公开(公告)号：US12278393B2

公开(公告)日：2025-04-15

申请号：US17976626

申请日：2022-10-28

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Farshid Roumi

IPC: H01M50/44 ,  H01G9/00 ,  H01G11/52 ,  H01M4/131 ,  H01M4/133 ,  H01M4/134 ,  H01M4/136 ,  H01M4/38 ,  H01M4/525 ,  H01M4/58 ,  H01M4/587 ,  H01M4/62 ,  H01M8/02 ,  H01M8/0245 ,  H01M8/1016 ,  H01M10/0525 ,  H01M10/0562 ,  H01M10/0568 ,  H01M10/0569 ,  H01M10/0585 ,  H01M12/08 ,  H01M50/403 ,  H01M50/411 ,  H01M50/414 ,  H01M50/431 ,  H01M50/434 ,  H01M50/437 ,  H01M50/446 ,  H01M50/449 ,  H01M50/457 ,  H01M50/463 ,  H01M4/02 ,  H01M10/052 ,  H01M50/489 ,  H01M50/491 ,  H01M50/494

Abstract: Separator systems for electrochemical systems providing electronic, mechanical and chemical properties useful for a variety of applications including electrochemical storage and conversion. Embodiments provide structural, physical and electrostatic attributes useful for managing and controlling dendrite formation and for improving the cycle life and rate capability of electrochemical cells including silicon anode based batteries, air cathode based batteries, redox flow batteries, solid electrolyte based systems, fuel cells, flow batteries and semisolid batteries.

公开(公告)号：US20250112807A1

公开(公告)日：2025-04-03

申请号：US18904924

申请日：2024-10-02

Applicant: California Institute of Technology

Inventor： Adrian J. Tang ,  Goutam Chattopadhyay ,  Omkar Pradhan ,  Subash Khanal

IPC: H04L27/00 ,  H04B1/10

Abstract: A circuit comprising a first Fourier Transform block operable to perform a Fourier Transform and having a first input configured for receiving an I signal and a second input configured for receiving a Q signal; a first plurality of n of outputs for I channels and Q channels each comprising a different frequency bin output from the Fourier Transform; I and Q summing blocks comprising a set of connector lines connecting an ith one of I channels with an ith one of the Q channels; an inverse Fourier Transform block connected to the summing blocks and operable to perform an inverse Fourier Transform; a correlator for correlating the outputs of the inverse Fourier Transform; a Fourier Transform block for Fourier Transforming the correlator output; a comparator for comparing the correlation term to zero; and an error correction circuit for tuning the magnitude and phase of the I and Q channels using the comparator output as feedback.

公开(公告)号：US12258605B2

公开(公告)日：2025-03-25

申请号：US17560753

申请日：2021-12-23

Applicant: The California Institute of Technology

Inventor： Frances Arnold ,  Peter Meinhold ,  Matthew W. Peters ,  Rudi Fasan ,  Mike M. Y. Chen

IPC: C12N9/00 ,  C07K14/32 ,  C12N9/02 ,  C12P7/04 ,  C12P7/06

Abstract: This invention relates to modified hydroxylases. The invention further relates to cells expressing such modified hydroxylases and methods of producing hydroxylated alkanes by contacting a suitable substrate with such cells.

公开(公告)号：US20250085607A1

公开(公告)日：2025-03-13

申请号：US18805408

申请日：2024-08-14

Applicant: California Institute of Technology

Inventor： Ryoto Sekine ,  Robert M. Gray ,  Alireza Marandi

IPC: G02F1/365 ,  G01N21/31 ,  G02F1/39

Abstract: An on-chip pulse synthesizer including an integrated photonic chip that temporally and spectrally shapes pulses of light using primarily quadratic optical nonlinearities. Through this synthesis, the light pulses undergo temporal shortening or reshaping, spectral broadening, wavelength conversion, or a combination thereof. A key aspect of this synthesis is the mode engineering of the waveguides, which includes converting the pump source mode to the relevant mode in the nonlinear optical region and tailoring the waveguide geometry and material stack to enable dispersion-engineering as well as engineering of the phase matching for various nonlinear processes.

