公开(公告)号：US20150002848A1

公开(公告)日：2015-01-01

申请号：US14372093

申请日：2013-01-15

Applicant: FEMTOLASERS PRODUCTIONS GMBH

Inventor： Gabriel-Florin Tempea

IPC: G01J3/45 ,  G01N21/25

CPC classification number: G01J3/45 ,  E01H5/045 ,  G01J3/4531 ,  G01J2003/283 ,  G01J2003/451 ,  G01J2003/4538 ,  G01M11/005 ,  G01N21/25 ,  G01N21/45 ,  G01N2021/4126 ,  G01N2201/126 ,  G02B1/115 ,  G02B5/0825

Abstract: Method and device for optical inspection of a sample using spectral interferometry, wherein a beam (2″) emitted by a radiation source (1) is directed onto the sample (5) and a reference beam (2′) is directed onto a reference sample (4), and the spectral interference of both beams after being reflected on the samples or after passing the samples is recorded by means of a spectrograph (6); the interferogram I(ω) thus obtained is numerically derived with respect to the angular frequency ω. For the function I′(ω) thus obtained the zeros ωi are calculated numerically as solutions to the equation I′(ω)=0 and the frequency-dependent group delay τ(ω) is then calculated from the zeros ωi according to the equation τ(ωn)=π/(ωi+1−ωi), wherein i=1, 2 . . . and ωn=(ωi+1+ωi)2.

Abstract translation: 用于使用光谱干涉测量法对样品进行光学检查的方法和装置，其中由辐射源（1）发射的光束（2“）被引导到样品（5）上，并且参考光束（2'）被引导到参考样品 （4），并且两个光束在样品上反射之后或在通过样品之后的光谱干涉通过光谱仪（6）记录; 这样获得的干涉图I（ω）相对于角频率ω被数值地导出。 对于由此获得的函数I'（ω），零数值被计算为等式I'（ω）= 0的解，并且然后根据等式从零的ωi计算频率相关组延迟τ（ω） τ（ωn）=＆pgr; /（ωi+ 1-ωi），其中i = 1,2。 。 。 和ωn=（ωi+ 1 +ωi）2。

公开(公告)号：US08237786B2

公开(公告)日：2012-08-07

申请号：US12751816

申请日：2010-03-31

Applicant: Gaudenz Danuser ,  Paul C. Goodwin

Inventor： Gaudenz Danuser ,  Paul C. Goodwin

IPC: H04N9/47 ,  H04N13/04

CPC classification number: G01N21/6428 ,  G01N21/636 ,  G01N21/6458 ,  G01N2021/6415 ,  G01N2021/6419 ,  G01N2201/126 ,  G02B21/365 ,  G02B21/367 ,  G06T3/4053

Abstract: Embodiments of the present invention are directed to imaging technologies, and, in particular, to an imaging system that detects relatively weak signals, over time, and that uses the detected signals to determine the positions of signal emitters. Particular embodiments of the present invention are directed to methods and systems for imaging fluorophore-labeled samples in order to produce images of the sample at resolutions significantly greater than the diffraction-limited resolution associated with optical microscopy. Embodiments of the present invention employ overlapping-emitter-image disambiguation to allow data to be collected from densely arranged emitters, which significantly decreases the data-collection time for producing intermediate images as well as the number of intermediate images needed to computationally construct high-resolution final images. Additional embodiments of the present invention employ hierarchical image-processing techniques to further resolve and interpret disambiguated images.

Abstract translation: 本发明的实施例涉及成像技术，特别涉及一种随时间检测相对较弱信号的成像系统，并且使用所检测的信号来确定信号发射器的位置。 本发明的具体实施方案涉及用于成像荧光团标记的样品的方法和系统，以便以明显大于与光学显微镜相关联的衍射限制分辨率的分辨率产生样品的图像。 本发明的实施例采用重叠 - 发射 - 图像消歧以允许从密集布置的发射器收集数据，这显着减少用于产生中间图像的数据收集时间以及计算构建高分辨率所需的中间图像的数量 最终图像。 本发明的另外的实施例采用分层图像处理技术来进一步解析和解释消歧图像。

