公开(公告)号：US08649022B2

公开(公告)日：2014-02-11

申请号：US13102686

申请日：2011-05-06

Applicant: Robert M. Montgomery ,  Randy L. Carmean ,  Charles Franklin Middleton, IV ,  James G. Tonti

Inventor： Robert M. Montgomery ,  Randy L. Carmean ,  Charles Franklin Middleton, IV ,  James G. Tonti

IPC: G01B11/02 ,  G01B9/02

CPC classification number: G01B9/0205 ,  A61B1/0684 ,  A61B1/24 ,  A61B1/32 ,  A61B5/0084 ,  A61B5/02007 ,  A61B5/4233 ,  A61B5/4238 ,  A61B5/4255 ,  A61B5/6886 ,  A61B2562/0233 ,  G01B9/02068 ,  G01B11/0666 ,  G01N9/00 ,  G01N21/1717 ,  G01N21/63 ,  G01N33/48 ,  G01N2201/06113 ,  G01N2201/067 ,  G01N2201/0697 ,  G01N2201/08 ,  G02B6/10

Abstract: A material sensing apparatus comprises an excitation source configured to induce waves in a workpiece, and an optical waveguide interferometer configured to sense the induced waves in the workpiece. The optical waveguide interferometer comprises a probe segment having a probe segment end, and an adjustable coupler configured to permit setting a gap between the probe segment end and the workpiece. A controller is coupled to the adjustable coupler and configured to set the gap between the probe segment end and the workpiece.

Abstract translation: 材料感测装置包括被配置为在工件中感应波的激励源和被配置为感测工件中的感应波的光波导干涉仪。 光波导干涉仪包括具有探针段末端的探针段和被配置为允许设置探针段端和工件之间的间隙的可调耦合器。 控制器耦合到可调节耦合器并且被配置成设置探针段端部和工件之间的间隙。

公开(公告)号：US08649005B2

公开(公告)日：2014-02-11

申请号：US13522880

申请日：2011-01-26

Applicant: Stig Tormod

Inventor： Stig Tormod

IPC: G01N1/10

CPC classification number: G01N21/05 ,  G01N21/0303 ,  G01N2021/0346 ,  G01N2201/08

Abstract: Optical flow cell detector comprising a sample inlet and outlet in fluidic communication through a flow cell channel of cross sectional area A, an input light guide with an light exit surface arranged adjacent and in optical alignment with a light entrance surface of an output light guide, wherein the input light guide and the output light guide protrudes into the flow cell channel and wherein the distance between the light exit surface and the light entrance surface is less than 1.0 mm, and wherein the cross sectional area of the protruding portions of the input light guide and the output light guide in the flow direction is less than A/2.

Abstract translation: 光学流通池检测器，其包括通过横截面积A的流动池通道流体连通的样品入口和出口，输出光导，其具有邻近并与输出光导的光入射表面光学对准布置的光出射表面， 其中所述输入光导和所述输出光导突出到所述流通池通道中，并且其中所述光出射表面和所述光入射表面之间的距离小于1.0mm，并且其中所述输入光的所述突出部分的横截面积 引导和输出光导在流向方向小于A / 2。

公开(公告)号：US08597578B2

公开(公告)日：2013-12-03

申请号：US13213525

申请日：2011-08-19

Applicant: Hong Tan ,  Yushan Tan ,  Erhua Cao ,  Min Xia ,  Robert F. Zuk

Inventor： Hong Tan ,  Yushan Tan ,  Erhua Cao ,  Min Xia ,  Robert F. Zuk

IPC: G01N21/00 ,  G01B9/02 ,  G02B6/26 ,  G02B6/36 ,  G02B6/00 ,  G01N21/63

CPC classification number: G01N21/7703 ,  G01J3/45 ,  G01N21/45 ,  G01N21/648 ,  G01N21/8507 ,  G01N2021/7779 ,  G01N2201/062 ,  G01N2201/08 ,  G02B6/262 ,  G02B6/30

