公开(公告)号：US20210125816A1

公开(公告)日：2021-04-29

申请号：US16604538

申请日：2018-04-11

Applicant: Micromass UK Limited

Inventor： Martin Raymond Green ,  Jason Lee Wildgoose ,  Keith Richardson

IPC: H01J49/00 ,  G01N30/72

Abstract: A method of mass spectrometry is disclosed comprising: a) providing temporally separated precursor ions; b) mass analyzing separated precursor ions, and/or product ions derived therefrom, during a plurality of sequential acquisition periods, wherein the value of an operational parameter of the spectrometer is varied during the different acquisition periods; c) storing the spectral data obtained in each acquisition period along with its respective value of the operational parameter; d) interrogating the stored spectral data and determining which of the spectral data for a precursor ion or product ions meets a predetermined criterion, and determining the value of the operational parameter that provides this mass spectral data as a target operational parameter value; and e) mass analyzing again the precursor or product ions whilst the operational parameter is set to the target operational parameter value.

公开(公告)号：US10861687B2

公开(公告)日：2020-12-08

申请号：US15568601

申请日：2016-04-25

Applicant: Micromass UK Limited

Inventor： Jason Lee Wildgoose ,  Keith Richardson ,  David J. Langridge ,  Martin Raymond Green ,  Steven Derek Pringle

IPC: H01J49/00 ,  H01J49/42 ,  G01N27/62

Abstract: A method is disclosed comprising: trapping ions in an ion trap (40); applying a first force on the ions within the ion trap in a first direction, said force having a magnitude that is dependent upon the value of a physicochemical property of the ions; applying a second force on these ions in the opposite direction so that the ions separate according to the physicochemical property value as a result of the first and second forces; and then pulsing or driving ions out of one or more regions of the ion trap.

公开(公告)号：US10777398B2

公开(公告)日：2020-09-15

申请号：US15555860

申请日：2016-03-07

Applicant: Micromass UK Limited

Inventor： Keith Richardson ,  Steven Derek Pringle ,  Julia Balog ,  Zoltan Takats

IPC: H01J49/00 ,  H01J49/04 ,  A61B10/02 ,  A61B17/32 ,  A61B18/00 ,  A61B18/14 ,  A61B18/20 ,  G01N3/00 ,  G01N9/00 ,  G01N33/68 ,  H01J49/06 ,  H01J49/16 ,  A61B90/13 ,  A61B1/04 ,  A61B1/273 ,  A61B5/00 ,  A61B5/01 ,  A61B5/05 ,  A61B5/055 ,  A61B6/03 ,  A61B8/13 ,  A61B10/00 ,  A61B17/00 ,  A61B18/04 ,  A61B18/18 ,  A61F13/38 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/24 ,  G01N1/22 ,  G01N27/62 ,  G01N30/72 ,  G01N33/487 ,  G01N33/92 ,  H01J49/02 ,  H01J49/10 ,  H01J49/14 ,  H01J49/26 ,  G16B20/00 ,  G16H10/40 ,  G16H15/00 ,  G16H50/20 ,  A61B1/00 ,  A61B1/31 ,  A61B5/145 ,  G06F19/00

Abstract: A method of spectrometric analysis comprises obtaining one or more sample spectra for an aerosol, smoke or vapour sample. The one or more sample spectra are subjected to pre-processing and then multivariate and/or library based analysis so as to classify the aerosol, smoke or vapour sample. The results of the analysis are used for various surgical or non-surgical applications.

公开(公告)号：US10727036B2

公开(公告)日：2020-07-28

申请号：US16093443

申请日：2017-04-13

Applicant: Micromass UK Limited

Inventor： Keith Richardson ,  Jason Lee Wildgoose

IPC: H01J49/02 ,  H01J49/00

Abstract: A method of mass spectrometry is disclosed comprising: performing a plurality of cycles of operation during a single experimental run, wherein each cycle comprises: mass selectively transmitting precursor ions of a single mass, or range of masses, through or out of a mass separator or mass filter at any given time, wherein the mass separator or mass filter is operated such that the single mass or range of masses transmitted therefrom is varied with time; operating the mass separator or filter in a wideband mode between at least some of said plurality of cycles, wherein in each wideband mode the mass separator or filter transmits ions in a non-mass resolving manner; and mass analysing ions.

公开(公告)号：US10600627B2

公开(公告)日：2020-03-24

申请号：US15314359

申请日：2015-05-29

Applicant: Micromass UK Limited

Inventor： Kevin Giles ,  David J. Langridge ,  Steven Derek Pringle ,  Keith Richardson ,  Jason Lee Wildgoose

IPC: H01J49/00 ,  H01J49/06 ,  G01N27/62 ,  H01J49/40

Abstract: A method of mass spectrometry is disclosed comprising separating ions temporally in a first device and analysing the mass or mass to charge ratio of the ions or of product or fragment ions derived from the ions in a mass or mass to charge ratio analyser disposed downstream of the first device. The method further comprises obtaining a first set of drift times for the ions through the first device by measuring ion arrival times and determining the transit time of the ions and/or of the product or fragment ions through one or more intermediate regions or devices disposed between the first device and the mass to charge ratio analyser. The method further comprises obtaining a second set of drift times for the ions through the first device by correcting the first set of drift times to account for the determined transit times.

