Abstract:
The present invention provides apparatuses and methods for sample analysis, such as tissue analysis, that integrate high wavenumber (HW) Raman spectroscopy for chemical composition analysis and spectral-domain optical coherence tomography (SD-OCT) to provide depth and morphological information. Intravascular catheter embodiments and related vascular diagnostic methods are also provided.
Abstract:
The present invention relates to a solid-state based light source, a corresponding circuitry and a method of emitting light, including one or more light source elements for generating light, a first sensor for receiving light emitted by the light source elements and ambient light and for generating a first sensor signal (S1) representing the received light, a second sensor for only receiving ambient light and for generating a second sensor signal (S2) representing the received ambient light. Moreover, the solid-state based light source comprises a control unit for receiving the first and the second sensor signals (S1, S2) and for generating control signals (Sc) for controlling the light source elements, based on the difference between the first and the second sensor signals (S1, S2), to compensate for the influence of the ambient light.
Abstract:
A portable device includes a base unit, an extension, and a mirror. The base unit includes a light source, a light detector, and at least one window through which light exits from, and is received by, the base unit. The extension is configured, during use, to be attached to the base unit and to extend from the at least one window, in a direction away from the base unit, the extension defining at least a portion of a sample volume in fluid communication with gases substantially surrounding one or more of the extension and the base unit. The mirror is attached to the extension at a distance from the at least one window. An optical path is defined between the mirror and the at least one window such that light from the light source moves through the sample volume along the optical path, and the mirror is aligned to reflect the light back to the at least one window for detection by the light detector.
Abstract:
Provided is a device for determining the surface topology and associated color of a structure, such as a teeth segment, including a scanner for providing depth data for points along a two-dimensional array substantially orthogonal to the depth direction, and an image acquisition means for providing color data for each of the points of the array, while the spatial disposition of the device with respect to the structure is maintained substantially unchanged. A processor combines the color data and depth data for each point in the array, thereby providing a three-dimensional color virtual model of the surface of the structure. A corresponding method for determining the surface topology and associated color of a structure is also provided.
Abstract:
An optical analysis system includes a light source configured to radiate a first light along a first ray path; a modulator disposed in the first ray path, the modulator configured to modulate the first light to a desired frequency; a spectral element disposed proximate the modulator, the spectral element configured to filter the first light for a spectral range of interest of a sample; a cavity in communication with the spectral element, the cavity configured to direct the first light in a direction of the sample; a conical mirror configured to convert the first light reflecting from the sample into a second light, the cavity being further configured to direct the second light; a beamsplitter configured to split the second light into a first beam and a second beam; an optical filter mechanism disposed to receive the first beam, the optical filter mechanism configured to optically filter data carried by the first beam into at least one orthogonal component of the first beam; a first detector mechanism in communication with the optical filter mechanism to measure a property of the orthogonal component to measure the data; a second detector mechanism configured to receive the second beam for comparison of the property of the orthogonal component to the second beam; an accelerometer configured to control the data acquisition such that only detector signals during the period of time when the system is in the proper orientation such that the material sample (e.g., aspirin) is in proximity to the interrogation window are used for calculation; a computer having a data acquisition and conversion card, the computer disposed in the system in communication with the first and second detector mechanisms for signal processing; and a battery and charging system disposed in the system in electrical communication with the system to provide stand-alone operation capability.
Abstract:
A spectrophotometer includes a plurality of LEDs arranged in a circular array, each having a calibrated power input determined by the use of pulse width modulation and each having a unique wavelength band determined by the utilization of a unique fluorescent phosphor coating or lens. At least one of the LEDs comprising a phosphor-free high energy UV LED. Light reflected to the spectrophotometer is divided into predetermined wavelength ranges through the utilization of a linear variable filter and photo detectors wherein the analog signal from a photo detector is converted to a digital value through the use of auto-ranging gain technique.
Abstract:
The disclosure relates to a portable system for obtaining a spatially accurate wavelength-resolved image of a sample having a first and a second spatial dimension that can be used for the detection of hazardous agents by irradiating a sample with light, forming an image of all or part of the sample using Raman shifted light from the sample, and analyzing the Raman shifted light for patterns characteristic of one or more hazardous agents.
Abstract:
Systems and methods for performing two-dimensional (2D) high resolution spectral-spatial mapping are described. At least one embodiment includes a spectrometer for performing two-dimensional (2D) high resolution spectral-spatial mapping comprising a Fabry-Perot component configured to receive a diffuse input beam and provide a high resolution spectral mapping of the diffuse input beam in a first direction. The spectrometer further comprises a volume hologram for increasing a spectral operating range, the volume hologram configured to perform spectral mapping in a second direction orthogonal to the first direction to increase the spectral operating range. The spectrometer further comprises a charged coupled device (CCD) configured to receive output beams, the output beams used to provide spectral analysis of the input beams.
Abstract:
A spectrometry device comprising at least one wavefront-dividing interferometer comprising at least two unbalanced arms and at least one air wedge, a device for imaging interference fringes, an imaging sensor of the fringes and a processor that processes a signal derived from the sensor.
Abstract:
Various embodiments of the present invention relate generally to systems for performing Raman spectroscopy. In one embodiment, a system for performing Raman spectroscopy comprises an analyte holder having a surface configured to retain an analyte and a light concentrator configured to receive an incident beam of light, split the incident beam into one or more beams, and direct the one or more beams to substantially intersect at the surface. The system may also include a collector configured to focus each of the one or more beams onto the surface, collect the Raman scattered light emitted from the analyte, and direct the Raman scattered light away from the surface.