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    Iodine-dispensing antifoulant implemented with dispensing shutter
    21.
    发明授权
    Iodine-dispensing antifoulant implemented with dispensing shutter 有权
    配有分配快门的碘分配防污剂

    公开(公告)号：US08617484B1

    公开(公告)日：2013-12-31

    申请号：US12749850

    申请日：2010-03-30

    Applicant: Kimberly Leung ,  Charles Ringer

    Inventor： Kimberly Leung ,  Charles Ringer

    IPC: A61L2/00 ,  G07F11/00

    CPC classification number: C02F1/687 ,  C02F1/008 ,  C02F1/766 ,  G01N21/15 ,  G01N2201/0218 ,  G01N2201/0227

    Abstract: Sensors, such as optical sensors and other sensors used in an aqueous environment are protected from biological contamination by applying a biocide behind a shutter. The shutter is capable of covering a subject portion of the sensor or surrounding mounting surface adjacent the sensor in at least a semi-sealing manner. A well or reservoir forms a chamber in the shutter that is capable of holding a biocide having a limited water solubility and a low environmental toxicity in the aqueous environment, for example, anhydrous iodine crystals. The reservoir is in communication with the portion of the sensor while positioned against the portion of the sensor or surrounding mounting surface adjacent the sensor.

    Abstract translation: 在水性环境中使用的传感器，例如光学传感器和其它传感器通过在快门后施用杀生物剂来保护免受生物污染。 挡板能够以至少半密封的方式覆盖邻近传感器的传感器或周围安装表面的主体部分。 井或储层在闸门中形成能够在水性环境例如无水碘晶体中保持具有有限水溶性和低环境毒性的杀生物剂的室。 储存器与传感器的部分连通，同时抵靠传感器的一部分或与传感器相邻的周围的安装表面。

    Illumination system for an imaging apparatus with low profile output device
    22.
    发明授权
    Illumination system for an imaging apparatus with low profile output device 有权
    具有低调输出设备的成像设备的照明系统

    公开(公告)号：US07474398B2

    公开(公告)日：2009-01-06

    申请号：US11434605

    申请日：2006-05-15

    Applicant: David Nilson ,  Brad Rice ,  Tamara Troy

    Inventor： David Nilson ,  Brad Rice ,  Tamara Troy

    IPC: G01J3/30 ,  G01N21/25

    CPC classification number: G01N21/6456 ,  G01N2021/1787 ,  G01N2021/6471 ,  G01N2021/6484 ,  G01N2201/0227 ,  G01N2201/0826

    Abstract: A fluorescence illumination system is provided for use with an imaging apparatus that defines a light-tight imaging compartment. The fluorescence illumination system includes a trans-illumination component configured to direct excitation light into a first surface of the specimen wherein diffused light emanates from a second surface thereof for receipt through the view port to acquire fluorescence data of the specimen. Further, the fluorescence illumination system includes an epi-illumination component configured to direct excitation light onto a third surface of the specimen wherein the diffused light exits the third surface thereof for receipt through the view port to acquire fluorescence data of the specimen.

    Abstract translation: 荧光照明系统被提供用于与定义不透光成像室的成像装置一起使用。 荧光照明系统包括反射照明部件，其被配置为将激发光引导到样品的第一表面，其中散射光从其第二表面发出，以通过视口接收，以获取样品的荧光数据。 此外，荧光照明系统包括被配置为将激发光引导到样本的第三表面上的外照明部件，其中扩散的光离开其第三表面以通过视口接收以获取样本的荧光数据。

    Ultrasensitive spectrophotometer
    23.
    发明授权
    Ultrasensitive spectrophotometer 有权
    超声分光光度计

    公开(公告)号：US07262844B2

    公开(公告)日：2007-08-28

    申请号：US11035034

    申请日：2005-01-13

    Applicant: David W. Larsen ,  Zhi Xu

    Inventor： David W. Larsen ,  Zhi Xu

    IPC: G01J3/42

    CPC classification number: G01N21/31 ,  G01J3/02 ,  G01J3/0224 ,  G01J3/0262 ,  G01J3/0286 ,  G01J3/0291 ,  G01J3/42 ,  G01J2003/425 ,  G01N21/274 ,  G01N2021/3137 ,  G01N2201/0227 ,  G01N2201/0642 ,  G01N2201/127

    Abstract: The invention concerns measurements in which light interacts with matter to generate light intensity changes, and spectrophotometer devices of the invention provide ultrasensitive measurements. Light source noise in these measurements can be reduced in accordance with the invention. Exemplary embodiments of the invention use sealed housings lacking an internal light source. In some embodiments a substantially solid thermally conductive housing is used. Other embodiments include particular reflection based sample and reference cells. One embodiment includes a prism including an interaction surface, a detector, a lens that focuses a prism beam output onto the detector, and a closed interaction volume for delivering gas or liquid to the interaction surface. Another embodiment replaces a prism with a reflective surface. Another embodiment replaces a prism with a scattering matte surface. Aspects of the invention identify noise-contributing components in spectrophotometry and realize noise levels very near the shot noise limit.

