公开(公告)号：US20240302357A1

公开(公告)日：2024-09-12

申请号：US18405536

申请日：2024-01-05

Applicant: Redcoat Solutions, Inc.

Inventor： William John HALL ,  Benedict Louis ZIN ,  Andy STURMAN ,  Min WANG

IPC: G01N33/53 ,  C07K16/00 ,  C07K16/18 ,  G01N21/77 ,  G01N21/78 ,  G01N21/84 ,  G01N33/543 ,  G01N33/553 ,  G01N33/68

CPC classification number: G01N33/5308 ,  C07K16/00 ,  C07K16/18 ,  G01N21/78 ,  G01N21/8483 ,  G01N33/54388 ,  G01N33/553 ,  G01N33/68 ,  C07K2317/14 ,  C07K2317/565 ,  G01N2021/7759 ,  G01N2201/12 ,  G01N2333/43552

Abstract: System and method embodiments for analyzing a test fluid to detect prior or present infestations of bed bugs are described. In an embodiment, the method may include receiving the test fluid on a test strip within the detection device. The test strip may include a reaction portion and a reagent portion containing an antibody or antigen-binding fragment that is conjugated to a colored particle. The test fluid may include bed bug antigen that reacts with the conjugated antibody. The detection device may include a first and a second optical sensor for monitoring a reaction and a background color intensity, respectively. Upon a predetermined time delay elapsing, the detection device determines whether bed bug antigen is present in the test fluid using the monitored color intensities and minimum and maximum color intensity thresholds associated with bed bugs. Then, the detection device outputs a result using a visual display.

公开(公告)号：US12072336B2

公开(公告)日：2024-08-27

申请号：US16342297

申请日：2017-10-20

Applicant: CEDARS-SINAI MEDICAL CENTER ,  TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

Inventor： Jian Tajbakhsh ,  Darko Stefanovski

IPC: G01N33/574 ,  C12Q1/6804 ,  G01N1/30 ,  G01N21/64

CPC classification number: G01N33/57434 ,  C12Q1/6804 ,  G01N1/30 ,  G01N21/6428 ,  G01N21/6447 ,  G01N21/6458 ,  G01N2001/302 ,  G01N2021/6439 ,  G01N2201/12

Abstract: In certain embodiments, this application discloses methods for the diagnosis and prognosis of prostate cancer. In some embodiments, the invention takes advantage of the combinatorial utility of certain biomarkers to prognose and diagnose prostate cancer at an early stage. In certain embodiments, the methods described herein do not require the selection of cells from a particular tissue compartment, and are therefore suitable for analysis of cancer tissue in which compartmentalization is lost.

公开(公告)号：US20240268680A1

公开(公告)日：2024-08-15

申请号：US18646390

申请日：2024-04-25

Applicant: Omni Medsci, Inc.

Inventor： Mohammed N. ISLAM

IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  A61C1/00 ,  A61C19/04 ,  G01J3/02 ,  G01J3/10 ,  G01J3/12 ,  G01J3/14 ,  G01J3/18 ,  G01J3/28 ,  G01J3/42 ,  G01J3/453 ,  G01M3/38 ,  G01N21/35 ,  G01N21/3504 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/39 ,  G01N21/85 ,  G01N21/88 ,  G01N21/95 ,  G01N33/02 ,  G01N33/15 ,  G01N33/44 ,  G01N33/49 ,  G16H40/67 ,  G16Z99/00 ,  H01S3/00 ,  H01S3/067 ,  H01S3/30

CPC classification number: A61B5/0088 ,  A61B5/0013 ,  A61B5/0022 ,  A61B5/0075 ,  A61B5/0086 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/4547 ,  A61B5/6801 ,  A61B5/7203 ,  A61B5/7257 ,  A61B5/7405 ,  A61B5/742 ,  A61C19/04 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/108 ,  G01J3/14 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/42 ,  G01J3/453 ,  G01N21/35 ,  G01N21/3504 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/39 ,  G01N21/88 ,  G01N33/02 ,  G01N33/025 ,  G01N33/15 ,  G01N33/442 ,  G01N33/49 ,  G16H40/67 ,  G16Z99/00 ,  A61B5/0024 ,  A61B2562/0233 ,  A61B2562/0238 ,  A61B2562/146 ,  A61B2576/02 ,  A61C1/0046 ,  G01J2003/104 ,  G01J2003/1208 ,  G01J3/1838 ,  G01J2003/2826 ,  G01M3/38 ,  G01N2021/3513 ,  G01N2021/3595 ,  G01N2021/399 ,  G01N21/85 ,  G01N21/9508 ,  G01N2201/061 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/08 ,  G01N2201/12 ,  G01N2201/129 ,  H01S3/0092 ,  H01S3/06758 ,  H01S3/302 ,  Y02A90/10

