公开(公告)号：US20190185585A1

公开(公告)日：2019-06-20

申请号：US16312600

申请日：2017-06-30

Applicant: XYLOCEL OY

Inventor： Antti LAUKKANEN ,  Jason MCKEE ,  Nikolaos PAHIMANOLIS

IPC: C08B1/00 ,  C08L1/02

CPC classification number: C08B1/00 ,  C08J9/0004 ,  C08J9/28 ,  C08J2201/03 ,  C08J2201/0484 ,  C08J2205/022 ,  C08J2205/042 ,  C08J2205/044 ,  C08J2207/10 ,  C08J2301/02 ,  C08J2301/18 ,  C08L1/02 ,  C08L2205/16 ,  F26B5/06

Abstract: Methods for manufacturing, re-activating and using compositions including fibrillated parenchymal cellulose and activator are provided. The activator has a low molecular weight and is used to facilitate reactivation.

公开(公告)号：US09926528B2

公开(公告)日：2018-03-27

申请号：US15169521

申请日：2016-05-31

Applicant: The Regents of the University of California

Inventor： C. Chang I Lee

IPC: C08B37/00 ,  C12N5/00 ,  C12N5/0775 ,  C08L5/00 ,  C08J9/28 ,  C08J9/36 ,  C12N5/074

CPC classification number: C12N5/0068 ,  C08B37/0087 ,  C08J9/28 ,  C08J9/36 ,  C08J2201/0484 ,  C08J2207/10 ,  C08J2305/00 ,  C08L5/00 ,  C12N5/0607 ,  C12N5/0663 ,  C12N2513/00 ,  C12N2533/70 ,  C08L89/06 ,  C08L89/00 ,  C08L77/04

Abstract: The present invention provides a neutralized glucomannan scaffold capable of promoting cell growth and suitable for three-dimensional tissue culture and engineering. The present invention also provides methods for making and degrading the neutralized glucomannan scaffold. The present invention further provides a method of growing cells on a neutralized glucomannan scaffold.

公开(公告)号：US09862807B2

公开(公告)日：2018-01-09

申请号：US14507523

申请日：2014-10-06

Applicant: The Regents of the University of Michigan

Inventor： Peter X. Ma ,  Zhanpeng Zhang

IPC: C08J9/28 ,  C08J9/16

CPC classification number: C08J9/28 ,  C08J9/16 ,  C08J2201/0484 ,  C08J2201/0522 ,  C08J2205/044 ,  C08J2207/10 ,  C08J2300/206 ,  C08J2367/04

Abstract: A nanofibrous spongy microsphere includes porous walls that define an exterior of the microsphere and that extend through an interior of the microsphere. The porous walls consist of interconnected nanofibers and spaces formed between the interconnected nanofibers. A plurality of micro-scale pores are formed throughout the interior of the microsphere. Each of the micro-scale pores i) is partially defined by the porous walls, ii) has an interpore opening that opens to an adjacent micro-scale pores, and iii) has a diameter ranging from about 1 μm to about 100 μm. A total diameter of the microsphere ranges from about 5 μm to about 1000 μm.

公开(公告)号：US20170204241A1

公开(公告)日：2017-07-20

申请号：US15324943

申请日：2015-07-09

Applicant: RHODIA OPERATIONS

Inventor： Amelie NICOLAY ,  Bertrand PAVAGEAU ,  Chantal BADRE ,  Lawrence Alan HOUGH

IPC: C08J9/28 ,  C08J9/00 ,  H01L29/84 ,  H01L35/24 ,  H01L31/0224 ,  H01L33/40 ,  H01M4/62 ,  H01M10/0525 ,  H01M10/0567 ,  H01M4/131 ,  H01M4/134 ,  H01M4/133 ,  H01M4/38 ,  H01M4/525 ,  H01M4/587 ,  H01M4/485 ,  C08L65/00

CPC classification number: C08J9/28 ,  C08G61/126 ,  C08G73/0266 ,  C08G2261/1424 ,  C08G2261/3223 ,  C08G2261/512 ,  C08G2261/794 ,  C08G2261/94 ,  C08J9/0061 ,  C08J2201/0484 ,  C08J2201/0504 ,  C08J2201/0546 ,  C08J2205/022 ,  C08J2205/026 ,  C08J2205/028 ,  C08J2205/044 ,  C08J2207/00 ,  C08J2325/18 ,  C08J2465/00 ,  C08K5/19 ,  C08K5/29 ,  C08K5/3445 ,  C08L25/18 ,  C08L65/00 ,  C08L79/02 ,  H01L29/84 ,  H01L31/0224 ,  H01L33/40 ,  H01L35/24 ,  H01M4/131 ,  H01M4/133 ,  H01M4/134 ,  H01M4/38 ,  H01M4/485 ,  H01M4/525 ,  H01M4/587 ,  H01M4/624 ,  H01M10/052 ,  H01M10/0525 ,  H01M10/0565 ,  H01M10/0567 ,  H01M2004/027 ,  H01M2004/028

Abstract: Described herein are polymer complexes, including polymer gels and polymer foams, containing electrically conductive polymers and ionic liquids. The polymer complexes described herein are useful as components of electronic devices.

