公开(公告)号：US09546902B2

公开(公告)日：2017-01-17

申请号：US14662307

申请日：2015-03-19

Applicant: Servomex Group Limited

Inventor： Richard P. Kovacich ,  Bahram Alizadeh ,  Ian C. Gaskin ,  James D. Hobby ,  Martin Lopez

IPC: G01N21/00 ,  G01J3/02 ,  G01J3/10 ,  G01J3/433 ,  G01N21/39 ,  G01N21/27 ,  G01J3/42

CPC classification number: G01J3/027 ,  G01J3/0297 ,  G01J3/10 ,  G01J3/433 ,  G01J2003/423 ,  G01N21/274 ,  G01N21/39 ,  G01N2021/399 ,  G01N2201/0612 ,  G01N2201/121 ,  G01N2201/1215

Abstract: A method and system for correcting the effect of intensity fluctuations of the transmitted light in an absorption spectroscopy system used for the detection or measurement of chemical species in a medium, whereby one or more modulation bursts are imposed onto a light beam that passes through the medium. This burst signal may be obtained by modulating the bias current of a tunable diode laser, and the modulation burst signal may be optimally at the second harmonic of the modulation frequency of a wavelength modulated beam to allow usage of the same signal path processing used for the spectroscopic detection of the measurand for a second harmonic detection system. The burst signal can be controlled using a smooth window function to minimise the effects of non-linear perturbations that are inherent in tunable diode laser wavelength modulation spectroscopy systems, of optical interference fringes (etalons) and of the residual light absorption by background chemical species or the measurand at the wavelength coinciding with the modulation burst.

Abstract translation: 一种用于校正用于检测或测量介质中的化学物质的吸收光谱系统中的透射光的强度波动的影响的方法和系统，由此一个或多个调制脉冲串被施加到通过介质的光束 。 可以通过调制可调二极管激光器的偏置电流来获得该脉冲串信号，并且调制脉冲串信号可以在波长调制波束的调制频率的二次谐波处最佳地进行，以允许使用与 用于二次谐波检测系统的被测量的光谱检测。 可以使用平滑窗函数来控制突发信号，以最小化可调谐二极管激光波长调制光谱系统固有的非线性扰动，光学干涉条纹（标准具）和背景化学物质的残余光吸收的影响， 在波长上的被测量与调制脉冲串一致。

公开(公告)号：US09476770B1

公开(公告)日：2016-10-25

申请号：US15008664

申请日：2016-01-28

Applicant: International Business Machines Corporation

Inventor： William M. J. Green ,  Lionel Tombez ,  Eric Zhang

IPC: G01N21/00 ,  G01J3/45 ,  G01J3/42 ,  G01N33/00

CPC classification number: G01N33/0027 ,  G01J3/0218 ,  G01J3/42 ,  G01J3/433 ,  G01J3/453

Abstract: Disclosed herein is a system for detecting the presence of an chemical in a sample comprising a laser light source for generating a beam of light; a beam splitter that is operative to split the beam of light into a first beam of light and a second beam of light; a reference cell and a first recording device that are operative to receive the first beam of light; where the first recording device is downstream of the reference cell; a resonator that is operative to receive the second beam of light via a coupler; where the resonator contains the sample that contains the chemical; a phase modulator and a second recording device that lie downstream of the resonator and are operative to receive the second beam of light.

Abstract translation: 本文公开了一种用于检测样品中存在化学物质的系统，其包括用于产生光束的激光光源; 分束器，其可操作地将光束分成第一光束和第二光束; 可操作地接收第一光束的参考单元和第一记录装置; 其中第一记录装置在参考单元的下游; 可操作地通过耦合器接收第二光束的谐振器; 谐振器包含含有化学物质的样品; 相位调制器和第二记录装置，其位于谐振器的下游并且可操作以接收第二光束。

公开(公告)号：US20160252510A1

公开(公告)日：2016-09-01

申请号：US15059797

申请日：2016-03-03

Applicant: UNIVERSITY OF CENTRAL LANCASHIRE

Inventor： Matthew James BAKER ,  Peter ABEL ,  Robert William LEA

IPC: G01N33/574 ,  G01N21/552

CPC classification number: G01N33/57407 ,  G01J3/433 ,  G01N21/35 ,  G01N21/552 ,  G01N21/63 ,  G01N33/49 ,  G01N33/574 ,  G01N2021/3196 ,  G01N2021/3595 ,  G01N2030/743 ,  G01N2201/129 ,  G01N2800/52 ,  G01N2800/7028

