公开(公告)号：US20190195778A1

公开(公告)日：2019-06-27

申请号：US16229097

申请日：2018-12-21

Applicant: ELT SENSOR Corp.

Inventor： Ihn LEE ,  Donghwan KIM

IPC: G01N21/01 ,  G02B5/10 ,  G01N21/61

CPC classification number: G01N21/01 ,  G01N21/61 ,  G01N2201/068 ,  G02B5/10 ,  G02B2207/117

Abstract: Provided are an optical cavity 100 for a gas sensor which has a space therein and a gas sensor using the optical cavity, in which in the space of the optical cavity 100, an elliptical reflective surface 133, which constitutes a part of an ellipse (133, 133a) and reflects the light emitted from a position of one focal point F1 of the ellipse to concentrate the light on the other focal point F2 of the ellipse, is formed, a hyperbolic reflective surface, which constitutes a part of a hyperbola (135a, 135b) having one focal point that coincides with the other focal point of the ellipse, and reflects the light, which is reflected by the elliptical reflective surface and concentrated on the other focal point of the ellipse, to concentrate the light on the other focal point f2 of the hyperbola, is formed, and a hyperbola centerline B-B′, which connects one focal point of the hyperbola and the other focal point of the hyperbola, is inclined toward a side opposite to the elliptical reflective surface by a predetermined angle with respect to an ellipse centerline A-A′ which connects one focal point of the ellipse and the other focal point of the ellipse.

公开(公告)号：US20190177218A1

公开(公告)日：2019-06-13

申请号：US16218895

申请日：2018-12-13

Applicant: PIKE Technologies of Wisconsin, Inc.

Inventor： Alec Cameron Fisher ,  Kent Gundlach

IPC: C03C27/08 ,  C22C28/00 ,  G01N21/09

CPC classification number: C03C27/08 ,  C03C3/06 ,  C03C3/32 ,  C03C3/321 ,  C03C3/325 ,  C22C28/00 ,  G01N21/09 ,  G01N2021/0389 ,  G01N2201/0227 ,  G01N2201/068

Abstract: Disclosed herein are seals for liquid-tight bonding of an optical window comprising a Bi—In alloy. Also disclosed are optical cells comprising the Bi—In alloy seals to provide a liquid-tight seal between a cell housing and a drilled optical window.

公开(公告)号：US20180364152A1

公开(公告)日：2018-12-20

申请号：US16001966

申请日：2018-06-07

Applicant: CI SYSTEMS (ISRAEL) LTD.

Inventor： Yoram Naor

IPC: G01N21/01 ,  G01N21/59

CPC classification number: G01N21/01 ,  G01N21/05 ,  G01N21/59 ,  G01N2021/0106 ,  G01N2201/068 ,  G01N2201/08 ,  G01N2201/128

Abstract: A flow cell analyzes a fluid sample. A flow cell body contains a reference material and includes at least one hollow chamber to contain the fluid sample. Opposing surfaces of the flow cell body each have at least one transparent portion thereof. An optical path for light traversing through the flow cell body is defined in part by the transparent portions. A switching mechanism adjusts the amount of the reference material in the optical path to effect switching of the flow cell between a reference measurement state and a fluid sample measurement state. The reference measurement state corresponds to a first light intensity measurement and the fluid sample measurement state corresponds to a second light intensity measurement.

公开(公告)号：US20180348142A1

公开(公告)日：2018-12-06

申请号：US16054681

申请日：2018-08-03

Applicant: SamanTree Medical SA

Inventor： Bastien Rachet ,  Davor Kosanic ,  Etienne Shaffer

IPC: G01N21/77 ,  G02B21/36 ,  G01N21/64 ,  G02B21/26 ,  G02B21/34 ,  G01N33/483 ,  G02B21/00 ,  G02B21/16 ,  G02B21/24

CPC classification number: G01N21/77 ,  G01N21/6428 ,  G01N21/6458 ,  G01N33/4833 ,  G01N2021/6439 ,  G01N2021/6463 ,  G01N2021/7786 ,  G01N2201/0633 ,  G01N2201/068 ,  G02B21/0012 ,  G02B21/0032 ,  G02B21/004 ,  G02B21/0044 ,  G02B21/0076 ,  G02B21/0088 ,  G02B21/16 ,  G02B21/24 ,  G02B21/26 ,  G02B21/34 ,  G02B21/361