公开(公告)号：US09550871B2

公开(公告)日：2017-01-24

申请号：US14077103

申请日：2013-11-11

Applicant: Wisconsin Alumni Research Foundation ,  The United States of America as Represented by the Secretary of Agriculture

Inventor： Shaoqin Gong ,  Alireza Javadi ,  Qifeng Zheng ,  Zhiyong Cai ,  Ronald Sabo

IPC: B32B7/02 ,  A61F13/15 ,  B32B27/32 ,  C08J9/28 ,  C08J9/00

CPC classification number: C08J9/28 ,  C08J9/0076 ,  C08J2201/0484 ,  C08J2205/026 ,  C08J2300/14

Abstract: Highly porous, lightweight, and sustainable hybrid organic aerogels with ultra-low densities and excellent material properties and methods for preparing them are provided, including, e.g., PVA/CNF/GONS, RF/CNF/GONS, and PVA/CNF/MWCNT. The aerogels are modified to have a super-hydrophobic surface, thus leading to an extremely low swelling ratio and rate of moisture absorption.

Abstract translation: 提供了具有超低密度和优异材料性质的高度多孔，轻质和可持续的混合有机气凝胶及其制备方法，包括例如PVA / CNF / GONS，RF / CNF / GONS和PVA / CNF / MWCNT。 气凝胶被改性为具有超疏水表面，因此导致非常低的溶胀比和吸湿率。

公开(公告)号：US09522218B2

公开(公告)日：2016-12-20

申请号：US12681682

申请日：2008-10-10

Applicant: Catherine Le Visage ,  Didier Letourneur

Inventor： Catherine Le Visage ,  Didier Letourneur

IPC: A61L27/20 ,  C08J3/075 ,  C08B37/00 ,  C08B37/02 ,  C08B37/04 ,  C08B37/10 ,  C08B37/12 ,  C08J9/08 ,  A61L27/52 ,  A61L27/56 ,  A61L27/38 ,  A61L27/50 ,  C12N5/00 ,  C08B37/08 ,  C08J9/28

CPC classification number: A61L27/20 ,  A61L27/3804 ,  A61L27/3834 ,  A61L27/3847 ,  A61L27/3852 ,  A61L27/507 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  C08B37/0018 ,  C08B37/0021 ,  C08B37/003 ,  C08B37/0039 ,  C08B37/0054 ,  C08B37/0063 ,  C08B37/0072 ,  C08B37/0075 ,  C08B37/0084 ,  C08J9/08 ,  C08J9/28 ,  C08J9/283 ,  C08J2201/026 ,  C08J2201/0484 ,  C08J2201/0504 ,  C08J2205/022 ,  C08J2207/10 ,  C08J2305/00 ,  C08J2305/02 ,  C08J2305/04 ,  C08J2305/08 ,  C08J2305/10 ,  C08J2305/12 ,  C12N5/0068 ,  C12N2533/70 ,  C12N2533/72 ,  C12N2533/74

Abstract: The present invention relates to a method for preparing a porous scaffold for tissue engineering. It is another object of the present invention to provide a porous scaffold obtainable by the method as above described, and its use for tissue engineering, cell culture and cell delivery. The method of the invention comprises the steps consisting of: a) preparing an alkaline aqueous solution comprising an amount of at least one polysaccharide, an amount of a cross-linking agent and an amount of a porogen agent b) transforming the solution into a hydrogel by placing said solution at a temperature from about 4° C. to about 80° C. for a sufficient time to allow the cross-linking of said amount of polysaccharide and c) submerging said hydrogel into an aqueous solution d) washing the porous scaffold obtained at step c).