Abstract: The present invention is directed to an assembly for use in detecting an analyte in a sample based on thin-film spectral interference. The assembly comprises a waveguide, a monolithic substrate optically coupled to the waveguide, and a thin-film layer directly bonded to the sensing side of the monolithic substrate. The refractive index of the monolithic substrate is higher than the refractive index of the transparent material of the thin-film layer. A spectral interference between the light reflected into the waveguide from a first reflecting surface and a second reflecting surface varies as analyte molecules in a sample bind to the analyte binding molecules coated on the thin-film layer.

公开(公告)号：US08582096B2

公开(公告)日：2013-11-12

申请号：US12969295

申请日：2010-12-15

Applicant: Zhongping Chen ,  Gangjun Liu ,  Mihael Balu ,  Bruce Tromberg ,  Eric Olaf Potma

Inventor： Zhongping Chen ,  Gangjun Liu ,  Mihael Balu ,  Bruce Tromberg ,  Eric Olaf Potma

IPC: G01J3/44

CPC classification number: G01J3/44 ,  A61B1/00165 ,  A61B1/043 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/02007 ,  A61B5/441 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0297 ,  G01N21/65 ,  G01N2021/653 ,  G01N2201/08 ,  G01N2201/0866

Abstract: A fiber-delivered probe suitable for CARS imaging of thick tissues is practical. The disclosed design is based on two advances. First, a major problem in CARS probe design is the presence of a very strong anti-Stokes component in silica delivery fibers generated through a FWM process. Without proper spectral filtering, this component affects the CARS image from the tissue sample. The illustrated embodiments of the invention efficiently suppress this spurious anti-Stokes component through the use of a separate fiber for excitation delivery and for signal detection, which allows the incorporation of dichroic optics for anti-Stokes rejection. Second, the detection of backscattered CARS radiation from the sample is optimized by using a large core multi mode fiber in the detection channel. This scheme produces high quality CARS images free of detector aperture effects. Miniaturization of this fiber-delivered probe results in a practical handheld probe for clinical CARS imaging.

Abstract translation: 适用于厚组织CARS成像的纤维输送探针是实用的。 所公开的设计基于两个进展。 首先，CARS探针设计中的一个主要问题是在通过FWM工艺生成的二氧化硅输送纤维中存在非常强的反斯托克斯组分。 没有适当的光谱过滤，该组件会影响来自组织样本的CARS图像。 本发明的所示实施例通过使用用于激发传递和信号检测的单独光纤来有效地抑制这种寄生的反斯托克斯分量，这允许并入用于反斯托克斯抑制的二向色光学器件。 其次，通过在检测通道中使用大型核心多模光纤，优化了样品背散射CARS辐射的检测。 该方案可生成高品质的CARS图像，无需检测器孔径效果。 该光纤传送探针的小型化导致临床CARS成像的实用手持式探头。

公开(公告)号：US08534129B2

公开(公告)日：2013-09-17

申请号：US12593177

申请日：2008-03-27

Applicant: Andras Miklos ,  Judit Angster

Inventor： Andras Miklos ,  Judit Angster

IPC: G01H9/00

CPC classification number: G01N21/031 ,  G01N21/1702 ,  G01N2021/1704 ,  G01N2201/08

Abstract: A photoacoustic multipass cell includes a light source, an acoustic resonator and a reflecting arrangement configured in a concentrating manner for reflecting light into the acoustic resonator. Additionally, the light source is arranged at least partially within the reflecting arrangement.

Abstract translation: 光声多通道单元包括光源，声谐振器和以集中方式配置以将光反射入声谐振器的反射装置。 另外，光源至少部分地布置在反射装置内。

公开(公告)号：US08525985B2

公开(公告)日：2013-09-03

申请号：US13658872

申请日：2012-10-24

Applicant: Hitachi, Ltd.