Abstract: The present invention relates to methods of diagnosing and/or prognosing proliferative disorders, especially brain cancers (e.g. gliomas). In particular, the present invention provides a means to conveniently detect malignant tumours merely by as saying or analysing blood (particularly blood serum). Cytokines and/or angiogenesis factors in blood serum have been found to be surprisingly powerful at indicating the presence of brain cancers in a subject. Moreover, spectroscopic analysis, especially ATR-FTIR analysis, of a blood sample has been demonstrated to be surprisingly effective at producing a signature that can be correlated with the presence, extent, severity, or aggressiveness of malignant tumours in a subject.

Abstract translation: 本发明涉及诊断和/或预测增殖性疾病，特别是脑癌（例如神经胶质瘤）的方法。 特别地，本发明提供了仅通过说话或分析血液（特别是血清）方便地检测恶性肿瘤的手段。 已经发现血清中的细胞因子和/或血管生成因子在表明受试者中脑癌的存在方面令人惊讶地强大。 此外，血液样品的光谱分析，特别是ATR-FTIR分析已经被证明在产生可以与受试者中恶性肿瘤的存在，程度，严重性或侵袭性相关的特征方面令人惊奇地有效。

公开(公告)号：US20160252393A1

公开(公告)日：2016-09-01

申请号：US15056245

申请日：2016-02-29

Applicant: NOVATRANS GROUP SA

Inventor： John F. ROULSTON ,  Daniel MANDELIK

IPC: G01J3/10 ,  G01J3/433

CPC classification number: G01J3/108 ,  G01J3/42 ,  G01J3/433 ,  G01J3/4338 ,  G01J2003/4332 ,  G01N21/3581

Abstract: A terahertz spectrometer includes: a terahertz-wave emitter and a terahertz receiver elements. The terahertz wave generated by means of generating beat frequency corresponding to the difference between two rapidly tunable continuous wave lasers. Having a difference in time between the interrogating signal and the reference signal at the receiver end side, which corresponds to intermediate frequency (IF), not centered around the baseband, i.e. zero Hertz. The offset step size of the intermediate frequency from zero Hertz is linearly correlated to the position of the interrogated object position.

Abstract translation: 太赫兹光谱仪包括：太赫波发射器和太赫兹接收器元件。 通过产生对应于两个快速可调连续波激光器之间的差异的拍频产生的太赫兹波。 在询问信号和对应于中频（IF）的接收机端侧的参考信号之间的时间差不以基带为中心，即零赫兹。 中间频率从零赫兹的偏移步长与询问对象位置的位置线性相关。

公开(公告)号：US20160231239A1

公开(公告)日：2016-08-11

申请号：US15017610

申请日：2016-02-06

Applicant: Block Engineering, LLC

Inventor： Petros Kotidis ,  Erik Deutsch ,  Hongke Ye ,  Alexander Mazurenko ,  Anish K. Goyal ,  Jeffrey S. Socha

IPC: G01N21/39 ,  H01S5/34 ,  H01S5/40 ,  G01N21/3504

CPC classification number: G01N21/39 ,  G01J3/108 ,  G01J3/433 ,  G01N21/031 ,  G01N21/3504 ,  G01N2021/1704 ,  G01N2021/3513 ,  G01N2021/399 ,  G01N2201/0612 ,  H01S5/0622 ,  H01S5/3401 ,  H01S5/4012 ,  H01S5/4025 ,  H01S5/4087

Abstract: A system and method are disclosed for gas sensing over a wide tunable wavelength range provided by one or more quantum cascade lasers. A laser beam is generated within the wide tunable wavelength range, which is given by the sum of the wavelength ranges from the individual lasers. Gas sensing or detection is achieved by obtaining an infrared absorption spectrum for a sample contained in one or more cells having different path lengths for the laser beam.

