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31.发明申请公开(公告)号：US20110211763A1
公开(公告)日：2011-09-01
申请号：US12931868
申请日：2011-02-11
Applicant: John Maier , Michael Fuhrman
Inventor： John Maier , Michael Fuhrman
CPC classification number: G01J3/02 , G01J3/0297 , G01J3/44 , G01N21/276 , G01N21/65 , G01N2201/1293
Abstract: A system and method for providing an instrument response correction. A sample is illuminated to generate a first plurality and a second plurality of interacted photons. The first plurality of interacted photons may be detected by a dispersive spectrometer to generate a reference spectrum representative of the sample. The second plurality of interacted photons may be passed through a tunable filter and detected using an imaging detector to generate at least one hyperspectral image. This hyperspectral image may comprise a Raman hyperspectral image or an infrared hyperspectral image. A system may comprise an illumination source, a collection optics, a dispersive spectrometer, a fiber optic, a tunable filter, and an imaging detector.
Abstract translation: 一种用于提供仪器响应校正的系统和方法。 照射样品以产生第一多个和第二多个相互作用的光子。 可以通过色散光谱仪检测第一组多个相互作用的光子，以产生代表样品的参考光谱。 可以将第二多个相互作用的光子通过可调滤光器并使用成像检测器进行检测，以产生至少一个高光谱图像。 该高光谱图像可以包括拉曼高光谱图像或红外光谱图像。 系统可以包括照明源，收集光学器件，分散光谱仪，光纤，可调谐滤光器和成像检测器。
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公开(公告)号：US08009289B2
公开(公告)日：2011-08-30
申请号：US12308258
申请日：2007-06-18
Applicant: Ute Cappel
Inventor： Ute Cappel
IPC: G01J3/40
CPC classification number: G01J3/44 , G01N21/65 , G01N2021/6423 , G01N2201/1293
Abstract: A spectroscopic analysis method in which spectral data of mixtures obtained from a plurality of points on a sample surface are resolved into component spectra and concentrations. A new alternating least squares multivariate curve resolution technique is presented which iteratively resolves the components. The technique starts from an initial estimate that the spectral values of a first component of the sample are all equal (an ‘empty model’), and resolves that component. Then successive further components are iteratively resolved, from initial ‘empty model’ estimates of those components and from previously resolved spectra. In the common case where the main component is present in nearly pure form in the data set, this empty modelling technique results in more accurate resolution of the components. This is due to the ability of the technique to resolve the pure spectra of minor components without modelling concentrations of the main component into them.
Abstract translation: 一种光谱分析方法，其中从样品表面上的多个点获得的混合物的光谱数据被分解成分量光谱和浓度。 提出了一种新的交替最小二乘法多元曲线分解技术，其迭代地解决了组件。 该技术从初始估计开始，即样本的第一分量的光谱值全部相等（“空模型”），并且解析该分量。 然后从这些组件的初始“空模型”估计和先前已解析的光谱中迭代地解析连续的其他组件。 在主要组件以数据集中几乎纯粹的形式存在的常见情况下，这种空建模技术可以更准确地分辨组件。 这是由于该技术能够解析次要组分的纯谱，而不对其中的主要成分进行模拟浓度。
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33.发明授权System and method for analyzing biological samples using Raman molecular imaging 有权使用拉曼分子成像分析生物样品的系统和方法公开(公告)号：US07990533B2
公开(公告)日：2011-08-02
申请号：US12834370
申请日：2010-07-12
Applicant: John Maier , Shona Stewart , Jeffrey Cohen
Inventor： John Maier , Shona Stewart , Jeffrey Cohen
CPC classification number: G01J3/10 , A61B5/0071 , A61B5/0075 , A61B5/417 , A61B5/7264 , G01J3/02 , G01J3/0291 , G01J3/0294 , G01J3/2823 , G01J3/32 , G01J3/44 , G01J2003/2826 , G01N21/65 , G01N21/658 , G01N2021/656 , G01N2201/1293 , G01N2201/1296 , G02B21/365 , G06F19/00 , G16H50/70
Abstract: A system and method for determining at least one of: a disease state, a metabolic state, a clinical outcome, and a disease progression of a test renal or prostate sample. A test Raman data set is obtained from the sample wherein said test Raman data set may comprise at least one of a plurality of Raman spectra and a plurality of spatially accurate wavelength resolved Raman images. The test Raman data set is compared to a plurality of reference Raman data sets using a chemometric technique. For analysis of renal samples, each of these reference Raman data sets may have an associated known renal sample and an associated known metabolic state, clinical outcome, and/or disease progression. For analysis of prostate samples, each of these reference Raman data sets may have an associated known prostate sample and an associated known disease state, metabolic state, clinical outcome, and/or disease progression.
