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    Sampling Interface for a Mass Spectrometer
    11.
    发明申请
    Sampling Interface for a Mass Spectrometer 有权

    公开(公告)号：US20210249246A1

    公开(公告)日：2021-08-12

    申请号：US16972925

    申请日：2019-06-07

    Applicant: DH Technologies Development Pte. Ltd.

    Inventor： Thomas R Covey ,  Chang Liu

    IPC: H01J49/16 ,  H01J49/04 ,  G01N30/72

    Abstract: Sampling probes and interfaces for mass spectrometry systems and methods are described to analyze a composition of a substance. The system includes a liquid reservoir containing solvent; a gas reservoir containing nebulizer gas; a conduit that is in fluid communication with the liquid reservoir, the conduit comprising a first and second portion and a junction portion, the first and second portion being joined at the junction portion, and defining an angle therebetween at the junction and the junction portion contains an aperture that is open to the atmosphere. A nebulizer conduit that is co-axial and partially surrounds the second portion and completely surrounds an end of the second portion can also be present, the nebulizer conduit being fluidly connected to the gas reservoir and that allows a gas to flow from the gas reservoir over an external surface of the second portion and the end of the second portion.

    Magnetic Elements for Processing Fluids
    12.
    发明申请
    Magnetic Elements for Processing Fluids 审中-公开
    加工液磁性元件

    公开(公告)号：US20170074871A1

    公开(公告)日：2017-03-16

    申请号：US15121803

    申请日：2015-02-27

    Applicant: DH Technologies Development PTE Ltd.

    Inventor： John L. Campbell ,  Thomas R. Covey ,  Chang Liu ,  Subhasish Purkayastha

    IPC: G01N33/543 ,  B01F13/08 ,  B01F13/00 ,  B01L3/00 ,  G01N1/38

    CPC classification number: G01N33/54326 ,  B01F13/0059 ,  B01F13/0818 ,  B01L3/50273 ,  B01L3/502792 ,  B01L2200/0647 ,  B01L2300/0819 ,  B01L2400/0427 ,  B01L2400/043 ,  G01N1/38 ,  G01N27/745 ,  G01N35/0098 ,  G01N2001/386

    Abstract: Methods and apparatus for processing fluids on a macro- or micro-scale are described. In various aspects, a fluid may have a plurality of elongated (i.e., substantially rod-shaped) magnetic elements disposed therein within a fluid container. An illustrative fluid container is an actuator electrode or a processing vial of a microfluidic device, such as a digital microfluidic device. A magnet component may be configured to generate a magnetic force sufficient to influence the movement of the plurality of elongated magnetic elements within the fluid to be processed. For example, the magnetic force (or magnetic force gradient) may influence the plurality of elongated magnetic elements to rotate, spin, and/or move laterally side-to-side. The shape and movements of the plurality of elongated magnetic elements facilitate the rapid and efficient processing of the fluid, such as fluid mixing and/or fluid separation.

    Abstract translation: 描述了在宏观或微观尺度上处理流体的方法和装置。 在各个方面，流体可以具有设置在流体容器内的多个细长（即基本棒状）的磁性元件。 说明性的流体容器是诸如数字微流体装置的微流体装置的致动器电极或处理小瓶。 磁体部件可以被配置为产生足以影响待处理流体中的多个细长磁性元件的运动的磁力。 例如，磁力（或磁力梯度）可以影响多个细长的磁性元件以使它们在侧面上相互旋转，旋转和/或横向移动。 多个细长磁性元件的形状和运动有助于流体的快速和有效的处理，例如流体混合和/或流体分离。

    Simplification of method or system using scout MRM
    13.
    发明授权
    Simplification of method or system using scout MRM 有权

    公开(公告)号：US12300478B2

    公开(公告)日：2025-05-13

    申请号：US17999569

    申请日：2021-05-21

    Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

    Inventor： David M. Cox ,  Chang Liu

    IPC: H01J49/00 ,  H01J49/04 ,  H01J49/16

    Abstract: Each sample of a series of samples is ejected at an ejection time and according to a sample order. Each ejected sample of the series is ionized, producing ion beam. A list of different sets of MRM transitions is received. Each set of the list corresponds to a different sample. A group of one or more different sets is selected from the list. Initially, each set selected for the group corresponds to a different sample of one or more first samples of the series. A mass spectrometer is instructed to execute each transition of each set of the group on the ion beam until a transition of a set of the group is detected, upon which, one or more next sets are selected from the list to be monitored using the set of the detected transition and the sample order.

    Methods and Systems for Increasing Sensitivity of Direct Sampling Interfaces for Mass Spectrometric Analysis
    15.
    发明公开
    Methods and Systems for Increasing Sensitivity of Direct Sampling Interfaces for Mass Spectrometric Analysis 审中-公开

    公开(公告)号：US20240347333A1

    公开(公告)日：2024-10-17

    申请号：US18507940

    申请日：2023-11-13

    Applicant: DH Technologies Development Pte. Ltd.

