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公开(公告)号：US20250118544A1
公开(公告)日：2025-04-10
申请号：US18694874
申请日：2022-09-21
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Robert Lang
Abstract: The present invention relates to a composition comprising (i) cesium iodide, (ii) ethylamine and/or formic acid, and (iii) methanol and/or water. The present invention further relates to a method for calibrating a mass spectrometry (MS) device comprising (I) determining a mass spectrum of a composition as specified; and (II) calibrating the MS device based on the mass spectrum determined in step (I). The present invention further relates to devices, kits, uses, and methods related thereto.
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公开(公告)号：US20250112033A1
公开(公告)日：2025-04-03
申请号：US18479114
申请日：2023-10-02
Applicant: Guy Lawrence Cavet , Taran Driver
Inventor： Guy Lawrence Cavet , Taran Driver
IPC: H01J49/00
Abstract: The present invention features improved methods, computing devices, and computer-readable media to allow analysis of the composition of structures of matter. These innovations extract correlations between signals in spectral measurements and use these correlations to make inferences about the matter from which those measurements are derived.
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公开(公告)号：US20250104985A1
公开(公告)日：2025-03-27
申请号：US18729736
申请日：2023-01-17
Applicant: Micromass UK Limited
Inventor： David Langridge , Keith Richardson
Abstract: There is provided a method of operating an electrostatic ion trap, the electrostatic ion trap including a plurality of electrodes, the method including setting the voltage of the plurality of electrodes to a first voltage map, wherein the voltage map is configured such that: at a first ion kinetic energy per unit charge (KE) range, more than a first percentage of ions are stable, at a second ion KE range, less than a second percentage of ions are stable, and at a third ion KE range, more than the first percentage of ions are stable, wherein the first percentage is at least 4 times greater than the second percentage, and wherein the second ion KE range is between the first ion KE range and the third ion KE range.
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公开(公告)号：US12261032B2
公开(公告)日：2025-03-25
申请号：US18607766
申请日：2024-03-18
Applicant: Leidoc, Inc.
Inventor： Noah Peter Christian
Abstract: A low power mass spectrometer assembly includes at least an ionization component, an electrostatic analyzer, a lens assembly, a magnet assembly and at least one detector located in a same plane as the entrance to the magnet assembly for detecting the deflected sample ions and/or fragments of sample ions, including ions or ion fragments indicative of the Vitamin D metabolite within the sample.
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公开(公告)号：US20250095978A1
公开(公告)日：2025-03-20
申请号：US18294436
申请日：2022-08-02
Applicant: Thermo Fisher Scientific (Bremen) GmbH
Inventor： Jens Radke , Nils Stoebener , Nina Albrecht , Johannes Schwieters , Michael Krummen , Issaku Kohl , Jens Radke
Abstract: A method of operating a multiple inlet apparatus for an isotope ratio spectrometer, the multiple inlet apparatus having a first bellows containing a first gas and a second bellows containing a second gas. The compression of the first bellows is adjusted to a first compression value such that a first pressure of the first gas is equal to a target pressure value and the compression of the second bellows is adjusted to a second compression value such that a second pressure of the second gas is equal to the target pressure value. A first compression function is determined, configured to maintain the first pressure at the target pressure value and a second compression function configured to maintain the second pressure at the target pressure value. The first bellows are continuously compressed according to the first compression function and the second bellows are continuously compressed according to the second compression function.
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Patent Agency Ranking
公开(公告)号：US20250095976A1
公开(公告)日：2025-03-20
申请号：US18961044
申请日：2024-11-26
Applicant: Thermo Finnigan LLC
Inventor： Philip M. REMES , Jesse D. CANTERBURY
Abstract: A computer-implemented method of training a machine learning model comprises: accessing an elution profile comprising a plurality of detection points representing intensity of ions derived from components eluting from a chromatography column and detected by a mass analyzer as a function of time; generating, based on the elution profile, training data comprising a plurality of training examples, a training example of the plurality of training examples comprising a set of detection points and a target next detection point, the target next detection point comprising a detection point of the plurality of detection points following the set of detection points; and training, using the training data, the machine learning model to determine a predicted next detection point, the predicted next detection point following the set of detection points.
