公开(公告)号：US20100085566A1

公开(公告)日：2010-04-08

申请号：US12586516

申请日：2009-09-22

Applicant: Brian T. Cunningham

Inventor： Brian T. Cunningham

IPC: G01J3/44 ,  B05D5/12

CPC classification number: G01J3/44 ,  G01N21/658 ,  G02B1/005

Abstract: Highly sensitive Surface Enhanced Raman Spectroscopy (SERS) sensors are described in the form of a optical resonator and a metal nanostructure deposited on surface of the optical resonator. In one embodiment the optical resonator is in the form of a photonic crystal, but other optical resonators are contemplated. Examples are described in which the resonant near-fields of a large-area replica molded photonic crystal efficiently couples light from a laser to dielectric-metal “post-cap” nanostructures deposited on the photonic crystal surface by a glancing angle evaporation technique, achieving a high SERS enhancement factor. Other constructions are also contemplated a metal nanostructure formed on a dielectric support deposited on the photonic crystal, including a metallic film deposited over close-packed surface of nanospheres, arrays of metallic nanotriangles, metallic nanorods, metallic nanohelices, arrays of metallic nanospheres, and roughened metal surfaces.

Abstract translation: 高灵敏度表面增强拉曼光谱（SERS）传感器以沉积在光学谐振器表面上的光学谐振器和金属纳米结构的形式进行描述。 在一个实施例中，光学谐振器是光子晶体的形式，但是可以考虑其它光学谐振器。 描述了大面积复制光子晶体的共振近场效应地将光从激光耦合到通过扫掠角蒸发技术沉积在光子晶体表面上的电介质金属“后盖”纳米结构，实现了 高SERS增强因子。 还考虑了其​​它结构，其形成在沉积在光子晶体上的电介质载体上，包括沉积在纳米球的紧密堆积表面上的金属膜，金属纳米管阵列，金属纳米棒，金属纳米螺旋，金属纳米球阵列和粗糙化 金属表面。

公开(公告)号：US07692786B2

公开(公告)日：2010-04-06

申请号：US11873718

申请日：2007-10-17

Applicant: James M. Tedesco ,  Joseph B. Slater

Inventor： James M. Tedesco ,  Joseph B. Slater

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01J3/44 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0227 ,  G01J3/0262

Abstract: Raman measurement apparatus optimized for gaseous and other low-concentration samples includes a focusing objective that uses only first-surface mirrors instead of lenses, thereby dramatically reducing background noise. In the preferred embodiment, the focusing and collimation functions performed by the objective section are performed by an off-axis parabolic mirror. A spherical first-surface mirror opposing the parabolic mirror re-images the counter-propagating beam back through the same focus for re-collimation by the parabolic mirror. A probe-head section operative to generate the counter-propagating beam has substrates and surfaces arranged such that the excitation beam does not pass through any substrates after it is filtered by the bandpass coating, thereby further decreasing background signals. Additionally, when the objective section includes the opposing spherical mirror, the excitation beam is collected substantially in its entirety and neutralized out of the collection path by the probe-head section.

Abstract translation: 针对气态和其他低浓度样品优化的拉曼测量装置包括仅使用第一表面镜而不是透镜的聚焦目标，从而显着降低背景噪声。 在优选实施例中，由目标部分执行的聚焦和准直功能由离轴抛物面镜执行。 与抛物面镜相对的球形第一表面镜将通过相同的焦点重新对反向传播的光束进行反像，以通过抛物面反射镜进行再准直。 可操作以产生反向传播光束的探针头部分具有布置成使得激发光束在被带通涂层过滤之后不通过任何基底的基板和表面，从而进一步减小背景信号。 此外，当目标部分包括相对的球面镜时，基本上整体地收集激发光束，并且通过探头部被中心到收集路径之外。

公开(公告)号：US07692785B2

公开(公告)日：2010-04-06

申请号：US11693277

申请日：2007-03-29

Applicant: Willam Scott Sutherland ,  Anis Zribi ,  Long Que ,  Glenn Scott Claydon ,  Stacey Joy Kennerly ,  Ayan Banerjee ,  Shivappa Ningappa Goravar ,  Shankar Chandrasekaran ,  David Cecil Hays ,  Victor Samper ,  Dirk Lange ,  Marko Baller ,  Min-Yi Shih ,  Sandip Maity

