公开(公告)号：US20130116523A1

公开(公告)日：2013-05-09

申请号：US13809703

申请日：2011-07-08

Applicant: Hyung II Jung ,  Kwang Lee ,  Sin Kil Cho ,  Young Dook Byeon

Inventor： Hyung II Jung ,  Kwang Lee ,  Sin Kil Cho ,  Young Dook Byeon

IPC: A61M5/00 ,  A61B5/1486 ,  B29D23/00 ,  A61F9/007

CPC classification number: A61M5/00 ,  A61B5/14532 ,  A61B5/14865 ,  A61B5/685 ,  A61F9/00781 ,  A61K9/0021 ,  A61M37/0015 ,  A61M2037/003 ,  A61M2037/0053 ,  B29C41/08 ,  B29C41/36 ,  B29C41/38 ,  B29D23/00 ,  B29L2031/7544 ,  B81B2201/055 ,  B81C1/00111 ,  G01N33/49

Abstract: The present invention relates to a method for fabricating a hollow microneedle having a variable appearance. The method makes it possible to vary the length of the microneedle, the outer and inner diameters of the upper and lower parts thereof, the aspect ratio, the sharpness, and the structural bending rate thereof, in accordance with the purposes of the same. Accordingly, the appearance of the hollow microneedles according to the present invention can be varied with flexibility according to various purposes, such as the transferring of medication and the taking of a blood sample, and to various factors, such as the target part for the medication transfer, the depth of the medication transfer, and the amount and viscosity of the medication. Thus, the microneedle can be used as a multi-purpose device for transferring medication.

Abstract translation: 本发明涉及具有可变外观的中空微针的制造方法。 该方法根据其目的，可以改变微针的长度，其上部和下部的外径和内径，纵横比，锐度和结构弯曲率。 因此，根据本发明的中空微针的外观可以根据各种目的的灵活性而变化，例如药物的转移和血液样品的摄取，以及各种因素，例如药物的目标部分 转移，药物转移的深度以及药物的量和粘度。 因此，微针可以用作用于转移药物的多用途装置。

公开(公告)号：US08202434B2

公开(公告)日：2012-06-19

申请号：US12621594

申请日：2009-11-19

Applicant: Dae Sik Lee ,  Hyun Woo Song ,  Moon Youn Jung ,  Seon Hee Park

Inventor： Dae Sik Lee ,  Hyun Woo Song ,  Moon Youn Jung ,  Seon Hee Park

IPC: B44C1/22

CPC classification number: A61M37/0015 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2037/0046 ,  A61M2037/0053 ,  B29C33/3842 ,  B29L2031/7544 ,  B29L2031/756 ,  B81B2201/055 ,  B81C1/00111

Abstract: Provided is a method of manufacturing a hollow microneedle structure. The method includes forming an injection mold having a through hole, filling the injection mold with a photoresist formed of a viscous material, and extruding the photoresist from the injection mold through the through hole, solidifying the extruded photoresist to form a needle-type photoresist structure, forming a seed layer on the surface of the photoresist structure, forming a metal plated layer on the seed layer, inclining an end tip of the photoresist structure having the metal plated layer, and removing the photoresist from the metal plated layer to form a hollow. Thus, the hollow microneedle structure can be manufactured to have such diameter, length, hardness, and inclination angle as to minimize pain. The hollow microneedle structure can be combined with an apparatus for detecting a biomaterial or injecting cosmetic substances or medicines, and variously applied.

Abstract translation: 提供一种制造中空微针结构的方法。 该方法包括形成具有通孔的注射模具，用由粘性材料形成的光致抗蚀剂填充注射模具，并且通过通孔从注射模具中挤出光致抗蚀剂，固化挤出的光致抗蚀剂以形成针型光致抗蚀剂结构 在光致抗蚀剂结构的表面上形成种子层，在种子层上形成金属镀层，使具有金属镀层的光致抗蚀剂结构的末端倾斜，从金属镀层除去光致抗蚀剂，形成中空 。 因此，可以制造中空微针结构以具有使疼痛最小化的直径，长度，硬度和倾斜角度。 中空微针结构可以与用于检测生物材料或注射化妆品物质或药物的装置组合，并进行各种应用。