Inventor： Toru Fujimura ,  Kosuke Kuwabara ,  Tatsuro Ide

IPC: G01N21/00 ,  G01N30/74

CPC classification number: G01N21/05 ,  G01N21/31 ,  G01N21/55 ,  G01N33/54373 ,  G01N2021/0346 ,  G01N2201/061 ,  G01N2201/08

Abstract: The invention makes it possible to measure binding of a biochemical substance with a high throughput and with high sensitivity using a small cell capable of being filled with a small amount of chemical solution. A space between a first substrate and a second substrate such that probes are immobilized on their mutually facing planes is used as a cell that houses a specimen solution. Light is irradiated from a first substrate side, and reflected light is subjected to spectroscopy. Binding of the target with the probe is detected by a wavelength shift in the refection spectrum.

Abstract translation: 本发明能够使用能够填充少量化学溶液的小细胞来测量生物化学物质与高产量和高灵敏度的结合。 使用第一基板和第二基板之间的空间，使得将探针固定在其相互面对的平面上，作为容纳样本溶液的单元。 从第一基板侧照射光，反射光进行光谱分析。 通过反射光谱中的波长偏移来检测目标与探针的结合。

公开(公告)号：US20130128262A1

公开(公告)日：2013-05-23

申请号：US13698988

申请日：2011-05-18

Applicant: Hiroshi Kajioka

Inventor： Hiroshi Kajioka

IPC: G01N21/55 ,  G01N21/59

CPC classification number: G01N21/55 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/14558 ,  G01N21/21 ,  G01N21/59 ,  G01N2201/08

Abstract: There is provided an optical rotation measurement apparatus and a measuring system which are user-friendly, capable of measuring glucose concentration in drawn blood and living bodies with high accuracy in real time such that it is available for use at an actual medical site without depending on a reagent, and capable of measuring glucose concentration in a living body noninvasively with high accuracy, a new polarized light converting optical system that can be used for the measuring system, and an optical rotation measurement method using the optical system.The problems are resolved by inserting a non-reciprocal optical system sandwiching a specimen in an optical fiber ring interferometer, using input/output optical fibers of the non-reciprocal optical system, which are comprised of a large core diameter low NA single mode optical fiber, as an input/output part, connected via a mode-matching unit to a small core diameter and high NA polarization preserving fiber as a transmission part, and employing a defocused configuration without deploying the optical fiber ends at focal points of lenses.

Abstract translation: 提供了一种用户友好的光学旋转测量装置和测量系统，能够实时高精度地测量抽取的血液和活体中的葡萄糖浓度，使其可以在实际的医疗场所使用而不依赖于 能够高精度地测量生物体中的葡萄糖浓度的试剂，能够用于测定系统的新的偏振光转换光学系统和使用该光学系统的光学旋转测定方法。 通过将不可逆的光学系统插入到光纤环形干涉仪中，使用不可逆光学系统的输入/输出光纤将大型芯径的低NA单模光纤 作为输入/输出部分，通过模式匹配单元连接到小芯直径和高NA偏振保留光纤作为透射部分，并且采用散焦构造而不将光纤端部部署在透镜的焦点处。

公开(公告)号：US20130100439A1

公开(公告)日：2013-04-25

申请号：US13513458

申请日：2010-12-06

Applicant: Bing Yu ,  Nirmala Ramanujam

Inventor： Bing Yu ,  Nirmala Ramanujam

IPC: G01N21/25

CPC classification number: G01N21/255 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/4331 ,  A61B5/4552 ,  A61B5/6885 ,  A61B2560/0228 ,  G01J3/0218 ,  G01J3/28 ,  G01J3/42 ,  G01L9/0079 ,  G01N21/274 ,  G01N21/645 ,  G01N2201/0627 ,  G01N2201/08

Abstract: Smart fiber optic sensors, systems, and methods for performing quantitative optical spectroscopy are disclosed. In one embodiment, smart fiber optic sensor can include a sensing channel, a calibration channel, and a pressure sensing channel. External force or pressure can be calculated at pressure sensing channel for monitoring and controlling pressure at a sensor-specimen interface thereby ensuring more accurate specimen spectral data is collected. Contact pressure can be adjusted to remain within a specified range. A calibration light of the calibration channel and an illumination light of the sensing channel can be generated simultaneously from a shared light source. Pressure sensing channel can transmit light from a second light source and collect pressure spectral data.

