公开(公告)号：US20160305886A1

公开(公告)日：2016-10-20

申请号：US15194630

申请日：2016-06-28

Applicant: MannKind Corporation

Inventor： Jason J. Antunovich ,  Arthur T. Hamfeldt ,  Rodney J. Woods ,  Sam C. Shum

IPC: G01N21/65 ,  G01N15/06 ,  G01G9/00

CPC classification number: G01N21/65 ,  G01G9/00 ,  G01N15/06 ,  G01N2201/06113 ,  G01N2201/121 ,  G01N2201/127

Abstract: Methods and apparatus are provided for determining weight percent of solids in a suspension using Raman spectroscopy. The methods can be utilized to acquire Raman spectral data from the suspension and to determine weight percent of solids in a process being carried out, for example, in a vessel, without the need to remove samples for analysis. The weight percent of the solids can be determined with a desired accuracy in a relatively short time, typically 10 minutes or less. The acquired Raman spectral data may be processed by chemometric software using, for example, a partial least squares algorithm and data pretreatment to provide a predicted value of weight percent solids. In some embodiments, the invention is used to determine the weight percent of microparticles of a diketopiperazine in an aqueous solution.

公开(公告)号：US20160230209A1

公开(公告)日：2016-08-11

申请号：US15017034

申请日：2016-02-05

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Yong Chu ,  Jacob Freudenthal ,  Jeffrey Marks

IPC: C12Q1/68 ,  G01N21/64

CPC classification number: C12Q1/686 ,  G01N21/274 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/6456 ,  G01N2021/6421 ,  G01N2021/6441 ,  G01N2201/127

Abstract: Some embodiments describe a computer-implemented method for calibrating a fluorescent dye. The method can comprise imaging a sample holder, loaded into an instrument, at more than one channel. The sample holder can comprise a plurality of reaction sites and more than one dye type, with each dye occupying more than one reaction site. The method can further comprise identifying a peak channel for each dye on the sample holder, normalizing each channel to the peak channel for each dye, and producing a dye matrix that can comprise a set of dye reference values.

Abstract translation: 一些实施例描述了用于校准荧光染料的计算机实现的方法。 该方法可以包括在多个通道上成像加载到仪器中的样品架。 样品架可以包括多个反应位点和多于一种染料类型，每种染料占据多于一个反应位点。 该方法还可以包括鉴定样品架上每种染料的峰通道，将每个通道标准化为每种染料的峰通道，以及产生可包含一组染料参考值的染料基质。

公开(公告)号：US20160172185A1

公开(公告)日：2016-06-16

申请号：US14903538

申请日：2014-06-23

Applicant: Haruyoshi YAMAKAWA ,  KURITA WATER INDUSTRIES LTD.

Inventor： Haruyoshi YAMAKAWA

IPC: H01L21/02 ,  G01N21/25 ,  C25B1/30 ,  H01L21/67 ,  C25B15/02 ,  C25B15/08 ,  B08B3/04 ,  H01L21/66 ,  G01N21/33 ,  C25B9/00

CPC classification number: H01L21/02057 ,  B08B3/04 ,  C25B1/30 ,  C25B9/00 ,  C25B15/02 ,  C25B15/08 ,  G01N21/255 ,  G01N21/274 ,  G01N21/33 ,  G01N2201/127 ,  H01L21/67017 ,  H01L21/6704 ,  H01L21/67253 ,  H01L22/10

Abstract: To allow online monitoring of the overall concentration of oxidizing substances in electrolyzed sulfuric acid, for example, in a cleaning system, absorbance data having undergone baseline correction in relation to the overall concentration of oxidizing substances by using a standard sample liquid in the form of an electrolyzed sulfuric acid preparation liquid having the same sulfuric acid concentration as the sulfuric acid concentration of the electrolyzed sulfuric acid is prepared, and absorbance is measured over wavelengths ranging from 190 to 290 nm by using a sample liquid in the form of electrolyzed sulfuric acid having a sulfuric acid concentration ranging from 60 to 97% by mass and a liquid temperature ranging from 20 to 70° C. to measure the overall concentration of oxidizing substances in the electrolyzed sulfuric acid on the basis of the data. The overall concentration of oxidizing substances in the electrolyzed sulfuric acid can thus be immediately measured.