公开(公告)号：US20110291027A1

公开(公告)日：2011-12-01

申请号：US13102551

申请日：2011-05-06

Applicant: Paul Lundquist ,  Denis Zaccarin ,  Yves Lacroix ,  Mark Maxham ,  Mathieu Foquet ,  Stephen Turner

Inventor： Paul Lundquist ,  Denis Zaccarin ,  Yves Lacroix ,  Mark Maxham ,  Mathieu Foquet ,  Stephen Turner

IPC: G01N21/64 ,  G01J1/58

CPC classification number: G01N21/6452 ,  G01J3/02 ,  G01J3/0224 ,  G01J3/10 ,  G01J3/14 ,  G01J3/2803 ,  G01N21/6445 ,  G01N21/6456 ,  G01N21/648 ,  G01N2021/6417 ,  G01N2201/126

Abstract: Methods and systems for real-time monitoring of optical signals from arrays of signal sources, and particularly optical signal sources that have spectrally different signal components. Systems include signal source arrays in optical communication with optical trains that direct excitation radiation to and emitted signals from such arrays and image the signals onto detector arrays, from which such signals may be subjected to additional processing.

Abstract translation: 用于实时监测来自信号源阵列的光信号的方法和系统，特别是具有频谱不同信号分量的光信号源。 系统包括与光学列车光学通信的信号源阵列，其将激发辐射引导到来自这种阵列的信号和从这些阵列发出的信号，并将信号映射到检测器阵列上，从而可以对这些信号进行额外的处理。

公开(公告)号：US20100284602A1

公开(公告)日：2010-11-11

申请号：US12785314

申请日：2010-05-21

Applicant: James WINKELMAN ,  Milenko TANASIJEVIC ,  David ZAHNISER

Inventor： James WINKELMAN ,  Milenko TANASIJEVIC ,  David ZAHNISER

IPC: G06K9/00

CPC classification number: G01N15/1475 ,  G01N1/2813 ,  G01N1/312 ,  G01N21/255 ,  G01N33/49 ,  G01N35/00029 ,  G01N35/00871 ,  G01N35/1016 ,  G01N2015/0073 ,  G01N2015/008 ,  G01N2015/0084 ,  G01N2015/1006 ,  G01N2015/1472 ,  G01N2015/1486 ,  G01N2015/1497 ,  G01N2035/00138 ,  G01N2035/00465 ,  G01N2035/0091 ,  G01N2201/062 ,  G01N2201/126 ,  G01N2333/805 ,  G06K9/4652 ,  G06K9/6267 ,  G06T7/0012 ,  H04N5/2256 ,  H04N5/23293 ,  H04N5/265

Abstract: Systems and methods analyzing body fluids such as blood and bone marrow are disclosed. The systems and methods may utilize an improved technique for applying a monolayer of cells to a slide to generate a substantially uniform distribution of cells on the slide. Additionally aspects of the invention also relate to systems and methods for utilizing multi color microscopy for improving the quality of images captured by a light receiving device.

Abstract translation: 公开了分析体液如血液和骨髓的系统和方法。 系统和方法可以利用改进的技术将单层细胞施加到载玻片上以在载玻片上产生基本均匀的细胞分布。 本发明的另外方面还涉及用于利用多色显微镜来提高由光接收装置捕获的图像的质量的系统和方法。

公开(公告)号：US07626704B2

公开(公告)日：2009-12-01

申请号：US11978138

申请日：2007-10-26

Applicant: Paul Lundquist ,  Denis Zaccarin ,  Yves Lacroix ,  Mark Maxham ,  Mathieu Foquet ,  Stephen Turner

Inventor： Paul Lundquist ,  Denis Zaccarin ,  Yves Lacroix ,  Mark Maxham ,  Mathieu Foquet ,  Stephen Turner

IPC: G01N21/25

CPC classification number: G01N21/6452 ,  G01J3/02 ,  G01J3/0224 ,  G01J3/10 ,  G01J3/14 ,  G01J3/2803 ,  G01N21/6445 ,  G01N21/6456 ,  G01N21/648 ,  G01N2021/6417 ,  G01N2201/126

Abstract: Methods and systems for real-time monitoring of optical signals from arrays of signal sources, and particularly optical signal sources that have spectrally different signal components. Systems include signal source arrays in optical communication with optical trains that direct excitation radiation to and emitted signals from such arrays and image the signals onto detector arrays, from which such signals may be subjected to additional processing.

