公开(公告)号：US12027360B2

公开(公告)日：2024-07-02

申请号：US17723652

申请日：2022-04-19

Applicant: SHIMADZU CORPORATION

Inventor： Hiroyuki Miura ,  Hideaki Izumi

IPC: H01J49/40 ,  H01J49/24

CPC classification number: H01J49/408 ,  H01J49/24

Abstract: A mass spectrometer 1 includes a vacuum container 5 divided into a first chamber 51 containing an ion trap 3 and a second chamber 52 containing a time-of-flight mass spectrometer 4. The ion trap 3 is held within an ion-trap-holding space 610 surrounded by a wall 61. In this wall 61, a cooling-gas discharge port 64 is formed in addition to an introduction-side ion passage port 62 and an ejection-side ion passage port 63. A cooling gas supplied into an ion-capturing space 315 of the ion trap 3 is discharged from the ion-trap-holding space 610 through the three ports. The provision of the cooling-gas discharge port 64 reduces the amount of cooling gas flowing into the ejection-side ion passage port 63 and interfering with the ejection of ions from the ion trap 3 into the time-of-flight mass spectrometer 4. Consequently, the detection intensity of the ions is improved.

公开(公告)号：US20180337030A1

公开(公告)日：2018-11-22

申请号：US15980298

申请日：2018-05-15

Applicant: Micromass UK Limited

Inventor： Kevin Giles ,  David J. Langridge ,  Jason Lee Wildgoose

IPC: H01J49/06 ,  H01J49/00 ,  G01N27/62 ,  H01J49/40

CPC classification number: H01J49/061 ,  G01N27/622 ,  H01J49/0031 ,  H01J49/408 ,  H01J49/422

Abstract: A method of introducing and ejecting ions from an ion entry/exit device (4) is disclosed. The ion entry/exit device (4) has at least two arrays of electrodes (20,22). The device is operated in a first mode wherein DC potentials are successively applied to successive electrodes of at least one of the electrode arrays ((20,22) in a first direction such that a potential barrier moves along the at least one array in the first direction and drives ions into and/or out of the device in the first direction. The device is also operated in a second mode, wherein DC potentials are successively applied to successive electrodes of at least one of the electrode arrays (20,22) in a second, different direction such that a potential barrier moves along the array in the second direction and drives ions into and/or out of the device in the second direction. The device provides a single, relatively simple device for manipulating ions in multiple directions. For example, the device may be used to load ions into or eject ions from an ion mobility separator in a first direction, and may then be used to cause ions to move through the ion mobility separator in the second direction so as to cause the ions to separate.

公开(公告)号：US09997343B2

公开(公告)日：2018-06-12

申请号：US15618959

申请日：2017-06-09

Applicant: SHIMADZU CORPORATION

Inventor： Li Ding ,  Mikhail Sudakov ,  Sumio Kumashiro

IPC: H01J49/40 ,  H01J49/02 ,  H01J49/42 ,  H01J49/00 ,  H01J49/06

CPC classification number: H01J49/027 ,  H01J49/0031 ,  H01J49/061 ,  H01J49/406 ,  H01J49/408 ,  H01J49/4245

Abstract: An electrostatic ion trap for mass analysis includes a first array of electrodes and a second array of electrodes, spaced from the first array of electrode. The first and second arrays of electrodes may be planar arrays formed by parallel strip electrodes or by concentric, circular or part-circular electrically conductive rings. The electrodes of the arrays are supplied with substantially the same pattern of voltage whereby the distribution of electrical potential in the space between the arrays is such as to reflect ions isochronously in a flight direction causing them to undergo periodic, oscillatory motion in the space, focused substantially mid-way between the arrays. Amplifier circuitry is used to detect image current having frequency components related to the mass-to-charge ratio of ions undergoing the periodic, oscillatory motion.

公开(公告)号：US09761431B2

公开(公告)日：2017-09-12

申请号：US15249370

申请日：2016-08-27

Applicant: NOAA Technology Partnerships Office

Inventor： Daniel Murphy

IPC: H01J49/00 ,  H01J49/40

CPC classification number: H01J49/408

Abstract: A system for expressing an ion path in a time-of-flight (TOF) mass spectrometer. The present invention uses two successive curved sectors, with the second one reversed, to form S-shaped configuration such that an output ion beam is parallel to an input ion beam, such that the ions makes two identical but opposed turns, and such that the geometry of the entire system folds into a very compact volume. Geometry of a TOF mass spectrometer system in accordance with embodiments of the present invention further includes straight drift regions positioned before and after the S-shaped configuration and, optionally, a short straight region positioned between the two curved sectors with total length equal to about the length of the central arc of both curved sectors.