公开(公告)号：US08192787B2

公开(公告)日：2012-06-05

申请号：US11660341

申请日：2005-08-16

Applicant: Andrew James Kirby

Inventor： Andrew James Kirby

IPC: B05D1/36

CPC classification number: B81C1/00111 ,  A61M37/0015 ,  A61M2037/0053 ,  B29C37/0053 ,  B29C64/135 ,  B29C2035/0827 ,  B29L2031/759 ,  B33Y80/00 ,  B81B2201/055

Abstract: A method of manufacturing microneedles is provided, the method includes (i) depositing a substance onto a first surface and (ii) forming a solid needle-like shape from the substance. The substance may be deposited in non-solid form and subsequently solidified. A method provides an array of such microneedles.

Abstract translation: 提供了制造微针的方法，该方法包括（i）将物质沉积到第一表面上，和（ii）从该物质形成固体针状形状。 该物质可以以非固体形式沉积并随后固化。 一种方法提供这种微针的阵列。

公开(公告)号：US20120043300A1

公开(公告)日：2012-02-23

申请号：US13215220

申请日：2011-08-22

Applicant: Mehdi Yazdanpanah

Inventor： Mehdi Yazdanpanah

IPC: B05D5/00 ,  B05D1/00 ,  B05D3/10 ,  B05C13/00

CPC classification number: B81C1/00031 ,  B81B2201/055 ,  B81B2203/0361 ,  B81C99/0025

Abstract: The present invention provides a description for an instrument for creating arrays of metal nanostructures allows on various substrates at the wafer scale. Embodiment methods permit for the formation of individual and arrays of metal alloys of nanostructures by bringing an array of liquid metal droplets droplet in contact with an array of metal patterns by using high precision manipulation mechanism. Top view and side view optical lenses are used to observe the manipulation process and also allow for aligning the metal droplets with film of solid metal patterns. As one example, this instrument is capable of pattering high aspect ratio nanostructures such as silver-gallium (Ag2Ga) nanowires onto prefabricated microstructures. This invention also describes a method for forming arrays of liquid metal droplets on the tip of micro structures by bringing a flexible membrane containing a liquid metal film, in contact with a pattern of microstructures.

Abstract translation: 本发明提供了一种用于创建金属纳米结构阵列的仪器的描述，其允许在晶片规模上的各种基板上。 实施方式允许通过使用高精度操纵机构使金属液滴与金属图案阵列接触而形成纳米结构的金属合金的个体和阵列。 顶视图和侧视光学透镜用于观察操作过程，并且还允许将金属液滴与固体金属图案的膜对准。 作为一个示例，该仪器能够将诸如银镓（Ag 2 Ga）纳米线的高纵横比纳米结构图案化到预制微结构上。 本发明还描述了一种通过使含有液态金属膜的柔性膜与微结构图案相接触来在微结构的尖端上形成液态金属液滴阵列的方法。

公开(公告)号：US20120016261A1

公开(公告)日：2012-01-19

申请号：US13257721

申请日：2010-03-19

Applicant: Makoto Ishida ,  Takeshi Kawano ,  Takahiro Kawashima ,  Kuniharu Takei

Inventor： Makoto Ishida ,  Takeshi Kawano ,  Takahiro Kawashima ,  Kuniharu Takei

IPC: A61B10/02 ,  H01L21/28 ,  H01L23/48

CPC classification number: A61B5/04001 ,  A61B5/0017 ,  A61B5/0084 ,  A61B10/0233 ,  A61B2562/028 ,  B81B2201/055 ,  B81C1/00111 ,  H01L2924/0002 ,  H01L2924/00

Abstract: A hollow microtube structure capable of being used as a minimally invasive electrode, a production method thereof, and a biopsy device using the hollow microtube structure. The hollow microtube structure includes a semiconductor substrate and at least one hollow tube formed on a surface of the semiconductor substrate. The hollow tube includes a metal coating film layer on the inner surface and an electrically insulating coating film layer on the outer surface. The semiconductor substrate includes a through hole communicated with an interior of a hollow tube at a location where the hollow tube is formed. The production method includes an etching, a sacrificial layer forming, a metal coating film layer forming, an electrically insulating coating film layer forming, a tip portion removing, and a piercing. The biopsy device can be provided on a substrate side of the hollow microtube structure with at least one of an electric signal transmitter, an optical signal generator, a chemical fluid injector, an electrical measuring device, a chemical measuring device, and an optical measuring device.

