公开(公告)号：US10074525B2

公开(公告)日：2018-09-11

申请号：US15026240

申请日：2014-10-07

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Bruce Andrew Collings ,  Bruce A. Thomson

IPC: H01J49/00 ,  H01J49/04 ,  H01J49/06 ,  H01J49/40 ,  H01J49/42

CPC classification number: H01J49/0045 ,  H01J49/0063 ,  H01J49/04 ,  H01J49/063 ,  H01J49/40 ,  H01J49/4215 ,  H01J49/4225 ,  H01J49/4285

Abstract: Systems and methods are provided for selecting and fragmenting a first precursor ion in an MS3 experiment. One or more first excitation parameters are calculated that define a first dipole excitation using a processor. The first dipole excitation is used to select a first precursor ion and fragment the first precursor ion to produce a second precursor ion. The first dipole excitation is applied to the continuous beam of ions by sending a first set of data including the first excitation parameters to a mass spectrometer. The first set of data is sent so that a first quadrupole applies the first dipole excitation to a continuous beam of ions. The mass spectrometer includes an ion source that provides the continuous beam of ions and the first quadrupole that receives the continuous beam of ions and is adapted to apply dipole excitation to the continuous beam of ions.

公开(公告)号：US09378936B2

公开(公告)日：2016-06-28

申请号：US14373248

申请日：2013-01-16

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Bruce Andrew Collings ,  Martian Daniel Dima

IPC: H01J49/00 ,  H01J49/02 ,  H01J49/26 ,  H02M1/088 ,  H02M7/10

CPC classification number: H01J49/022 ,  H01J49/0027 ,  H01J49/26 ,  H02M1/088 ,  H02M7/103

Abstract: Systems, devices, circuits, and methods are provided for an improved mass spectrometry detection system that comprises an ion source and a detector that operate at opposite polarities. In some embodiments, the system can comprise a positive and negative multiplier, each of which can be configured to provide voltage to each of the ion source and the detector. In some embodiments, the system can comprise switches that allow the change between positive and negative polarities for the ion source or detector to occur quickly. A variety of embodiments of systems, devices, circuits, and methods in conjunction with the disclosures are provided.

Abstract translation: 提供了用于改进的质谱检测系统的系统，装置，电路和方法，其包括以相反极性操作的离子源和检测器。 在一些实施例中，系统可以包括正和负乘法器，其中的每一个可被配置为向离子源和检测器中的每一个提供电压。 在一些实施例中，系统可以包括允许离子源或检测器的正极性和负极性之间的变化快速发生的开关。 提供了结合公开的系统，设备，电路和方法的各种实施例。