公开(公告)号：US10593533B2

公开(公告)日：2020-03-17

申请号：US15776704

申请日：2016-11-16

Applicant: Micromass UK Limited ,  LECO CORPORATION

Inventor： John Brian Hoyes ,  Anatoly Verenchikov ,  Mikhail Yavor ,  Keith Richardson ,  Jason Wildgoose

IPC: H01J49/40 ,  H01J49/00 ,  H01J49/06

Abstract: A time-of-flight mass spectrometer is disclosed comprising: an ion deflector (305) configured to deflect ions to different positions in a first array of positions at different times; a position sensitive ion detector (187); and ion optics (180) arranged and configured to guide ions from the first array of positions to the position sensitive detector (187) so as to map ions from the first array of positions to a second array of positions on the position sensitive detector (187); wherein the ion optics includes at least one ion mirror for reflecting the ions.

公开(公告)号：US20200075307A1

公开(公告)日：2020-03-05

申请号：US16604852

申请日：2018-04-12

Applicant: Micromass UK Limited

Inventor： Martin Raymond Green ,  Jason Lee Wildgoose ,  Keith Richardson

IPC: H01J49/42

Abstract: A method of mass spectrometry is disclosed comprising: applying voltages to a mass filter or ion trap such that it is capable of transmitting or ejecting ions having mass to charge ratios within separate first and second mass to charge ratio windows; varying said voltages with time such that the first and second windows are moved simultaneously across different ranges of mass to charge ratio; detecting ions transmitted or ejected in the windows, or ions derived therefrom, with an ion detector; and deconvolving the resulting ion signal, wherein said deconvolving comprises: a) modelling an ion signal expected to be detected at the detector; b) comparing the model signal to the ion signal from the detector; and c) determining if the model signal matches the ion signal from the detector.

公开(公告)号：US20190214238A1

公开(公告)日：2019-07-11

申请号：US16093443

申请日：2017-04-13

Applicant: Micromass UK Limited

Inventor： Keith Richardson ,  Jason Lee Wildgoose

IPC: H01J49/00 ,  H01J49/02

CPC classification number: H01J49/0031 ,  H01J49/0009 ,  H01J49/004 ,  H01J49/005 ,  H01J49/0072 ,  H01J49/025

Abstract: A method of mass spectrometry is disclosed comprising: performing a plurality of cycles of operation during a single experimental run, wherein each cycle comprises: mass selectively transmitting precursor ions of a single mass, or range of masses, through or out of a mass separator or mass filter at any given time, wherein the mass separator or mass filter is operated such that the single mass or range of masses transmitted therefrom is varied with time; operating the mass separator or filter in a wideband mode between at least some of said plurality of cycles, wherein in each wideband mode the mass separator or filter transmits ions in a non-mass resolving manner; and mass analysing ions.

公开(公告)号：US10281426B2

公开(公告)日：2019-05-07

申请号：US15713884

申请日：2017-09-25

Applicant: Micromass UK Limited

Inventor： Martin Raymond Green ,  Keith Richardson ,  Jason Lee Wildgoose

IPC: G01N27/44 ,  G01N27/447 ,  H01J49/00 ,  G01N27/62 ,  H01J49/04

Abstract: A method of mass spectrometry or ion mobility spectrometry is disclosed in which analyte ions of a desired charge state are isolated. The method comprises: separating analytes according to their electrophoretic mobility; ionizing the analytes; and mass filtering the resulting analyte ions, wherein the mass to charge ratios of the ions transmitted by a mass filter are varied as a function of the electrophoretic mobility and according to a predetermined relationship such that substantially only ions having said desired charge state are transmitted by the mass filter.

公开(公告)号：US20190096654A1

公开(公告)日：2019-03-28

申请号：US16144580

申请日：2018-09-27

Applicant: Micromass UK Limited

Inventor： Martin Raymond Green ,  Keith Richardson ,  Jason Lee Wildgoose

IPC: H01J49/42 ,  H01J49/00 ,  G01N27/62

CPC classification number: H01J49/4215 ,  G01N27/622 ,  H01J49/0036 ,  H01J49/004 ,  H01J49/0045

Abstract: A mass spectrometer is disclosed comprising an ion mobility separation device for separating ions according to their ion mobility, a first quadrupole mass filter downstream of the ion mobility separation device, a control system arranged and adapted to scan and/or step the set mass of the first quadrupole mass filter a plurality of times over a first mass to charge ratio range of