Abstract translation: 用于实时监测来自信号源阵列的光信号的方法和系统，特别是具有频谱不同信号分量的光信号源。 系统包括与光学列车光学通信的信号源阵列，其将激发辐射引导到来自这种阵列的信号和从这些阵列发出的信号，并将信号映射到检测器阵列上，从而可以对这些信号进行额外的处理。

公开(公告)号：US5866349A

公开(公告)日：1999-02-02

申请号：US768255

申请日：1991-10-16

Applicant: Jan Evert Lilja ,  Sven-Erik Lennart Nilsson

Inventor： Jan Evert Lilja ,  Sven-Erik Lennart Nilsson

IPC: C12M1/34 ,  C12Q1/26 ,  C12Q1/32 ,  C12Q1/533 ,  C12Q1/54 ,  G01N15/00 ,  G01N21/03 ,  G01N21/31 ,  G01N21/35 ,  G01N21/78 ,  G01N33/48 ,  G01N33/493

CPC classification number: C12Q1/54 ,  G01N21/03 ,  G01N21/314 ,  G01N2015/0069 ,  G01N2021/0321 ,  G01N2021/0325 ,  G01N2021/0346 ,  G01N2021/3181 ,  G01N21/78 ,  G01N2201/1222 ,  G01N2201/126 ,  G01N33/493

Abstract: A sample of whole blood is contacted with a reagent which by chemical reaction with glucose in the sample brings about a detectable dye concentration change (10) the size of which is determined as a measure of the glucose content of the sample. The sample is initially introduced undiluted in a microcuvette having at least one cavity for receiving the sample. The cavity is internally pretreated with the reagent in dry form, and the chemical reaction takes place in the cavity. Active components of the reagent comprise at least a hemolyzing agent for exposing glucose contained in the blood cells of the sample for allowing total glucose determination, and agents taking part in the chemical reaction and ensuring that the dye concentration change (10) takes place at least in a wavelength range (14) outside the absorption range (12) of the blood hemoglobin. An absorption measurement is performed in said wavelength range directly on the sample in the cuvette. A pretreated disposable cuvette with such a reagent and a photometer are also described.

Abstract translation: PCT No.PCT / SE90 / 00273 Sec。 371日期1991年10月16日 102（e）日期1991年10月16日PCT 1990年4月24日PCT PCT。 WO90 / 12890 PCT出版物 日期1990年11月1日全血样品与试剂接触，该试剂通过与样品中的葡萄糖的化学反应产生可检测的染料浓度变化（10），其大小被确定为样品的葡萄糖含量的量度 。 样品最初在具有至少一个用于接收样品的空腔的微量储存器中未稀释地引入。 空腔内部用干燥形式的预处理，化学反应发生在空腔中。 试剂的活性组分至少包含用于暴露样品血细胞中所含的葡萄糖的溶血剂，以允许总葡萄糖测定，以及参与化学反应的试剂，并确保染料浓度变化（10）至少发生 在血红蛋白的吸收范围（12）之外的波长范围（14）中。 在比色皿中的样品上直接在所述波长范围内进行吸收测量。 还描述了具有这种试剂和光度计的预处理的一次性比色杯。

公开(公告)号：US5118183A

公开(公告)日：1992-06-02

申请号：US480331

申请日：1990-02-13

Applicant: Mark A. Cargill ,  Bernard J. Berg ,  Steven H. Peterson ,  Timothy R. Friend ,  Thomas J. Boes

Inventor： Mark A. Cargill ,  Bernard J. Berg ,  Steven H. Peterson ,  Timothy R. Friend ,  Thomas J. Boes

IPC: G01J3/10 ,  G01J3/51 ,  G01N21/01 ,  G01N21/59 ,  G01N21/86 ,  G01N35/00

CPC classification number: G01J3/51 ,  G01J3/10 ,  G01J3/524 ,  G01N21/86 ,  G01J3/513 ,  G01N2021/0162 ,  G01N2021/1734 ,  G01N21/4738 ,  G01N21/59 ,  G01N21/8483 ,  G01N2201/0694 ,  G01N2201/126 ,  G01N35/00029

