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公开(公告)号：US20210249246A1
公开(公告)日：2021-08-12
申请号：US16972925
申请日：2019-06-07
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Thomas R Covey , Chang Liu
Abstract: Sampling probes and interfaces for mass spectrometry systems and methods are described to analyze a composition of a substance. The system includes a liquid reservoir containing solvent; a gas reservoir containing nebulizer gas; a conduit that is in fluid communication with the liquid reservoir, the conduit comprising a first and second portion and a junction portion, the first and second portion being joined at the junction portion, and defining an angle therebetween at the junction and the junction portion contains an aperture that is open to the atmosphere. A nebulizer conduit that is co-axial and partially surrounds the second portion and completely surrounds an end of the second portion can also be present, the nebulizer conduit being fluidly connected to the gas reservoir and that allows a gas to flow from the gas reservoir over an external surface of the second portion and the end of the second portion.
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公开(公告)号：US20210265150A1
公开(公告)日：2021-08-26
申请号：US17255861
申请日：2019-06-28
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Don W Arnold , Thomas R Covey , Chang Liu
IPC: H01J49/04
Abstract: Methods and systems for delivering liquid sample to an ion source and subsequent analysis by mass spectrometry. In accordance with various aspects of the present teachings, MS-based systems and methods are provided in which desorption solvent is used in sampling interface to desorb analyte species from an SPME device that is coupled to an ion source to ionize analyte species desorbed into the desorption solvent for MS analysis (e.g., without a liquid chromatography (LC) column between the sampling interface and the ion source). In various aspects of the methods and systems described herein, configuring the sampling interface can be optimized so as to reduce the fluid volume dead space about the fluid inlet so as to concentrate the one or more analyte species desorbed at optimized conditions from the SPME substrate in a decreased volume of the desorption solvent when the SPME device is inserted into sampling interface.
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公开(公告)号：US09870904B2
公开(公告)日：2018-01-16
申请号：US15104638
申请日：2014-10-31
Applicant: DH Technologies Development PTE Ltd.
Inventor： Thomas R Covey , Peter Kovarik
CPC classification number: H01J49/045 , G01N30/724 , G01N30/7246 , G01N30/7273 , H01J49/0404 , H01J49/044 , H01J49/0468 , H01J49/167
Abstract: Systems and methods for delivering a sample to a mass spectrometer are provided. In one aspect, the systems and methods can provide efficient cooling of an ion source probe to prevent overheating and the resulting degradation in ion sampling. In some aspects, such cooling can result in improved consistency and/or efficiency of ion formation. Moreover, ion source cooling in accordance with various aspects of the present teachings can allow for the use of higher temperatures in the ionization chamber (thereby improving desolvation) and/or can enable the use of lower flow rate sample sources than with conventional techniques.
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公开(公告)号：US12036568B2
公开(公告)日：2024-07-16
申请号：US16973801
申请日：2019-06-11
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Thomas R Covey , Chang Liu
CPC classification number: B05B12/004 , B05B12/082 , G01F22/00 , H01J49/0031 , H01J49/165 , B05B17/06
Abstract: Improvements in acoustically dispensed samples that are injected into an open port probe (OPP) are described. Apparatus and method are described that calibrate the volume dispensing determination and mechanisms in the acoustic dispenser to produce accurate and precise volumetric delivery.
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公开(公告)号：US11232938B2
公开(公告)日：2022-01-25
申请号：US17255861
申请日：2019-06-28
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Don W Arnold , Thomas R Covey , Chang Liu
Abstract: Methods and systems for delivering liquid sample to an ion source and subsequent analysis by mass spectrometry. In accordance with various aspects of the present teachings, MS-based systems and methods are provided in which desorption solvent is used in sampling interface to desorb analyte species from an SPME device that is coupled to an ion source to ionize analyte species desorbed into the desorption solvent for MS analysis (e.g., without a liquid chromatography (LC) column between the sampling interface and the ion source). In various aspects of the methods and systems described herein, configuring the sampling interface can be optimized so as to reduce the fluid volume dead space about the fluid inlet so as to concentrate the one or more analyte species desorbed at optimized conditions from the SPME substrate in a decreased volume of the desorption solvent when the SPME device is inserted into sampling interface.
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Patent Agency Ranking
6.发明申请公开(公告)号：US20170336356A1
公开(公告)日：2017-11-23
申请号：US15520867
申请日：2015-10-21
Applicant: DH Technologies Development PTE Ltd.