Inventor： Willam Scott Sutherland ,  Anis Zribi ,  Long Que ,  Glenn Scott Claydon ,  Stacey Joy Kennerly ,  Ayan Banerjee ,  Shivappa Ningappa Goravar ,  Shankar Chandrasekaran ,  David Cecil Hays ,  Victor Samper ,  Dirk Lange ,  Marko Baller ,  Min-Yi Shih ,  Sandip Maity

IPC: G01J3/44

CPC classification number: G01N21/65 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0232 ,  G01J3/0237 ,  G01J3/027 ,  G01J3/0289 ,  G01J3/10 ,  G01J3/1895 ,  G01J3/44 ,  G02B26/02 ,  G02B26/0808 ,  G02B26/0816

Abstract: A system and method for managing optical power for controlling thermal alteration of a sample undergoing spectroscopic analysis is provided. The system includes a moveable laser beam generator for irradiating the sample and a beam shaping device for moving and shaping the laser beam to prevent thermal overload or build up in the sample. The moveable laser beam generator includes at least one beam shaping device selected from the group consisting of at least one optical lens, at least one optical diffractor, at least one optical path difference modulator, at least one moveable mirror, at least one Micro-Electro-Mechanical Systems (MEMS) integrated circuit (IC), and/or a liquid droplet. The system also includes an at least two degree of freedom (2 DOF) moveable substrate platform and a controller for controlling the laser beam generator and the substrate platform, and for analyzing light reflected from the sample.

Abstract translation: 提供了一种用于管理用于控制进行光谱分析的样品的热变化的光功率的系统和方法。 该系统包括用于照射样品的可移动激光束发生器和用于移动和成形激光束的光束整形装置，以防止样品中的热过载或积聚。 可移动激光束发生器包括至少一个光束成形装置，其选自由至少一个光学透镜，至少一个光学衍射器，至少一个光程差调制器，至少一个可动反射镜，至少一个微电极 机电系统（MEMS）集成电路（IC）和/或液滴。 该系统还包括至少两个自由度（2自由度）可移动基板平台和用于控制激光束发生器和基板平台的控制器，并用于分析从样品反射的光。

公开(公告)号：US07692776B2

公开(公告)日：2010-04-06

申请号：US11645132

申请日：2006-12-22

Applicant: Patrick J. Treado ,  Matthew P. Nelson

Inventor： Patrick J. Treado ,  Matthew P. Nelson

IPC: G01N21/00

CPC classification number: G01J3/44 ,  G01J3/02 ,  G01J3/0218 ,  G01N21/6456 ,  G01N21/65 ,  G01N33/227 ,  G01N2001/024 ,  G01N2021/6417 ,  G01N2021/6484

Abstract: A system and method of detecting explosive compounds located on a sample. The sample is irradiated with animal-safe ultra-violet radiation generating a fluorescence data set. A fluorescence database is searched based on the fluorescence data set in order to identify a known fluorescence data set. If the searching of the fluorescence database identifies a known fluorescence data set, an area of interest in the sample is identified based on the known fluorescence data set identified in the fluorescence database searching. The area of interest is irradiated with substantially monochromatic radiation to generate a Raman data set of the area of interest. A Raman database is searched based on the Raman data set in order to identify a known Raman data set. An explosive compound in the area of interest is identified based on the known Raman data set identified by searching the Raman database.

Abstract translation: 一种检测位于样品上的爆炸性化合物的系统和方法。 用动物安全的紫外线辐射照射样品，产生荧光数据集。 基于荧光数据集搜索荧光数据库，以识别已知的荧光数据集。 如果荧光数据库的搜索识别已知荧光数据集，则基于在荧光数据库搜索中识别的已知荧光数据集来识别样品中的感兴趣区域。 用基本上单色的辐射照射感兴趣的区域以产生感兴趣区域的拉曼数据集。 基于拉曼数据集搜索拉曼数据库，以便识别已知的拉曼数据集。 基于通过搜索拉曼数据库识别的已知拉曼数据集来识别感兴趣区域中的爆炸性化合物。

公开(公告)号：US07663748B2

公开(公告)日：2010-02-16

申请号：US11570132

申请日：2005-06-07

Applicant: Michael Cornelis Van Beek ,  Gerald Lucassen ,  Marjolein Van Der Voort ,  Wouter Harry Jacinth Rensen ,  Durk Jolmer De Vries