    Inventor： Don W. Arnold ,  Thomas R. Covey ,  Chang Liu

    IPC: H01J49/04 ,  G01N1/40 ,  G01N30/00 ,  H01J49/16

    CPC classification number: H01J49/0495 ,  G01N1/405 ,  H01J49/0404 ,  H01J49/165 ,  G01N2030/009

    Abstract: Methods and systems for delivering a liquid sample to an ion source for the generation of ions and subsequent analysis by mass spectrometry are provided herein. In accordance with various aspects of the present teachings, MS-based systems and methods are provided in which the flow of desorption solvent within a sampling probe fluidly coupled to an ion source can be selectively controlled such that one or more analyte species can be desorbed from a sample substrate inserted within the sampling probe within a decreased volume of desorption solvent for subsequently delivery to the ion source. In various aspects, sensitivity can be increased due to higher desorption efficiency (e.g., due to increased desorption time) and/or decreased dilution of the desorbed analytes. The methods and systems described herein can additionally or alternatively provide for the selective control of the flow rate of the desorption solvent within the sampling interface so as to enable additional processing steps to occur within the sampling probe (e.g., multiple samplings, reactions).

    Simplification of Method or System Using Scout MRM
    17.
    发明公开
    Simplification of Method or System Using Scout MRM 审中-公开

    公开(公告)号：US20230230825A1

    公开(公告)日：2023-07-20

    申请号：US17999569

    申请日：2021-05-21

    Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

    Inventor： David M. Cox ,  Chang Liu

    IPC: H01J49/00 ,  H01J49/04

    CPC classification number: H01J49/0081 ,  H01J49/0454 ,  H01J49/0404 ,  H01J49/164

    Abstract: Each sample of a series of samples is ejected at an ejection time and according to a sample order. Each ejected sample of the series is ionized, producing ion beam. A list of different sets of MRM transitions is received. Each set of the list corresponds to a different sample. A group of one or more different sets is selected from the list. Initially, each set selected for the group corresponds to a different sample of one or more first samples of the series. A mass spectrometer is instructed to execute each transition of each set of the group on the ion beam until a transition of a set of the group is detected, upon which, one or more next sets are selected from the list to be monitored using the set of the detected transition and the sample order.

    Methods and Systems for Increasing Sensitivity of Direct Sampling Interfaces for Mass Spectrometric Analysis
    18.
    发明申请
    Methods and Systems for Increasing Sensitivity of Direct Sampling Interfaces for Mass Spectrometric Analysis 有权

    公开(公告)号：US20230062622A1

    公开(公告)日：2023-03-02

    申请号：US18046986

    申请日：2022-10-17

    Applicant: DH Technologies Development Pte. Ltd.

    Inventor： Don W. Arnold ,  Thomas R. Covey ,  Chang Liu

    IPC: H01J49/04 ,  G01N1/40 ,  H01J49/16

    Abstract: Methods and systems for delivering a liquid sample to an ion source for the generation of ions and subsequent analysis by mass spectrometry are provided herein. In accordance with various aspects of the present teachings, MS-based systems and methods are provided in which the flow of desorption solvent within a sampling probe fluidly coupled to an ion source can be selectively controlled such that one or more analyte species can be desorbed from a sample substrate inserted within the sampling probe within a decreased volume of desorption solvent for subsequently delivery to the ion source. In various aspects, sensitivity can be increased due to higher desorption efficiency (e.g., due to increased desorption time) and/or decreased dilution of the desorbed analytes. The methods and systems described herein can additionally or alternatively provide for the selective control of the flow rate of the desorption solvent within the sampling interface so as to enable additional processing steps to occur within the sampling probe (e.g., multiple samplings, reactions).

    A System and Method to Conduct Correlated Chemical Mapping
    19.
    发明申请
    A System and Method to Conduct Correlated Chemical Mapping 有权

    公开(公告)号：US20220148866A1

    公开(公告)日：2022-05-12

    申请号：US17427300

    申请日：2020-02-03

    Applicant: DH Technologies Development Pte. Ltd.

    Inventor： Thomas R. Covey ,  Chang Liu ,  Gary J. Van Berkel

    IPC: H01J49/00 ,  H01J49/04 ,  H01J49/06

    Abstract: A method for the repeated analysis of a sample bearing location. The sample bearing location may include, for instance, a sampled point in a tissue slice that is spatially and temporally correlated to the original slice. The slice may be in whole, or in part, a complete item or a portion of a complete item such as, for example, a human organ. The method improves the analysis process, such as mass spectrometry analysis, by providing a much more complete characterization of the target. The method also allows for the splitting of the sample and chemical/physical alteration of the aliquots for enhanced chemical analysis.

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