Abstract translation: 本发明涉及一种用于组织工程的多孔支架的制备方法。 本发明的另一个目的是提供可通过上述方法获得的多孔支架及其在组织工程，细胞培养和细胞递送中的应用。 本发明的方法包括以下步骤：a）制备包含一定量的多糖，一定量的交联剂和一定量的致孔剂的碱性水溶液b）将溶液转化成水凝胶 通过将所述溶液置于约4℃至约80℃的温度下足够的时间以允许所述量的多糖的交联和c）将所述水凝胶浸入水溶液中d）洗涤多孔支架 在步骤c）获得。

公开(公告)号：US08975387B1

公开(公告)日：2015-03-10

申请号：US13052463

申请日：2011-03-21

Applicant: Richard A. Venditti ,  Joel J. Pawlak ,  Abdus Salam ,  Khaled Fathy El-Tahlawy

Inventor： Richard A. Venditti ,  Joel J. Pawlak ,  Abdus Salam ,  Khaled Fathy El-Tahlawy

IPC: C08B37/08 ,  C08B37/00 ,  C08B31/00 ,  C08B31/14 ,  A61K31/732 ,  A61K31/718

CPC classification number: C08J9/28 ,  A61L15/225 ,  A61L15/425 ,  A61L15/60 ,  C02F1/286 ,  C02F2101/20 ,  C02F2103/08 ,  C08B31/04 ,  C08B31/12 ,  C08B37/003 ,  C08B37/0057 ,  C08J9/0061 ,  C08J2201/026 ,  C08J2201/0484 ,  C08J2205/022 ,  C08J2300/105 ,  C08J2303/04 ,  C08J2305/00 ,  C08J2305/08 ,  C08J2305/14 ,  C08J2400/105 ,  C08J2403/04 ,  C08J2405/00 ,  C08J2405/08 ,  C08J2405/14 ,  C08L5/08 ,  C08L3/00

Abstract: Compositions of matter are provided that include chitosan and a modified carbohydrate. The modified carbohydrate includes a carbohydrate component and a cross linking agent. The modified carbohydrate has increased carboxyl content as compared to an unmodified counterpart carbohydrate. A carboxyl group of the modified carbohydrate is covalently bonded with an amino group of chitosan. The compositions of matter provided herein may include cross linked starch citrate-chitosan and cross linked hemicellulose citrate-chitosan, including foams thereof. These compositions yield excellent absorbency and metal chelation properties. Methods of making cross linked modified carbohydrate-chitosan compounds are also provided.

Abstract translation: 提供了包括壳聚糖和修饰的碳水化合物的物质组合物。 修饰的碳水化合物包括碳水化合物组分和交联剂。 与未修饰的对应物碳水化合物相比，修饰的碳水化合物具有增加的羧基含量。 经修饰的碳水化合物的羧基与壳聚糖的氨基共价键合。 本文提供的物质组合物可包括交联的柠檬酸柠檬酸盐 - 壳聚糖和交联的半纤维素柠檬酸盐 - 壳聚糖，包括其泡沫。 这些组合物产生优异的吸收性和金属螯合性质。 还提供了制备交联的修饰的碳水化合物 - 壳聚糖化合物的方法。

公开(公告)号：US08877469B2

公开(公告)日：2014-11-04

申请号：US11701096

申请日：2007-02-01

Applicant: Timothy D. Durance ,  Parastoo Yaghmaee ,  Shafique Ahmad ,  Guopeng Zhang

Inventor： Timothy D. Durance ,  Parastoo Yaghmaee ,  Shafique Ahmad ,  Guopeng Zhang

IPC: C12N13/00 ,  F26B5/04 ,  C08J9/28 ,  F26B5/06

CPC classification number: C08J9/28 ,  C08J2201/0484 ,  C08J2201/0504 ,  C08J2301/00 ,  F26B5/048 ,  F26B5/06

Abstract: A method for producing foams containing biological materials is described. A solid or semi-solid paste is formed by combining biologically active material with a protecting agent in an aqueous solvent. The paste formed is allowed to set, and may optionally then be apportioned into the desired shape. The paste may be frozen to allow formation of ice crystals to act as porogens. Subsequently, the paste is exposed to travelling wave radiant energy under vacuum (t-REV) for drying. This causes the solvent to boil off, leaving dried material containing the biologically active material, the protecting agent, and a relatively low water content. Biologically active materials which can be used include cells, microbial cultures, live attenuated microbes, probiotics, yeasts, enzymes, vaccines, proteins, and any heat-sensitive biological material. By directing energy via a travelling wave through a sample, good control of temperature and process conditions can be achieved. The method provides an alternative to the conventional methods of particulate leaching or freeze drying.

