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公开(公告)号：US20240257921A1
公开(公告)日：2024-08-01
申请号：US18635717
申请日：2024-04-15
Applicant: SRI International
Inventor： Peter B. Madrid , Nathan Collins , Mario Latendresse , Jeremiah Malerich , Markus Krummenacker
Abstract: Retrosynthetic methods are described for determining one or more optimal synthetic routes to generate a target compound.
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公开(公告)号：US11639326B2
公开(公告)日：2023-05-02
申请号：US16500687
申请日：2018-04-06
Applicant: SRI INTERNATIONAL
Inventor： Nathan Collins , Jeremiah Malerich , Judy Szeto , Joseph A. Kozocas
IPC: C07C51/08 , C07C253/16 , C07C253/14 , C07C17/16 , C07C29/143 , C07C303/28 , C07C45/46 , C07C57/30 , C07C255/01
Abstract: This disclosure generally relates to methods of making ibuprofen, naproxen, and derivatives thereof. This disclosure also generally relates to compounds made by the disclosed methods. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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公开(公告)号：US20230117592A1
公开(公告)日：2023-04-20
申请号：US17788275
申请日：2020-12-18
Applicant: SRI International
Inventor： Ling Jong , Nathan Collins , Raymond Ng
IPC: C07C217/86 , C07C217/92 , C07D215/38 , C07D213/74 , C07D249/08 , C07D403/12 , C07D401/12 , C07D409/12 , C07D405/06 , C07D209/14 , C07C211/53 , C07D309/04 , C07D305/08 , C07D295/13 , C07C211/54 , C07D413/12 , C07D405/12 , C07C211/56 , C07D403/06 , C07D405/14
Abstract: Various embodiments of the present disclosure are directed to compounds having Formula I, Formula II, Formula IIA, Formula III, Formula IIIA, Formula IIIB, and/or pharmaceutically acceptable salts thereof. The compounds can be suitable for inhibiting lipoxygenases and/or treating associated diseases. In some embodiments, subject compounds are used to prepare a composition that is effective in treating neurodegenerative diseases.
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公开(公告)号：US10882020B1
公开(公告)日：2021-01-05
申请号：US15498145
申请日：2017-04-26
Applicant: SRI International
Inventor： Peter Madrid , Pauline Bourbon , Michal Avital-Shmilovici , Nathan Collins
IPC: C40B50/00 , C40B50/18 , B01J19/00 , C12Q1/6876 , C12Q1/68
Abstract: Embodiments in accordance with the present disclosure are directed to polymer beads and uses thereof, including forming libraries of compounds for screening and assay purposes. A polymer bead, in accordance with embodiments, has an interior surface and an exterior surface that are topologically segregated from one another. The interior surface includes a protecting group and the exterior surface includes a deprotected group, which can also be referred to as a deprotected functional group. The protecting group can includes a nitrobenzenesulfonamide group that protects an amine group.
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公开(公告)号：US20240209041A1
公开(公告)日：2024-06-27
申请号：US18390354
申请日：2023-12-20
Applicant: SRI International
Inventor： Kathlynn C. Brown , Nathan Collins , Shunzi "Susan" Li , Curtis Allred , Keen Chung , Michael McGuire
CPC classification number: C07K14/4702 , A61K47/64 , A61P35/00 , C07K16/2803 , A61K38/00
Abstract: Disclosed are compositions comprising an antibody conjugated to one or more molecular guidance system (MGS) peptides. Disclosed are methods of treating a subject in need thereof comprising administering to the subject in need thereof an effective amount of an antibody conjugated to one or more MGS peptides, wherein the antibody targets an intracellular target involved in the disease process. Disclosed are methods of targeting an intracellular target comprising administering an antibody conjugated to one or more MGS peptides, wherein the antibody targets an intracellular target.
