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公开(公告)号：US20180356562A1
公开(公告)日：2018-12-13
申请号：US16000930
申请日：2018-06-06
Applicant: Novartis AG
Inventor： Daqing Wu , Junhao Ge , Steve Yun Zhang , Richard Charles Breitkopf , Xinming Qian , Zach Munoz , Matthew D. Nelson , Augustine Twum Kumi , Weihong Lang , Ying Zheng , Feng Jing , Frank Chang
CPC classification number: G02B1/043 , B29D11/00134 , C08F230/08 , C08L83/04
Abstract: The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.
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公开(公告)号：US20180355112A1
公开(公告)日：2018-12-13
申请号：US16000933
申请日：2018-06-06
Applicant: Novartis AG
Inventor： Steve Yun Zhang , Daqing Wu , Junhao Ge , Richard Charles Breitkopf , Xinming Qian , Zach Munoz , Matthew D. Nelson , Augustine Twum Kumi , Weihong Lang , Ying Zheng , Feng Jing , Frank Chang
IPC: C08G77/442 , C08G77/20 , C08G77/388 , C08G77/392 , C08G77/14 , C08G77/12 , C08L83/10 , G02B1/04
CPC classification number: C08G77/442 , B29D11/00134 , C08G77/12 , C08G77/14 , C08G77/20 , C08G77/388 , C08G77/392 , C08G2210/00 , C08L83/10 , C08L2201/10 , G02B1/043 , G02B2207/109 , G02C7/04
Abstract: The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.
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公开(公告)号：US20170306178A1
公开(公告)日：2017-10-26
申请号：US15646291
申请日：2017-07-11
Applicant: Novartis AG
Inventor： Yongxing Qiu , Newton T. Samuel , John Dallas Pruitt , Chandana Kolluru , Arturo Norberto Medina , Lynn Cook Winterton , Daqing Wu , Xinming Qian , Jared Nelson
IPC: C09D177/06 , B29D11/00 , C08G77/388 , C08J5/00 , C08J7/04 , C08L83/04 , G02B1/18 , G02C7/04 , G02B1/10 , G02B1/04 , C09D171/02 , C09D133/26 , C09D133/14 , C09D133/02 , C09D5/16
CPC classification number: C09D177/06 , B29D11/00067 , C08G77/388 , C08J5/00 , C08J7/042 , C08J2383/04 , C08J2383/08 , C08J2433/02 , C08J2433/26 , C08J2487/00 , C08L83/04 , C09D5/1637 , C09D5/1681 , C09D133/02 , C09D133/14 , C09D133/26 , C09D171/02 , G02B1/043 , G02B1/10 , G02B1/18 , G02C7/049 , G02C2202/06 , G02C2202/16 , C08L101/14
Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.
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公开(公告)号：US20150099822A1
公开(公告)日：2015-04-09
申请号：US14571350
申请日：2014-12-16
Applicant: Novartis AG
Inventor： Yongxing Qiu , Newton T. Samuel , John Dallas Pruitt , Chandana Kolluru , Arturo Norberto Medina , Lynn Cook Winterton , Daqing Wu , Xinming Qian , Jared Nelson
CPC classification number: C09D177/06 , B29D11/00067 , C08G77/388 , C08J5/00 , C08J7/042 , C08J2383/04 , C08J2383/08 , C08J2433/02 , C08J2433/26 , C08J2487/00 , C08L83/04 , C09D5/1637 , C09D5/1681 , C09D133/02 , C09D133/14 , C09D133/26 , C09D171/02 , G02B1/043 , G02B1/10 , G02B1/18 , G02C7/049 , G02C2202/06 , G02C2202/16 , C08L101/14
Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.
Abstract translation: 本发明涉及制备其上具有交联亲水性涂层的硅氧水凝胶隐形眼镜的成本有效的方法。 本发明的方法涉及在具有带正电荷的氮杂环丁烷基团的水溶性，高度支化，热交联的亲水性聚合物材料存在下，在约40℃的温度下，在水溶液中加热硅酮水凝胶隐形眼镜 在约140℃下进行足够的时间以将可热交联的亲水聚合物材料共价连接到硅氧烷水凝胶隐形眼镜的表面上，通过共价连接，每个共价键在一个氮杂环丁烷基团和一个反应性官能团之间形成， 和/或靠近硅酮水凝胶隐形眼镜的表面，从而在硅氧水凝胶隐形眼镜上形成交联的亲水涂层。 这种方法可以有利地在高压釜中直接在密封的透镜包装中实现。
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公开(公告)号：US20130228943A1
公开(公告)日：2013-09-05
申请号：US13847112
申请日：2013-03-19
Applicant: NOVARTIS AG
Inventor： Yongxing Qiu , John Martin Lally , Manal M. Gabriel , Xinming Qian
IPC: B29D11/00
CPC classification number: G02B1/043 , A01N59/16 , A61L12/088 , A61L27/54 , A61L2300/104 , A61L2300/404 , A61L2300/442 , A61L2300/624 , B29D11/00038 , B82Y30/00
Abstract: The present invention provides methods for making an antimicrobial medical device, preferably an antimicrobial ophthalmic device, more preferably an antimicrobial extended-wear contact lens, which contains silver nano-particles distributed uniformly therein. The antimicrobial medical device can exhibit antimicrobial activity over an extended period of time.