Inventor： Michael Cornelis Van Beek ,  Gerald Lucassen ,  Marjolein Van Der Voort ,  Wouter Harry Jacinth Rensen ,  Durk Jolmer De Vries

IPC: G01J3/30

CPC classification number: G02B21/247 ,  G01J3/02 ,  G01J3/0237 ,  G01J3/44 ,  G01N21/645 ,  G01N21/65 ,  G01N2021/6463 ,  G01N2021/653 ,  G01N2021/655

Abstract: An autofocus mechanism for a spectroscopic system determines a time varying optical property of a volume of interest. The mechanism measures the fluctuations of the optical property of the volume of interest for determining the position of the volume of interest. The spectroscopic system focuses an excitation beam into the determined volume of interest and collects return radiation emanating from the volume of interest for spectroscopic analysis. Preferably, inelastically scattered radiation of an excitation beam is separated from elastically scattered radiation for spectroscopic analysis. The elastically scattered radiation of the excitation beam is measured for fluctuations of the optical property of the volume of interest. A control loop maximizes the amplitude and/or intensity of the fluctuations and specifies the position of a volume of interest e.g. the center of a capillary vessel.

Abstract translation: 用于分光系统的自动对焦机构确定感兴趣体积的时变光学性质。 该机制测量感兴趣体积的光学性质的波动以确定感兴趣体积的位置。 光谱系统将激发光束聚焦到所确定的感兴趣体积中，并收集从感兴趣体积发出的回波辐射用于光谱分析。 优选地，激发光束的非弹性散射辐射与用于光谱分析的弹性散射辐射分离。 针对感兴趣体积的光学特性的波动来测量激发光束的弹性散射辐射。 控制回路使波动的幅度和/或强度最大化并且指定感兴趣的体积的位置，例如， 毛细血管的中心。

公开(公告)号：US20100034743A1

公开(公告)日：2010-02-11

申请号：US12537513

申请日：2009-08-07

Applicant: Jeffrey Cohen ,  John S. Maier ,  Shona Stewart

Inventor： Jeffrey Cohen ,  John S. Maier ,  Shona Stewart

IPC: A61K49/00 ,  G01J3/44 ,  G01N21/65 ,  A61P43/00

CPC classification number: G01N21/65 ,  G01J3/02 ,  G01J3/0237 ,  G01J3/0291 ,  G01J3/0294 ,  G01J3/44 ,  G01N2021/656

Abstract: A system and method for determining a disease state and clinical outcome of a sample. A sample is illuminated to produce Raman scattered photons, the Raman scattered photons are assessed to generate a Raman spectroscopic data set representative of the sample, wherein said Raman spectroscopic data set comprises at least one of: a Raman spectra of the sample and a spatially accurate wavelength resolved Raman image of the sample; the Raman spectroscopic data set is evaluated using a chemometric technique to classify the disease state of the sample as: acute, chronic, incipient, or none. In one embodiment, the chemontric technique is principle component analysis. In another embodiment, the sample is obtained prior to transplantation and analysis can determine the likelihood of rejection by a host.

Abstract translation: 用于确定样品的疾病状态和临床结果的系统和方法。 照射样品以产生拉曼散射光子，评估拉曼散射光子以产生代表样品的拉曼光谱数据集，其中所述拉曼光谱数据集包括以下至少一个：样品的拉曼光谱和空间准确的 样品的波长分辨拉曼图像; 使用化学计量技术评估拉曼光谱数据集，以将样品的疾病状态分类为急性，慢性，初期或无。 在一个实施方案中，化学方法是主要成分分析。 在另一个实施方案中，在移植之前获得样品，并且分析可以确定宿主排斥的可能性。

公开(公告)号：US07659977B2

公开(公告)日：2010-02-09

申请号：US11408185

申请日：2006-04-21

Applicant: Tae-Woong Koo

Inventor： Tae-Woong Koo

IPC: G01J3/44

CPC classification number: G01N21/658 ,  G01J3/44

Abstract: The embodiments of the invention are directed to improved SERS and SECARS devices and method of manufacturing and using the same. In one embodiment of the invention, a device having at least one laser, a sample stage and a detector, wherein the sample stage is moveable and has as SERS active material is disclosed. In another embodiment of the invention, the device has at least one laser, a scanning mirror, a sample stage having a SERS active material and a detector, wherein the scanning mirror is adapted to steer a laser beam across a surface of the sample stage.