Abstract translation: 公开了一种用于在由一个或多个量子级联激光器提供的宽可调波长范围上的气体感测的系统和方法。 在宽可调波长范围内产生激光束，该波长范围由各个激光器的波长范围之和给出。 通过获得用于激光束的不同路径长度的一个或多个单元中包含的样品的红外吸收光谱来实现气体感测或检测。

公开(公告)号：US20160169740A1

公开(公告)日：2016-06-16

申请号：US14964956

申请日：2015-12-10

Applicant: Thorlabs, Inc.

Inventor： James Jiang ,  Marshall Scott ,  Eric Geoffrion ,  Alex Cable

IPC: G01J3/427 ,  G01J3/10

CPC classification number: G01J3/36 ,  G01J3/433 ,  G01J3/4338 ,  G01N21/1702 ,  G01N21/39 ,  G01N2201/06113 ,  G01N2201/0691 ,  G01N2201/12

Abstract: A system capable of highly sensitive measurement of material concentration values in a sample using an optical spectroscopic method is disclosed. The system utilizes high-speed data acquisition and high resolution sampling of the raw signals output by the sensors with reduced total channel counts, and performs frequency analysis of the signals using the Fourier transform method to process all sensor channels in parallel. When each sensor is targeting the detection of some certain materials at some certain frequencies, the system is capable of simultaneous detection of multiple materials of interest in the sample with high measurement sensitivity and high speed.

Abstract translation: 公开了一种能够使用光学分光法对样品中的材料浓度值进行高灵敏度测量的系统。 该系统利用传感器输出的原始信号进行高速数据采集和高分辨率采样，总信道数减少，并使用傅里叶变换方法对信号进行频率分析，并行处理所有传感器通道。 当每个传感器以某些特定频率对某些材料进行检测时，系统能够以高测量灵敏度和高速度同时检测样品中感兴趣的多种材料。

公开(公告)号：US20160109294A1

公开(公告)日：2016-04-21

申请号：US14515852

申请日：2014-10-16

Applicant: Joseph R. Demers

Inventor： Bryon L. Kasper ,  Joseph R. Demers

IPC: G01J3/433 ,  G01J3/10

CPC classification number: G01J3/4338 ,  G01J3/108 ,  G01J3/42 ,  G01J3/433

Abstract: Highly advantageous spectrometer systems and associated methods are disclosed which utilize phase modulation in conjunction with first and second harmonic detection to reduce or eliminate negative impacts from interference patterns.

Abstract translation: 公开了高效益的光谱仪系统和相关方法，其利用与第一和第二谐波检测结合的相位调制来减少或消除干扰图案的负面影响。

公开(公告)号：US20150323448A1

公开(公告)日：2015-11-12

申请号：US14270855

申请日：2014-05-06

Applicant: Raytheon Company

Inventor： James W. Rakeman

IPC: G01N21/27 ,  F02K9/08 ,  G01S13/58

CPC classification number: G01N21/71 ,  F02K9/08 ,  F41H11/02 ,  G01J3/0208 ,  G01J3/0289 ,  G01J3/2803 ,  G01J3/433 ,  G01N21/27 ,  G01N21/716 ,  G01N2201/12 ,  G01S13/58 ,  G01S13/72 ,  G01S13/86

Abstract: Pressure variations within a solid propellant rocket motor produce like variations in the optical radiance of the motor exhaust plume. The periodicity of the variation is related to the length L of the rocket motor or speed of sound in the rocket motor combustion chamber to length ratio a/L. The optical radiance is collected and converted to electrical signals that are sampled at or above the Nyquist rate. An array of single-pixel photo detectors is well suited to provide amplitude data at high sample rates. The sampled data from the one or more detectors is assembled to form a high fidelity time sequence. A window of sampled data is processed to form a signal frequency spectrum. The mode structure in the frequency spectrum is related to the rocket motor length or speed of sound in the rocket motor chamber to length ratio. The rocket motor length or speed of sound to length ratio is used alone or in combination with other information to either classify or identify the rocket motor.