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Patent Agency Ranking
公开(公告)号：US20240159784A1
公开(公告)日：2024-05-16
申请号：US18389930
申请日：2023-12-20
Applicant: SRI International
Inventor： Nathan Collins , Jeremiah Malerich , Jason D. White , Kevin Luebke , Kristina Rucker , Brian McCoy
CPC classification number: G01N35/00613 , B01J19/0046 , G01N35/00871 , G01N35/04 , G01N35/1002 , G16C10/00 , G16C20/10 , G16C20/70 , B01J2219/00344 , B01J2219/00351 , B01J2219/00495 , B01J2219/00689 , B01J2219/00693 , B01J2219/00695 , B01J2219/00698 , G01N2035/00346 , G01N2035/0403 , G01N2035/0496
Abstract: Embodiments in accordance with the present disclosure are directed to apparatuses used for reaction screening and optimization purposes. An example apparatus includes a plurality of reaction vessels, a dispensing subsystem, at least one reactor module, an analysis subsystem, an automation subsystem, and control circuitry. The dispensing subsystem delivers reagents to the plurality of reaction vessels for a plurality of reaction mixtures having varied reaction conditions. The at least one reactor module drives a plurality of reactions within the plurality of reaction vessels. The analysis subsystem analyzes compositions contained in the plurality of reaction vessels. The automation subsystem selectively moves the plurality of reaction vessels from a location proximal to the dispensing subsystem to the at least one reactor module based on experimental design parameters. And, the control circuitry identifies optimum reaction conditions for a target end product based on the analysis.
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公开(公告)号：US11885822B2
公开(公告)日：2024-01-30
申请号：US16626495
申请日：2018-06-29
Applicant: SRI International
Inventor： Nathan Collins , Jeremiah Malerich , Jason D. White , Kevin Luebke , Kristina Rucker , Brian McCoy
CPC classification number: G01N35/00613 , B01J19/0046 , G01N35/00871 , G01N35/04 , G01N35/1002 , G16C10/00 , G16C20/10 , G16C20/70 , B01J2219/00344 , B01J2219/00351 , B01J2219/00495 , B01J2219/00689 , B01J2219/00693 , B01J2219/00695 , B01J2219/00698 , G01N2035/00346 , G01N2035/0403 , G01N2035/0496
Abstract: Embodiments in accordance with the present disclosure are directed to apparatuses used for reaction screening and optimization purposes. An example apparatus includes a plurality of reaction vessels, a dispensing subsystem, at least one reactor module, an analysis subsystem, an automation subsystem, and control circuitry. The dispensing subsystem delivers reagents to the plurality of reaction vessels for a plurality of reaction mixtures having varied reaction conditions. The at least one reactor module drives a plurality of reactions within the plurality of reaction vessels. The analysis subsystem analyzes compositions contained in the plurality of reaction vessels. The automation subsystem selectively moves the plurality of reaction vessels from a location proximal to the dispensing subsystem to the at least one reactor module based on experimental design parameters. And, the control circuitry identifies optimum reaction conditions for a target end product based on the analysis.
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公开(公告)号：US20220227823A1
公开(公告)日：2022-07-21
申请号：US16629799
申请日：2018-07-10
Applicant: SRI INTERNATIONAL
Inventor： Kathlynn C. Brown , Nathan Collins , Shunzi "Susan" Li , Curtis Allred , Keen Chung , Michael McGuire
Abstract: Disclosed are compositions comprising an antibody conjugated to one or more molecular guidance system (MGS) peptides. Disclosed are methods of treating a subject in need thereof comprising administering to the subject in need thereof an effective amount of an antibody conjugated to one or more MGS peptides, wherein the antibody targets an intracellular target involved in the disease process. Disclosed are methods of targeting an intracellular target comprising administering an antibody conjugated to one or more MGS peptides, wherein the antibody targets an intracellular target.
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公开(公告)号：US20210065851A1
公开(公告)日：2021-03-04
申请号：US16965222
申请日：2019-01-30
Applicant: SRI INTERNATIONAL
Inventor： Peter Madrid , Nathan Collins , Mario Latendresse , Jeremiah Malerich , Markus Krummenacker
Abstract: Retrosynthetic methods are described for determining one or more optimal synthetic routes to generate a target compound.
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公开(公告)号：US20190056398A1
公开(公告)日：2019-02-21
申请号：US16079946
申请日：2017-02-24
Applicant: SRI International
Inventor： Feng Wang-Johanning , Gary L. Johanning , Nathan Collins , Xiaohe Liu , Zheng Ao , Lidia Sambucetti
IPC: G01N33/569 , C07K16/18 , C12N5/0783 , C07K16/06 , G01N33/58
Abstract: Embodiments in accordance with the present disclosure include apparatuses, devices, and methods. For example, a method is directed to method exposing immobilized white blood cells from a blood sample to an antigen. And, scanning the immobilized white blood cells and, therefrom, identify and isolate white blood cells from among the immobilized white blood cells that produce an antibody in response to the exposure to the antigen.
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