Abstract translation: 本发明的实施例涉及改进的SERS和SECARS装置及其制造和使用方法。 在本发明的一个实施例中，具有至少一个激光器，样品台和检测器的装置，其中样品台是可移动的并且具有作为SERS活性材料的公开。 在本发明的另一个实施例中，该装置具有至少一个激光器，扫描镜，具有SERS活性材料和检测器的样品台，其中该扫描镜适于引导穿过样品台表面的激光束。

公开(公告)号：US20090285538A1

公开(公告)日：2009-11-19

申请号：US12466930

申请日：2009-05-15

Applicant: Eric Marple

Inventor： Eric Marple

IPC: G02B6/04 ,  G01J3/44

CPC classification number: G01J3/44 ,  G01J3/02 ,  G01J3/0216 ,  G01J3/0218 ,  G01N21/65 ,  G01N2021/656 ,  G02B6/262

Abstract: The invention provides miniature side-viewing fiber optic probes that achieve high collection efficiency by maximizing the overlap of a laser delivery fiber's illumination and a collection fiber's collection cone. The probes can be made with as few as one optical piece, in addition to the optical fibers. In one embodiment of the invention, the probes are configured for performing Raman spectroscopy. Spectroscopy systems utilizing the probes of the invention are also provided.

Abstract translation: 本发明提供了通过最大化激光输送纤维的照明和收集纤维收集锥的重叠来实现高收集效率的微型侧视光纤探针。 除了光纤之外，探针也可以由少至少一个光学片构成。 在本发明的一个实施例中，探针被配置用于进行拉曼光谱。 还提供了利用本发明的探针的光谱系统。

公开(公告)号：US07595873B1

公开(公告)日：2009-09-29

申请号：US12029427

申请日：2008-02-11

Applicant: Francis J. Deck

Inventor： Francis J. Deck

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01N21/65 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/44 ,  G01N2021/656

Abstract: An optical method and apparatus is utilized to provide rapid spatial averaging over a large sample area in a Raman spectrometer, without defocusing of the optical source or the collection optics. Spatial averaging provides a representative spectrum of a sample that is inhomogeneous, either in its composition or surface characteristics. The spatial averaging configurations and methods disclosed herein also reduce sample degradation or burning resulting from the high intensity of the directed optical source. Moreover, the dimensions of the sample area of the spatial averaging methods and configurations of the present invention are adjusted to match specific sampling requirements.

Abstract translation: 利用光学方法和装置在拉曼光谱仪的大样本区域上提供快速的空间平均，而不会使光源或收集光学器件散焦。 空间平均提供了在其组成或表面特征中不均匀的样品的代表性光谱。 本文公开的空间平均配置和方法还降低了由定向光源的高强度导致的样品劣化或燃烧。 此外，调整本发明的空间平均方法和结构的样本面积的尺寸以匹配特定的采样要求。

公开(公告)号：US07586602B2

公开(公告)日：2009-09-08

申请号：US11459449

申请日：2006-07-24

Applicant: Sandip Maity ,  Ayan Banerjee ,  Anis Zribi ,  Stacey Kennerly ,  Long Que ,  Glenn Claydon ,  Shankar Chandrasekaran ,  Shivappa Goravar

Inventor： Sandip Maity ,  Ayan Banerjee ,  Anis Zribi ,  Stacey Kennerly ,  Long Que ,  Glenn Claydon ,  Shankar Chandrasekaran ,  Shivappa Goravar

IPC: G01J3/44

CPC classification number: G01J3/44 ,  G01J1/44 ,  G01J3/02 ,  G01J3/0229 ,  G01J3/0232 ,  G01J3/0256 ,  G01J3/0264 ,  G01J3/0272 ,  G01J3/0286 ,  G01J3/0297 ,  G01J3/1895 ,  G01J3/4338 ,  G02B26/04 ,  H01L31/107

Abstract: A method of Raman detection for a portable, integrated spectrometer instrument includes directing Raman scattered photons by a sample to an avalanche photodiode (APD), the APD configured to generate an output signal responsive to the intensity of the Raman scattered photons incident thereon. The output signal of the APD is amplified and passed through a discriminator so as to reject at least one or more of amplifier noise and dark noise. A number of discrete output pulses within a set operational range of the discriminator is counted so as to determine a number of photons detected by the APD.