Abstract translation: 用于确定测试的肾或前列腺样品的疾病状态，代谢状态，临床结果和疾病进展中的至少一个的系统和方法。 从样品获得测试拉曼数据集，其中所述测试拉曼数据集可以包括多个拉曼光谱和多个空间上准确的波长分辨拉曼图像中的至少一个。 使用化学计量技术将测试拉曼数据集与多个参考拉曼数据集进行比较。 对于肾样品的分析，这些参考拉曼数据集中的每一个可以具有相关联的已知肾样品和相关联的已知代谢状态，临床结果和/或疾病进展。 对于前列腺样品的分析，这些参考拉曼数据集中的每一个可以具有相关联的已知前列腺样品和相关的已知疾病状态，代谢状态，临床结果和/或疾病进展。
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公开(公告)号：US20110087470A1
公开(公告)日：2011-04-14
申请号：US12740941
申请日：2008-10-31
Applicant: Bonnie Hames , Tanya Kruse , Steven R. Thomas , Amr Saad Ragab
Inventor： Bonnie Hames , Tanya Kruse , Steven R. Thomas , Amr Saad Ragab
CPC classification number: G06F19/12 , G01N21/3563 , G01N21/359 , G01N2021/8466 , G01N2201/1293
Abstract: Methods and materials for measuring the composition of plant biomass and predicting the efficiency of conversion of such biomass to various end products under various processing conditions are disclosed. For example, methods and materials for identifying plant material having higher levels of accessible carbohydrate, as well as materials and methods for processing plant material having higher levels of accessible carbohydrate are disclosed. Also disclosed are computer-implemented methods and systems that provide improved economic efficiencies to biorefineries.
Abstract translation: 公开了用于测量植物生物量的组成并预测在各种加工条件下将这种生物质转化成各种最终产品的效率的方法和材料。 例如，公开了用于鉴定具有较高水平的可接近的碳水化合物的植物材料的方法和材料，以及用于处理具有较高水平的可接近的碳水化合物的植物材料的材料和方法。 还公开了为生物炼制提供改进的经济效率的计算机实现的方法和系统。
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35.发明申请Multimodal Spectroscopic Systems and Methods for Classifying Biological Tissue 有权用于分类生物组织的多峰光谱系统和方法公开(公告)号：US20100330611A1
公开(公告)日：2010-12-30
申请号：US12882131
申请日：2010-09-14
Applicant: Mary-Ann Mycek , Malavika Chandra , James Scheiman , Robert H. Wilson , Diane Simeone , Barbara McKenna , Julianne Purdy , Jeremy Taylor , Oliver Lee
Inventor： Mary-Ann Mycek , Malavika Chandra , James Scheiman , Robert H. Wilson , Diane Simeone , Barbara McKenna , Julianne Purdy , Jeremy Taylor , Oliver Lee
CPC classification number: A61B5/415 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/418 , A61B5/7264 , A61B5/7267 , G01J3/10 , G01J3/4406 , G01N21/474 , G01N21/6408 , G01N21/645 , G01N21/6486 , G01N33/57438 , G01N2021/4742 , G01N2021/6484 , G01N2201/1293
Abstract: Multimodal optical spectroscopy systems and methods produce a spectroscopic event to obtain spectroscopic response data from biological tissue and compare the response data with an empirical equation configured to correlate the measured response data and the most probable attributes of the tissue, thus facilitating classification of the tissue based on those attributes for subsequent biopsy or remedial measures as necessary.