Abstract: The disclosed technology brings histopathology into the operating theatre, to enable real-time intra-operative digital pathology. The disclosed technology utilizes confocal imaging devices image, in the operating theatre, “optical slices” of fresh tissue—without the need to physically slice and otherwise process the resected tissue as required by frozen section analysis (FSA). The disclosed technology, in certain embodiments, includes a simple, operating-table-side digital histology scanner, with the capability of rapidly scanning all outer margins of a tissue sample (e.g., resection lump, removed tissue mass). Using point-scanning microscopy technology, the disclosed technology, in certain embodiments, precisely scans a thin “optical section” of the resected tissue, and sends the digital image to a pathologist rather than the real tissue, thereby providing the pathologist with the opportunity to analyze the tissue intra-operatively. Thus, the disclosed technology provides digital images with similar information content as FSA, but faster and without destroying the tissue sample itself.

公开(公告)号：US20180328850A1

公开(公告)日：2018-11-15

申请号：US16028159

申请日：2018-07-05

Applicant: Quantum-Si Incorporated

Inventor： Jonathan M. Rothberg ,  Ali Kabiri ,  Jason W. Sickler ,  Brett J. Gyarfas ,  Jeremy Lackey ,  Gerard Schmid ,  Benjamin Cipriany ,  Jack Jewell ,  Lawrence C. West ,  Michael Ferrigno ,  Paul E. Glenn ,  Anthony Bellofiore

IPC: G01N21/64 ,  B01L3/00 ,  C12Q1/6869 ,  C12Q1/6874 ,  G01N21/77

CPC classification number: G01N21/6486 ,  B01L3/5085 ,  B01L2200/12 ,  B01L2300/0829 ,  B01L2300/0887 ,  B01L2300/0893 ,  B01L2300/168 ,  C12Q1/6869 ,  C12Q1/6874 ,  C12Q2521/101 ,  C12Q2537/157 ,  C12Q2563/107 ,  C12Q2565/607 ,  G01N21/64 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/648 ,  G01N21/7743 ,  G01N21/7746 ,  G01N2021/6419 ,  G01N2021/6441 ,  G01N2021/6478 ,  G01N2201/02 ,  G01N2201/06113 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/068 ,  G01N2201/125 ,  Y10T29/49016 ,  C12Q2525/101

Abstract: Apparatus and methods for analyzing single molecule and performing nucleic acid sequencing. An integrated device includes multiple pixels with sample wells configured to receive a sample, which, when excited, emits radiation; at least one element for directing the emission radiation in a particular direction; and a light path along which the emission radiation travels from the sample well toward a sensor. The apparatus also includes an instrument that interfaces with the integrated device. Each sensor may detect emission radiation from a sample in a respective sample well. The instrument includes an excitation light source for exciting the sample in each sample well.

公开(公告)号：US10082461B2

公开(公告)日：2018-09-25

申请号：US14809054

申请日：2015-07-24

Applicant: Nanometrics Incorporated

Inventor： Andrew S. Klassen ,  Andrew J. Hazelton ,  Andrew H. Barada ,  Todd M. Petit ,  Chuan Sheng Tu

IPC: G01N21/01 ,  G01N21/88 ,  G01N21/94 ,  G01N21/47 ,  G01N21/15 ,  G03F7/20

CPC classification number: G01N21/4785 ,  G01N21/01 ,  G01N21/15 ,  G01N2021/151 ,  G01N2201/02 ,  G01N2201/068 ,  G03F7/70933

Abstract: An integrated metrology module includes a chuck for holding a sample and positioning the sample with respect to an optical metrology device, a reference chip for the optical metrology device, the reference chip being movable to various positions with respect to the optical metrology device, and a reference chip purge device provides a flow of purge gas or air over the reference chip while the reference chip is in the various positions. The reference chip purge device may be static or movable with the reference chip.