Abstract translation: 本发明提供了制备抗微生物医疗器械，优选抗微生物眼科装置，更优选抗微生物延长耐磨隐形眼镜的方法，该隐形眼镜含有均匀分布的银纳米颗粒。 抗微生物医疗装置可以在长时间内显示出抗菌活性。
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Patent Agency Ranking
公开(公告)号：US11001647B2
公开(公告)日：2021-05-11
申请号：US16280081
申请日：2019-02-20
Applicant: Novartis AG
Inventor： Frank Chang , Troy Vernon Holland , Xinming Qian , Robert Scott , Joseph Michael Lindacher , Uwe Haken
Abstract: The invention is related to a method for producing silicone medical devices, in particular, silicone contact lenses, having consistent mechanical properties in a cost-effective manner. The invention is also related to a silicone medical device, especially a soft silicone contact lens.
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公开(公告)号：US20200157378A1
公开(公告)日：2020-05-21
申请号：US16720932
申请日：2019-12-19
Applicant: Novartis AG
Inventor： Yongxing Qiu , Newton T. Samuel , John Dallas Pruitt , Chandana Kolluru , Arturo Norberto Medina , Lynn Cook Winterton , Daqing Wu , Xinming Qian , Jared Nelson
IPC: C09D177/06 , C09D171/02 , C09D133/26 , C09D133/14 , C09D133/02 , C09D5/16 , C08J5/00 , C08G77/388 , C08L83/04 , C08J7/04 , G02B1/18 , G02B1/10 , G02C7/04 , G02B1/04 , B29D11/00
Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.
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公开(公告)号：US10563090B2
公开(公告)日：2020-02-18
申请号：US16397255
申请日：2019-04-29
Applicant: Novartis AG
Inventor： Yongxing Qiu , Newton T. Samuel , John Dallas Pruitt , Chandana Kolluru , Arturo Norberto Medina , Lynn Cook Winterton , Daqing Wu , Xinming Qian , Jared Nelson
IPC: C08L83/04 , C09D177/06 , B29D11/00 , G02B1/04 , G02C7/04 , G02B1/10 , G02B1/18 , C08J7/04 , C08G77/388 , C08J5/00 , C09D5/16 , C09D133/02 , C09D133/14 , C09D133/26 , C09D171/02
Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.
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公开(公告)号：US20190309188A1
公开(公告)日：2019-10-10
申请号：US16397255
申请日：2019-04-29
Applicant: Novartis AG
Inventor： Yongxing Qiu , Newton T. Samuel , John Dallas Pruitt , Chandana Kolluru , Arturo Norberto Medina , Lynn Cook Winterton , Daqing Wu , Xinming Qian , Jared Nelson
IPC: C09D177/06 , C08L83/04 , G02B1/04 , C09D133/02 , C09D133/14 , C09D133/26 , C09D171/02 , C08J5/00 , C08G77/388 , G02C7/04 , B29D11/00 , G02B1/10 , G02B1/18 , C08J7/04 , C09D5/16
Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.
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公开(公告)号：US20180354214A1
公开(公告)日：2018-12-13
申请号：US16000928
申请日：2018-06-06
Applicant: Novartis AG
Inventor： Daqing Wu , Steve Yun Zhang , Xinming Qian , Zach Munoz , Frank Chang , Wei Liang , Ying Zheng , Richard Charles Breitkopf , Matthew D. Nelson , Augustine Twum Kumi
CPC classification number: B29D11/00134 , B29D11/00067 , B29D11/00076 , C08G77/442 , C08L83/04 , G02B1/043
Abstract: The present invention generally relates to a method for producing inherently wettable silicone hydrogel contact lenses with a robusteness of lens shape and having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus.
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