公开(公告)号：US12239698B2

公开(公告)日：2025-03-04

申请号：US17299852

申请日：2019-11-27

Applicant: The Rockefeller University ,  California Institute of Technology

Inventor： Michel Nussenzweig ,  Pamela J. Bjorkman ,  Amelia Escolano ,  Harry Gristick

IPC: A61K39/12 ,  A61P31/18 ,  C07K14/005 ,  A61K39/00

Abstract: This disclosure provides HIV immunogens and use thereof for generating an immune response in a subject. Also disclosed is a method of isolating anti-HIV antibodies and use thereof. This disclosure further provides a method for treating or preventing a human immunodeficiency type 1 (HIV-1) infection in a subject using the disclosed HIV immunogens and/or antibodies.

公开(公告)号：US20250066457A1

公开(公告)日：2025-02-27

申请号：US18939998

申请日：2024-11-07

Applicant: The Rockefeller University ,  California Institute of Technology

Inventor： Ron Diskin ,  Anthony P. West ,  Michel C. Nussenzweig ,  Pamela J. Bjorkman

IPC: C07K16/10 ,  A61K39/00

Abstract: Embodiments of the present invention are directed to compositions and methods for anti-HIV (anti-CD4 binding site) broadly neutralizing antibodies having improved potency and breadth for neutralizing a range of HIV strains. Combinations of broadly neutralizing antibodies can also improve potency over a single antibody composition.

公开(公告)号：US12237137B2

公开(公告)日：2025-02-25

申请号：US17221170

申请日：2021-04-02

Applicant: California Institute of Technology

Inventor： Pedro P. Guerrero Vela ,  James E. Polk

IPC: H01J1/02 ,  C04B41/00 ,  C04B41/91 ,  H01J1/146 ,  H01J9/04

Abstract: Aspects include a method for treating a polycrystalline material, the method comprising: exposing a surface of the polycrystalline material to a plasma thereby changing the surface of the polycrystalline material from being characterized by a starting condition to being characterized by a treated condition; wherein: the surface comprises a plurality of crystallites each having the composition MB6, M being a metal element; the plasma comprises ions, the ions being characterized by an average ion flux selected from the range of 1.5 to 100 A/cm2 and an average ion energy that is less than a sputtering threshold energy; the starting condition of the surface is characterized by a first average work function and the treated condition of the surface is characterized by a second average work function; and the second average work function is less than the first average work function.

公开(公告)号：US12237094B2

公开(公告)日：2025-02-25

申请号：US17455640

申请日：2021-11-18

Applicant: California Institute of Technology

Inventor： Guoan Zheng ,  Changhuei Yang ,  Roarke W. Horstmeyer

IPC: G02B21/00 ,  G02B21/06 ,  G02B21/36 ,  G02B27/58 ,  G06V20/69 ,  G21K7/00

Abstract: Systems, devices, and methods of Fourier ptychographic imaging by computationally reconstructing a high-resolution image by iteratively updating overlapping regions of variably-illuminated, low-resolution intensity images in Fourier space.

公开(公告)号：US20250043340A1

公开(公告)日：2025-02-06

申请号：US18906096

申请日：2024-10-03

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Long CAI ,  Eric LUBECK ,  Timur ZHIYENTAYEV ,  Ahmet COSKUN ,  Ting-Fang HE ,  Chang Ho SOHN ,  Sheel SHAH

IPC: C12Q1/6841 ,  C12N15/10 ,  G01N21/64 ,  G02B21/06 ,  G02B21/16

Abstract: The present invention, among other things, provides technologies for detecting and/or quantifying nucleic acids in cells, tissues, organs or organisms. In some embodiments, through sequential barcoding, the present invention provides methods for high-throughput profiling of a large number of targets, such as transcripts and/or DNA loci.

公开(公告)号：US12217968B2

公开(公告)日：2025-02-04

申请号：US17224037

申请日：2021-04-06

Applicant: California Institute of Technology

Inventor： Harold Frank Greer

IPC: H01L21/306 ,  H01L21/3105 ,  H01L21/321 ,  H01L21/67 ,  H01L21/677

Abstract: A method for etching a surface including obtaining a substrate comprising a material; reacting a surface of a substrate with a reactant, comprising a gas or a plasma, to form a reactive layer on the substrate, the reactive layer comprising a chemical compound including the reactant and the material; and wet etching or dissolving the reactive layer with a liquid wet etchant of solvent that selectively etches or dissolves the reactive layer but not the substrate.