Inventor： Thomas R Covey , Yang Kang , Frank Londry , Bradley B Schneider
CPC classification number: G01N27/624 , H01J49/0031 , H01J49/004 , H01J49/04 , H01J49/06 , H01J49/24
Abstract: A sample analysis system having a continuous beam ion mobility filter incorporates an ion removal mechanism for removing residual ions from the ion mobility filter to reduce cross-talk. A sample to be analyzed by the sample analysis system can be entered into the continuous beam ion mobility filter, which filters the ions of the sample and passes the filtered group of ions to a detector or a mass analyzer (e.g., via an ion optics assembly disposed between the mass analyzer and the ion mobility filter), where some or all of the ions in the group are detected. The ion removal mechanism then removes all or a substantial portion of the residual ions from the ion mobility filter that are left over from the first filtered group before a second filtered group is passed through. In some aspects, the ion removal mechanism can be operated concurrent with an ion removal mechanism for removing residual ions from an ion optics assembly.
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公开(公告)号：US20230207299A1
公开(公告)日：2023-06-29
申请号：US17999641
申请日：2021-05-21
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventor： Thomas R Covey , Gordana Ivosev , Peter Kovarik , Chang Liu
CPC classification number: H01J49/0454 , H01J49/0418 , H01J49/0036
Abstract: A trace of intensity versus time values is received for a series of samples produced by a mass spectrometer. Also, a series of ejections times corresponding to the series of samples produced by a sample introduction system is received. A series of expected peak times corresponding to the series of ejection times are calculated using a known delay time from ejection to mass analysis. At least one isolated peak of the trace is identified using the series of expected peak times. A peak profile is calculated by fitting a mixture of at least two different distribution functions to the at least one isolated peak. For at least one time of the series of expected peak times, an area of a peak at the one time is calculated by fitting the peak profile to the trace at the one time and calculating an area of the fitted peak profile.
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公开(公告)号：US11450519B2
公开(公告)日：2022-09-20
申请号：US16972925
申请日：2019-06-07
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Thomas R Covey , Chang Liu
Abstract: Sampling probes and interfaces for mass spectrometry systems and methods are described to analyze a composition of a substance. The system includes a liquid reservoir containing solvent; a gas reservoir containing nebulizer gas; a conduit that is in fluid communication with the liquid reservoir, the conduit comprising a first and second portion and a junction portion, the first and second portion being joined at the junction portion, and defining an angle therebetween at the junction and the junction portion contains an aperture that is open to the atmosphere. A nebulizer conduit that is co-axial and partially surrounds the second portion and completely surrounds an end of the second portion can also be present, the nebulizer conduit being fluidly connected to the gas reservoir and that allows a gas to flow from the gas reservoir over an external surface of the second portion and the end of the second portion.
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公开(公告)号：US20210121905A1
公开(公告)日：2021-04-29
申请号：US16973801
申请日：2019-06-11
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Thomas R Covey , Chang Liu
Abstract: Improvements in acoustically dispensed samples that are injected into an open port probe (OPP) are described. Apparatus and method are described that calibrate the volume dispensing determination and mechanisms in the acoustic dispenser to produce accurate and precise volumetric delivery.
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公开(公告)号：US20170032949A1
公开(公告)日：2017-02-02
申请号：US15104638
申请日：2014-10-31
Applicant: DH Technologies Development PTE Ltd.
Inventor： Thomas R Covey , Peter Kovarik
CPC classification number: H01J49/045 , G01N30/724 , G01N30/7246 , G01N30/7273 , H01J49/0404 , H01J49/044 , H01J49/0468 , H01J49/167
Abstract: Systems and methods for delivering a sample to a mass spectrometer are provided. In one aspect, the systems and methods can provide efficient cooling of an ion source probe to prevent overheating and the resulting degradation in ion sampling. In some aspects, such cooling can result in improved consistency and/or efficiency of ion formation. Moreover, ion source cooling in accordance with various aspects of the present teachings can allow for the use of higher temperatures in the ionization chamber (thereby improving desolvation) and/or can enable the use of lower flow rate sample sources than with conventional techniques.
Abstract translation: 提供了将样品递送到质谱仪的系统和方法。 在一个方面，系统和方法可以提供离子源探针的有效冷却，以防止过热和离子取样导致的降解。 在一些方面，这种冷却可导致提高离子形成的一致性和/或效率。 此外，根据本教导的各个方面的离子源冷却可以允许在电离室中使用更高的温度（从而改善去溶剂化）和/或可以使用比常规技术更低的流速样品源。
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