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31.发明申请公开(公告)号：US20230062622A1
公开(公告)日：2023-03-02
申请号：US18046986
申请日：2022-10-17
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Don W. Arnold , Thomas R. Covey , Chang Liu
Abstract: Methods and systems for delivering a liquid sample to an ion source for the generation of ions and subsequent analysis by mass spectrometry are provided herein. In accordance with various aspects of the present teachings, MS-based systems and methods are provided in which the flow of desorption solvent within a sampling probe fluidly coupled to an ion source can be selectively controlled such that one or more analyte species can be desorbed from a sample substrate inserted within the sampling probe within a decreased volume of desorption solvent for subsequently delivery to the ion source. In various aspects, sensitivity can be increased due to higher desorption efficiency (e.g., due to increased desorption time) and/or decreased dilution of the desorbed analytes. The methods and systems described herein can additionally or alternatively provide for the selective control of the flow rate of the desorption solvent within the sampling interface so as to enable additional processing steps to occur within the sampling probe (e.g., multiple samplings, reactions).
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公开(公告)号：US20220148866A1
公开(公告)日：2022-05-12
申请号：US17427300
申请日：2020-02-03
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Thomas R. Covey , Chang Liu , Gary J. Van Berkel
Abstract: A method for the repeated analysis of a sample bearing location. The sample bearing location may include, for instance, a sampled point in a tissue slice that is spatially and temporally correlated to the original slice. The slice may be in whole, or in part, a complete item or a portion of a complete item such as, for example, a human organ. The method improves the analysis process, such as mass spectrometry analysis, by providing a much more complete characterization of the target. The method also allows for the splitting of the sample and chemical/physical alteration of the aliquots for enhanced chemical analysis.
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公开(公告)号：US11031225B2
公开(公告)日：2021-06-08
申请号：US16335077
申请日：2017-09-13
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Thomas R. Covey , Yves LeBlanc , Bradley B. Schneider
Abstract: Because most ion optics of mass spectrometry systems are subject to ion deposition and may exhibit significantly different behavior following substantial contamination (e.g., loss of sensitivity), fouled surfaces must be regularly cleaned to maintain sensitivity. While the surfaces of front-end components (e.g., curtain plates, orifice plates, Qjet, Q0, IQ0) may be relatively easy to clean, the fouling of components contained within the downstream high-vacuum chambers (e.g., Q1, IQ1) can incur substantial delays and expense as the high-vacuum chambers must be vented and substantially disassembled prior to cleaning. Methods and systems for controlling contamination of components of mass spectrometer systems are provided herein. By reducing the transmission of contaminating ions during non-data acquisition periods, the present teachings can increase throughput, improve robustness, and/or decrease the downtime typically required to vent/disassemble/clean the fouled components.
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公开(公告)号：US20210020423A1
公开(公告)日：2021-01-21
申请号：US16971436
申请日：2019-02-20
Applicant: DH Technologies Development Pte. Ltd.
Inventor： John J. Corr , Thomas R. Covey , Peter Kovarik , Bradley B. Schneider
Abstract: In one aspect, an ion source for use in a mass spectrometry system is disclosed, which comprises a housing, a first and a second ion probe coupled to said housing, and a first and a second emitter configured for coupling, respectively, to said first and second ion probes. The first ion probe is configured for receiving a sample at a flow rate in nanoflow regime and the second ion probe is configured for receiving a sample at a flow rate above the nanoflow regime. Each of the ion probes includes a discharge end (herein also referred to as the discharge tip) for ionizing at least one constituent of the received sample. In some embodiment, each ion probe receives the sample from a liquid chromatography (LC) column. Further, the ion probes can be interchangeably disposed within the housing.
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公开(公告)号：US10656147B2
公开(公告)日：2020-05-19
申请号：US15121803
申请日：2015-02-27
Applicant: DH Technologies Development PTE Ltd.
Inventor： John L. Campbell , Thomas R. Covey , Chang Liu , Subhasish Purkayastha
IPC: G01N33/553 , G01N33/543 , G01N1/38 , B01F13/00 , B01F13/08 , G01N35/00 , B01L3/00 , G01N27/74
Abstract: Methods and apparatus for processing fluids on a macro- or micro-scale are described. In various aspects, a fluid may have a plurality of elongated (i.e., substantially rod-shaped) magnetic elements disposed therein within a fluid container. An illustrative fluid container is an actuator electrode or a processing vial of a microfluidic device, such as a digital microfluidic device. A magnet component may be configured to generate a magnetic force sufficient to influence the movement of the plurality of elongated magnetic elements within the fluid to be processed. For example, the magnetic force (or magnetic force gradient) may influence the plurality of elongated magnetic elements to rotate, spin, and/or move laterally side-to-side. The shape and movements of the plurality of elongated magnetic elements facilitate the rapid and efficient processing of the fluid, such as fluid mixing and/or fluid separation.