Abstract: A densitometer apparatus (410) is disclosed and is adapted to provide color density measurements of object samples. The densitometer apparatus (410) comprises a source light (580) for projecting light toward an object sample comprising a control strip (588, 620). A reflection optics assembly (576) is adapted to measure light density reflected from the object sample when the object sample is in the form of a paper control strip. A transmission optics assembly (618) is adapted to measure transmission density of light rays projected through the object sample when the object sample is in the form of a film control strip. A motor assembly (426) operating with a drive wheel assembly (434) and idler wheel assembly (440) automatically moves the object sample (588, 620) through the apparatus (410) adjacent the source light (580). A pair of guides (468, 470) are selectively adjustable by the operator to control movement of the object sample (588, 620) through the apparatus (410). In response to input from a key switch assembly (492) activatable by the operator, the apparatus (410) is adapted to perform various color density measurement and calibration functions, and display appropriate information to the operator through the use of a visual display (490).

Abstract translation: 公开了一种密度计装置（410），并且适用于提供对象样品的颜色浓度测量。 密度计装置（410）包括用于向包括控制条（588,620）的物体样品投射光的源光（580）。 反射光学组件（576）适用于当对象样本呈纸控制条的形式时，测量从对象样本反射的光密度。 传输光学组件（618）适于测量当对象样本呈胶卷控制条形式时通过对象样品投射的光线的透射密度。 用驱动轮组件（434）和惰轮组件（440）操作的马达组件（426）自动地使物体样品（588,620）通过邻近源光（580）的设备（410）移动。 一对引导件（468,470）可由操作者选择性调节，以控制物体样品（588,620）通过设备（410）的移动。 响应于由操作员激活的钥匙开关组件（492）的输入，装置（410）适于执行各种颜色浓度测量和校准功能，并且通过使用视觉显示器（490）向操作者显示适当的信息 ）。

公开(公告)号：US5029583A

公开(公告)日：1991-07-09

申请号：US431914

申请日：1989-11-06

Applicant: Peter M. Meserol ,  Thomas Palmieri

Inventor： Peter M. Meserol ,  Thomas Palmieri

IPC: A61B5/00 ,  A61B5/15 ,  G01N21/03 ,  G01N21/25 ,  G01N21/78

CPC classification number: A61B5/157 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/150022 ,  A61B5/150412 ,  A61B5/150633 ,  A61B5/150702 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15128 ,  A61B5/15194 ,  G01N21/251 ,  G01N2021/0371 ,  G01N21/78 ,  G01N2201/122 ,  G01N2201/126

Abstract: An optical analyzer for determining an analyte in a fluid of interest such as a body fluid of interest satisfying the foregoing need and embodying the present invention may include a housing; combination optically transparent cuvette and lancet mounted removably in the housing, the cuvette may receive an optically transparent reagent test system for reacting with the body fluid to produce a change in at least one optical transmissive characteristic of the system indicative of the analyte; a cuvette carrier mounted slidably in the housing and for removably receiving the cuvette; a spring actuator mounted in the housing and connected to the cuvette carrier, the spring actuator may be compressed and released to advance the carrier and thereby advance the lancet into engagement with a portion of a body to produce the body fluid; depth control apparatus for controlling the depth of penetration of the lancet into the body portion; an electrooptical system mounted in the housing in optical engagement with the cuvette and for passing a light beam through the cuvette and the reagent system and for receiving the light beam modified by the change in optical transmissive characteristic of the system and for transmitting computation signals indicative of the analyte to a computer; a computer mounted in the housing for receiving the computation signals and for comparing the computation signals against predetermined data to produce display signals indicative of the analyte; a display mounted in the housing and for receiving the display signals and for providing a vehicle display indicative of the analyte; and control switches mounted in the housing and connected to the computer for controlling the operation of the computer.