Abstract translation: 为了允许在线监测电解硫酸中的氧化物质的总浓度，例如在清洁系统中，通过使用标准样品液体形式的吸收性数据已经经历了与氧化物质总浓度相关的基线校正 制备具有与电解硫酸的硫酸浓度相同的硫酸浓度的电解硫酸制备液，通过使用电解硫酸形式的样品液体，在190〜290nm的波长范围内测定吸光度， 硫酸浓度为60〜97质量％，液温为20〜70℃，根据数据测定电解硫酸中氧化物质的总浓度。 因此可以立即测量电解硫酸中的氧化物质的总浓度。

公开(公告)号：US09360424B2

公开(公告)日：2016-06-07

申请号：US14372175

申请日：2013-01-14

Applicant: ROBERT BOSCH GMBH

Inventor： Daniel Strack ,  Reinhard Hoss ,  Michael Neuendorf ,  Gerhard Haaga ,  Karl Stengel ,  Andrea Matteucci

IPC: G01N15/06 ,  G01N21/47

CPC classification number: G01N21/4785 ,  G01N15/06 ,  G01N2015/0693 ,  G01N2201/06113 ,  G01N2201/127

Abstract: A calibration device is described for calibrating a scatterometer, which is designed in particular for measuring a particle concentration in exhaust gases of motor vehicles. The calibration device has at least one scattering body which emits scattered light having a defined intensity and distribution when irradiated with a light beam, the scattering body having an emission surface for the scattered light, to which is assigned at least one light sensor for detecting the scattered light exiting the emission surface. A screening body having at least one screen opening through which the scattered light exits in the direction of the at least one light sensor is assigned to the emission surface of the scattering body.

Abstract translation: 描述了用于校准散射仪的校准装置，其特别用于测量机动车辆废气中的颗粒浓度。 校准装置具有至少一个散射体，该散射体在用光束照射时发射具有确定的强度和分布的散射光，散射体具有用于散射光的发射表面，并分配有至少一个光传感器，用于检测 离开发射表面的散射光。 具有至少一个屏幕开口的屏蔽体被分配给散射体的发射表面，散射光沿着至少一个光传感器的方向射出。

公开(公告)号：US20160153899A1

公开(公告)日：2016-06-02

申请号：US14904634

申请日：2014-07-10

Applicant: TOPNIR SYSTEMS SAS

Inventor： Didier Lambert ,  Claude Saint Martin ,  Sanchez Miguel ,  Bernard Ribeiro

IPC: G01N21/359 ,  G01N21/27

CPC classification number: G01N21/359 ,  G01N21/274 ,  G01N21/35 ,  G01N2201/127

Abstract: The present invention relates to a method for characterizing a sample-product X by spectral analysis by means of a novel spectrometer II using information acquired by means of a first spectrometer I.

Abstract translation: 本发明涉及通过使用通过第一光谱仪I获得的信息的新型光谱仪II的光谱分析来表征样品X的方法。

公开(公告)号：US20160091431A1

公开(公告)日：2016-03-31

申请号：US14959063

申请日：2015-12-04

Applicant: Step Ahead Innovations, Inc.

Inventor： James E. Clark

IPC: G01N21/77 ,  G01N27/06

CPC classification number: G01N21/77 ,  A61K36/185 ,  G01N21/274 ,  G01N21/6428 ,  G01N21/643 ,  G01N21/78 ,  G01N21/8507 ,  G01N27/06 ,  G01N33/18 ,  G01N2021/6439 ,  G01N2201/062 ,  G01N2201/1211 ,  G01N2201/127 ,  G06Q30/0282

Abstract: An aquatic environment water parameter testing system and related methods and chemical indicator elements. The aquatic environment water parameter testing system includes an electronics portion having an optical reader element and a sample chamber portion. Conductivity and/or temperature may be utilized to calibrate readings by the optical reader element. A system may optionally have a sample chamber portion having a chemical indicator element which may be removably connected. A chemical indicator element may include an information storage and communication element used, in part, to provide identification of a chemical indicator of the chemical indicator element.

