公开(公告)号：US10761030B2

公开(公告)日：2020-09-01

申请号：US14481264

申请日：2014-09-09

Applicant: Labrador Diagnostics LLC

Inventor： Elizabeth A. Holmes ,  Ian Gibbons ,  Timothy M. Kemp ,  John Howard ,  Shaunak Roy

IPC: G01N21/76 ,  B01L3/00 ,  G01N33/53 ,  A61B5/151 ,  A61B5/157 ,  A61B5/145 ,  A61B5/00 ,  G16H40/63 ,  A61B5/15 ,  G01N33/50 ,  A61B5/155 ,  G01N33/543 ,  A61B5/1495

Abstract: This invention is in the field of medical devices. Specifically, the present invention provides portable medical devices that allow real-time detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications.

公开(公告)号：US12209290B2

公开(公告)日：2025-01-28

申请号：US17319906

申请日：2021-05-13

Applicant: Labrador Diagnostics LLC

Inventor： Elizabeth A. Holmes ,  Timothy Smith ,  Samartha Anekal ,  James R. Wasson ,  Daniel L. Young ,  Chinmay Pangarkar

IPC: B01L3/00 ,  B01L7/00 ,  C12Q1/70 ,  G01N33/569

Abstract: In one embodiment, a method is provided comprising analyte testing on one or more types of samples.

公开(公告)号：US12059681B2

公开(公告)日：2024-08-13

申请号：US16524604

申请日：2019-07-29

Applicant: Labrador Diagnostics, LLC

Inventor： Clarissa Lui ,  Elizabeth A. Holmes

IPC: C12M3/00 ,  A61B10/00 ,  B01L3/00 ,  G01N1/02 ,  G01N1/10 ,  B01L1/00

CPC classification number: B01L3/508 ,  A61B10/0096 ,  B01L3/5029 ,  G01N1/02 ,  G01N1/10 ,  A61B10/007 ,  B01L1/52 ,  B01L2200/026 ,  B01L2200/10 ,  B01L2300/0627 ,  B01L2300/0832 ,  B01L2300/087 ,  B01L2300/123 ,  G01N2001/028

Abstract: Methods, devices, systems, and kits useful for the collection and analysis of samples obtained by swabs are disclosed. Swab containers configured for receiving a swab containing a sample; cartridges for holding one or more of: a swab container, a swab, assay units, pipette tips, vessels, transport units, and implements; systems (which may include a sample processing device); kits; and methods for their use are disclosed. A swab container may include an entry port; an assay chamber having an assay port; a conduit comprising an interior channel connecting the entry port; and an interior channel providing fluidic communication between the entry port and assay chamber. An interior channel may be configured to squeeze a portion of a swab placed in or through the conduit. A cartridge may include a cartridge frame configured to receive one or more of swab containers, assay units, transport units, pipette tips, vessels or implements.

公开(公告)号：US11644410B2

公开(公告)日：2023-05-09

申请号：US17135437

申请日：2020-12-28

Applicant: Labrador Diagnostics LLC

Inventor： Anthony J. Nugent ,  Daniel L. Young ,  Elizabeth A. Holmes ,  Michael Siegel ,  Ryan Wistort

IPC: G01N21/51 ,  G01N21/03 ,  B04B5/04 ,  G01N21/00 ,  B01L3/02 ,  G01N33/543 ,  H04N23/60 ,  C12Q1/42 ,  C12Q1/48 ,  C12Q1/6809 ,  C12Q1/689 ,  G01N21/59 ,  G01N33/569 ,  G01N33/573 ,  G01N33/74 ,  G01N33/80 ,  G06T3/40 ,  G06T7/00 ,  C12Q1/52 ,  C12Q1/6806 ,  G01N1/40 ,  G01N33/53 ,  G01N33/82 ,  G01N33/92 ,  G01N35/10 ,  G16C20/20 ,  G01N35/00

CPC classification number: G01N21/0303 ,  B01L3/0275 ,  B04B5/0421 ,  C12Q1/42 ,  C12Q1/48 ,  C12Q1/52 ,  C12Q1/6806 ,  C12Q1/689 ,  C12Q1/6809 ,  G01N1/4077 ,  G01N21/00 ,  G01N21/51 ,  G01N21/59 ,  G01N33/5308 ,  G01N33/54326 ,  G01N33/54393 ,  G01N33/56972 ,  G01N33/56983 ,  G01N33/573 ,  G01N33/74 ,  G01N33/743 ,  G01N33/80 ,  G01N33/82 ,  G01N33/92 ,  G01N35/10 ,  G06T3/4084 ,  G06T7/0002 ,  G06T7/0012 ,  H04N23/64 ,  B01L2300/168 ,  C12Q2600/158 ,  G01N2001/4083 ,  G01N2035/00495 ,  G01N2035/1018 ,  G01N2333/575 ,  G01N2333/62 ,  G01N2333/91188 ,  G01N2333/96463 ,  G06T2207/30004 ,  G06T2207/30168 ,  G16C20/20

Abstract: The present invention provides systems, devices, and methods for point-of-care and/or distributed testing services. The methods and devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device can be modified to allow for more flexible and robust use with the disclosed methods for a variety of medical, laboratory, and other applications. The systems, devices, and methods of the present invention can allow for effective use of samples by improved sample preparation and analysis.

