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公开(公告)号：US11085925B2
公开(公告)日：2021-08-10
申请号：US15779944
申请日：2016-11-29
Applicant: DH Technologies Development Pte. Ltd.
Inventor： John L. Campbell , Yves LeBlanc , Chang Liu
IPC: G01N33/00 , G01N33/58 , G01N27/624 , G01N33/68 , H01J49/00
Abstract: Methods and systems for separating and/or quantifying compounds, using differential mobility spectrometry (DMS) are provided herein. In accordance with various aspects of the applicants' teachings, the methods and systems can provide for the quantification of one or more compounds, for example, using isomeric labels that can be less costly to produce relative to conventional tags that incorporate stable-isotope labels. The present teachings can quantify the relative amount of a compound based on the effect of using an easily charged functional group as well as a functional group positioned at a resonant or non-resonant position through a DMS. In some aspects, methods and systems in accordance with various aspects of the present teachings provide for the detection and/or quantification of the analytes labeled with isomeric tags that can be differentiated via a DMS upstream of a first stage mass analyzer and/or prior to fragmentation of the labeled analyte, for example.
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公开(公告)号：US20210090867A1
公开(公告)日：2021-03-25
申请号：US16985076
申请日：2020-08-04
Applicant: Labcyte, Inc. , DH Technologies Development Pte. Ltd.
Inventor： Sammy Datwani , Don W. Arnold , Lucien P. Ghislain , Chang Liu , Thomas Covey
Abstract: A system and method are provided for loading a sample into an analytical instrument using acoustic droplet ejection (“ADE”) in combination with a continuous flow sampling probe. An acoustic droplet ejector is used to eject small droplets of a fluid sample containing an analyte into the sampling tip of a continuous flow sampling probe, where the acoustically ejected droplet combines with a continuous, circulating flow stream of solvent within the flow probe. Fluid circulation within the probe transports the sample through a sample transport capillary to an outlet that directs the analyte away from the probe to an analytical instrument, e.g., a device that detects the presence, concentration quantity, and/or identity of the analyte. When the analytical instrument is a mass spectrometer or other type of device requiring the analyte to be in ionized form, the exiting droplets pass through an ionization region, e.g., an electrospray ion source, prior to entering the mass spectrometer or other analytical instrument. The method employs active flow control and enables real-time kinetic measurements.
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公开(公告)号：US10656147B2
公开(公告)日：2020-05-19
申请号：US15121803
申请日：2015-02-27
Applicant: DH Technologies Development PTE Ltd.
Inventor： John L. Campbell , Thomas R. Covey , Chang Liu , Subhasish Purkayastha
IPC: G01N33/553 , G01N33/543 , G01N1/38 , B01F13/00 , B01F13/08 , G01N35/00 , B01L3/00 , G01N27/74
Abstract: Methods and apparatus for processing fluids on a macro- or micro-scale are described. In various aspects, a fluid may have a plurality of elongated (i.e., substantially rod-shaped) magnetic elements disposed therein within a fluid container. An illustrative fluid container is an actuator electrode or a processing vial of a microfluidic device, such as a digital microfluidic device. A magnet component may be configured to generate a magnetic force sufficient to influence the movement of the plurality of elongated magnetic elements within the fluid to be processed. For example, the magnetic force (or magnetic force gradient) may influence the plurality of elongated magnetic elements to rotate, spin, and/or move laterally side-to-side. The shape and movements of the plurality of elongated magnetic elements facilitate the rapid and efficient processing of the fluid, such as fluid mixing and/or fluid separation.
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24.发明申请公开(公告)号：US20200043712A1
公开(公告)日：2020-02-06
申请号：US16341718
申请日：2017-10-12
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Don W. Arnold , Thomas R. Covey , Chang Liu
Abstract: Methods and systems for delivering a liquid sample to an ion source for the generation of ions and subsequent analysis by mass spectrometry are provided herein. In accordance with various aspects of the present teachings, MS-based systems and methods are provided in which the flow of desorption solvent within a sampling probe fluidly coupled to an ion source can be selectively controlled such that one or more analyte species can be desorbed from a sample substrate inserted within the sampling probe within a decreased volume of desorption solvent for subsequently delivery to the ion source. In various aspects, sensitivity can be increased due to higher desorption efficiency (e.g., due to increased desorption time) and/or decreased dilution of the desorbed analytes. The methods and systems described herein can additionally or alternatively provide for the selective control of the flow rate of the desorption solvent within the sampling interface so as to enable additional processing steps to occur within the sampling probe (e.g., multiple samplings, reactions).
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公开(公告)号：US20180369831A1
公开(公告)日：2018-12-27
申请号：US15779933
申请日：2016-11-29
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Don W. Arnold , Thomas R. Covey , Yves LeBlanc , Chang Liu , John L. Campbell
Abstract: Methods and apparatus for processing fluids are described. In various aspects, a fluid processing system may include a magnetic assembly that includes a plurality of magnetic structures configured to generate a magnetic field gradient within a fluid container. The magnetic structures may be formed as a plurality of electromagnets configured to be individually actuated by a controller. Each of the electromagnets may generate a magnetic field within the fluid container. The electromagnets may be differentially actuated to create a magnetic field gradient within the fluid container to agitate, mix, or otherwise influence magnetic particles disposed within the fluid container. Activation of the electromagnets of an electromagnetic structure may generate a magnetic field gradient that influences magnetic particles in an x-y direction. In addition, activation of the electromagnets of a plurality of electromagnetic structures may generate magnetic field gradients that influences magnetic particles in an x-y direction and z-direction.
