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    METHOD AND SYSTEM FOR DETERMINING THE CONCENTRATION OF AN ANALYTE IN A FLUID SAMPLE
    11.
    发明申请
    METHOD AND SYSTEM FOR DETERMINING THE CONCENTRATION OF AN ANALYTE IN A FLUID SAMPLE 有权
    用于确定流体样品中分析物浓度的方法和系统

    公开(公告)号：US20160109336A1

    公开(公告)日：2016-04-21

    申请号：US14887320

    申请日：2015-10-19

    Applicant: Labcyte Inc.

    Inventor： Richard N. Ellson ,  Richard G. Stearns ,  Joseph D. Olechno ,  Ian Sinclair ,  Jonathan Wingfield

    IPC: G01N1/28 ,  H01J49/04

    CPC classification number: G01N1/28 ,  C12Q1/68 ,  G01N33/6848 ,  G01N33/6851 ,  H01J49/04 ,  H01J49/0422 ,  H01J49/0431 ,  Y10T436/24 ,  Y10T436/25875

    Abstract: A method and system are provided for detecting the concentration of an analyte in a fluid sample. The method and system involve analysis of a volatilized, ionized fluid sample using a mass spectrometer or other ionic analyte detection device that provides a signal proportional in intensity to the quantity of ionized analyte detected. The improvement involves replacement of a necessary non-analyte component in the fluid sample with a substitute component that serves the same purpose as the original component but is either more volatile than the original component and/or the analyte or undergoes a reaction to provide lower molecular weight reaction products, and results in an increased intensity in signal and signal-to-noise ratio. Acoustic fluid ejection is a preferred method of generating nanoliter-sized droplets of fluid sample that are then volatilized, ionized, and analyzed. Also provided are zwitterionic compounds suitable as the substitute components that when ionized and heated decompose to provide carbonic dioxide, a nitrogenous species such as ammonia, an amine, or nitrogen gas, and a volatile aromatic compound.

    Abstract translation: 提供了一种用于检测流体样品中分析物浓度的方法和系统。 该方法和系统涉及使用质谱仪或其他离子分析物检测装置对挥发的离子化流体样品进行分析，其提供与所检测的电离分析物的量的强度成比例的信号。 该改进涉及用具有与原始组分相同目的的替代组分替代流体样品中必需的非分析物组分，但是比原始组分和/或分析物更易挥发，或者经历反应以提供较低分子量 重量反应产物，并导致信号和信噪比的强度增加。 声流体喷射是产生流体样品的纳升级大小的液滴的优选方法，然后将其挥发，电离和分析。 还提供了两种离子化合物，其适合作为当电离和加热分解以提供二氧化碳，含氮物质如氨，胺或氮气和挥发性芳族化合物时的替代成分。

    SAMPLE CONTAINERS HAVING IDENTIFICATION MARKS EMBEDDED THEREIN AND BEING ADAPTED FOR ACOUSTIC EJECTIONS
    13.
    发明申请
    SAMPLE CONTAINERS HAVING IDENTIFICATION MARKS EMBEDDED THEREIN AND BEING ADAPTED FOR ACOUSTIC EJECTIONS 审中-公开
    具有嵌入式标识的样品容器，适用于声音喷射

    公开(公告)号：US20150197372A1

    公开(公告)日：2015-07-16

    申请号：US14595073

    申请日：2015-01-12

    Applicant: LABCYTE INC.

    Inventor： Lars MAJLOF ,  Richard N. ELLSON

    IPC: B65D25/20 ,  B65D41/02 ,  G06K19/06

    CPC classification number: G06K19/06037 ,  B01L3/508 ,  B01L2300/021 ,  B01L2300/0832 ,  B01L2300/0841 ,  B01L2300/0858 ,  B01L2400/0439 ,  G06K1/128 ,  G06K19/06028 ,  G06K19/06121 ,  G06K19/06159

    Abstract: A container may include a tubular sidewall defining interior and exterior surfaces of the container, and including first and second regions disposed relative to one another along a major axis of the tubular sidewall. The container further may include an identification mark embedded within the tubular sidewall at a plurality of sectors about the tubular sidewall within the first region. Each sector may have a width, and the identification mark is machine readable by a reader viewing any arbitrary one or more of the sectors. An exemplary method for preparing such a container is also provided.

