公开(公告)号：US20180328785A1

公开(公告)日：2018-11-15

申请号：US16043652

申请日：2018-07-24

Applicant: Kaiser Optical Systems Inc.

Inventor： Patrick Wiegand ,  James M. Tedesco ,  Joseph B. Slater ,  Francis Esmonde-White ,  Darren Schipper

IPC: G01J3/02 ,  G01J3/44 ,  G01J3/28 ,  G01N21/65

CPC classification number: G01J3/0297 ,  G01J3/027 ,  G01J3/28 ,  G01J3/44 ,  G01N21/65

Abstract: Methods and systems for spectrometer dark correction are described which achieve more stable baselines, especially towards the edges where intensity correction magnifies any non-zero results of dark subtraction, and changes in dark current due to changes in temperature of the camera window frame are typically more pronounced. The resulting induced curvature of the baseline makes quantitation difficult in these regions. Use of the present disclosure may provide metrics for the identification of system failure states such as loss of camera vacuum seal, drift in the temperature stabilization, and light leaks. In system aspects of the present disclosure, a processor receives signals from a light detector in the spectrometer and executes software programs to calculate spectral responses, sum or average results, and perform other operations necessary to carry out the disclosed methods. In most preferred embodiments, the light signals received from a sample are used for Raman analysis.

公开(公告)号：US20180292323A1

公开(公告)日：2018-10-11

申请号：US15766516

申请日：2016-10-07

Applicant: CellTool GmbH

Inventor： Karin SCHÜTZE ,  Raimund SCHÜTZE

IPC: G01N21/65 ,  G01J3/44

CPC classification number: G01N21/65 ,  G01J3/44 ,  G01N2021/656 ,  G06N20/00

Abstract: The invention relates to a device (1) for detecting and/or evaluating a pathological condition comprising a Raman spectroscopy system (10) and an electronic evaluation device (20), which is configured to perform a detection and/or evaluation of the pathological condition in accordance with an evaluation of at least one Raman spectrum detected in stroma.

公开(公告)号：US20180275065A1

公开(公告)日：2018-09-27

申请号：US15764240

申请日：2016-01-29

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Anita Rogacs ,  Viktor Shkolnikov ,  Ning Ge

IPC: G01N21/65 ,  G01J3/44 ,  G01N21/64

CPC classification number: G01N21/658 ,  G01J3/0202 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0237 ,  G01J3/0256 ,  G01J3/0291 ,  G01J3/44 ,  G01N21/648

Abstract: An analyte detection system includes an analyte detection package to be presented to a reading device, and a focus mechanism to adjust a focal point of the analyte detection package relative to the reading device, with the analyte detection package including a surface-enhanced luminescence analyte stage, the reading device including optics to receive scattered radiation emitted luminescence from the analyte stage, and the focus mechanism to adjust the focal point relative to the optics.

公开(公告)号：US20180263606A1

公开(公告)日：2018-09-20

申请号：US15762904

申请日：2016-09-23

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN ,  INVENIO IMAGING, INC.

Inventor： Daniel ORRINGER ,  Christian FREUDIGER ,  Jay TRAUTMAN ,  Andrew KELLY

IPC: A61B10/02 ,  G01N21/65 ,  G01J3/44

CPC classification number: A61B10/0283 ,  A61B10/02 ,  A61B10/04 ,  G01J3/0205 ,  G01J3/44 ,  G01N21/65 ,  G01N2021/653

Abstract: Devices and systems for analyzing biological samples are provided. Devices include a hollow body extending from a first end to a second end. The body defines a sample collecting portion. A first opening at the first end of the body is operable to receive a source of negative pressure and a second opening at the second end of the body is operable to receive a biological sample. The body also includes an optically transparent region disposed in a region corresponding to the sample collecting portion, the optically transparent region being configured to transmit electromagnetic radiation therethrough from an imaging device capable of imaging the biological sample when disposed in the sample collecting portion.

公开(公告)号：US20180241854A1

公开(公告)日：2018-08-23

申请号：US15908196

申请日：2018-02-28

Applicant: SRI SPORTS LIMITED

Inventor： John J. RAE ,  Nathaniel J. RADCLIFFE ,  Daniel J. STONE ,  Trent E. GARNER ,  Brad S. HOOLEY ,  Robert J. HORACEK ,  Sam G. LACEY ,  Jeff D. BRUNSKI ,  Kevin SCHAEFFER ,  Scott A. CARLYLE ,  Stephen C. CHIEN ,  Craig R. SCHNELL ,  Douglas E. ROBERTS ,  Dan S. NIVANH ,  Michael J. WALLANS

IPC: H04L29/06 ,  G01J3/44

CPC classification number: H04L69/164 ,  A63B53/04 ,  A63B53/0466 ,  A63B60/00 ,  A63B2053/005 ,  A63B2053/0408 ,  A63B2053/0412 ,  A63B2053/0437 ,  G01J3/44 ,  H04L65/1069 ,  H04L65/60 ,  H04L69/10

Abstract: An exemplary golf club head having an increased amount of discretionary mass may be realized by utilizing improved drop angles, an improved average crown height, and/or articulation points. The discretionary mass may be placed low and deep in the club head to improve the location of the center of gravity as well as the inertial properties. A preferred break length may also be utilized to further improve the depth of the center of gravity. In one example, the center of gravity may be positioned to substantially align the sweet spot with the face center of the club head.