Abstract translation: 公开了用于执行定量光谱的智能光纤传感器，系统和方法。 在一个实施例中，智能光纤传感器可以包括感测通道，校准通道和压力感测通道。 可以在压力感测通道处计算外部力或压力，用于监测和控制传感器 - 样本接口处的压力，从而确保收集更准确的样本光谱数据。 接触压力可以调整到一定范围内。 可以从共享光源同时生成校准通道的校准光和感测通道的照明光。 压力感测通道可以传输来自第二光源的光并收集压力光谱数据。

公开(公告)号：US20130070108A1

公开(公告)日：2013-03-21

申请号：US13582164

申请日：2011-03-08

Applicant: Maarten Aerts ,  Donny Tytgat ,  Jean-Francois Macq ,  Sammy Lievens

Inventor： Maarten Aerts ,  Donny Tytgat ,  Jean-Francois Macq ,  Sammy Lievens

IPC: H04N17/00 ,  G06K9/46

CPC classification number: F01D21/003 ,  F01D25/00 ,  F05D2260/80 ,  G01N21/15 ,  G01N21/85 ,  G01N21/954 ,  G01N2021/151 ,  G01N2201/08 ,  G02B23/2492 ,  G06T7/85 ,  G06T2207/10012

Abstract: A method for determining calibration data for at least two cameras (camera1, camera2) in a multi view position, includes a step of determining respective parameters ((h100, . . . , h122), (h200, . . . , h222)) for identifying at least one respective homographic transformation on respective images (image1,image2) taken by said cameras of a same scene, by performing respective geometry analyses on said respective images (image1, image2), a step of performing at least one respective combined homographic transformation/feature detection step on said respective images thereby obtaining respective sets (feature set1, feature set2) of features on respective transformed images, such that said calibration data are obtained from matches (m1, . . . , mk) determined between said respective sets of features.

Abstract translation: 一种用于确定多视点位置中的至少两个照相机（camera1，camera2）的校准数据的方法，包括确定各个参数（（h100，...，h122），（h200，...，h222））的步骤 用于通过对所述各个图像（image1，image2）执行相应的几何分析来识别由相同场景的所述相机拍摄的各个图像（image1，image2）上的至少一个相应的单色变换;执行至少一个相应的组合同形 变换/特征检测步骤，从而获得各个变换图像上的特征的各个集合（特征集1，特征集2），使得所述校准数据从在所述各个集合之间确定的匹配（m1，...，mk） 的功能。

公开(公告)号：US20130058829A1

公开(公告)日：2013-03-07

申请号：US13658872

申请日：2012-10-24

Applicant: Hitachi, Ltd.

Inventor： Toru FUJIMARA ,  Kosuke Kuwabara ,  Tatsuro Ide

IPC: G01N21/75

CPC classification number: G01N21/05 ,  G01N21/31 ,  G01N21/55 ,  G01N33/54373 ,  G01N2021/0346 ,  G01N2201/061 ,  G01N2201/08

Abstract: The invention makes it possible to measure binding of a biochemical substance with a high throughput and with high sensitivity using a small cell capable of being filled with a small amount of chemical solution. A space between a first substrate and a second substrate such that probes are immobilized on their mutually facing planes is used as a cell that houses a specimen solution. Light is irradiated from a first substrate side, and reflected light is subjected to spectroscopy. Binding of the target with the probe is detected by a wavelength shift in the refection spectrum.