICHARD , FRIEMAN BRYAN A , GROOTENHUIS PETER DIEDERIK JAN , GROSS RAYMOND STANLEY , HADIDA-RUAH SARA SABINA , KHATUYA HARIPADA , JOSHI PRAMOD VIRUPAX , KRENITSKY PAUL JOHN , LIN CHUN-CHIEH , MARELIUS GULIN ERDOGAN , MELILLO VITO , MCCARTNEY JASON , NICHOLLS GEORGIA MCGAUGHEY , PIERRE FABRICE JEAN DENIS , SILINA ALINA , TERMIN ANDREAS P , UY JOHNNY , ZHOU JINGLAN
IPC: A61K31/00 , A01N41/00 , C07D209/00 , C07D213/00 , C07D231/00 , C07D235/00 , C07D239/00 , C07D401/00 , C07D403/00 , C07D407/00 , C07D413/00
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公开(公告)号：MA41051A
公开(公告)日：2017-08-16
申请号：MA41051
申请日：2015-10-06
Applicant: VERTEX PHARMA
Inventor： ANDERSON COREY , ARUMUGAM VIJAYALAKSMI , BEAR BRIAN RICHARD , BINCH HAYLEY MARIE , CLEMENS JEREMY J , CLEVELAND THOMAS , CONROY ERICA , COON TIMOTHY RICHARD , FRIEMAN BRYAN A , GROOTENHUIS PETER DIEDERIK JAN , GROSS RAYMOND STANLEY , HADIDA-RUAH SARA SABINA , JOSHI PRAMOD VIRUPAX , KHATUYA HARIPADA , KRENITSKY PAUL JOHN , LIN CHUN-CHIEH , MARELIUS GULIN ERDOGAN , MCCARTNEY JASON , MELILLO VITO , MILLER MARK THOMAS , NICHOLLS GEORGIA MCGAUGHEY , PIERRE FABRICE JEAN DENIS , SILINA ALINA , TERMIN ANDREAS P , UY JOHNNY , ZHOU JINGLAN
IPC: A01N41/06 , A61K31/18 , C07D209/18 , C07D209/49 , C07D213/64 , C07D213/73 , C07D231/20 , C07D235/24 , C07D239/34 , C07D401/04 , C07D403/10 , C07D403/12 , C07D407/12 , C07D413/14
Abstract: La présente invention concerne un composé de formule (i): (i) ou un sel pharmaceutiquement acceptable de celui-ci, où r1, r2, r3, w, x, y, z, n, o, p et q sont tels que définis dans la description, lequel composé est utile pour le traitement de maladies médiées par le cftr, telles que la mucoviscidose. La présente invention concerne également des compositions pharmaceutiques, une méthode de traitement et des kits correspondants.
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公开(公告)号：UA125245C2
公开(公告)日：2022-02-09
申请号：UAA201704446
申请日：2015-10-06
Applicant: VERTEX PHARMA
Inventor： MILLER MARK THOMAS , ANDERSON COREY , ARUMUGAM VIJAYALAKSMI , BEAR BRIAN RICHARD , BINCH HAYLEY MARIE , CLEMENS JEREMY J , CLEVELAND THOMAS , CONROY ERICA , COON TIMOTHY RICHARD , FRIEMAN BRYAN A , GROOTENHUIS PETER DIEDERIK JAN , GROSS RAYMOND STANLEY , HADIDA-RUAH SARA SABINA , KHATUYA HARIPADA , JOSHI PRAMOD VIRUPAX , KRENITSKY PAUL JOHN , LIN CHUN-CHIEH , MARELIUS GULIN ERDOGAN , MELILLO VITO , MCCARTNEY JASON , NICHOLLS GEORGIA MCGAUGHEY , PIERRE FABRICE JEAN DENIS , SILINA ALINA , TERMIN ANDREAS P , UY JOHNNY , ZHOU JINGLAN
Abstract: ДанийвинахідстосуєтьсясполукиформулиІ , I абоїїфармацевтичноприйнятноїсолі, де R1, R2, R3, W, X, Y, Z, n, о, рі q маютьзначення, визначенів даномудокументі, длялікуванняопосередкованих CFTR захворювань, такихяккістознийфіброз. Данийвинахідтакожміститьу собіфармацевтичнікомпозиції, методлікуванняі набори.
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公开(公告)号：HUE051972T2
公开(公告)日：2021-04-28
申请号：HUE15849396
申请日：2015-10-06
Applicant: VERTEX PHARMA
Inventor： MILLER MARK THOMAS , ANDERSON COREY , ARUMUGAM VIJAYALAKSMI , BEAR BRIAN RICHARD , BINCH HAYLEY MARIE , CLEMENS JEREMY J , CLEVELAND THOMAS , CONROY ERICA , COON TIMOTHY RICHARD , FRIEMAN BRYAN A , GROOTENHUIS PETER DIEDERIK JAN , GROSS RAYMOND STANLEY , HADIDA-RUAH SARA SABINA , KHATUYA HARIPADA , JOSHI PRAMOD VIRUPAX , KRENITSKY PAUL JOHN , LIN CHUN-CHIEH , MARELIUS GULIN ERDOGAN , MELILLO VITO , MCCARTNEY JASON , NICHOLLS GEORGIA MCGAUGHEY , PIERRE FABRICE JEAN DENIS , SILINA ALINA , TERMIN ANDREAS P , UY JOHNNY , ZHOU JINGLAN
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公开(公告)号：DK3203840T3
公开(公告)日：2020-08-31
申请号：DK15849396
申请日：2015-10-06
Applicant: VERTEX PHARMA
Inventor： ARUMUGAM VIJAYALAKSMI , BEAR BRIAN RICHARD , BINCH HAYLEY MARIE , CLEMENS JEREMY J , CLEVELAND THOMAS , CONROY ERICA , COON TIMOTHY RICHARD , MILLER MARK THOMAS , ANDERSON COREY , FRIEMAN BRYAN A , GROOTENHUIS PETER DIEDERIK JAN , GROSS RAYMOND STANLEY , HADIDA-RUAH SARA SABINA , KHATUYA HARIPADA , JOSHI PRAMOD VIRUPAX , KRENITSKY PAUL JOHN , LIN CHUN-CHIEH , MARELIUS GULIN ERDOGAN , MELILLO VITO , MCCARTNEY JASON , NICHOLLS GEORGIA MCGAUGHEY , PIERRE FABRICE JEAN DENIS , SILINA ALINA , TERMIN ANDREAS P , UY JOHNNY , ZHOU JINGLAN
IPC: A01N41/06 , A61K31/18 , C07D209/18 , C07D209/49 , C07D213/64 , C07D213/73 , C07D231/20 , C07D235/24 , C07D239/34 , C07D401/04 , C07D403/10 , C07D403/12 , C07D407/12 , C07D413/14
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