公开(公告)号：US10078047B2

公开(公告)日：2018-09-18

申请号：US15491119

申请日：2017-04-19

Applicant: OLYTHE

Inventor： Guillaume Nesa ,  Etienne Flesch

IPC: G01N21/05 ,  G01N33/497 ,  G01N33/98 ,  G01N21/3504 ,  G01N21/03

CPC classification number: G01N21/05 ,  G01N21/0303 ,  G01N21/3504 ,  G01N33/497 ,  G01N33/4972 ,  G01N33/98 ,  G01N2021/0307 ,  G01N2021/052 ,  G01N2201/068

Abstract: A measuring vessel in which a gas to be analyzed by spectrometry is intended to flow, the vessel being in the form of a hollow tube provided with a reflective material forming an optical-reflection layer, including a hollow tube is produced from a non-metallic material, and a removable supple optical article is applied against the internal surface of the hollow tube, the article including a supple flexible support, one face of the support being covered with a reflective metal material, the article being inserted in the tube so that the reflective metal material forms the optical-reflection layer.

公开(公告)号：US20180252643A1

公开(公告)日：2018-09-06

申请号：US15912919

申请日：2018-03-06

Applicant: RENISHAW PLC

Inventor： Robert James Brown ,  Ruth Alice Lawson

IPC: G01N21/63 ,  G01N21/65 ,  G02B7/09 ,  G02B7/34

CPC classification number: G01N21/63 ,  G01N21/64 ,  G01N21/65 ,  G01N2201/06113 ,  G01N2201/068 ,  G02B7/09 ,  G02B7/34

Abstract: An auto-focus system suitable for a spectroscopy system uses the same illumination beam as the exciting light for spectroscopy. This is focused to a spot or line focus on the sample. An image of the spot or line focus is directed to a detector via one or more pupils located eccentrically of the optical axis, so that the focus condition is indicated by displacement of the image on the detector. The spot or line focus on the sample provides contrast in the image to enable auto-focusing without the need to observe contrast over an area of the sample. A method of scanning the surface of a sample is also described, in which a topographical map of the sample is built in a pre-scan with an objective lens having a long working distance. This enables selection of an objective with a shorter working distance for a subsequent scan.

公开(公告)号：US10025077B2

公开(公告)日：2018-07-17

申请号：US15334462

申请日：2016-10-26

Applicant: Chun Kuang Optics Corp.

Inventor： Hsin-Chieh Huang ,  Cheng-Yu Huang ,  Shun Wang ,  Shun-Wen Teng

IPC: G02B17/00 ,  G02B17/08 ,  G01N21/41

CPC classification number: G02B17/086 ,  G01N21/4133 ,  G01N2021/4153 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/068 ,  G02B17/0864

Abstract: A device for measuring solution concentration includes housing, a catadioptric structure, an electromagnetic radiation emitter and an electromagnetic radiation detector. The housing is formed with a detecting part for receiving a solution to be detected. The catadioptric structure is received in the housing, and includes a ray entrance portion, a first total internal reflection part, a second total internal reflection part and a ray exit portion. An accommodation part corresponds to the detecting part. The emitter is disposed at one side of the ray entrance portion, and a ray sequentially passes the ray entrance portion, the detecting part, the solution to be detected, and the first total internal reflection part. Then, the ray is totally internally reflected and converged to the second total internal reflection part, and is reflected again. Finally, the ray passes the ray exit portion and is received by the detector.

公开(公告)号：US09983136B2

公开(公告)日：2018-05-29

申请号：US14374933

申请日：2013-09-02

Applicant: INDIAN INSTITUTE OF SCIENCE

Inventor： Siva Umapathy ,  Sanchita Sil ,  John Kiran

IPC: G01N21/65 ,  G01J3/44

CPC classification number: G01N21/65 ,  G01J3/4412 ,  G01N2201/06113 ,  G01N2201/068 ,  G01N2201/129

Abstract: The invention provides a method for obtaining sample specific signatures. The method comprises of irradiating the sample at a predefined location with an electromagnetic radiation of specific wavelength; selectively capturing a certain component of the scattered electromagnetic radiation to obtain a plurality of profiles; and filtering the profiles to obtain a sample specific signature. The invention provides an apparatus for obtaining sample specific signatures.