    Abstract translation: 容器可以包括限定容器的内部和外部表面的管状侧壁，并且包括沿着管状侧壁的长轴线相对于彼此设置的第一和第二区域。 容器还可以包括在第一区域内围绕管状侧壁的多个扇区处嵌入管状侧壁内的识别标记。 每个扇区可以具有宽度，并且识别标记由阅读器观看任意一个或多个扇区的机器可读取。 还提供了制备这种容器的示例性方法。

    FOCUSED ACOUSTIC RADIATION FOR THE EJECTION OF SUBWAVELENGTH DROPLETS
    16.
    发明公开
    FOCUSED ACOUSTIC RADIATION FOR THE EJECTION OF SUBWAVELENGTH DROPLETS 审中-公开

    公开(公告)号：US20230338942A1

    公开(公告)日：2023-10-26

    申请号：US18335764

    申请日：2023-06-15

    Applicant: Labcyte Inc.

    Inventor： Richard G. Stearns

    IPC: B01L3/02 ,  H01J49/04

    CPC classification number: B01L3/0268 ,  H01J49/0454 ,  B01L2200/0642 ,  B01L2200/141 ,  B01L2400/0436

    Abstract: Focused acoustic radiation, referred to as tonebursts, are applied to a volume of liquid to generate a set of droplets. The droplets generated are substantially smaller in scale than the focal spot size of the acoustic beam (e.g., the frequency at which the acoustic transducer operates). Further, the droplets have trajectories that are substantially in the direction of the acoustic beam propagation direction. In one embodiment, a first toneburst is applied to temporarily raise a protuberance on a free surface of the fluid. After the protuberance has reached a certain state, a second toneburst is applied to the protuberance to break it into very small droplets. In one embodiment, the state of the protuberance at which the second toneburst is supplied is the time period shortly after the protuberance reaches its maximum height but before the protuberance recedes back into the volume of fluid.

    THERMAL ADAPTER FOR AUTOMATED THERMAL CYCLING
    18.
    发明公开
    THERMAL ADAPTER FOR AUTOMATED THERMAL CYCLING 审中-公开

    公开(公告)号：US20230249191A1

    公开(公告)日：2023-08-10

    申请号：US18014354

    申请日：2021-08-30

    Applicant: Labcyte Inc.

    Inventor： Richard N. Ellson

    IPC: B01L7/00 ,  B01L3/00

    CPC classification number: B01L7/52 ,  B01L3/50853 ,  B01L2300/0829 ,  B01L2400/0436 ,  B01L2200/16 ,  B01L2300/1805

    Abstract: Systems and methods for processing samples in a multi-well reaction vessel can include inserting a multi-well reaction vessel into a heating chamber of a thermal cycler, enclosing the multi-well reaction vessel in the heating chamber, and compressing a bottom surface of the multi-well reaction vessel into a compliant thermally conductive insert to increase a thermal contact area between the bottom surface and the compliant thermally conductive insert. The compliant thermally conductive insert can be placed between the multi-well reaction vessel and a heating element of the thermal cycler, where heat flux from the heating element passes through the compliant thermally conductive insert to the reaction vessel. The compliant thermally conductive insert can include an elastically deformable creped graphite sheet that can reversibly deform according to different compression profiles depending on the topography or flexure of the reaction vessel and/or heating element.

    Focused acoustic radiation for rapid sequential ejection of subwavelength droplets
    19.
    发明授权
    Focused acoustic radiation for rapid sequential ejection of subwavelength droplets 有权

    公开(公告)号：US11688597B1

    公开(公告)日：2023-06-27

    申请号：US17077870

    申请日：2020-10-22

    Applicant: Labcyte Inc.

    Inventor： Richard G. Stearns

    IPC: H01J49/04 ,  B01L3/00

    CPC classification number: H01J49/0445 ,  B01L3/502 ,  B01L2200/06 ,  B01L2200/14 ,  B01L2400/0436

    Abstract: Focused acoustic radiation, referred to as tonebursts, are applied to a volume of liquid to generate a set of droplets. In one embodiment, a first toneburst is applied to temporarily raise a mound or protuberance on a free surface of the fluid. After the mound has reached a certain state, at least two additional toneburst can be applied to the protuberance to sequentially eject multiple bursts of multiple droplets. In one embodiment, the state of the mound can be maintained by a sustained acoustic signal, during which time multiple additional tonebursts can be applied to sequentially eject multiple bursts of multiple droplets from the mound.

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