公开(公告)号：US20230080810A1

公开(公告)日：2023-03-16

申请号：US17990139

申请日：2022-11-18

Applicant: RSP SYSTEMS A/S

Inventor： Stefan Ovesen BANKE

IPC: G01J3/44 ,  A61B5/145 ,  A61B5/1455 ,  G01J3/12 ,  G01J3/28 ,  G01J3/36 ,  G01N21/65 ,  A61B5/00 ,  G01J3/02

Abstract: An analyte detection apparatus includes a radiation source for irradiating a sample and a receiver to receive an optical Raman spectrum of radiation transmitted back from the sample, the spectrum including one or more parts of significance to an analyte to be detected and one or more parts not of significance to an analyte to be detected. The receiver includes different types of analysis device each arranged to receive a selected part of the spectrum. The different types of analysis device include at least one analysis device having high resolution and/or high signal to noise ratio for detecting a part of the spectrum of significance to the analyte to be detected and at least one second type of analysis device which provides lower resolution and/or lower signal-to-noise ratio, for detecting a part of the spectrum not of significance to the analyte to be detected.

公开(公告)号：US12241784B2

公开(公告)日：2025-03-04

申请号：US17990139

申请日：2022-11-18

Applicant: RSP SYSTEMS A/S

Inventor： Stefan Ovesen Banke

IPC: G01J3/44 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  G01J3/02 ,  G01J3/12 ,  G01J3/18 ,  G01J3/28 ,  G01J3/36 ,  G01N21/65

Abstract: An analyte detection apparatus includes a radiation source for irradiating a sample and a receiver to receive an optical Raman spectrum of radiation transmitted back from the sample, the spectrum including one or more parts of significance to an analyte to be detected and one or more parts not of significance to an analyte to be detected. The receiver includes different types of analysis device each arranged to receive a selected part of the spectrum. The different types of analysis device include at least one analysis device having high resolution and/or high signal to noise ratio for detecting a part of the spectrum of significance to the analyte to be detected and at least one second type of analysis device which provides lower resolution and/or lower signal-to-noise ratio, for detecting a part of the spectrum not of significance to the analyte to be detected.

公开(公告)号：US20200256733A1

公开(公告)日：2020-08-13

申请号：US16467362

申请日：2017-10-24

Applicant: RSP SYSTEMS A/S

Inventor： Stefan Ovesen BANKE

IPC: G01J3/44 ,  G01J3/12 ,  G01J3/28 ,  G01J3/36 ,  G01N21/65 ,  A61B5/1455 ,  A61B5/145

Abstract: An analyte detection apparatus, includes a radiation source for irradiating a sample; a receiver, to receive an optical Raman spectrum of radiation transmitted back from the sample in response to the received radiation from the source, wherein the receiver includes a plurality of different types of analysis device each arranged to receive a selected part of the received optical spectrum transmitted back from the sample.

公开(公告)号：US10674919B2

公开(公告)日：2020-06-09

申请号：US15508580

申请日：2015-08-24

Applicant: RSP SYSTEMS A/S

Inventor： Stefan Ovesen Banke

IPC: A61B5/00 ,  G01J3/44 ,  G01N21/65 ,  G01J3/02 ,  G01J1/42 ,  A61B5/1455 ,  A61B5/145

Abstract: The use of a transdermal Raman spectrum to measure glucose or other substance concentration can give an inaccurate result if the Raman signals originate at a wrong skin depth. To predict whether a spectrum of Raman signals received transdermally in a confocal detector apparatus and having at least one component expected to have an intensity representing the concentration of glucose or another skin component at a point of origin of the Raman signals below the surface of the skin will accurately represent the concentration, peaks in the spectrum at 883/4 cm−1 and 894 cm−1 are measured to determine whether the Raman signals originate primarily within the stratum corneum so that the spectrum will be less likely to represent the concentration accurately or originate primarily below the stratum corneum so that the spectrum will be more likely to represent the concentration accurately.

公开(公告)号：US20250057451A1

公开(公告)日：2025-02-20

申请号：US18712567

申请日：2022-10-12

Applicant: RSP SYSTEMS A/S

Inventor： Signe Maria LUNDSGAARD-NIELSEN ,  Anders PORS ,  Anders WEBER

IPC: A61B5/1495 ,  A61B5/145 ,  A61B5/1455 ,  G01N21/27 ,  G01N21/65

Abstract: A system and method of calibrating a model used in a device for non-invasive in vivo measurement of an analyte concentration using Raman spectroscopy, the device including an optical source for providing an optical signal and an optical detector to receive a Raman scattered optical output, the method including: in response to the laser source being directed to a user's skin gathering Raman scattered radiation from the user's skin and based on that, calibrating the model based on reference data and the received Raman spectra over an extended period of days, such as 10 days or more.