Abstract translation: 能够用作微创电极的中空微管结构，其制造方法和使用中空微管结构的活检装置。 中空微管结构包括半导体衬底和形成在半导体衬底的表面上的至少一个中空管。 中空管包括在内表面上的金属涂膜层和外表面上的电绝缘涂膜层。 半导体衬底包括在形成中空管的位置处与中空管的内部连通的通孔。 制造方法包括蚀刻，牺牲层形成，金属涂膜层形成，电绝缘涂膜层形成，尖端部分去除和穿孔。 活检装置可以在电信号发送器，光信号发生器，化学流体注入器，电测量装置，化学测量装置和光学测量装置中的至少一个上设置在中空微管结构的基板侧上 。

公开(公告)号：US20120004614A1

公开(公告)日：2012-01-05

申请号：US13171942

申请日：2011-06-29

Applicant: Michael Stumber ,  Frank Schatz

Inventor： Michael Stumber ,  Frank Schatz

IPC: A61M5/00 ,  C23F1/04

CPC classification number: A01K11/005 ,  A61M37/0015 ,  A61M37/0076 ,  A61M2037/0046 ,  A61M2037/0053 ,  A61M2037/0061 ,  B81B2201/055 ,  B81B2203/0361 ,  B81C1/00111 ,  B81C2201/0132

Abstract: A production process for a microneedle arrangement and a corresponding microneedle arrangement as well as a use for it is disclosed. The process has the following steps: forming an etching mask in grid form, with grid bars with corresponding grid crossing regions and grid openings in between on a substrate; carrying out an etching process to form the microneedle arrangement on the substrate using the etching mask and removing the etching mask. The etching mask in grid form has at least some of the grid crossing regions flat reinforcing regions, which extend beyond the grid bars.

Abstract translation: 公开了一种用于微针布置和相应的微针布置的生产方法以及其用途。 该方法具有以下步骤：以栅格形式形成蚀刻掩模，其中栅格条具有相应的栅格交叉区域和位于衬底之间的栅格开口; 进行蚀刻处理，以使用蚀刻掩模在衬底上形成微针布置并去除蚀刻掩模。 格栅形式的蚀刻掩模具有至少一些格栅交叉区域，其平坦的加强区域延伸超过网格条。

公开(公告)号：US08062835B2

公开(公告)日：2011-11-22

申请号：US12379308

申请日：2009-02-18

Applicant: Takao Tomono

Inventor： Takao Tomono

IPC: G03F7/26 ,  A61M3/00

CPC classification number: B81C1/00111 ,  A61M37/00 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0053 ,  B81B2201/055 ,  G03F7/201 ,  G03F7/2022 ,  Y10T428/24479

Abstract: A method of manufacturing a master plate includes the steps of forming a photoresist film on a substrate, disposing a photomask having a plurality of island radiation shields on the photoresist film followed by integrating the photomask and the photoresist film, applying light from a light source to the photoresist film through the photomask for selectively exposing the photoresist film, and developing the photoresist film to form a master plate, in which the method includes irradiating the photoresist film with the light from plural directions through the photomask to selectively expose the photoresist film from the respective directions.

Abstract translation: 制造母板的方法包括以下步骤：在衬底上形成光致抗蚀剂膜，将具有多个岛状辐射屏蔽的光掩模设置在光致抗蚀剂膜上，然后将光掩模和光致抗蚀剂膜整合，将来自光源的光施加到 所述光致抗蚀剂膜通过所述光掩模用于选择性地暴露所述光致抗蚀剂膜，以及显影所述光致抗蚀剂膜以形成母板，其中所述方法包括用来自多个方向的光照射所述光致抗蚀剂膜通过所述光掩模，以选择性地将所述光致抗蚀剂膜从 各自的方向。