公开(公告)号：US20180188180A1

公开(公告)日：2018-07-05

申请号：US15398096

申请日：2017-01-04

Applicant: Kaiser Optical Systems Inc.

Inventor： James M. Tedesco ,  Joseph B. Slater

IPC: G01N21/65 ,  G01N21/03

CPC classification number: G01N21/65 ,  C12M23/14 ,  C12M41/00 ,  G01J3/0208 ,  G01J3/0291 ,  G01J3/44 ,  G01N21/0303 ,  G01N21/8507 ,  G01N2021/0321 ,  G01N2021/651

Abstract: Systems and methods are used to couple an optical sampling probe to a port in a single-use bioreactor bag for in-process monitoring. A combination of re-useable and disposable components maintain precision while reducing costs. A disposable barb with an integral window, received by the port of the reaction vessel, is coupled to a re-useable optic component with a focusing lens. A separate focus alignment tool is used to set the lens position to a precise focal point before placement of the optic component into the barb. The fixture includes a window to simulate the window in a barb component, a target with a known spectral signature, and a probe head coupled to a spectral analyzer. The axial position of the lens is adjusted with respect to the spacer component to maximize the spectral signature from a sample target, whereupon the spacer component is bonded to the lens mount.

公开(公告)号：US20180172592A1

公开(公告)日：2018-06-21

申请号：US15834406

申请日：2017-12-07

Applicant: IFP Energies Nouvelles

Inventor： Javier PEREZ PELLITERO ,  Catherine LAROCHE ,  Olivier DELPOUX ,  David GONCALVES

IPC: G01N21/65 ,  B01D15/18 ,  G01J3/44

CPC classification number: G01N21/65 ,  B01D15/1821 ,  B01D15/1828 ,  B01D15/1842 ,  C07C7/12 ,  C07C15/08 ,  G01J3/44 ,  G01N21/85 ,  G01N21/8507 ,  G01N2021/8411 ,  G01N2021/8416 ,  G01N2201/1211 ,  G01N2201/129

Abstract: A method for measuring the concentrations of species present at at least one point of a separation unit operating in simulated moving bed (SMB) mode, or a hybrid separation unit employing a step for simulated moving bed (SMB) separation and a step for crystallization, by calibration by inline acquisition of Raman spectra for different mixtures; analysis by inline signal processing of the Raman spectrum.

公开(公告)号：US09989472B2

公开(公告)日：2018-06-05

申请号：US15274303

申请日：2016-09-23

Applicant: ALBERTA INNOVATES-TECHNOLOGY FUTURES

Inventor： Stuart Garth Schroeder ,  Theodore Meyer Garver ,  Paul Peter Pastushak

IPC: G01J3/30 ,  G01N21/67 ,  G01N21/69 ,  G01N33/20 ,  G01J3/44

CPC classification number: G01N21/67 ,  G01J3/44 ,  G01N21/69 ,  G01N33/20

Abstract: A method and apparatus for solution cathode glow discharge (SCGD) elemental analysis. A solution-catching collar, in the form of a weir, a wicking element, or combinations thereof between the outlet tip of the capillary tube and the base of a grounding electrode tip maintain a solution sample level proximate the plasma emission region.

公开(公告)号：US20180113075A1

公开(公告)日：2018-04-26

申请号：US15793120

申请日：2017-10-25

Applicant: The University of Massachusetts

Inventor： Lili He

IPC: G01N21/65 ,  G01J3/44 ,  G01N33/50

CPC classification number: G01N21/658 ,  B82Y15/00 ,  G01J3/44 ,  G01N33/50

Abstract: The present disclosure provides a method for mapping one or more analytes that contact a biological structure. The method uses surface-enhanced Raman spectroscopy and includes contacting the biological structure and a metallic nanoparticle. The method further includes collecting a spectrum with a Raman spectrometer. The method further includes determining a location of the analyte along at least one of an x-direction, a y-direction and a z-direction on the structure.

公开(公告)号：US20180100788A1

公开(公告)日：2018-04-12

申请号：US15830513

申请日：2017-12-04

Applicant: The Penn State Research Foundation

Inventor： Benjamin Hall ,  Jonathan Lynch ,  Edward W. Reutzel ,  Galen Lynch ,  Brian T. Reinhardt

IPC: G01N1/44 ,  G01J3/28 ,  G01N1/06 ,  G01J3/00 ,  G01N1/28 ,  G01N1/04

CPC classification number: G01N1/44 ,  G01J3/00 ,  G01J3/2823 ,  G01J3/44 ,  G01J3/443 ,  G01J2003/106 ,  G01N1/06 ,  G01N2001/045 ,  G01N2001/2886 ,  G01N2201/06113

Abstract: A laser ablation tomography system includes a specimen stage for supporting a specimen. A specimen axis is defined such that a specimen disposed generally on the axis may be imaged. A laser system is operable to produce a laser sheet in a plane intersecting the specimen axis and generally perpendicular thereto. An imaging system is operable to image the area where the laser sheet intersects the specimen axis.