公开(公告)号：US09721779B2

公开(公告)日：2017-08-01

申请号：US14401722

申请日：2013-05-16

Applicant: Micromass UK Limited

Inventor： John Brian Hoyes ,  David J. Langridge ,  Jason Lee Wildgoose

IPC: H01J49/40 ,  H01J49/00

CPC classification number: H01J49/401 ,  G01N2223/506 ,  H01J49/0031 ,  H01J49/405 ,  H01J49/406 ,  H01J49/408

Abstract: A Time of Flight mass analyzer is disclosed comprising an annular ion guide having a longitudinal axis and comprising a first annular ion guide section and a second annular ion guide section. Ions are introduced into the first annular ion guide section so that the ions form substantially stable circular orbits within the first annular ion guide section about the longitudinal axis. The ions are then orthogonally accelerated ions from the first annular ion guide section into the second annular ion guide section. An ion detector is disposed within the annular ion guide and has an ion detecting surface arranged in a plane which is substantially perpendicular to the longitudinal axis.

公开(公告)号：US20120112060A1

公开(公告)日：2012-05-10

申请号：US13289908

申请日：2011-11-04

Applicant: Tohru KINUGAWA ,  Osamu FURUHASHI

Inventor： Tohru KINUGAWA ,  Osamu FURUHASHI

IPC: H01J49/40

CPC classification number: H01J49/408

Abstract: A multi-turn time-of-flight mass spectrometer creates, an accurate mass spectrum of a wide mass range, with the smallest number of measurements. Deflecting electrodes are provided on an ejection path through which ions deviating from a loop orbit fly to a detector having a two-dimensional array elements. A varying voltage applied to the deflecting electrodes creates an electric field. When two ions having different mass-to-charge ratios simultaneously arrive at the detector, these ions are affected with differing strengths since they pass through the deflecting electric field at different times. This results in arrival for the ions on a detection surface. The time an ion passing through the deflecting electric field can be calculated from the displacement of the arrival position of that ion. Then the flight speed of the ion is obtained and its number of turns is roughly deduced to arrive at its mass-to-charge ratio.

Abstract translation: 多圈飞行时间质谱仪产生了质量范围广的精确质谱，测量数量最小。 偏转电极设置在离开环路轨道的离子通过其到具有二维阵列元件的检测器的喷射路径上。 施加到偏转电极的变化的电压产生电场。 当具有不同质量 - 电荷比的两个离子同时到达检测器时，这些离子受到不同强度的影响，因为它们在不同时间通过偏转电场。 这导致离子在检测表面上的到达。 通过偏转电场的离子可以从该离子的到达位置的位移计算出来。 然后获得离子的飞行速度，并大致推断其匝数达到其质荷比。

公开(公告)号：US08093554B2

公开(公告)日：2012-01-10

申请号：US12444838

申请日：2007-10-17

Applicant: Alexander A. Makarov

Inventor： Alexander A. Makarov

IPC: H01J49/40

CPC classification number: H01J49/406 ,  H01J49/004 ,  H01J49/025 ,  H01J49/061 ,  H01J49/408

Abstract: A mass spectrometer and method of mass spectrometry wherein charged particles in a beam undergo multiple changes of direction. A detection arrangement detects a first portion of the charged particle beam, and provides a first output based upon the intensity of the detected first portion of the charged particle beam. The detection arrangement detects a second portion of the charged particle beam that has travelled a greater path length through the mass spectrometer than the first portion of the charged particle beam, and provides a second output based upon the detected second portion of the charged particle beam. A controller adjusts the parameters of the charged particle beam and/or the detection arrangement, based upon the first output of the detection arrangement, so as to adjust the second output of the detection arrangement.

Abstract translation: 质谱仪和质谱法，其中光束中的带电粒子经历多个方向改变。 检测装置检测带电粒子束的第一部分，并且基于所检测到的带电粒子束的第一部分的强度提供第一输出。 检测装置检测带电粒子束的第二部分，该第二部分已经比通过质谱仪行进了比带电粒子束的第一部分更大的路径长度，并且基于检测到的带电粒子束的第二部分提供第二输出。 控制器基于检测装置的第一输出来调整带电粒子束和/或检测装置的参数，以便调整检测装置的第二输出。

公开(公告)号：US20110192971A1

公开(公告)日：2011-08-11

申请号：US13125545

申请日：2008-10-30

Applicant: Shinichi Yamaguchi

Inventor： Shinichi Yamaguchi

IPC: H01J49/40

CPC classification number: H01J49/408

Abstract: A variety of ions generated in an ion source are made to fly while bypassing a loop orbit and mass analyzed to create a mass spectrum. Among the peaks appearing on the mass spectrum, peaks complying with predetermined conditions are extracted to determine a plurality of mass ranges to be measured (S1 through S3). Next, the ion selection conditions for the timing when ions should be injected into the loop orbit and on the loop orbit are determined for each mass range. In addition, deviation conditions under which selected ions will not be mixed are determined (S4 and S5). When the second measurement is performed for the same sample, ions are put into the loop orbit and unnecessary ions are removed from the loop orbit in accordance with the ion selection conditions (S6 and S7). Thus, only the ions to be measured are left on the loop orbit with a high mass resolving power. Then, these ions are sequentially deviated from the loop orbit in accordance with the ion deviation conditions, dissociated, and then mass analyzed (S8). In this manner, MS/MS analyses are performed for each of the plurality of ions to be measured to create an MS/MS spectrum (S10).