Abstract: A remote sensing system for time-of-flight measurements may comprise an array of laser diodes with Bragg reflectors operating in the near-infrared wavelength range synchronized to a detection system comprising lenses, spectral filters and a photodiode array coupled to a processor. The time-of-flight depth information may be combined with various camera imaging systems. The camera system may comprise a lens system, prism and a sensor. In another embodiment, the data from two cameras may be combined with the time-of-flight depth information. Yet another embodiment comprises an imaging system with another array of laser diodes followed by a beam splitter and a detection system. The remote sensing system may be coupled to a smart phone, tablet or wearable device, and the combined data may provide three-dimensional information about at least some part of an object. Also, artificial intelligence may be used in the processing to make decisions regarding the depth and images.

公开(公告)号：US11992291B2

公开(公告)日：2024-05-28

申请号：US18211354

申请日：2023-06-19

Applicant: Omni Medsci, Inc.

Inventor： Mohammed N. Islam

IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  A61C19/04 ,  G01J3/02 ,  G01J3/10 ,  G01J3/14 ,  G01J3/28 ,  G01J3/42 ,  G01J3/453 ,  G01N21/35 ,  G01N21/3504 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/39 ,  G01N21/88 ,  G01N33/02 ,  G01N33/15 ,  G01N33/44 ,  G01N33/49 ,  G16H40/67 ,  G16Z99/00 ,  A61C1/00 ,  G01J3/12 ,  G01J3/18 ,  G01M3/38 ,  G01N21/85 ,  G01N21/95 ,  H01S3/00 ,  H01S3/067 ,  H01S3/30

CPC classification number: A61B5/0088 ,  A61B5/0013 ,  A61B5/0022 ,  A61B5/0075 ,  A61B5/0086 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/4547 ,  A61B5/6801 ,  A61B5/7203 ,  A61B5/7257 ,  A61B5/7405 ,  A61B5/742 ,  A61C19/04 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/108 ,  G01J3/14 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/42 ,  G01J3/453 ,  G01N21/35 ,  G01N21/3504 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/39 ,  G01N21/88 ,  G01N33/02 ,  G01N33/025 ,  G01N33/15 ,  G01N33/442 ,  G01N33/49 ,  G16H40/67 ,  G16Z99/00 ,  A61B5/0024 ,  A61B2562/0233 ,  A61B2562/0238 ,  A61B2562/146 ,  A61B2576/02 ,  A61C1/0046 ,  G01J2003/104 ,  G01J2003/1208 ,  G01J3/1838 ,  G01J2003/2826 ,  G01M3/38 ,  G01N2021/3513 ,  G01N2021/3595 ,  G01N2021/399 ,  G01N21/85 ,  G01N21/9508 ,  G01N2201/061 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/08 ,  G01N2201/12 ,  G01N2201/129 ,  H01S3/0092 ,  H01S3/06758 ,  H01S3/302 ,  Y02A90/10

Abstract: A sensing system includes laser diodes with Bragg reflectors generating light having an initial light intensity and one or more near-infrared optical wavelengths. The laser diodes are modulated with a pulsed output with 0.5 to 2 nanosecond pulse duration. A beam splitter receives light from the laser diodes, splits the light into a received sample arm light directed to an object and a received reference arm light. A detection system includes a second lens and spectral filters in front of a photodiode array. The photodiode array is coupled to CMOS transistors and receives at least a portion of the received reference arm light and generates a reference detector signal. The detection system is synchronized with the laser diodes. A time-of-flight measurement is based on a comparison of the sample detector signal and the reference detector signal and measures a temporal distribution of photons in the received reflected sample arm light.

