公开(公告)号：US08389957B2

公开(公告)日：2013-03-05

申请号：US13007535

申请日：2011-01-14

Applicant: Claudia B. Jaffe ,  Steven M. Jaffe ,  David Larsen

Inventor： Claudia B. Jaffe ,  Steven M. Jaffe ,  David Larsen

IPC: F21V9/16 ,  G01J1/58 ,  G01T1/10 ,  G21H3/02 ,  G21K5/00 ,  H01J65/06 ,  H01J65/08 ,  H05B37/02 ,  H05B39/04 ,  H01J3/14 ,  H01J5/16 ,  G01N21/85

CPC classification number: H05B33/0869 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/6458 ,  G01N2021/6419

Abstract: A system and method for metered dosage illumination in a bioanalysis or other system. In accordance with an embodiment, an illumination system or subsystem is described that can provide optimized amounts of excitation light within the short exposure times necessary to measure fast biological activity. The amount of light can be precisely measured to provide quantitative results. The light flux can also be precisely controlled to generate only a prescribed minimum amount of light, in order to reduce adverse lighting effects on both fluors and samples. Although the examples herein illustrate the providing of metered dosage illumination in the context of a bioanalysis system, the techniques can be similarly used to provide metered dosage illumination in the context of other types of system.

Abstract translation: 生物分析或其他系统中计量剂量照明的系统和方法。 根据实施例，描述了可以在测量快速生物活性所需的短曝光时间内提供优化量的激发光的照明系统或子系统。 可以精确测量光量以提供定量结果。 也可以精确地控制光通量以仅产生规定的最小量的光，以减少对荧光和样品的不利的照明效果。 虽然本文的实施例说明了在生物分析系统的背景下提供计量剂量照明，但是这些技术可以类似地用于在其他类型的系统的上下文中提供计量剂量照明。

公开(公告)号：US20080180655A1

公开(公告)日：2008-07-31

申请号：US10809932

申请日：2004-03-26

Applicant: Reinhard Bruch ,  Jutta Gietl

Inventor： Reinhard Bruch ,  Jutta Gietl

IPC: G01N21/00 ,  G01J3/44 ,  G01J3/30 ,  G01T1/10 ,  G01J1/58 ,  G21H3/02 ,  G21K5/00 ,  F21V9/16 ,  H01J65/06 ,  H01J65/08

CPC classification number: G01J3/42 ,  G01J3/10 ,  G01J3/36 ,  G01J3/44 ,  G01J11/00 ,  G01N21/636 ,  G01N21/65 ,  G01N2021/1793 ,  G01N2021/6417 ,  G01N2201/0697

Abstract: The present invention relates to a system for detection and identification of airborne biological, chemical and/or nuclear threats such as toxins, spores, bacteria, and viruses in real time at distances from a few meters to several kilometers. Compact femtosecond terawatt laser technology is combined with spectroscopic and mathematical methods for spectral sensing of airborne warfare agents such as bio-aerosols. Trigger sensors and standoff devices based on mobile terawatt femtosecond laser systems are provided that may be placed at strategic monitoring locations. Furthermore, the invention relates to the propagation of airborne ultra-short, ultra-intense laser pulses giving rise to plasma channels (filamentation) producing white light supercontinuum ranging from the ultraviolet (UV), visible (VIS), near infra-red (NIR) and middle infra-red (MIR). According to this invention, the supercontinuum can be directly produced in a particle cloud and hence is uniquely suitable for multi-spectral long-range atmospheric agent and radioactive isotope detection.