Abstract translation: 用于确定感兴趣的流体（例如满足上述需要的体液的分析物）并体现本发明的光学分析仪可以包括壳体; 组合的光学透明比色杯和可拆卸地安装在壳体中的刺血针，反应杯可以接收光学透明的试剂测试系统，用于与体液反应以产生指示分析物的系统的至少一个光学透射特性的变化; 比色杯托架，其可滑动地安装在所述壳体中并用于可移除地接收所述比色皿; 安装在壳体中并连接到比色杯托架的弹簧致动器可以压缩和释放弹簧致动器以使托架前进，从而使刺血针与身体的一部分接合以产生体液; 深度控制装置，用于控制刺血针穿入体部的深度; 安装在壳体中的电光学系统与比色皿光学接合并使光束通过比色杯和试剂系统，并用于接收由系统的光学透射特性的改变而修改的光束，并且用于发射指示 分析物到计算机; 安装在壳体中用于接收计算信号并用于将计算信号与预定数据进行比较以产生指示分析物的显示信号的计算机; 安装在壳体中并用于接收显示信号并提供指示分析物的车辆显示器的显示器; 以及安装在壳体中并连接到计算机以控制计算机的操作的控制开关。

公开(公告)号：US4986285A

公开(公告)日：1991-01-22

申请号：US279407

申请日：1988-12-02

Applicant: Andrzej Radzio ,  Wolfgang Stems

Inventor： Andrzej Radzio ,  Wolfgang Stems

IPC: A24C5/34 ,  G01N21/35 ,  G01N21/84 ,  G01N21/952

CPC classification number: G01N9/24 ,  A24C5/3412 ,  G01N21/84 ,  G01N2021/1744 ,  G01N2021/8427 ,  G01N21/35 ,  G01N21/952 ,  G01N2201/1245 ,  G01N2201/126 ,  Y10S131/905 ,  Y10S131/906 ,  Y10S131/908

Abstract: The density of successive increments of a cigarette rod is measured by an apparatus which employs one or more photocells operating with ultraviolet, infrared or visible light. The radiation source of each photocell emits a beam of ultraviolet, infrared or visible light which penetrates through the wrapper and the filler of the rod and thereupon impinges upon one or more transducers which transmit signals denoting the density of the monitored portion of the rod to an evaluating circuit. The beams which are emitted by two or more discrete radiation sources are or can be angularly offset with reference to each other, and the evaluating circuit processes the signals from the photocells to generate a single signal which is indicative of the density of the monitored increment of the rod and is used to adjust the trimming device and/or the ejector for defective cigarettes.

Abstract translation: 香烟棒的连续增量的密度通过使用一个或多个用紫外线，红外线或可见光操作的光电池的装置来测量。 每个光电池的辐射源发射紫外线，红外线或可见光束，其穿透包裹物并且杆的填料随后撞击在一个或多个换能器上，该换能器将表示杆的监测部分的密度的信号传递到 评估电路。 由两个或更多个离散辐射源发射的光束或者可以相互参考地成角度地偏移，并且评估电路处理来自光电管的信号以产生指示所监视的增量的密度的单个信号 该杆用于调整修整装置和/或用于有缺陷的香烟的喷射器。

公开(公告)号：US4935875A

公开(公告)日：1990-06-19

申请号：US312353

申请日：1989-02-13

Applicant: Ramesh M. Shah ,  Thomas H. Ridgway

Inventor： Ramesh M. Shah ,  Thomas H. Ridgway

IPC: G01J3/42 ,  G01N21/25 ,  G01N33/49 ,  G01N35/00

CPC classification number: G01N35/00732 ,  G01N21/253 ,  G01N33/4905 ,  G01J3/42 ,  G01N2035/00752 ,  G01N2201/0231 ,  G01N2201/1232 ,  G01N2201/1235 ,  G01N2201/126 ,  G01N2201/127 ,  G01N33/49

Abstract: An automatic chemical analyzer for the analysis of physiological samples. A scanning monochromatic spectrophotometer may be used to determine the absorbance of the sample under control of a central processing unit. Outputs from one of several ion selective electrodes may also be selected by the system. The information obtained from the measurements is stored in memory or ouputted to output devices. Information about the test parameters may be read from an optical bar code associated with the test kit for the particular chemical analysis.

Abstract translation: 一种用于生理样品分析的自动化学分析仪。 扫描单色分光光度计可用于在中央处理单元的控制下确定样品的吸光度。 来自几个离子选择性电极之一的输出也可以由系统选择。 从测量获得的信息存储在存储器中或输出到输出设备。 关于测试参数的信息可以从与特定化学分析的测试试剂盒相关联的光学条形码读取。