Abstract translation: 多光谱光谱系统和方法产生光谱事件以从生物组织获得光谱响应数据，并将响应数据与配置为将测量的响应数据和组织的最可能属性相关联的经验方程进行比较，从而促进基于组织的分类 关于随后活检的这些属性或必要的补救措施。
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Patent Agency Ranking
36.发明申请System and Method for Analyzing Biological Samples Using Raman Molecular Imaging 有权使用拉曼分子成像分析生物样品的系统和方法公开(公告)号：US20100280762A1
公开(公告)日：2010-11-04
申请号：US12834370
申请日：2010-07-12
Applicant: John Maier , Shona Stewart , Jeffrey Cohen
Inventor： John Maier , Shona Stewart , Jeffrey Cohen
CPC classification number: G01J3/10 , A61B5/0071 , A61B5/0075 , A61B5/417 , A61B5/7264 , G01J3/02 , G01J3/0291 , G01J3/0294 , G01J3/2823 , G01J3/32 , G01J3/44 , G01J2003/2826 , G01N21/65 , G01N21/658 , G01N2021/656 , G01N2201/1293 , G01N2201/1296 , G02B21/365 , G06F19/00 , G16H50/70
Abstract: A system and method for determining at least one of: a disease state, a metabolic state, a clinical outcome, and a disease progression of a test renal or prostate sample. A test Raman data set is obtained from the sample wherein said test Raman data set may comprise at least one of a plurality of Raman spectra and a plurality of spatially accurate wavelength resolved Raman images. The test Raman data set is compared to a plurality of reference Raman data sets using a chemometric technique. For analysis of renal samples, each of these reference Raman data sets may have an associated known renal sample and an associated known metabolic state, clinical outcome, and/or disease progression. For analysis of prostate samples, each of these reference Raman data sets may have an associated known prostate sample and an associated known disease state, metabolic state, clinical outcome, and/or disease progression.
Abstract translation: 用于确定测试的肾或前列腺样品的疾病状态，代谢状态，临床结果和疾病进展中的至少一个的系统和方法。 从样品获得测试拉曼数据集，其中所述测试拉曼数据集可以包括多个拉曼光谱和多个空间上准确的波长分辨拉曼图像中的至少一个。 使用化学计量技术将测试拉曼数据集与多个参考拉曼数据集进行比较。 对于肾样品的分析，这些参考拉曼数据集中的每一个可以具有相关联的已知肾样品和相关联的已知代谢状态，临床结果和/或疾病进展。 对于前列腺样品的分析，这些参考拉曼数据集中的每一个可以具有相关联的已知前列腺样品和相关的已知疾病状态，代谢状态，临床结果和/或疾病进展。
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公开(公告)号：US07785258B2
公开(公告)日：2010-08-31
申请号：US11316523
申请日：2005-12-21
Applicant: James R. Braig , Peter Rule
Inventor： James R. Braig , Peter Rule
CPC classification number: G06F19/3468 , A61B5/14532 , A61B5/14546 , A61B5/14557 , A61B5/1486 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61B5/4839 , A61M5/14212 , A61M2230/20 , G01N21/274 , G01N21/35 , G01N2201/1293 , G06F19/00
Abstract: In certain embodiments, a method of maintaining health of a patient uses an analyte detection system. The analyte detection system is coupled to the patient such that a bodily fluid of the patient is accessible to the analyte detection system. The method includes automatically initiating and conducting a measurement of an analyte in the bodily fluid using the analyte detection system. The method further includes determining a treatment dose for the patient based on the measurement using the analyte detection system.