Abstract translation: 固体推进剂火箭发动机内的压力变化产生类似于电动机排气羽流的光学辐射度的变化。 变化的周期性与火箭发动机的长度L或火箭发动机燃烧室中的声速相关，与长度比a / L有关。 光学辐射被收集并转换成以奈奎斯特速率或更高采样的电信号。 单像素光电检测器阵列非常适合以高采样率提供幅度数据。 来自一个或多个检测器的采样数据被组合以形成高保真时间序列。 处理采样数据的窗口以形成信号频谱。 频谱中的模式结构与火箭发动机的长度或火箭发动机的声速比有关。 火箭发动机长度或声音与长度之比的速度单独使用或与其他信息组合使用，以分类或识别火箭发动机。

公开(公告)号：US09182284B2

公开(公告)日：2015-11-10

申请号：US13490862

申请日：2012-06-07

Applicant: Cristian Angelo Manzoni ,  Daniele Brida ,  Giulio Nicola Felice Cerullo

Inventor： Cristian Angelo Manzoni ,  Daniele Brida ,  Giulio Nicola Felice Cerullo

IPC: G01J3/45 ,  G01J3/28 ,  G01J3/433 ,  G01J3/453 ,  G01J11/00 ,  H01S3/00

CPC classification number: G01J3/2889 ,  G01J3/433 ,  G01J3/453 ,  G01J11/00 ,  H01S3/005

Abstract: A phase-locked delay device, including: an input port configured to receive an input electromagnetic radiation pulse; said input pulse being to be propagated along a propagation direction and having a first linear polarization different from both a first direction, which is orthogonal to the propagation direction, and a second direction, which is orthogonal to the first direction and the propagation direction; an adjustable Babinet-Soleil module optically coupled to said input port, having a first polarization direction parallel to said first direction. The adjustable Babinet-Soleil module is structured to: provide from the input pulse a first pulse polarized along the first direction and a second pulse collinear to said first pulse and polarized along the second direction, and introduce an adjustable group delay between the first pulse and the second pulse ranging from a minim value ΔTm and a maximum value ΔTM; the maximum value ΔTM being a value greater than 10 fs.

Abstract translation: 一种锁相延迟装置，包括：被配置为接收输入电磁辐射脉冲的输入端口; 所述输入脉冲沿着传播方向传播，并且具有与传播方向正交的第一方向和与第一方向和传播方向正交的第二方向不同的第一线性偏振; 光耦合到所述输入端口的可调节的Babinet-Soleil模块具有平行于所述第一方向的第一偏振方向。 可调节的Babinet-Soleil模块被构造成：从输入脉冲提供沿着第一方向偏振的第一脉冲和与所述第一脉冲共线的第二脉冲并沿着第二方向极化，并且在第一脉冲和 从最小值＆Dgr; Tm和最大值＆Dgr; TM的范围的第二脉冲; 最大值＆Dgr; TM是大于10fs的值。

公开(公告)号：US20150301017A1

公开(公告)日：2015-10-22

申请号：US14443134

申请日：2013-11-14

Applicant: UNIVERSITY OF CENTRAL LANCASHIRE

Inventor： Matthew James Baker ,  Peter Abel ,  Robert William Lea

IPC: G01N33/49

CPC classification number: G01N33/57407 ,  G01J3/433 ,  G01N21/35 ,  G01N21/552 ,  G01N21/63 ,  G01N33/49 ,  G01N33/574 ,  G01N2021/3196 ,  G01N2021/3595 ,  G01N2030/743 ,  G01N2201/129 ,  G01N2800/52 ,  G01N2800/7028

Abstract: The present invention relates to methods of diagnosing and/or prognosing proliferative disorders, especially brain cancers (e.g. gliomas). In particular, the present invention provides a means to conveniently detect malignant tumours merely by assaying or analysing blood (particularly blood serum). Cytokines and/or angiogenesis factors in blood serum have been found to be surprisingly powerful at indicating the presence of brain cancers in a subject. Moreover, spectroscopic analysis, especially ATR-FTIR analysis, of a blood sample has been demonstrated to be surprisingly effective at producing a signature that can be correlated with the presence, extent, severity, or aggressiveness of malignant tumours in a subject.

Abstract translation: 本发明涉及诊断和/或预测增殖性疾病，特别是脑癌（例如神经胶质瘤）的方法。 特别地，本发明提供了仅通过测定或分析血液（特别是血清）便利地检测恶性肿瘤的手段。 已经发现血清中的细胞因子和/或血管生成因子在表明受试者中脑癌的存在方面令人惊讶地强大。 此外，血液样品的光谱分析，特别是ATR-FTIR分析已经被证明在产生可以与受试者中恶性肿瘤的存在，程度，严重性或侵袭性相关的特征方面令人惊奇地有效。