Abstract:
The disclosure provides microstructured articles and methods useful for detecting an analyte in a sample. The articles include microwell arrays. The articles can be used with an optical system component in methods to detect or characterize an analyte.
Abstract:
A probe for determining a characteristic of the contents in a fuel tank. The probe includes at least one analysis element. The or each analysis element has an input for inputting light to a sampling region to be analysed and an output for outputting light that has passed through the sampling region from the input. A system including a probe and a spectrometer is also provided.
Abstract:
A dryness fraction measuring device, including a variability quantity measuring portion that measures the amount of variability in intensity of light that has been transmitted, or amount of light that has been absorbed, by moist steam that is the subject of measurement; and a dryness fraction measuring portion that measures the dryness fraction of the moist steam based on a correlation relationship between the dryness fraction and the amount of variability in the optical intensity or in the amount of light absorption.
Abstract:
An in-line holographic microscope is used for measurements of micrometer-scale particles and associated suspending fluid medium containing the particles. The system yields heterodyne scattering patterns that may be interpreted with Lorenz-Mie theory to obtain precise time-resolved information on the refractive index of the suspending medium for determining chemical composition, concentrations and makeup thereof. This approach can perform spatially resolved refractometry with measurements on calibrated refractive index standards and monitor chemical concentration in a microfluidic channel. Using commercially available colloidal spheres as probe particles and a standard video camera for detection yields volumetric refractive index measurements with a resolution of 2×10−3 RIU for each probe particle in each holographic snapshot.
Abstract:
A cabinet capable of guiding light, which is used for detecting a biological sample strained with a fluorescent dye, includes a main body, at least one light source, and at least one light guiding structure. The main body has a sample table to place the biological sample. The at least one light source is provided on the main body and near the sample table, wherein the at least one light source provides light required to excite the fluorescent dye incorporated in the biological sample. The at least one light guiding structure is provided between the sample table and the at least one light source to refract the light provided by the at least one light source onto the sample table and the biological sample. Whereby, the biological sample is exposed to more light, and therefore the intensity of the light released from the biological sample is enhanced.
Abstract:
Optical measuring apparatus configured for analysis of samples contained in liquid drops provided by a liquid handling system that comprises at least one liquid handling tip. The apparatus comprises a light source for irradiating the drop; a detector for measuring sample light; an optics system with first optical elements for transmitting irradiation light, and a processor for accepting and processing measurement signals. The drop is suspended at the liquid handling orifice of the tip in a position where the drop is penetrated by a first optical axis defined by the light source and the first optical elements. The drop is physically touched only by the tip and the liquid sample inside the tip. A robot arm to which the tip is attached is configured as a mechanism for adapting the position of the liquid drop with respect to at least one optical element of the optics system.
Abstract:
A system and method for using near-infrared or short-wave infrared (SWIR) sources such as lamps, thermal sources, LED's, laser diodes, super-luminescent laser diodes, and super-continuum light sources for early detection of dental caries measure transmission and/or reflectance. In the SWIR wavelength range, solid, intact teeth may have a low reflectance or high transmission with very few spectral features while a carious region exhibits more scattering, so the reflectance increases in amplitude. The spectral dependence of the transmitted or reflected light from the tooth may be used to detect and quantify the degree of caries. Instruments for applying SWIR light to one or more teeth may include a C-clamp design, a mouth guard design, or hand-held devices that may augment other dental tools. The measurement device may communicate with a smart phone or tablet, which may transmit a related signal to the cloud, where additional value-added services are performed.
Abstract:
An analytical device including an optically opaque cladding, a sequencing layer including a substrate disposed below the cladding, and a waveguide assembly for receiving optical illumination and introducing illumination into the device. The illumination may be received from a top, a side edge, and a bottom of the device. The waveguide assembly may include a nanoscale aperture disposed in the substrate and extending through the cladding. The aperture defines a reaction cell for receiving a set of reactants. In various aspects, the device includes a sensor element and the illumination pathway is through the sensor element. Waveguides and illumination devices, such as plasmonic illumination devices, are also disclosed. Methods for forming and operating the devices are also disclosed.
Abstract:
Disclosed are methods and apparatus for inspecting a vertical memory stack. On an inspection tool, incident light having a first wavelength range is used to detect defects on a surface of the vertical memory stack. On the inspection tool, incident light having a second wavelength range is used to detect defects on both the surface and throughout a depth of the vertical memory stack. The defects detected using the first and second wavelength range are compared to detect defects only throughout the depth of the vertical memory stack, excluding defects on the surface, as well as to detect defects only on the surface.
Abstract:
An optical probe 10 includes an optical fiber 11, an optical connecter 12 being connected to the optical fiber 11, a focusing optical system 13 and a deflection optical system 14 each being connected to the optical fiber 11, a support tube 15 and a jacket tube 16 each surrounding the optical fiber 11 to extend along the optical fiber 11, and a buffer fluid 17 filled in the inner lumen of the jacket tube. The optical fiber 11 has a cutoff wavelength shorter than 1.53 μm. The optical fiber 11, the focusing optical system 13, the deflection optical system 14, and the buffer fluid 17 and jacket tube 16 on an optical path coupled to a fundamental mode of the optical fiber each have the light transmittance of −2 dB to 0 dB in a wavelength band of 1.6 μm to 1.8 μm.