公开(公告)号：US07787117B1

公开(公告)日：2010-08-31

申请号：US12145018

申请日：2008-06-24

Applicant: Marco Leona ,  Thomas J. Tague, Jr.

Inventor： Marco Leona ,  Thomas J. Tague, Jr.

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01N21/658 ,  G01J3/44

Abstract: In apparatus for performing Surface Enhanced Raman Spectroscopy (SERS), rather than applying a sample to be analyzed to an SERS active substrate, the SERS active substrate is applied to the sample using an inkjet nozzle to apply a substance containing a colloidal metal, such as silver, to the sample. The prepared sample is then analyzed with a Raman spectrometer in a conventional fashion.

Abstract translation: 在用于进行表面增强拉曼光谱（SERS）的装置中，使用喷墨喷嘴将SERS活性基板施加到样品上，而不是将待分析的样品施加到SERS活性基板上，以将含有胶体金属的物质 银，样品。 然后用拉曼光谱仪以常规方式分析制备的样品。

公开(公告)号：US07773217B2

公开(公告)日：2010-08-10

申请号：US11357899

申请日：2006-02-17

Applicant: Tirunelveli S. Sriram ,  David A. Coppeta ,  James Zambuto

Inventor： Tirunelveli S. Sriram ,  David A. Coppeta ,  James Zambuto

IPC: G01J3/44

CPC classification number: G01N21/65 ,  G01J3/02 ,  G01J3/0224 ,  G01J3/0291 ,  G01J3/10 ,  G01J3/26 ,  G01J3/28 ,  G01J3/44

Abstract: A probe of a Raman spectroscopy system has a wavelength and/or amplitude referencing system for determining a wavelength of the excitation signal. Preferably, this referencing system is near an output aperture, through which the excitation signal is transmitted to the sample. In this way, any birefringence or polarization dependent loss (PDL) that may be introduced by optical elements in the system can be compensated for since the wavelength reference system will detect the effect or impact of these elements.

Abstract translation: 拉曼光谱系统的探针具有用于确定激发信号的波长的波长和/或幅度参考系统。 优选地，该参考系统靠近输出孔径，通过该输出孔径将激发信号传输到样品。 以这种方式，可以补偿由系统中的光学元件引入的任何双折射或偏振相关损耗（PDL），因为波长参考系将检测这些元件的影响或影响。

公开(公告)号：US07760354B2

公开(公告)日：2010-07-20

申请号：US12248272

申请日：2008-10-09

Applicant: Jacob Grun ,  Sergei Nikitin ,  Charles K Manka

Inventor： Jacob Grun ,  Sergei Nikitin ,  Charles K Manka

IPC: G01N21/63 ,  G01N21/64 ,  G01N21/65

CPC classification number: G01J3/28 ,  G01J3/44 ,  G01N21/65 ,  G01N2201/1293

Abstract: A spectroscopic detector includes a tunable light source, such as a continuously tunable, optical parametric oscillator laser; means for measuring the emitted radiation at a plurality of emission wavelengths to obtain a plurality of spectral measurement data; and a processor for processing the spectral measurement data, where the processor includes a multispectral data processing algorithm or is configured for 1) combining the plurality of spectral measurement data into a composite spectrum, and 2) applying the algorithm to the composite spectrum. The spectra such as resonant and near-resonant Raman Spectra that are acquired are more complete and contain more information. A powerful multispectral analysis code such as IHPS, CHOMPS, or ENN analyzes the acquired data points, examining details of the spectra that could not be handled by traditional methods.

Abstract translation: 光谱检测器包括可调谐光源，例如连续可调的光学参量振荡器激光器; 用于测量多个发射波长处的发射辐射以获得多个光谱测量数据的装置; 以及用于处理所述光谱测量数据的处理器，其中所述处理器包括多光谱数据处理算法或者被配置为1）将所述多个光谱测量数据组合成复合光谱，以及2）将所述算法应用于所述复合光谱。 所获得的诸如共振和近共振拉曼光谱的光谱更完整并包含更多信息。 一个强大的多光谱分析代码，如IHPS，CHOMPS或ENN，分析所获得的数据点，检查传统方法无法处理的光谱细节。

公开(公告)号：US20100179770A1

公开(公告)日：2010-07-15

申请号：US12684495

申请日：2010-01-08

Applicant: Michael Fuhrman ,  Ryan Priore ,  Oksana Olkhovyk ,  Oksana Klueva

Inventor： Michael Fuhrman ,  Ryan Priore ,  Oksana Olkhovyk ,  Oksana Klueva

IPC: G06F19/00 ,  G01N33/00 ,  G01J3/44

CPC classification number: G01N15/0227 ,  G01J3/02 ,  G01J3/027 ,  G01J3/44 ,  G01N21/65

Abstract: A system and method for determining at least one geometric property of a particle in a sample. A sample is irradiated to thereby generate Raman scattered photons. These photons are collected to generate a Raman chemical image. A first threshold is applied wherein the first threshold is such that all particles in the sample are detected. A particle in the sample is selected and a second threshold is applied so that at least one geometric property of the selected particle can be determined. At least one spectrum representative of the selected particle is analyzed to determine whether or not it is a particle of interest. The step of determining a second threshold may be iterative and automated via software so that candidate second thresholds are applied until a satisfactory result is achieved.