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17.发明申请公开(公告)号：US20250087474A1
公开(公告)日：2025-03-13
申请号：US18832984
申请日：2023-01-24
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Sebin CHERIAN , William LOYD , Pavel RYUMIN
Abstract: Methods and systems for controlling a filament of an electron emitter associated with an ion reaction cell in accordance with various aspects of the present teachings may account for inter-filament and inter-instrument variability and can provide improved reproducibility in EAD experiments and ease of use. In some aspects, a method of operating an ion reaction device of a mass spectrometer system is provided. The method comprises applying a calibration drive voltage to a filament of an electron emitter associated with an ion reaction cell and determining a value representative of the calibration electron emission current generated by the filament while having the calibration drive voltage applied thereto. A calibration saturation voltage can be determined by iteratively increasing the calibration drive voltage applied to the filament and determining the value of the calibration electron emission current at each corresponding calibration drive voltage until the filament reaches a saturation condition.
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公开(公告)号：US12243736B2
公开(公告)日：2025-03-04
申请号：US17811816
申请日：2022-07-11
Applicant: Shanghai Polaris Biology Co., Ltd.
Inventor： Yupeng Cheng , Shuangwu Sun
Abstract: Systems and methods are provided for the analysis of single particles with inductively coupled plasma-time of flight mass spectrometry. An ion compression device is operated in combination with an image current detector to improve a duty cycle of particle analysis. The image current detection device is used to determine a start time and an end time of a separate ion cloud which is derived from a single particle. The ion compression device stores and compresses each ion cloud based on instructions from the image current detector. The duty cycle of the particle analysis can be improved up to nearly 100%. The ion compression device is additionally operated with an ion filtration device to achieve a lower detection limit and a higher signal-to-noise ratio.
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公开(公告)号：US12243731B2
公开(公告)日：2025-03-04
申请号：US17682391
申请日：2022-02-28
Applicant: WATERS TECHNOLOGIES CORPORATION
Inventor： Jose De Corral
Abstract: Described are techniques for processing data. Sample analysis is performed generating scans of data. Each scan comprises a set of data elements each associating an ion intensity count with a plurality of dimensions including a retention time dimension and a mass to charge ratio dimension. The scans are analyzed to identify one or more ion peaks. Analyzing includes filtering a first plurality of the scans producing a first plurality of filtered output scans. The filtering including first filtering producing a first filtering output, wherein the first filtering includes executing a plurality of threads in parallel which apply a first filter to the first plurality of scans to produce the first filtering output. Each of the plurality of threads computes at least one filtered output point for at least one corresponding input point included in the plurality of scans. Analyzing includes detecting one or more peaks using the filtered output scans.
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公开(公告)号：US12237161B2
公开(公告)日：2025-02-25
申请号：US18436697
申请日：2024-02-08
Applicant: THE TRUSTEES OF INDIANA UNIVERSITY
Inventor： David E. Clemmer , Martin F. Jarrold , Tarick J. El-Baba , Corinne A. Lutomski
Abstract: A method for analyzing charged particles may include generating, in or into an ion source region, charged particles from a sample of particles, causing the charged particles to enter a mass spectrometer from the ion source region at each of a plurality of differing physical and/or chemical conditions in a range of physical and/or chemical conditions in which the sample particles undergo structural changes, controlling the mass spectrometer to measure at least the charge magnitudes of the generated charged particles at each of the plurality of differing physical and/or chemical conditions, determining, with a processor, an average charge magnitude of the generated charged particles at each of the plurality of differing physical and/or chemical conditions based on the measured charge magnitudes, and determining, with the processor, an average charge magnitude profile over the range of physical and/or chemical conditions based on the determined average charge magnitudes.
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