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Patent Agency Ranking
公开(公告)号：US10103015B2
公开(公告)日：2018-10-16
申请号：US15581172
申请日：2017-04-28
Inventor： Don W. Arnold , Thomas R. Covey , German Augusto Gomez Rios , Chang Liu , Janusz B. Pawliszyn
Abstract: Methods and systems for delivering a liquid sample to an ion source for the generation of ions and subsequent analysis by mass spectrometry are provided herein. In accordance with various aspects of the present teachings, MS-based systems and methods are provided in which a desorption solvent utilized in a sampling interface to desorb one or more analyte species from an SPME device is fluidly coupled to an ion source for ionizing the one or more analyte species desorbed into the desorption solvent for subsequent mass spectrometric analysis (e.g., without a liquid chromatography (LC) column between the sampling interface and the ion source). In accordance with various aspects of the methods and systems described herein, the configuration the sampling interface can be optimized so as to reduce the fluid volume dead space about the fluid inlet so as to concentrate the one or more analyte species desorbed at optimized conditions from the SPME substrate in a decreased volume of the desorption solvent when the SPME device is inserted into sampling interface.
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公开(公告)号：US20170316926A1
公开(公告)日：2017-11-02
申请号：US15581172
申请日：2017-04-28
Inventor： Don W. Arnold , Thomas R. Covey , German Augusto Gomez Rios , Chang Liu , Janusz B. Pawliszyn
CPC classification number: H01J49/0404 , G01N1/405 , H01J49/0031 , H01J49/0459
Abstract: Methods and systems for delivering a liquid sample to an ion source for the generation of ions and subsequent analysis by mass spectrometry are provided herein. In accordance with various aspects of the present teachings, MS-based systems and methods are provided in which a desorption solvent utilized in a sampling interface to desorb one or more analyte species from an SPME device is fluidly coupled to an ion source for ionizing the one or more analyte species desorbed into the desorption solvent for subsequent mass spectrometric analysis (e.g., without a liquid chromatography (LC) column between the sampling interface and the ion source). In accordance with various aspects of the methods and systems described herein, the configuration the sampling interface can be optimized so as to reduce the fluid volume dead space about the fluid inlet so as to concentrate the one or more analyte species desorbed at optimized conditions from the SPME substrate in a decreased volume of the desorption solvent when the SPME device is inserted into sampling interface.
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公开(公告)号：US12209989B2
公开(公告)日：2025-01-28
申请号：US17753921
申请日：2020-09-29
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventor： Thomas R. Covey , Chang Liu
IPC: G01N27/62 , G01N27/623 , G01N27/624 , H01J49/04
Abstract: MS-based methods and systems are provided herein in which a desorption solvent desorbs one or more analyte species from an SPME device within a sampling interface that is fluidly coupled to an ion source for subsequent mass spectrometric analysis. In accordance with various aspects of the applicants teachings, the sampling interface includes an internal sampling conduit that provides increased interaction between the desorption solvent and the sampling substrate, thereby improving mass transfer (e.g., increased extraction or desorption speed).
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公开(公告)号：US12138606B2
公开(公告)日：2024-11-12
申请号：US16765854
申请日：2018-11-20
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Don W Arnold , Thomas R. Covey , Chang Liu
IPC: B01F33/451 , B01F23/50 , B01F35/221 , B03C1/01 , B03C1/033 , B03C1/28 , B03C1/30 , G01R33/12 , B01F101/23
Abstract: A fluid processing system that can include a sample container having a sample chamber for containing a fluid and a plurality of magnetic particles and at least one movable magnetic assembly configured to be movably inserted into or out of the sample chamber. The movable magnetic assembly can include a plurality of electromagnets that generate a magnetic field within at least a portion of the sample chamber when the assembly is inserted at least partially into the sample chamber. The fluid processing system can also include a signal generator that applies electrical signals, e.g., AC electrical signals, to the electromagnets of the magnetic assembly and a controller coupled to the signal generator that is configured to control phases of the electrical signals applied to the electromagnets to generate magnetic field gradients within the portion of the sample chamber effective to magnetically influence the plurality of the magnetic particles.
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公开(公告)号：US20240345044A1
公开(公告)日：2024-10-17
申请号：US18294348
申请日：2022-08-04
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
CPC classification number: G01N30/724 , G01N30/02 , G01N30/06 , H01J49/0454 , G01N2030/027
Abstract: Disclosed are methods for separating target and non-target analytes in a sample. The methods can utilize an acoustic droplet ejector (ADE) and an open port interface (OPI) to achieve liquid chromatography (LC)-like separation for an analytical instrument such as, for example, a mass spectrometer.
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