Abstract translation: 用于确定样品中颗粒的至少一个几何性质的系统和方法。 照射样品从而产生拉曼散射光子。 收集这些光子以产生拉曼化学图像。 应用第一阈值，其中第一阈值使得检测样品中的所有颗粒。 选择样品中的颗粒并施加第二阈值，使得可以确定所选择的颗粒的至少一个几何性质。 分析代表所选粒子的至少一个光谱，以确定其是否是感兴趣的粒子。 确定第二阈值的步骤可以是经由软件的迭代和自动化，使得应用候选的第二阈值直到达到令人满意的结果。

公开(公告)号：US20100179436A1

公开(公告)日：2010-07-15

申请号：US12525006

申请日：2008-01-31

Applicant: Moshe Sarfaty ,  Amir Lev

Inventor： Moshe Sarfaty ,  Amir Lev

IPC: A61B6/00

CPC classification number: A61B5/415 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0091 ,  A61B5/418 ,  A61B2562/0233 ,  A61B2562/16 ,  G01J3/0218 ,  G01J3/0291 ,  G01J3/44 ,  G01N21/658

Abstract: An optical system and apparatus for the diagnosis of a biological sample is disclosed. An embodiment of the apparatus includes an optical probe, a probe head distally connectable to the optical probe, the optical probe further comprising at least one optical clement for applying an electromagnetic radiation of a first wavelength to the biological sample, and one or more collection elements positioned proximate the at least one optical element; and an analyzer for analyzing a signal received from the biological sample by the one or more collection elements.

Abstract translation: 公开了用于诊断生物样品的光学系统和装置。 该装置的实施例包括光学探针，可远端连接到光学探针的探针头，该光学探针还包括用于将第一波长的电磁辐射施加到生物样品的至少一个光学元件，以及一个或多个收集元件 定位在所述至少一个光学元件附近; 以及用于分析由所述一个或多个收集元件从所述生物样品接收的信号的分析器。

公开(公告)号：US20100171951A1

公开(公告)日：2010-07-08

申请号：US12639393

申请日：2009-12-16

Applicant: Anupam Kumar MISRA ,  Shiv Kumar SHARMA ,  Paul Grandmont LUCEY

Inventor： Anupam Kumar MISRA ,  Shiv Kumar SHARMA ,  Paul Grandmont LUCEY

IPC: G01J3/44

CPC classification number: G01J3/44 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0227 ,  G01J3/0289 ,  G01J3/10 ,  G01J3/443

Abstract: An spectrometer including Raman and LIBS spectroscopy capabilities is disclosed. The spectrometer includes a laser source configurable to produce a lased light directable towards a target substance, the laser source having a single wavelength and having sufficient power to cause a portion of the target to emit Raman scattering and sufficient to ablate a portion of the target substance to produce a plasma plume. A separate remote light collector is optically configurable to collect light emitted from the portion of the target emitting Raman scattering and from the portion of the target producing the plasma plume. A filter is optically coupled to the remote light collector to remove reflected light and Rayleigh-scattered light, and a spectroscope is optically coupled to the filter and configured to separate the collected and filtered light into a frequency spectrum comprising a Raman spectrum and a laser-induced breakdown spectrum. Finally, an electronic light sensor is used to record the frequency spectrum.

Abstract translation: 公开了包括拉曼和LIBS光谱能力的光谱仪。 光谱仪包括可配置为产生可朝向目标物质定向的激光的激光源，激光源具有单一波长并具有足够的功率以使靶的一部分发射拉曼散射并足以消除目标物质的一部分 以产生等离子体羽流。 单独的远程收光器是可光学配置的，以收集从发射拉曼散射的目标的部分和从产生等离子体羽流的目标的部分发射的光。 滤光器光耦合到远程光收集器以去除反射光和瑞利散射光，并且光谱仪光学耦合到滤光器并且被配置为将收集的和经过滤光的光分离成包括拉曼光谱和激光 - 诱发击穿光谱。 最后，使用电子光传感器来记录频谱。

公开(公告)号：US20100114514A1

公开(公告)日：2010-05-06

申请号：US12643689

申请日：2009-12-21

Applicant: Hong Wang ,  Xun Guo

Inventor： Hong Wang ,  Xun Guo

IPC: G01J3/44 ,  G06F19/00

CPC classification number: G01J3/02 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0264 ,  G01J3/44 ,  G01N21/65

Abstract: A method is disclosed for providing quality assurance in an industrial process. The method includes obtaining a manufacturing material from the industrial process, allowing the manufacturing material to contact with a nano-scale surface, which allows the harmful substance to adsorb to the nano-scale surface. The method also includes obtaining a Raman spectrum from the manufacturing material and the nano-scale surface using a spectrometer, searching for, using a spectral analyzer, a spectral signature of a harmful substance in a predetermined spectral region in the Raman spectrum to determine the existence of the harmful substance in the manufacturing material, determining the concentration of the manufacturing material if the spectral signature is found in the Raman spectrum, and rejecting the manufacturing material from the industrial process if the concentration of the manufacturing material is determined to be above a predetermined tolerance level.