Abstract translation: 在某些实施例中，维持患者健康的方法使用分析物检测系统。 分析物检测系统耦合到患者，使得患者的体液可被分析物检测系统访问。 该方法包括使用分析物检测系统自动启动和进行体液中的分析物的测量。 该方法还包括基于使用分析物检测系统的测量确定患者的治疗剂量。
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公开(公告)号：US20100182600A1
公开(公告)日：2010-07-22
申请号：US12513265
申请日：2007-11-01
Applicant: Robert P. Freese , Terrell K. Teague , David L. Perkins , William J. Soltmann
Inventor： Robert P. Freese , Terrell K. Teague , David L. Perkins , William J. Soltmann
IPC: G01J3/28
CPC classification number: G01J3/4338 , G01J3/02 , G01J3/0205 , G01J3/021 , G01J3/0264 , G01N21/255 , G01N21/31 , G01N21/35 , G01N21/3563 , G01N21/4738 , G01N2021/1793 , G01N2201/0691 , G01N2201/0693 , G01N2201/1293
Abstract: An optical analysis system includes a light source configured to radiate a first light along a first ray path; a modulator disposed in the first ray path, the modulator configured to modulate the first light to a desired frequency; a spectral element disposed proximate the modulator, the spectral element configured to filter the first light for a spectral range of interest of a sample; a cavity in communication with the spectral element, the cavity configured to direct the first light in a direction of the sample; a conical mirror configured to convert the first light reflecting from the sample into a second light, the cavity being further configured to direct the second light; a beamsplitter configured to split the second light into a first beam and a second beam; an optical filter mechanism disposed to receive the first beam, the optical filter mechanism configured to optically filter data carried by the first beam into at least one orthogonal component of the first beam; a first detector mechanism in communication with the optical filter mechanism to measure a property of the orthogonal component to measure the data; a second detector mechanism configured to receive the second beam for comparison of the property of the orthogonal component to the second beam; an accelerometer configured to control the data acquisition such that only detector signals during the period of time when the system is in the proper orientation such that the material sample (e.g., aspirin) is in proximity to the interrogation window are used for calculation; a computer having a data acquisition and conversion card, the computer disposed in the system in communication with the first and second detector mechanisms for signal processing; and a battery and charging system disposed in the system in electrical communication with the system to provide stand-alone operation capability.
Abstract translation: 光学分析系统包括被配置为沿第一射线路径辐射第一光的光源; 调制器，设置在第一射线路径中，调制器被配置为将第一光调制到期望的频率; 设置在所述调制器附近的光谱元件，所述光谱元件被配置为过滤所述第一光以获得样品的感兴趣的光谱范围; 与所述光谱元件连通的空腔，所述空腔被配置为沿所述样品的方向引导所述第一光; 锥形镜，被配置为将从样品反射的第一光转换成第二光，所述空腔进一步构造成引导第二光; 分束器，被配置为将所述第二光分成第一光束和第二光束; 滤光器机构，设置成接收第一光束，滤光器机构被配置为将由第一光束承载的数据光学滤波成第一光束的至少一个正交分量; 与所述光学滤波器机构通信以测量所述正交分量的属性以测量所述数据的第一检测器机构; 第二检测器机构，其被配置为接收所述第二光束，用于将所述正交分量的属性与所述第二光束进行比较; 加速度计被配置为控制数据采集，使得仅在系统处于正确定向的时间段内的检测器信号才能使材料样品（例如阿司匹林）接近询问窗口进行计算; 具有数据获取和转换卡的计算机，所述计算机设置在与所述第一和第二检测器机构通信以进行信号处理的系统中; 以及设置在系统中与系统电连通以提供独立操作能力的电池和充电系统。
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39.发明授权公开(公告)号：US07755757B2
公开(公告)日：2010-07-13
申请号：US12206467
申请日：2008-09-08
Applicant: John Maier , Jeffrey Cohen , Shona Stewart
Inventor： John Maier , Jeffrey Cohen , Shona Stewart
CPC classification number: G01J3/10 , A61B5/0071 , A61B5/0075 , A61B5/417 , A61B5/7264 , G01J3/02 , G01J3/0291 , G01J3/0294 , G01J3/2823 , G01J3/32 , G01J3/44 , G01J2003/2826 , G01N21/65 , G01N21/658 , G01N2021/656 , G01N2201/1293 , G01N2201/1296 , G02B21/365 , G06F19/00 , G16H50/70
Abstract: A system and method to provide a diagnosis of the renal disease state of a test renal sample. A database containing a plurality of reference Raman data sets is provided where each reference Raman data set has an associated known renal sample and an associated known renal disease state. A test renal sample is irradiated with substantially monochromatic light to generate scattered photons resulting in a test Raman data set. The test Raman data set is compared to the plurality of reference Raman data sets using a chemometric technique. Based on the comparison, a diagnosis of a renal disease state of the test renal sample is provided. The renal disease state includes renal oncocytoma or chromophobe renal carcinoma disease state.