公开(公告)号：US20170273564A1

公开(公告)日：2017-09-28

申请号：US15508580

申请日：2015-08-24

Applicant: RSP SYSTEMS A/S

Inventor： Stefan Ovesen BANKE

IPC: A61B5/00 ,  A61B5/1455

CPC classification number: A61B5/0075 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/14551 ,  A61B5/7221 ,  G01J1/4257 ,  G01J3/0208 ,  G01J3/0216 ,  G01J3/44 ,  G01N21/65

Abstract: The use of a transdermal Raman spectrum to measure glucose or other substance concentration can give an inaccurate result if the Raman signals originate at a wrong skin depth. To predict whether a spectrum of Raman signals received transdermally in a confocal detector apparatus and having at least one component expected to have an intensity representing the concentration of glucose or another skin component at a point of origin of the Raman signals below the surface of the skin will accurately represent the concentration, peaks in the spectrum at 883/4 cm−1 and 894 cm−1 are measured to determine whether the Raman signals originate primarily within the stratum corneum so that the spectrum will be less likely to represent the concentration accurately or originate primarily below the stratum corneum so that the spectrum will be more likely to represent the concentration accurately.

公开(公告)号：US20240003741A1

公开(公告)日：2024-01-04

申请号：US18033247

申请日：2021-10-22

Applicant: RSP SYSTEMS A/S

Inventor： Martin SCHJOLDAGER NIELSEN ,  Joshua John GIBSON ,  Thomas James WATSON

IPC: G01J3/10 ,  G01J3/44 ,  G01N21/65 ,  A61B5/1455

CPC classification number: G01J3/10 ,  G01J3/44 ,  G01N21/65 ,  A61B5/1455 ,  G01N2201/06113 ,  A61B2562/0238 ,  G01J2003/102 ,  G01J2003/4424

Abstract: The present invention relates to an apparatus and method for non-invasive in vivo measurement, by Raman spectroscopy, of glucose present in interstitial fluid in the skin of a subject. The apparatus comprises at least one detector; a plurality of vertical-cavity surface-emitting lasers spatially distributed around the at least one detector, for irradiating the skin of a subject; wherein the at least one detector is configured to receive Raman scattered radiation transmitted from the sample in response to the received radiation from the vertical-cavity surface-emitting lasers.

公开(公告)号：US11815398B2

公开(公告)日：2023-11-14

申请号：US16467362

申请日：2017-10-24

Applicant: RSP SYSTEMS A/S

Inventor： Stefan Ovesen Banke

IPC: G01J3/44 ,  A61B5/145 ,  A61B5/1455 ,  G01J3/12 ,  G01J3/28 ,  G01J3/36 ,  G01N21/65 ,  G01J3/18 ,  A61B5/00 ,  G01J3/02

CPC classification number: G01J3/44 ,  A61B5/0075 ,  A61B5/1455 ,  A61B5/14532 ,  A61B5/14546 ,  G01J3/0256 ,  G01J3/1256 ,  G01J3/2803 ,  G01J3/36 ,  G01N21/65 ,  G01J3/18

Abstract: An analyte detection apparatus, includes a radiation source for irradiating a sample; a receiver, to receive an optical Raman spectrum of radiation transmitted back from the sample in response to the received radiation from the source, wherein the receiver includes a plurality of different types of analysis device each arranged to receive a selected part of the received optical spectrum transmitted back from the sample.

公开(公告)号：US20160287147A1

公开(公告)日：2016-10-06

申请号：US15182455

申请日：2016-06-14

Applicant: RSP SYSTEMS A/S

Inventor： Morten HENNEBERG ,  Stefan Ovesen BANKE ,  Anders WEBER

IPC: A61B5/1455 ,  A61B5/145

CPC classification number: A61B5/1455 ,  A61B5/0059 ,  A61B5/0068 ,  A61B5/0075 ,  A61B5/1451 ,  A61B5/14532 ,  A61B5/1495 ,  A61B5/441 ,  A61B2562/0238 ,  A61B2562/0242 ,  A61B2562/146 ,  G01N21/65

Abstract: A metabolite concentration is measured in vivo using Raman spectroscopy in such a way as to receive at a detector light scattered from the metabolite in interstitial fluid in skin in a measurement location at a depth of from 200-300 μm below the skin surface providing improved retention of correct calibration and transferability of calibration between individual subjects.

Abstract translation: 使用拉曼光谱法在体内测量代谢物浓度，使得在距离皮肤表面200-300μm深度的测量位置处接收来自皮肤间隙液中的代谢物散射的检测器光，从而提供改善的保留 正确的校准和个体对象之间校准的可转移性。

公开(公告)号：US10433775B2

公开(公告)日：2019-10-08

申请号：US15182455

申请日：2016-06-14

Applicant: RSP SYSTEMS A/S

Inventor： Morten Henneberg ,  Stefan Ovesen Banke ,  Anders Weber

IPC: A61B5/1455 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1495 ,  G01N21/65

Abstract: A metabolite concentration is measured in vivo using Raman spectroscopy in such a way as to receive at a detector light scattered from the metabolite in interstitial fluid in skin in a measurement location at a depth of from 200-300 μm below the skin surface providing improved retention of correct calibration and transferability of calibration between individual subjects.