公开(公告)号：US10796895B2

公开(公告)日：2020-10-06

申请号：US16551056

申请日：2019-08-26

Applicant: PERKINELMER HEALTH SCIENCES CANADA, INC.

Inventor： Chady Stephan ,  Hamid Badiei ,  Serguei Savtchenko ,  Samad Bazargan

IPC: H01J49/00 ,  H01J49/10 ,  G01N30/72 ,  H01J49/04 ,  H01J49/16

Abstract: Devices, systems and methods including a spray chamber are described. In certain examples, the spray chamber may be configured with an outer chamber configured to provide tangential gas flows. In other instances, an inner tube can be positioned within the outer chamber and may comprise a plurality of microchannels. In some examples, the outer chamber may comprise dual gas inlet ports. In some instances, the spray chamber may be configured to provide tangential gas flow and laminar gas flows to prevent droplet formation on surfaces of the spray chamber. Optical emission devices, optical absorption devices and mass spectrometers using the spray chamber are also described.

公开(公告)号：US20190244799A1

公开(公告)日：2019-08-08

申请号：US16209130

申请日：2018-12-04

Applicant: PERKINELMER HEALTH SCIENCES CANADA, INC.

Inventor： Chady Stephan ,  Ruth Merrifield

IPC: H01J49/10 ,  H01J49/04 ,  G01N30/72 ,  H01J49/16

CPC classification number: H01J49/107 ,  G01N30/7273 ,  H01J49/045 ,  H01J49/049 ,  H01J49/167

Abstract: Certain configurations of systems comprising a cell analyzer and a mass spectrometer are described. In some embodiments, the system can be used to determine both a cell phenotype or cellular response and an amount of at least one elemental species in the cell. The phenotype or other cellular characteristic and elemental content of each cell in a cell population can be determined and correlated.

公开(公告)号：US20230197431A1

公开(公告)日：2023-06-22

申请号：US18109119

申请日：2023-02-13

Applicant: PerkinElmer Health Sciences Canada, Inc.

Inventor： Chady Stephan

IPC: H01J49/10 ,  H01J49/04 ,  H01J49/16 ,  G01N30/72 ,  G01N21/73

CPC classification number: H01J49/105 ,  H01J49/045 ,  H01J49/049 ,  H01J49/107 ,  H01J49/167 ,  G01N30/7273 ,  G01N21/73

Abstract: Systems and methods for use in introducing samples to an analytical device for single particle compositional analysis. Suitable analytical devices include, for example, an inductively coupled plasma-optical emission spectrometer. Prior to introduction to the analytical device, the sample gas is exchanged with argon gas, for example, using a gas exchange device. The analytical device may be calibrated with a liquid sample which is aerosolized prior to entry into the analytical device.

公开(公告)号：US11037771B2

公开(公告)日：2021-06-15

申请号：US16836695

申请日：2020-03-31

Applicant: PERKINELMER HEALTH SCIENCES CANADA, INC.

Inventor： Pritesh Patel ,  Chady Stephan ,  Fadi Abou-Shakra

IPC: H01J49/02 ,  H01J49/00 ,  H01J49/06 ,  H01J49/10

Abstract: Certain configurations described herein are directed to mass spectrometer systems that can use a gas mixture to select and/or detect ions. In some instances, the gas mixture can be used in both a collision mode and in a reaction mode to provide improved detection limits using the same gas mixture.

公开(公告)号：US10804091B2

公开(公告)日：2020-10-13

申请号：US16209140

申请日：2018-12-04

Applicant: PERKINELMER HEALTH SCIENCES CANADA, INC.

Inventor： Chady Stephan ,  Samad Bazargan

IPC: H01J49/10 ,  H01J49/00 ,  H01J49/26 ,  H01J49/16 ,  G01N30/72 ,  H01J49/04

Abstract: Methods and systems of identifying two or more elements in a single individual particle are described. In some examples, an optical emission from each of an ionized first element and an ionized second element can simultaneously be detected to identify at least a first element in a particle from a plurality of particles using the optical emission from the ionized first element, and to identify at least a second element in the particle from the plurality of particles using the optical emission from the second ionized element. The identified first element and the identified second element can be used to identify a source of the particle from a plurality of particles.

公开(公告)号：US20200161117A1

公开(公告)日：2020-05-21

申请号：US16551056

申请日：2019-08-26

Applicant: PERKINELMER HEALTH SCIENCES CANADA, INC.

Inventor： Chady Stephan ,  Hamid Badiei ,  Serguei Savtchenko ,  Samad Bazargan

IPC: H01J49/10 ,  H01J49/16 ,  H01J49/04 ,  G01N30/72

Abstract: Devices, systems and methods including a spray chamber are described. In certain examples, the spray chamber may be configured with an outer chamber configured to provide tangential gas flows. In other instances, an inner tube can be positioned within the outer chamber and may comprise a plurality of microchannels. In some examples, the outer chamber may comprise dual gas inlet ports. In some instances, the spray chamber may be configured to provide tangential gas flow and laminar gas flows to prevent droplet formation on surfaces of the spray chamber. Optical emission devices, optical absorption devices and mass spectrometers using the spray chamber are also described.

公开(公告)号：US10395912B2

公开(公告)日：2019-08-27

申请号：US16146752

申请日：2018-09-28

Applicant: PERKINELMER HEALTH SCIENCES CANADA, INC.

Inventor： Chady Stephan ,  Hamid Badiei ,  Serguei Savtchenko ,  Samad Bazargan

IPC: H01J49/00 ,  H01J49/10 ,  H01J49/04 ,  H01J49/16 ,  G01N30/72

Abstract: Devices, systems and methods including a spray chamber are described. In certain examples, the spray chamber may be configured with an outer chamber configured to provide tangential gas flows. In other instances, an inner tube can be positioned within the outer chamber and may comprise a plurality of microchannels. In some examples, the outer chamber may comprise dual gas inlet ports. In some instances, the spray chamber may be configured to provide tangential gas flow and laminar gas flows to prevent droplet formation on surfaces of the spray chamber. Optical emission devices, optical absorption devices and mass spectrometers using the spray chamber are also described.