Abstract translation: 一种用于提供测试肾脏样本的肾脏疾病状态诊断的系统和方法。 提供了包含多个参考拉曼数据集的数据库，其中每个参考拉曼数据集具有相关联的已知肾脏样本和相关联的已知肾病状态。 用基本单色光照射测试肾脏样品，以产生散射光子，得到测试拉曼数据集。 使用化学计量技术将测试拉曼数据集与多个参考拉曼数据集进行比较。 基于比较，提供了测试肾脏样本的肾脏疾病状态的诊断。 肾脏疾病状态包括肾细胞瘤或发色团肾癌疾病状态。
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40.发明申请公开(公告)号：US20100042348A1
公开(公告)日：2010-02-18
申请号：US11721368
申请日：2005-12-12
Applicant: Bernardus Leonardus Gerardus BAKKER
Inventor： Bernardus Leonardus Gerardus BAKKER
CPC classification number: G01N21/65 , G01J3/28 , G01N21/276 , G01N2021/1748 , G01N2201/1293
Abstract: The invention provides a method of calibrating an optical analysis system that makes use of multivariate optical signal analysis allowing to realize cost-efficient and robust implementation of a spectral analysis of an optical signal. The calibration method makes use of determining a parameter of a reference sample by means of the optical analysis system and comparing the actually determined parameter with a reference parameter that represents a precise and real property of the reference sample. Based on this comparison a calibration value can be determined that is applicable to perform a calibration of the optical analysis system with respect to at least one compound or analyte of the reference sample. Parameters and reference parameters of a reference sample may refer to a concentration of an analyte dissolved in the sample, or to spectroscopic background signals that have to be taken into account when performing a spectral analysis based on optical signals obtained from the reference sample. Various different reference samples providing a reference with respect to different acquisition conditions and different analyte or compound concentrations can be universally used. Analyte-specific reference data is preferably stored in a calibration unit of the optical analysis system and allows a high degree of automation of the calibration process.
Abstract translation: 本发明提供了一种校准光学分析系统的方法，其利用多变量光信号分析，从而实现光信号的光谱分析的成本有效且鲁棒的实现。 校准方法利用通过光学分析系统确定参考样本的参数，并将实际确定的参数与表示参考样本的精确和不变性的参考参数进行比较。 基于该比较，可以确定适用于相对于参考样品的至少一种化合物或分析物执行光学分析系统的校准的校准值。 参考样品的参数和参考参数可以指溶解在样品中的分析物的浓度，或者基于从参考样品获得的光学信号进行光谱分析时必须考虑的光谱背景信号。 可以普遍使用提供关于不同采集条件和不同分析物或化合物浓度的参考的各种不同参考样品。 分析物特异性参考数据优选地存储在光学分析系统的校准单元中，并允许校准过程的高度自动化。
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