Abstract translation: 公开了一种在工业过程中提供质量保证的方法。 该方法包括从工业过程获得制造材料，允许制造材料与允许有害物质吸附到纳米级表面的纳米级表面接触。 该方法还包括使用光谱仪从制造材料和纳米级表面获得拉曼光谱，使用光谱分析仪搜索在拉曼光谱中的预定光谱区域中的有害物质的光谱特征，以确定存在 的制造材料中的有害物质，如果在拉曼光谱中发现光谱特征，则确定制造材料的浓度，并且如果将制造材料的浓度确定为高于预定值，则拒绝来自工业过程的制造材料 公差水平

公开(公告)号：US20100110425A1

公开(公告)日：2010-05-06

申请号：US12531265

申请日：2008-03-14

Applicant: Pavel Matousek

Inventor： Pavel Matousek

IPC: G01J3/44 ,  G02B27/00 ,  G01J3/00 ,  G02B5/02 ,  G02B5/20

CPC classification number: G01N21/47 ,  G01J3/10 ,  G01J3/44 ,  G01N21/49 ,  G01N21/65 ,  G01N21/658 ,  G01N2021/4735

Abstract: The invention provides a technique for increasing the illumination intensity of probe light in a diffusely scattering sample without increasing the power of the probe beam. Generally, an optical filter is used which permits a collimated probe beam of light to pass through to the sample, but which reflects back towards the sample much of the backscattered scattered probe light emerging at a wider range of angles. In particular embodiments a collimated laser beam is delivered to the sample through a multi-layer dielectric filter covering a portion of the sample. The filter is transmissive to the laser light at normal incidence, but reflective at shallower angles of incidence characteristic of the backscattered light.

Abstract translation: 本发明提供了一种用于在不增加探测光束的功率的情况下增加漫散射样品中的探测光的照明强度的技术。 通常，使用光学滤光器，其允许准直的探测光束通过样品，但是反射回样品大部分在更宽范围的角度上出现的背散射的散射探测光。 在特定实施例中，准直激光束通过覆盖样品的一部分的多层介质滤波器传送到样品。 滤光器在正常入射时对激光透射，但反射在较浅的背散射光入射角。

公开(公告)号：US20100110423A1

公开(公告)日：2010-05-06

申请号：US12478381

申请日：2009-06-04

Applicant: Julien S. Villaumie

Inventor： Julien S. Villaumie

IPC: G01J3/44

CPC classification number: G01J3/02 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/024 ,  G01J3/0291 ,  G01J3/0294 ,  G01J3/10 ,  G01J3/44 ,  G01J2003/1213 ,  G01J2003/1243 ,  G01N21/65 ,  G01N2021/6419 ,  G01N2021/6484 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: Certain examples described herein are directed to optical devices and systems that include first and second optical elements. In some examples, the first optical element may be configured to pass light received from an excitation source, and the second optical element may be optically coupled to the first optical element and may be configured to reflect incident light from the first optical element back to the first optical element and configured to pass the light reflected from the first optical element. Methods using the devices and systems are also described.

Abstract translation: 本文描述的某些示例涉及包括第一和第二光学元件的光学装置和系统。 在一些示例中，第一光学元件可以被配置为通过从激励源接收的光，并且第二光学元件可以光耦合到第一光学元件，并且可以被配置为将来自第一光学元件的入射光反射回到 第一光学元件并且被配置为使从第一光学元件反射的光通过。 还描述了使用装置和系统的方法。

公开(公告)号：US20100110422A1

公开(公告)日：2010-05-06

申请号：US12471787

申请日：2009-05-26

Applicant: Andrew Colm Dennis ,  David Mark Thompson

Inventor： Andrew Colm Dennis ,  David Mark Thompson

IPC: G01J3/44

CPC classification number: G01J3/44 ,  G01J3/02 ,  G01J3/021 ,  G01J3/0224 ,  G01J3/0237

Abstract: Certain examples described herein are directed to optical devices and systems for use in spectroscopy. In particular, certain embodiments described herein are directed to devices and methods that may separate excitation light and Raman optical pathways, prior to sample irradiation, so that, if desired, the excitation light and the Raman scattered radiation may be independently manipulated.

Abstract translation: 本文描述的某些示例涉及用于光谱学的光学装置和系统。 特别地，本文描述的某些实施例涉及在样品照射之前可以分离激发光和拉曼光学路径的装置和方法，使得如果需要，可以独立地操纵激发光和拉曼散射辐射。