公开(公告)号：US07753888B2

公开(公告)日：2010-07-13

申请号：US10995570

申请日：2004-11-22

Applicant: Erik V. Mukerjee ,  Rosemary L. Smith

Inventor： Erik V. Mukerjee ,  Rosemary L. Smith

IPC: A61M5/00

CPC classification number: B81C1/00111 ,  A61B5/14514 ,  A61B5/150022 ,  A61B5/150282 ,  A61B5/150297 ,  A61B5/150343 ,  A61B5/150389 ,  A61B5/150412 ,  A61B5/150969 ,  A61B5/150984 ,  A61B5/15105 ,  A61B5/15142 ,  A61M37/0015 ,  A61M2037/003 ,  A61M2037/0053 ,  B81B2201/055

Abstract: A method and apparatus for puncturing a surface for extraction, in situ monitoring, and/or substance delivery uses microneedles with improved properties. Applications include easy to handle glucose monitoring using a group of hollow out-of-plane silicon microneedles to sample substances in interstitial fluid from the epidermal skin layer.

Abstract translation: 用于刺穿表面以进行提取，原位监测和/或物质递送的方法和装置使用具有改进性质的微针。 应用包括容易处理使用一组中空的平面外显微镜进行葡萄糖监测，以从表皮皮肤层采集间质液中的物质。

公开(公告)号：US20090325424A1

公开(公告)日：2009-12-31

申请号：US12110676

申请日：2008-04-28

Applicant: Arno Aarts ,  Hercules Pereira Neves ,  Chris Van Hoof ,  Eric Beyne ,  Patrick Ruther ,  Robert Puers

Inventor： Arno Aarts ,  Hercules Pereira Neves ,  Chris Van Hoof ,  Eric Beyne ,  Patrick Ruther ,  Robert Puers

IPC: H01R24/00 ,  H01R43/00

CPC classification number: B81C3/008 ,  A61B5/04001 ,  A61B5/0478 ,  A61B2562/125 ,  A61N1/0529 ,  A61N1/0531 ,  B81B2201/055 ,  Y10T29/49222

Abstract: In the present disclosure a device for sensing and/or actuation purposes is presented in which microstructures (20) comprising shafts (2) with different functionality and dimensions can be inserted in a modular way. That way, out-of-plane connectivity, mechanical clamping between the microstructures (20) and a substrate (1) of the device, and electrical connection between electrodes (5) on the microstructures (20) and the substrate (1) can be realized. Connections to external circuitry can be realised. Microfluidic channels (10) in the microstructures (20) can be connected to external equipment. A method to fabricate and assemble the device is provided.

Abstract translation: 在本公开中，提出了用于感测和/或致动目的的装置，其中可以以模块化方式插入包括具有不同功能和尺寸的轴（2）的微结构（20）。 这样，平面外连接，微结构（20）和器件的衬底（1）之间的机械夹紧以及微结构（20）和衬底（1）上的电极（5）之间的电连接可以是 实现了 可以实现与外部电路的连接。 微结构（20）中的微流体通道（10）可以连接到外部设备。 提供了一种制造和组装该装置的方法。

公开(公告)号：US07578954B2

公开(公告)日：2009-08-25

申请号：US10373251

申请日：2003-02-24

Applicant: Vladimir Gartstein ,  Faiz Feisal Sherman

Inventor： Vladimir Gartstein ,  Faiz Feisal Sherman

IPC: B29C43/02 ,  B29C1/48

CPC classification number: B81C1/00111 ,  A61M37/0015 ,  A61M2037/003 ,  A61M2037/0053 ,  B26F1/24 ,  B26F1/26 ,  B81B2201/055 ,  B81C2201/034 ,  B81C2201/036

Abstract: A method is provided for manufacturing microstructures of the type which contain a substrate and an array of protruding microelements with through-holes, which are used in penetrating layers of skin. The microelements are embossed or pressed into an initial substrate structure, which in some embodiments is formed from extruded polymeric material, and in some cases from two layers of polymer that are co-extruded. The through-holes are formed from filled through-cylinders of a second material that is removed after the embossing or pressing step; in other instances, the through-holes are left hollow during the embossing or pressing step.

Abstract translation: 提供了一种用于制造包含基底的微结构的方法和具有通孔的突出微元件阵列，其用于穿透皮肤层。 微元件被压花或压制成初始的基底结构，其在一些实施方案中由挤出的聚合物材料形成，并且在一些情况下由共挤出的两层聚合物形成。 通孔由在压花或压制步骤之后被去除的第二材料的填充的通孔形成; 在其他情况下，在压花或压制步骤期间，通孔留空。