Abstract translation: 描述了生产含有生物材料的泡沫体的方法。 通过在水性溶剂中将生物活性物质与保护剂组合而形成固体或半固体糊状物。 允许形成的糊料固化，然后可任选地分配成所需的形状。 可以将糊状物冷冻以允许形成冰晶以充当致孔剂。 随后，将该糊剂暴露于真空下的行波辐射能（t-REV）以进行干燥。 这导致溶剂沸腾，留下含有生物活性物质的干燥物质，保护剂和相对较低的含水量。 可以使用的生物活性材料包括细胞，微生物培养物，活减毒微生物，益生菌，酵母，酶，疫苗，蛋白质和任何热敏生物材料。 通过将能量经由行波引导通过样品，可以实现温度和工艺条件的良好控制。 该方法提供了常规的微粒浸出或冷冻干燥方法的替代方案。

公开(公告)号：US08828288B2

公开(公告)日：2014-09-09

申请号：US13484322

申请日：2012-05-31

Applicant: Qi Liao ,  Walter A. Scrivens ,  Philip T. Wilson ,  Darin L. Dotson ,  Hao Zhou

Inventor： Qi Liao ,  Walter A. Scrivens ,  Philip T. Wilson ,  Darin L. Dotson ,  Hao Zhou

IPC: B29C35/16

CPC classification number: C08K3/346 ,  C04B33/04 ,  C04B38/0045 ,  C04B2111/2046 ,  C04B2111/52 ,  C04B2235/349 ,  C04B2235/5454 ,  C04B2235/606 ,  C08J3/075 ,  C08J9/008 ,  C08J9/28 ,  C08J2201/0484 ,  C08J2305/00 ,  C08J2305/12 ,  C08J2329/04 ,  C08J2361/28 ,  C08J2389/00 ,  C08J2405/12 ,  C08K5/053 ,  C08L5/12 ,  C08L29/04 ,  Y10T442/2861 ,  C04B38/0054 ,  C04B38/0605

Abstract: Disclosed are porous, low density nanoclay composites that exhibit highly homogeneous microcellular morphology and methods for forming the nanocomposites. The nanocomposites include a three-dimensional matrix having a non-lamellar, generally isotropic cellular structure with little or no macroscopic pores. The nanocomposites also include a gel that may be a noncovalently cross-linked, thermoreversible gel. The nanocomposites may include a binder and/or fibrous reinforcement materials. The nanocomposites may be formed according to a freeze-drying process in which ice crystal growth is controlled to prevent formation of macroscopic pores in the composite materials.

Abstract translation: 公开了多孔，低密度纳米粘土复合材料，其表现出高度均匀的微孔形态和形成纳米复合材料的方法。 纳米复合材料包括具有非层状，通常各向同性的细胞结构，具有很少或不具有宏观孔的三维基质。 纳米复合材料还包括可以是非共价交联的热可逆凝胶的凝胶。 纳米复合材料可以包括粘合剂和/或纤维增强材料。 可以根据冷冻干燥方法形成纳米复合材料，其中控制冰晶生长以防止在复合材料中形成宏观孔。

公开(公告)号：US08569062B2

公开(公告)日：2013-10-29

申请号：US13880020

申请日：2011-08-08

Applicant: Ashok Kumar

Inventor： Ashok Kumar

IPC: C12N5/02 ,  C08G18/38

CPC classification number: C08F16/06 ,  C08F20/00 ,  C08F220/34 ,  C08J9/0061 ,  C08J9/28 ,  C08J2201/0484 ,  C08J2205/022 ,  C08J2205/026 ,  C08J2333/04 ,  C08J2333/24 ,  C08J2343/00 ,  C08J2405/00 ,  C08J2429/04 ,  C08L29/04 ,  C12N5/0068 ,  C12N5/0602 ,  C12N2533/30 ,  C08L33/26

Abstract: The present invention relates to a cryogel which contains a polyol selected from polyvinyl alcohol or galactomannan and a co-polymer of Formula I: The cryogel is formed by mixing the monomers of the co-polymer of Formula I at a temperature of less about 5 degrees C. with the polyol and a free radical initiator in an aqueous solution and polymerizing the solution to form the cryogel. The cryogel is used for culturing cells and can be decomposed by contact with a monosaccharide.

Abstract translation: 本发明涉及一种含有选自聚乙烯醇或半乳甘露聚糖的多元醇和式I的共聚物的冷冻凝胶。冷冻凝胶通过将式I的共聚物的单体在小于约5度的温度下混合而形成 与多元醇和自由基引发剂在水溶液中聚合并使溶液聚合以形成冷冻凝胶。 冷冻凝胶用于培养细胞，并可通过与单糖接触分解。