公开(公告)号：US20240094193A1

公开(公告)日：2024-03-21

申请号：US18449351

申请日：2023-08-14

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Adela Ben-Yakar ,  Evan Hegarty ,  Sudip Mondal ,  Navid Ghorashian ,  Sertan Kutal Gökçe ,  Christopher Martin

IPC: G01N33/50 ,  B01L3/00 ,  G01N21/05 ,  G01N21/64 ,  G01N35/00 ,  G06V20/69

CPC classification number: G01N33/5085 ,  B01L3/502715 ,  B01L3/502723 ,  B01L3/502746 ,  B01L3/502761 ,  G01N21/05 ,  G01N21/6458 ,  G01N33/502 ,  G01N35/00029 ,  G01N35/00871 ,  G06V20/693 ,  G06V20/695 ,  B01L2200/0668 ,  B01L2300/023 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2300/14 ,  B01L2400/0487 ,  B01L2400/086 ,  G01N2021/6482 ,  G01N2035/00148 ,  G01N2201/12

Abstract: A microfluidic device capable of trapping contents in a manner suitable for high-throughput imaging is described herein. The microfluidic device may include one or more trapping devices, with each trapping device having a plurality of trapping channels. The trapping channels may be configured to receive contents via an inlet channel that connects a sample reservoir to the trapping channels via fluid communication. The trapping channels are shaped such that contents within the trapping channels are positioned for optimal imaging purposes. The trapping channels are also connect to at least one exit channel via fluid communication. The fluid, and contents within the fluid, maybe controlled via hydraulic pressure.

公开(公告)号：US20240094124A1

公开(公告)日：2024-03-21

申请号：US18527064

申请日：2023-12-01

Applicant: AGAR Corporation, Inc.

Inventor： David FARCHY ,  Vikram SIDDAVARAM ,  Yonathan DATTNER

IPC: G01N21/64 ,  G01N33/28

CPC classification number: G01N21/64 ,  G01N33/28 ,  G01N2021/6417 ,  G01N2021/6478 ,  G01N2021/6497 ,  G01N2201/12

Abstract: An apparatus and method of inline measurement of low-concentration hydrocarbons overlaps fluorescence, scatter and absorption spectroscopy devices so as to measure scatter and absorption of fluorescing oil and the excited fluorescence itself. The apparatus includes a fitting, an input port, an output port, and a sapphire tube having a hollow interior in fluid connection with the input port and the output port. Flow medium passes through the input port, the sapphire tube, and the output port. The apparatus also includes a light emitter, a first detector, and a second detector. The light emitter can include a lens, an absorption and scatter wavelength emitter, and a fluorescence wavelength emitter. An incident absorption and scatter beam and an incident fluorescence beam from the light emitter and parallel so as to determine free hydrocarbon, dissolved hydrocarbons, and solids in a sample within the sapphire tube.

公开(公告)号：US11896346B2

公开(公告)日：2024-02-13

申请号：US18103408

申请日：2023-01-30

Applicant: OMNI MEDSCI, INC.

Inventor： Mohammed N. Islam

IPC: A61B5/00 ,  G01J3/10 ,  G01J3/28 ,  G01J3/14 ,  G01J3/453 ,  G01J3/42 ,  G01J3/02 ,  G01N21/35 ,  G16H40/67 ,  G01N21/359 ,  A61B5/145 ,  G01N33/15 ,  G01N33/49 ,  G01N21/3563 ,  G01N21/39 ,  G01N33/02 ,  G01N33/44 ,  G01N21/88 ,  A61B5/1455 ,  G16Z99/00 ,  A61C19/04 ,  G01N21/3504 ,  H01S3/30 ,  G01J3/18 ,  G01J3/12 ,  G01N21/85 ,  G01N21/95 ,  H01S3/067 ,  H01S3/00 ,  G01M3/38 ,  A61C1/00

CPC classification number: A61B5/0088 ,  A61B5/0013 ,  A61B5/0022 ,  A61B5/0075 ,  A61B5/0086 ,  A61B5/1455 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/4547 ,  A61B5/6801 ,  A61B5/7203 ,  A61B5/7257 ,  A61B5/742 ,  A61B5/7405 ,  A61C19/04 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/108 ,  G01J3/14 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/42 ,  G01J3/453 ,  G01N21/35 ,  G01N21/3504 ,  G01N21/359 ,  G01N21/3563 ,  G01N21/39 ,  G01N21/88 ,  G01N33/02 ,  G01N33/025 ,  G01N33/15 ,  G01N33/442 ,  G01N33/49 ,  G16H40/67 ,  G16Z99/00 ,  A61B5/0024 ,  A61B2562/0233 ,  A61B2562/0238 ,  A61B2562/146 ,  A61B2576/02 ,  A61C1/0046 ,  G01J3/1838 ,  G01J2003/104 ,  G01J2003/1208 ,  G01J2003/2826 ,  G01M3/38 ,  G01N21/85 ,  G01N21/9508 ,  G01N2021/3513 ,  G01N2021/3595 ,  G01N2021/399 ,  G01N2201/061 ,  G01N2201/062 ,  G01N2201/06113 ,  G01N2201/08 ,  G01N2201/12 ,  G01N2201/129 ,  H01S3/0092 ,  H01S3/06758 ,  H01S3/302 ,  Y02A90/10