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Patent Agency Ranking
36.发明申请公开(公告)号：US20200043712A1
公开(公告)日：2020-02-06
申请号：US16341718
申请日：2017-10-12
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Don W. Arnold , Thomas R. Covey , Chang Liu
Abstract: Methods and systems for delivering a liquid sample to an ion source for the generation of ions and subsequent analysis by mass spectrometry are provided herein. In accordance with various aspects of the present teachings, MS-based systems and methods are provided in which the flow of desorption solvent within a sampling probe fluidly coupled to an ion source can be selectively controlled such that one or more analyte species can be desorbed from a sample substrate inserted within the sampling probe within a decreased volume of desorption solvent for subsequently delivery to the ion source. In various aspects, sensitivity can be increased due to higher desorption efficiency (e.g., due to increased desorption time) and/or decreased dilution of the desorbed analytes. The methods and systems described herein can additionally or alternatively provide for the selective control of the flow rate of the desorption solvent within the sampling interface so as to enable additional processing steps to occur within the sampling probe (e.g., multiple samplings, reactions).
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公开(公告)号：US20190006165A1
公开(公告)日：2019-01-03
申请号：US16062936
申请日：2016-12-08
Applicant: DH Technologies Development Pte. Ltd.
Inventor： John J. Corr , Thomas R. Covey , Peter Kovarik
Abstract: Methods and systems are provided for reducing the occurrence of unwanted electrical discharge when operating an electrospray ion source to generate ions for mass spectrometric analysis. In accordance with various aspects of the applicant's teachings, the methods and systems described herein can provide for controlling the ion emission current so as to limit the onset of avalanche of electrical discharge between the electrospray electrode and the counter electrode under ionization conditions that typically tend to increase the likelihood of such discharge (arcing), while nonetheless providing for maximal ionization efficiency. In various aspects, emission currents between the electrospray electrode and the counter electrode through which the ions are transmitted to a downstream mass analyzer can be maintained at elevated levels, below 10 μA, for example, without the electric potential between the electrospray electrode and the counter electrode initiating the electrical discharge avalanche that results from the dielectric break-down of the air gap therebetween, which can cause sputtering and effect the long-term operation of the ESI source.
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公开(公告)号：US20180369831A1
公开(公告)日：2018-12-27
申请号：US15779933
申请日：2016-11-29
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Don W. Arnold , Thomas R. Covey , Yves LeBlanc , Chang Liu , John L. Campbell
Abstract: Methods and apparatus for processing fluids are described. In various aspects, a fluid processing system may include a magnetic assembly that includes a plurality of magnetic structures configured to generate a magnetic field gradient within a fluid container. The magnetic structures may be formed as a plurality of electromagnets configured to be individually actuated by a controller. Each of the electromagnets may generate a magnetic field within the fluid container. The electromagnets may be differentially actuated to create a magnetic field gradient within the fluid container to agitate, mix, or otherwise influence magnetic particles disposed within the fluid container. Activation of the electromagnets of an electromagnetic structure may generate a magnetic field gradient that influences magnetic particles in an x-y direction. In addition, activation of the electromagnets of a plurality of electromagnetic structures may generate magnetic field gradients that influences magnetic particles in an x-y direction and z-direction.
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公开(公告)号：US10103015B2
公开(公告)日：2018-10-16
申请号：US15581172
申请日：2017-04-28
Inventor： Don W. Arnold , Thomas R. Covey , German Augusto Gomez Rios , Chang Liu , Janusz B. Pawliszyn
Abstract: Methods and systems for delivering a liquid sample to an ion source for the generation of ions and subsequent analysis by mass spectrometry are provided herein. In accordance with various aspects of the present teachings, MS-based systems and methods are provided in which a desorption solvent utilized in a sampling interface to desorb one or more analyte species from an SPME device is fluidly coupled to an ion source for ionizing the one or more analyte species desorbed into the desorption solvent for subsequent mass spectrometric analysis (e.g., without a liquid chromatography (LC) column between the sampling interface and the ion source). In accordance with various aspects of the methods and systems described herein, the configuration the sampling interface can be optimized so as to reduce the fluid volume dead space about the fluid inlet so as to concentrate the one or more analyte species desorbed at optimized conditions from the SPME substrate in a decreased volume of the desorption solvent when the SPME device is inserted into sampling interface.
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公开(公告)号：US09921183B2
公开(公告)日：2018-03-20
申请号：US15104954
申请日：2014-12-06
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Bradley B. Schneider , Hassan Javaheri , Thomas R. Covey
CPC classification number: G01N27/624 , H01J49/0031 , H01J49/063 , H01J49/066 , H01J49/24
Abstract: Differential mobility spectrometry is performed under vacuum. Ions generated in a high pressure region are received from the inlet orifice of a vacuum chamber using a first ion guide located in the vacuum chamber. The first ion guide focuses the generated ions on a DMS device inlet end using a plurality of tapered electrodes. The DMS device is coaxial and adjacent to the first ion guide. The DMS device separates the focused ions using a plurality of electrodes. The inscribed diameter at the DMS device inlet end is larger than the inscribed diameter at the first ion guide exit end to maximize ion transfer. The separated ions are received from the DMS device using a second ion guide coaxial and adjacent to the DMS device. The second ion guide focuses the separated ions on an exit orifice of the vacuum chamber using a plurality of tapered electrodes.
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