公开(公告)号：US11524299B2

公开(公告)日：2022-12-13

申请号：US16712664

申请日：2019-12-12

Applicant: Labrador Diagnostics LLC

Inventor： Elizabeth A. Holmes ,  Joy Roy ,  John Kent Frankovich ,  Daniel L. Young ,  Timothy Smith ,  Chinmay Pangarkar ,  Samartha Anekal

IPC: G01N35/00 ,  B01L3/00 ,  G01N35/10 ,  B01L3/02 ,  B01L7/00 ,  B01L9/06

Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.

公开(公告)号：US11268130B2

公开(公告)日：2022-03-08

申请号：US16530322

申请日：2019-08-02

Applicant: Labrador Diagnostics LLC

Inventor： Douglas Matje ,  Ian Gibbons ,  Paul Patel ,  Elizabeth A. Holmes

IPC: C12Q1/60 ,  C12Q1/61 ,  G01N33/92 ,  C12Q1/26 ,  C12Q1/44

Abstract: Reagents, assays, methods, kits, devices, and systems for rapid measurement of cholesterol and cholesterol sub-fractions from a blood sample are provided. Total cholesterol, low density lipoprotein cholesterol, and high density lipoprotein cholesterol can be measured in a single assay using kinetic measurements, under conditions in which cholesterol sub-species are converted to a detectable product at distinct rates. The detectable product is measured at different times after assay initiation. A lipase, cholesterol esterase, cholesterol oxidase and a peroxidase may be used together to produce colored product in amounts directly proportional to the quantity of cholesterol converted. Methods for calculating very-low density lipoprotein cholesterol levels by further including triglyceride measurements are disclosed. Assays may be performed in a single reaction mixture, allowing more accurate and precise cholesterol determinations, including ratios of cholesterol sub-fractions to total cholesterol, at less expense, than would be expected by performing several different assays in different reaction mixtures.

公开(公告)号：US20220056501A1

公开(公告)日：2022-02-24

申请号：US17361802

申请日：2021-06-29

Applicant: Labrador Diagnostics LLC

Inventor： Alexander Loo ,  Elizabeth A. Holmes

IPC: C12Q1/04 ,  B01F11/02 ,  G01N1/28 ,  G01N1/38 ,  G01N35/00

Abstract: Devices, systems and methods including a sonicator for sample preparation are provided. A sonicator may be used to mix, resuspend, aerosolize, disperse, disintegrate, or de-gas a solution. A sonicator may be used to disrupt a cell, such as a pathogen cell in a sample. Sample preparation may include exposing pathogen-identifying material by sonication to detect, identify, or measure pathogens. A sonicator may transfer ultrasonic energy to the sample solution by contacting its tip to an exterior wall of a vessel containing the sample. Multipurpose devices including a sonicator also include further components for additional actions and assays. Devices, and systems comprising such devices, may communicate with a laboratory or other devices in a system for sample assay and analysis. Methods utilizing such devices and systems are provided. The improved sample preparation devices, systems and methods are useful for analyzing samples, e.g. for diagnosing patients suffering from infection by pathogens.

公开(公告)号：US20210318348A1

公开(公告)日：2021-10-14

申请号：US17236835

申请日：2021-04-21

Applicant: Labrador Diagnostics LLC

Inventor： Elizabeth A. Holmes ,  Daniel Young ,  Samartha Anekal ,  Timothy Smith ,  James R. Wasson ,  Chinmay Pangarkar

IPC: G01N35/04 ,  G01J3/28 ,  G01N15/14

Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.

公开(公告)号：US20210269859A1

公开(公告)日：2021-09-02

申请号：US17171951

申请日：2021-02-09

Applicant: Labrador Diagnostics LLC

Inventor： Elizabeth A. Holmes ,  Chandan Shee ,  Clarissa Lui

IPC: C12Q1/689 ,  C12Q1/04 ,  G01N33/53 ,  G01N33/569

Abstract: Systems and methods for determining pathogens and antimicrobial resistance of pathogens in a sample are provided.

公开(公告)号：US20210262940A1

公开(公告)日：2021-08-26

申请号：US17164032

申请日：2021-02-01

Applicant: Labrador Diagnostics LLC

Inventor： Ian Gibbons (deceased) ,  Chengwang Wang ,  Shaunak Roy ,  Elizabeth A. Holmes

IPC: G01N21/76 ,  B01L3/00 ,  G01N33/53 ,  A61B5/151 ,  A61B5/157 ,  A61B5/145 ,  A61B5/00 ,  G16H40/63 ,  A61B5/15 ,  G01N33/50 ,  A61B5/155 ,  G01N33/543

Abstract: The present invention provides methods of calibrating a fluidic device useful for detecting an analyte of interest in a bodily fluid. The invention also provides methods for assessing the reliability of an assay for an analyte in a bodily fluid with the use of a fluidic device. Another aspect of the invention is a method for performing a trend analysis on the concentration of an analyte in a subject using a fluidic device.