Abstract: An optical system operating in the near or short-wave infrared wavelength range identifies an object based on water absorption. The system comprises a light source with modulated light emitting diodes operating at wavelengths near 1090 and 1440 nanometers, corresponding to lower and higher water absorption. The system further comprises one or more wavelength selective filters and a housing that is further coupled to an electrical circuit and a processor. The detection system comprises photodetectors that are synchronized to the light source, and the detection system receives at least a portion of light reflected from the object. The system is configured to identify the object by comparing the reflected light at the first and second wavelength to generate an output value, and then comparing the output value to a threshold. The optical system may be further coupled to a wearable device or a remote sensing system with a time-of-flight sensor.

公开(公告)号：US11885743B2

公开(公告)日：2024-01-30

申请号：US17383206

申请日：2021-07-22

Applicant: AGAR Corporation, Inc.

Inventor： David Farchy ,  Vikram Siddavaram ,  Yonathan Dattner

IPC: G01N21/64 ,  G01N33/28

CPC classification number: G01N21/64 ,  G01N33/28 ,  G01N2021/6417 ,  G01N2021/6478 ,  G01N2021/6497 ,  G01N2201/12

Abstract: An apparatus and method of inline measurement of low-concentration hydrocarbons overlaps fluorescence, scatter and absorption spectroscopy devices so as to measure scatter and absorption of fluorescing oil and the excited fluorescence itself. The apparatus includes a fitting, an input port, an output port, and a sapphire tube having a hollow interior in fluid connection with the input port and the output port. Flow medium passes through the input port, the sapphire tube, and the output port. The apparatus also includes a light emitter, a first detector, and a second detector. The light emitter can include a lens, an absorption and scatter wavelength emitter, and a fluorescence wavelength emitter. An incident absorption and scatter beam and an incident fluorescence beam from the light emitter and parallel so as to determine free hydrocarbon, dissolved hydrocarbons, and solids in a sample within the sapphire tube.

公开(公告)号：US20230407384A1

公开(公告)日：2023-12-21

申请号：US18325668

申请日：2023-05-30

Applicant: IsoPlexis Corporation

Inventor： Steven GORDON ,  Jerzy OLEJNIK

IPC: C12Q1/6869 ,  G01N21/64 ,  C12Q1/6874 ,  C07H19/00 ,  G01N21/05 ,  G01N21/03

CPC classification number: C12Q1/6869 ,  G01N21/6428 ,  C12Q1/6874 ,  G01N21/645 ,  C07H19/00 ,  G01N21/05 ,  G01N2201/062 ,  G01N2201/0627 ,  G01N2021/058 ,  G01N2021/6421 ,  G01N2021/0346 ,  G01N2201/12 ,  G01N2021/6417 ,  G01N2021/6471 ,  C12Q2535/101 ,  G01N2021/6441 ,  G01N2021/6439 ,  G01N2021/6419

Abstract: The invention provides methods and compositions, including, without limitation, algorithms, computer readable media, computer programs, apparatus, and systems for determining the identity of nucleic acids in nucleotide sequences using, for example, data obtained from sequencing by synthesis methods. The methods of the invention include correcting one or more phenomena that are encountered during nucleotide sequencing, such as using sequencing by synthesis methods. These phenomena include, without limitation, sequence lead, sequence lag, spectral crosstalk, and noise resulting from variations in illumination and/or filter responses.

公开(公告)号：US11821833B2

公开(公告)日：2023-11-21

申请号：US17803102

申请日：2022-02-05

Applicant: J.A. WOOLLAM CO., INC.

Inventor： Stefan Schoeche ,  Craig M. Herzinger ,  Steven E. Green ,  Martin M. Liphardt ,  James D. Welch

IPC: G01N21/21

CPC classification number: G01N21/211 ,  G01N2201/021 ,  G01N2201/06113 ,  G01N2201/12

Abstract: An ellipsometer, polarimeter and the like system operating in the infrared spectral range (0.75 μm to 1000 μm), utilizing a tunable quantum cascade laser (QCL) source with the capability if reducing speckle and standing wave effects, dual-rotatable optical elements, a single-point detector, as well as optional means of reducing the size of the probe beam at the measurement surface and optional chopper for lock-in detection.