    Abstract translation: 本发明涉及光与物质相互作用以产生光强度变化的测量，本发明的分光光度计装置提供超灵敏测量。 根据本发明，可以减少这些测量中的光源噪声。 本发明的示例性实施例使用缺少内部光源的密封外壳。 在一些实施例中，使用基本上固体的导热壳体。 其他实施方案包括特定的基于反射的样品和参比细胞。 一个实施例包括棱镜，其包括相互作用表面，检测器，将棱镜束输出聚焦到检测器上的透镜以及用于将气体或液体输送到相互作用表面的封闭相互作用体积。 另一个实施例用反射表面代替棱镜。 另一个实施例用散射磨砂表面代替棱镜。 本发明的方面在分光光度法中识别噪声贡献的组件，并且实现非常接近喷射噪声极限的噪声水平。

    Ultrasensitive spectrophotometer
    24.
    发明申请
    Ultrasensitive spectrophotometer 有权
    超声分光光度计

    公开(公告)号：US20060152726A1

    公开(公告)日：2006-07-13

    申请号：US11035034

    申请日：2005-01-13

    Applicant: David Larsen ,  Zhi Xu

    Inventor： David Larsen ,  Zhi Xu

    IPC: G01J3/51

    CPC classification number: G01N21/31 ,  G01J3/02 ,  G01J3/0224 ,  G01J3/0262 ,  G01J3/0286 ,  G01J3/0291 ,  G01J3/42 ,  G01J2003/425 ,  G01N21/274 ,  G01N2021/3137 ,  G01N2201/0227 ,  G01N2201/0642 ,  G01N2201/127

    Abstract: The invention concerns measurements in which light interacts with matter giving rise to changes in light intensity, and preferred embodiment spectrophotometer devices of the invention provide for ultrasensitive measurements through a reflection interaction with matter. The level of light source noise in these measurements can be reduced in accordance with the invention. Preferred embodiments of the invention use sealed housings lacking an internal light source, and reflection based sample and reference cells. In some embodiments a substantially solid thermally conductive housing is used. Other features of preferred embodiments include particular reflection based sample and reference cells. A total internal reflection embodiment includes, for example, a prism including an interaction surface, a detector, a lens that focuses a beam output from the prism onto the detector, and a closed interaction volume having an inlet and an outlet for delivering gas or liquid to the interaction surface. In a specular reflection embodiment, a reflective surface is used instead of a prism. In a diffuse reflection embodiment a matte surface is used instead of a prism and the matte surface produces scattering. Aspects of the invention include identification of noise-contributing components in spectrophotometry and the select set of preferred features in a given embodiment, and noise levels very near the shot noise limit may be realized with application of preferred embodiment devices.

    Abstract translation: 本发明涉及测量光，其中光与引起光强变化的物质相互作用，并且本发明的优选实施方式的分光光度计装置通过与物质的反射相互作用来提供超灵敏测量。 根据本发明，可以减少这些测量中的光源噪声的水平。 本发明的优选实施例使用缺少内部光源的密封壳体，以及基于反射的样品和参考单元。 在一些实施例中，使用基本上固体的导热壳体。 优选实施方案的其它特征包括特定的基于反射的样品和参考细胞。 全内反射实施例包括例如包括相互作用表面的棱镜，检测器，将从棱镜输出的光束聚焦到检测器上的透镜以及具有用于输送气体或液体的入口和出口的封闭相互作用体积 到相互作用的表面。 在镜面反射实施例中，使用反射表面代替棱镜。 在漫反射实施例中，使用无光泽表面代替棱镜，并且无光泽表面产生散射。 本发明的方面包括在给定实施例中识别分光光度法中的噪声贡献成分以及在一特定实施例中选择的一组优选特征，并且通过应用优选实施例装置可以实现非常接近散粒噪声极限的噪声水平。

    Bottom fluorescence illumination assembly for an imaging apparatus
    25.
    发明申请
    Bottom fluorescence illumination assembly for an imaging apparatus 有权
    用于成像装置的底部荧光照明组件