Abstract translation: 本发明涉及一种用于在几米到几公里的距离内实时检测和识别空中生物，化学和/或核威胁的系统，例如毒素，孢子，细菌和病毒。 紧凑飞秒激光技术结合光谱和数学方法，用于光谱传感机载战剂如生物气溶胶。 提供了基于移动式飞秒飞秒激光系统的触发传感器和支架装置，可以放置在战略监控位置。 此外，本发明涉及产生从紫外线（UV），可见光（VIS），近红外线（NIR）的白光超连续谱产生等离子体通道（细丝）的机载超短超激光脉冲的传播 ）和中红外（MIR）。 根据本发明，超连续谱可以直接在颗粒云中产生，因此独特地适用于多光谱远程大气剂和放射性同位素检测。

公开(公告)号：US4247800A

公开(公告)日：1981-01-27

申请号：US8807

申请日：1979-02-02

Applicant: Joseph M. Proud ,  Robert J. Regan ,  Paul O. Haugsjaa ,  Donald H. Baird

Inventor： Joseph M. Proud ,  Robert J. Regan ,  Paul O. Haugsjaa ,  Donald H. Baird

IPC: H01J65/04 ,  F21S2/00 ,  H01J65/06 ,  H05B41/24 ,  H05B41/233 ,  H01J7/40

CPC classification number: H01J65/06

Abstract: Radioactive materials are used to assist in starting a discharge in an electrodeless light source. The radioactive emissions predispose on the inner surface of the lamp envelope loosely bound charges which thereafter assist in initiating discharge. The radioactive material can be enclosed within the lamp envelope in gaseous or non-gaseous form. Preferred materials are krypton 85 and americium 241. In addition, the radioactive material can be dispersed in the lamp envelope material or can be a pellet imbedded in the envelope material. Finally, the radioactive material can be located in the termination fixture. Sources of alpha particles, beta particles, or gamma rays are suitable. Because charges accumulate with time on the inner surface of the lamp envelope, activity levels as low as 10.sup.-8 curie are effective as starting aids.

Abstract translation: 放射性物质用于协助在无电极光源中开始放电。 放射性排放易于在灯管的内表面松动地捆扎，此后有助于启动放电。 放射性物质可以以气态或非气态形式封装在灯管内。 优选的材料是氪85和ium 241。此外，放射性物质可以分散在灯管材料中，或者可以是嵌入包封材料中的颗粒。 最后，放射性物质可以位于终端夹具中。 α粒子，β粒子或γ射线的来源是合适的。 因为电荷在灯管内表面积累的电荷，所以低至10-8居里的活性水平作为助燃剂是有效的。

公开(公告)号：US3937968A

公开(公告)日：1976-02-10

申请号：US821177

申请日：1969-05-02

Applicant: Samuel G. Harris

Inventor： Samuel G. Harris

IPC: F21K2/00 ,  F41G1/14 ,  G02B27/34 ,  H01J65/06

CPC classification number: G02B27/34 ,  F21K2/00 ,  F41G1/14 ,  H01J65/06

Abstract: An aiming device of the general type shown in U.S. Pat. No. 2,488,541 is disclosed. The device comprises a tubular housing for mounting on a gun or other device which must be manually aimed and the housing contains a spot source of light which is projected rearwardly toward one eye of the user through a collimator contained within the housing. The light source is preferably a radiation activated phosphor of one color housed in a filter of a different color in order to present automatically a spot source of light of the color of the filter during high ambient lighting intensity and a spot source of light the color of the phosphor during low ambient lighting intensity.

Abstract translation: 美国专利中所示的通用型瞄准装置 公开了2,488,541号。 该装置包括用于安装在枪或其他装置上的管状壳体，该装置必须手动瞄准，并且壳体包含通过容纳在壳体内的准直器向后朝向使用者的一个眼睛向后突出的光源。 光源优选地是一种颜色的辐射活化荧光体，其容纳在不同颜色的滤光器中，以便在高环境照明强度期间自动呈现滤光器的颜色的光源，并且光源的颜色为 在低环境照明强度下的荧光粉。

公开(公告)号：US3483040A

公开(公告)日：1969-12-09

申请号：US3483040D

申请日：1966-06-27

Applicant: NORTH AMERICAN ROCKWELL

Inventor： PARKINS WILLIAM E

IPC: G21H1/12 ,  H01J65/06 ,  H01M15/02

CPC classification number: H01J65/06 ,  G21H1/12

公开(公告)号：US10948421B2

公开(公告)日：2021-03-16

申请号：US15506850

申请日：2015-08-27

Applicant: ASML Netherlands B.V.