Abstract translation: 水环境水参数检测系统及相关方法及化学指标要素。 水环境水参数测试系统包括具有光学读取器元件和样品室部分的电子部件。 可以使用电导率和/或温度来校准光学读取器元件的读数。 系统可以可选地具有样品室部分，其具有可拆卸地连接的化学指示元件。 化学指示元件可以包括信息存储和通信元件，其部分地用于提供化学指示元件的化学指示剂的识别。

公开(公告)号：US20150164389A1

公开(公告)日：2015-06-18

申请号：US14261043

申请日：2014-04-24

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Andrea Varsavsky ,  Xiaolong Li ,  Mike C. Liu ,  Yuxiang Zhong ,  Ning Yang

IPC: A61B5/145 ,  A61M5/172 ,  A61B5/1495 ,  A61B5/00 ,  A61B5/1455 ,  A61B5/1468

CPC classification number: A61B5/14532 ,  A61B5/0004 ,  A61B5/14503 ,  A61B5/1455 ,  A61B5/14556 ,  A61B5/1459 ,  A61B5/1468 ,  A61B5/1473 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/7221 ,  A61B5/7278 ,  A61B2560/0223 ,  A61B2560/0238 ,  A61B2562/06 ,  A61M5/142 ,  A61M5/14244 ,  A61M5/1723 ,  A61M2005/1726 ,  A61M2205/3306 ,  A61M2205/3584 ,  A61M2205/3592 ,  A61M2205/50 ,  A61M2205/505 ,  A61M2205/52 ,  A61M2230/005 ,  A61M2230/201 ,  C12Q1/006 ,  G01N21/00 ,  G01N21/59 ,  G01N21/84 ,  G01N27/27 ,  G01N27/3274 ,  G01N27/4163 ,  G01N33/49 ,  G01N33/66 ,  G01N2201/127

Abstract: Methods and systems for sensor calibration and sensor glucose (SG) fusion are used advantageously to improve the accuracy and reliability of orthogonally redundant glucose sensor devices, which may include optical and electrochemical glucose sensors. Calibration for both sensors may be achieved via fixed-offset and/or dynamic regression methodologies, depending, e.g., on sensor stability and Isig-Ratio pair correlation. For SG fusion, respective integrity checks may be performed for SG values from the optical and electrochemical sensors, and the SG values calibrated if the integrity checks are passed. Integrity checks may include checking for sensitivity loss, noise, and drift. If the integrity checks are failed, in-line sensor mapping between the electrochemical and optical sensors may be performed prior to calibration. The electrochemical and optical SG values may be weighted (as a function of the respective sensor's overall reliability index (RI)) and the weighted SGs combined to obtain a single, fused SG value.

公开(公告)号：US20150055134A1

公开(公告)日：2015-02-26

申请号：US14376324

申请日：2013-02-04

Applicant: University of Cincinnati ,  United States of America as Represented by the Secretary of the Air Force

Inventor： Ian Papautsky ,  Li Shen ,  Rajesh Naik ,  Joshua Hagen ,  Morley Stone

IPC: G01N21/25 ,  G01N21/27 ,  G01J3/46 ,  G01N21/78

CPC classification number: G01N21/25 ,  G01J3/46 ,  G01N21/278 ,  G01N21/293 ,  G01N21/78 ,  G01N2201/061 ,  G01N2201/127 ,  G01N2201/13

Abstract: Described herein is a method, system and computer program for analyzing a colorimetric assay that includes obtaining an image of the assay, optionally correcting for ambient lighting conditions in the image, converting the intensity data for at least one of the red channel, the green channel, or the blue channel to a first data point, recalling a predetermined standardized curve, comparing the first data point with the standardized curve, and identifying the value for the assay parameter from the standardized curve.