    公开(公告)号：US20030187344A1

    公开(公告)日：2003-10-02

    申请号：US10372763

    申请日：2003-02-21

    Applicant: XENOGEN CORPORATION

    Inventor： David Nilson ,  Brad Rice ,  Tamara Troy

    IPC: A61B005/05

    CPC classification number: G01N21/6456 ,  A01K1/031 ,  A61M16/104 ,  A61M16/18 ,  A61M16/202 ,  A61M2016/0039 ,  G01N2021/1787 ,  G01N2021/6463 ,  G01N2021/6471 ,  G01N2021/6484 ,  G01N2201/0227 ,  G01N2201/0826

    Abstract: A macroscopic fluorescence illumination assembly is provided for use with an imaging apparatus with a light-tight imaging compartment. The imaging apparatus includes an interior wall defining a view port extending into the imaging compartment to enable viewing of a specimen contained therein. The illumination assembly includes a specimen support surface sized and dimensioned for receipt in the imaging compartment, and oriented to face toward the view port of the imaging apparatus. The support surface is substantially opaque and defines a window portion that enables the passage of light there through. The window portion is selectively sized and dimensioned such that the specimen, when supported atop the support surface, can be positioned and seated over the window portion in a manner forming a light-tight seal substantially there between. The illumination assembly further includes an excitation light source, and a bundle of fiber optic strands having proximal ends thereof in optical communication with the light source. The distal ends of the strands terminate proximate the window portion of the support surface. The distal ends each emit a respective beam of light originating from the light source which are then collectively directed toward the window portion and into a bottom side of the specimen wherein the diffused light passes there through and exits a topside thereof for receipt through the view port to view the fluorescence of the specimen.

    Abstract translation: 提供了一种宏观荧光照明组件，用于与具有不透光成像室的成像装置一起使用。 该成像设备包括限定了一个视图端口的内壁，该视图端口延伸到成像室中以使得能够观察其中容纳的样本。 照明组件包括尺寸和尺寸适于接收在成像室中的样本支撑表面，并且被定向成面向成像设备的视口。 支撑表面基本上是不透明的，并且限定了能够使光通过的窗口部分。 窗口部分被选择性地定尺寸和尺寸使得当被支撑在支撑表面上方时，样本可以以基本上在其之间形成不透光密封的方式被定位和安置在窗口部分上。 照明组件还包括激发光源，以及一束光纤束，其光纤束的近端与光源光学连通。 股线的末端终止于支撑表面的窗口部分。 远端各自发出源自光源的相应光束，然后将它们共同指向窗口部分并进入样本的底侧，其中漫射光通过其并穿过其顶侧并通过观察端口接收 以观察样品的荧光。

    SPECTROMETRIC APPARATUS AND STORAGE CASE
    30.
    发明申请
    SPECTROMETRIC APPARATUS AND STORAGE CASE 审中-公开
    光谱设备和存储盒

    公开(公告)号：US20160120450A1

    公开(公告)日：2016-05-05

    申请号：US14926174

    申请日：2015-10-29

    Applicant: Seiko Epson Corporation

    Inventor： Kazunori SAKURAI

    IPC: A61B5/1455 ,  A61B5/00 ,  G01J3/02

    CPC classification number: A61B5/14552 ,  A61B5/6831 ,  A61B5/6833 ,  A61B2560/0406 ,  A61B2562/0233 ,  A61B2562/185 ,  G01J3/0202 ,  G01J3/0205 ,  G01J3/0259 ,  G01J3/0291 ,  G01J3/26 ,  G01N21/01 ,  G01N21/31 ,  G01N2201/0227 ,  G01N2201/064

    Abstract: A biological body inspection apparatus includes a measurement module that acquires an amount of light having a wavelength under measurement contained in light incident on the measurement module and an enclosure that accommodates the measurement module and has a window that transmits light traveling toward the measurement module. An adhesive member is provided on a surface of the enclosure at least in an area thereof that surrounds the window. The adhesive member has a light blocking section that is located in an area outside the window and surrounds the window in a plan view in the direction along the optical axis of the light traveling toward the measurement module and blocks light that belongs to a measurement wavelength region within which at least the wavelength under measurement is present.

    Abstract translation: 生物体检查装置包括测量模块，该测量模块获取入射在测量模块上的光所包含的测量波长的光量，以及容纳测量模块的外壳，并且具有透射朝向测量模块传播的光的窗口。 至少在其围绕窗户的区域中，在外壳的表面上设置粘合构件。 所述粘接部件具有遮光部，所述遮光部位于所述窗外部的区域中，并且沿着朝向所述测量模块行进的所述光的光轴方向的俯视图中包围所述窗，并且遮挡属于所述测量波长区域的光 其中至少存在测量波长。

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