Inventor： Martijn Petrus Christianus Van Heumen ,  Sergii Denega ,  Ralph Jozef Johannes Gerardus Anna Maria Smeets ,  Remco Marcel Van Dijk ,  Marc Van Kemenade

IPC: H01J65/04 ,  H01J65/06 ,  G01N21/88 ,  G01N21/956 ,  G03F7/20 ,  G01N21/95

Abstract: Disclosed is a laser-driven photon source comprising drive optics which focus drive radiation so as to maintain a plasma. The point spread function of the drive optics has a point spread function (75) which is configured such that a spectral position of a peak output wavelength of a black body portion of output radiation emitted by said plasma within a desired wavelength band.

公开(公告)号：US09187034B2

公开(公告)日：2015-11-17

申请号：US13833396

申请日：2013-03-15

Applicant: International Automotive Components Group North America, Inc.

Inventor： Sassan Tarahomi ,  Zachary Seguin

IPC: F21V9/16 ,  G01J1/58 ,  G01T1/10 ,  G21H3/02 ,  G21K5/00 ,  H01J65/06 ,  H01J65/08 ,  B60Q3/00 ,  B60Q3/02 ,  B60R13/02 ,  F21K2/00 ,  C09K11/02

CPC classification number: C09K11/025 ,  B60Q3/68 ,  B60Q3/745 ,  B60R13/02 ,  B60R2013/0287 ,  C09K11/08 ,  F21K2/00

Abstract: A component of a motor vehicle comprising a photoluminescent interior member formed of a plastic composition, wherein the plastic composition comprises at least one polymer and a plurality of additives comprising at least one photoluminescent material and at least a first ultraviolet protector, wherein the at least one photoluminescent material absorbs electromagnetic radiation in a first ultraviolet range of an electromagnetic spectrum, and thereafter emits electromagnetic radiation in a visible radiation range of the electromagnetic spectrum, and wherein the first ultraviolet protector is an ultraviolet absorber, wherein the ultraviolet absorber absorbs electromagnetic radiation in a second ultraviolet range of the electromagnetic spectrum and does not absorb electromagnetic radiation in the first ultraviolet range of the electromagnetic spectrum.

Abstract translation: 一种机动车辆的组件，包括由塑料组合物形成的光致发光内部构件，其中塑料组合物包含至少一种聚合物和多种添加剂，其包含至少一种光致发光材料和至少第一紫外线保护剂，其中至少一种 光致发光材料在电磁光谱的第一紫外线范围内吸收电磁辐射，然后在电磁光谱的可见光辐射范围内发射电磁辐射，其中第一紫外线保护器是紫外线吸收剂，其中紫外线吸收剂吸收电磁辐射 电磁波谱的第二紫外线范围，并且不吸收电磁波谱的第一紫外线范围内的电磁辐射。

公开(公告)号：US09066657B2

公开(公告)日：2015-06-30

申请号：US12952359

申请日：2010-11-23

Applicant: Siavash Yazdanfar ,  Floribertus Heukensfeldt Jansen ,  Stephen Lomnes ,  Xinghua Wang

Inventor： Siavash Yazdanfar ,  Floribertus Heukensfeldt Jansen ,  Stephen Lomnes ,  Xinghua Wang

IPC: G06K9/40 ,  F21V9/16 ,  G01J1/58 ,  G01T1/10 ,  G21H3/02 ,  G21K5/00 ,  H01J65/06 ,  H01J65/08 ,  H01L27/00 ,  G01N21/86 ,  G01V8/00 ,  A61B5/00

CPC classification number: A61B5/0059 ,  A61B5/0064

Abstract: A method for enhancing contrast in fluorescence imaging is provided. The method comprises providing a patterned illumination source for illuminating one or more regions corresponding to a scan step, scanning at least a portion of a surface of a subject using a plurality of scan steps, acquiring image frames corresponding to two or more scan steps, deducting a background fluorescence from the image frames corresponding to the two or more scan steps to form one or more processed image frames, and reconstructing an image using one or more of the processed image frames.