Abstract translation: 本文描述了一种用于分析比色测定法的方法，系统和计算机程序，其包括获得测定图像，可选地校正图像中的环境光照条件，转换红色通道，绿色通道中的至少一个的强度数据 或蓝色通道移动到第一数据点，回忆预定的标准化曲线，将第一数据点与标准化曲线进行比较，并从标准化曲线识别测定参数的值。

公开(公告)号：US08901513B2

公开(公告)日：2014-12-02

申请号：US13042920

申请日：2011-03-08

Applicant: Adam M. Gilmore ,  Xiaomei Tong

Inventor： Adam M. Gilmore ,  Xiaomei Tong

IPC: F21V9/16 ,  G01J3/12 ,  G01N21/64 ,  G01J3/02 ,  G01J3/18 ,  G01J3/42 ,  G01J3/44

CPC classification number: G01N33/18 ,  G01J3/021 ,  G01J3/0294 ,  G01J3/12 ,  G01J3/18 ,  G01J3/42 ,  G01J3/4406 ,  G01N21/33 ,  G01N21/645 ,  G01N2021/1734 ,  G01N2021/6417 ,  G01N2021/6421 ,  G01N2021/6491 ,  G01N2201/061 ,  G01N2201/127

Abstract: A system or method for analyzing a sample include an input light source, a double subtractive monochromator positioned to receive light from the input light source and to sequentially illuminate the sample with each of a plurality of wavelengths, a multi-channel fluorescence detector positioned to receive and substantially simultaneously detect multiple wavelengths of light emitted by the sample for each of the plurality of excitation wavelengths, an absorption detector positioned to receive and detect light passing through the sample, and a computer in communication with the monochromator, the fluorescence detector, and the absorption detector, the computer controlling the monochromator to sequentially illuminate the sample with each of the plurality of wavelengths while measuring absorption and fluorescence of the sample based on signals received from the fluorescence and absorption detectors.

Abstract translation: 用于分析样本的系统或方法包括输入光源，双折射单色仪，定位成接收来自输入光源的光并且以多个波长中的每一个顺序照射样本;多通道荧光检测器，定位成接收 并且基本上同时检测由所述样品对于所述多个激发波长中的每一个发射的多个波长的光;吸收检测器，定位成接收和检测通过所述样品的光;以及计算机，其与所述单色仪，所述荧光检测器和 吸收检测器，控制单色仪的计算机基于从荧光和吸收检测器接收的信号来测量样品的吸收和荧光，依次照射多个波长中的每个波长的样品。

公开(公告)号：US20140134623A1

公开(公告)日：2014-05-15

申请号：US13921455

申请日：2013-06-19

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Amy Hiddessen ,  Erin Steenblock

IPC: B01F5/00 ,  B01F9/00 ,  C12Q1/68 ,  B01F11/00

CPC classification number: C12Q1/6816 ,  B01F5/0085 ,  B01F5/0647 ,  B01F9/00 ,  B01F11/00 ,  B01F13/0062 ,  B01F13/0072 ,  B01F2215/0037 ,  B01L3/502784 ,  B01L3/52 ,  B01L2200/148 ,  B01L2200/185 ,  B01L2300/0867 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2300/1861 ,  C12Q1/6806 ,  G01N1/38 ,  G01N21/6428 ,  G01N21/645 ,  G01N2001/2893 ,  G01N2021/6439 ,  G01N2201/127 ,  C12Q2563/159

Abstract: Provided herein, are droplet mixture compositions and systems and methods for forming mixtures of droplets. The system may comprise two or more droplet generation units. Each unit may include at least one first input well, a second input well, and an output well connected to the first and second input wells by channels that form a droplet generator. The combined droplet populations can be mixed, heated, and collected for multiple uses, such as for use as calibration standards for instrument testing and analysis.

Abstract translation: 本文提供了液滴混合物组合物和用于形成液滴混合物的系统和方法。 该系统可以包括两个或更多个液滴产生单元。 每个单元可以包括至少一个第一输入井，第二输入井和通过形成液滴发生器的通道连接到第一和第二输入井的输出井。 组合的液滴种群可以混合，加热和收集用于多种用途，例如用作仪器测试和分析的校准标准。