Abstract translation: 在离子源中产生的各种离子被制成飞行，同时绕过环路轨道并进行质量分析以产生质谱。 在质谱中出现的峰中，提取符合预定条件的峰以确定待测量的多个质量范围（S1至S3）。 接下来，对于每个质量范围确定离子应注入环路轨道和环路轨道的定时的离子选择条件。 此外，确定不混合选定离子的偏差条件（S4和S5）。 当对相同的样品进行第二次测量时，根据离子选择条件将离子放入环轨道中，并从环路轨道中除去不需要的离子（S6和S7）。 因此，只有待测量的离子留在具有高质量分辨能力的环路轨道上。 然后，这些离子根据离子偏离条件依次偏离环路轨道，解离，然后进行质量分析（S8）。 以这种方式，对待测量的多个离子中的每一个执行MS / MS分析以产生MS / MS谱（S10）。

公开(公告)号：US20100282965A1

公开(公告)日：2010-11-11

申请号：US12747728

申请日：2007-12-13

Applicant: Masaru Nishiguchi ,  Shigeki Kajihara

Inventor： Masaru Nishiguchi ,  Shigeki Kajihara

IPC: H01J49/40

CPC classification number: H01J49/408

Abstract: A measurement is performed in a no-passing mode, in which ions having different masses are prevented from making a complete turn through a loop orbit, to obtain a time-of-flight spectrum without the passing of ions having different masses (S1 and S2). From the time of flight and other information of the peaks appearing on the time-of-flight spectrum (S3), the number of turns and the time of flight in the loop-turn mode are predicted. Based on this prediction, a set of segments are defined on a time-of-flight spectrum in the loop-turn mode. The time widths of those segments are determined taking into account the spreads of the time widths of the aforementioned peaks. Since the number of turns is unique within each segment, the numbers of turns and the masses of the peaks can be uniquely determined as long as none of the segments overlap each other. Accordingly, it is determined whether there is any overlapped portion in the segments defined on the time-of-flight spectrum in the loop-turn mode under provisionally predetermined conditions. When a condition under which no overlapping occurs has been found, the segment setting is fixed (S4-S6). As a result, the timing for switching an ejection switch, which is used for ejecting ions from the loop orbit, is also determined. Based on this timing, a measurement in the loop-turn mode is performed (S7).

Abstract translation: 在不通过模式中进行测量，其中防止具有不同质量的离子通过环轨道完全转动，以获得不具有不同质量的离子通过的飞行时间谱（S1和S2 ）。 从飞行时间和飞行时间频谱出现的峰值的其他信息（S3），可以预测回转模式下的匝数和飞行时间。 基于该预测，在循环模式中在飞行时间频谱上定义一组段。 考虑到上述峰值的时间宽度的扩展，确定了这些段的时间宽度。 由于每个段内的匝数是唯一的，只要没有一个段彼此重叠，可以唯一地确定峰的匝数和质量。 因此，在临时预定条件下，确定在循环转弯模式下在飞行时间频谱上定义的段中是否存在任何重叠部分。 当发现不发生重叠的条件时，段设定是固定的（S4-S6）。 结果，也确定了用于从环路轨道喷射离子的喷射开关切换的定时。 基于该定时，执行环路转向模式中的测量（S7）。

公开(公告)号：US07755036B2

公开(公告)日：2010-07-13

申请号：US11972365

申请日：2008-01-10

Applicant: Takaya Satoh

Inventor： Takaya Satoh

IPC: H01J49/00

CPC classification number: H01J49/004 ,  H01J49/408

Abstract: A novel instrument and method for TOF/TOF mass spectrometry is offered. A spiral trajectory time-of-flight mass spectrometer satisfies the spatial focusing conditions for the direction of flight and a direction orthogonal to the direction of flight whenever ions make a turn in the spiral trajectory. An ion gate for selecting precursor ions is placed in the spiral trajectory of the spiral trajectory time-of-flight mass spectrometer. Electric sectors are placed downstream of the ion gate.

Abstract translation: 提供TOF / TOF质谱仪的新型仪器和方法。 螺旋轨迹飞行时间质谱仪满足飞行方向的空间聚焦条件和每当离子在螺旋轨迹中转弯时与飞行方向垂直的方向。 用于选择前体离子的离子门放置在螺旋轨迹飞行时间质谱仪的螺旋轨迹中。 电气部门放置在离子门的下游。