Abstract translation: 提供了一种增强荧光成像对比度的方法。 该方法包括提供用于照亮与扫描步骤相对应的一个或多个区域的图案化照明源，使用多个扫描步骤扫描对象的表面的至少一部分，获取对应于两个或更多个扫描步骤的图像帧，扣除 来自对应于两个或更多个扫描步骤的图像帧的背景荧光，以形成一个或多个经处理的图像帧，以及使用一个或多个处理后的图像帧重建图像。

公开(公告)号：US08785886B2

公开(公告)日：2014-07-22

申请号：US13788972

申请日：2013-03-07

Applicant: Olympus Corporation

Inventor： Kazutaka Nishikawa ,  Tetsuya Tanabe ,  Mitsushiro Yamaguchi

IPC: G01N21/64 ,  H01J65/06 ,  G01N15/14

CPC classification number: G01N21/64 ,  G01N15/1463 ,  G01N21/6428 ,  G01N21/6452 ,  G01N2015/1493

Abstract: There is provided a scanning molecule counting method using an optical measurement with a confocal microscope or a multiphoton microscope, enabling characterization of a light-emitting particle or identification of a light-emitting particle with emitted light intensity of a single light-emitting particle measured individually. In the inventive optical analysis technique, with reference to the ratio of the intensities of simultaneously generated signals of the lights of at least two light-emitting sites having mutually different emission wavelengths, possessed by a light-emitting particle contained in a sample solution, the intensities being measured with moving the position of the light detection region of an optical system by changing the optical path of the optical system, a single light-emitting particle corresponding to the signals is identified, and the kind, the size, etc. of the light-emitting particle is identified.

Abstract translation: 提供了一种使用共焦显微镜或多光子显微镜的光学测量的扫描分子计数方法，能够单独测量发光粒子的特征或发光粒子的发射光强度的单个发光粒子的发光强度。 。 在本发明的光学分析技术中，参照包含在样品溶液中的发光粒子具有的具有相互不同的发射波长的至少两个发光部位的至少两个发光部位的同时产生的信号的强度的比例， 通过改变光学系​​统的光路来移动光学系统的光检测区域的位置来测量强度，识别与该信号相对应的单个发光粒子，并且确定该光学系统的种类，尺寸等 发现发光粒子。

公开(公告)号：US08334522B2

公开(公告)日：2012-12-18

申请号：US12616811

申请日：2009-11-12

Applicant: Rafael Egger

Inventor： Rafael Egger

IPC: F21V9/16 ,  G01J1/58 ,  G01T1/10 ,  G21H3/02 ,  G21K5/00 ,  H01J65/06 ,  H01J65/08

CPC classification number: G01N21/278 ,  G01N21/6428

Abstract: The invention concerns methods and apparatuses for quantitatively determining the concentration of fluorophores of a substance in a sample. A constant portion of the reference light of a reference light wave length (λr) emitted by a reference light source is coupled in by an optical element in the direction of a receiving element. A first value corresponding to the portion of the reference light coupled in which is incident on the receiving element is detected. The sample is irradiated with the excitation light of an excitation wave length (λex) emitted by an excitation light source. A second value corresponding to the portion of the fluorescent light of an emission wave length (λem) emitted by the sample which is incident on the receiving element. The ratio of the second value to the first value is determined. The number of fluorophores in the substance is determined based on the ratio.

Abstract translation: 本发明涉及用于定量测定样品中物质的荧光团浓度的方法和装置。 由参考光源发射的参考光波长（λr）的参考光的恒定部分通过光学元件沿接收元件的方向耦合。 检测对应于其中入射在接收元件上的参考光的部分的第一值。 用激发光源发射的激发波长（λex）的激发光照射样品。 对应于由入射在接收元件上的样品发射的发射波长（λem）的荧光的部分的第二值。 确定第二值与第一值的比率。 该物质中荧光团的数量是根据比例来确定的。