公开(公告)号：US20230018482A1

公开(公告)日：2023-01-19

申请号：US17951682

申请日：2022-09-23

Applicant: Cardiac Pacemakers, Inc.

Inventor： Joseph T. Delaney ,  Andrew J. Ro ,  David R. Wulfman ,  Niraj Gurung ,  Patrick Willoughby

IPC: C08G18/62 ,  C08G18/48 ,  A61L31/14 ,  C08G18/76 ,  A61L31/12 ,  C08G18/40 ,  C08G18/12 ,  A61L29/04 ,  C08G18/83 ,  C08G18/28 ,  A61L31/04 ,  A61L27/16

Abstract: A polymeric material includes a polyisobutylene-polyurethane block copolymer. The polyisobutylene-polyurethane block copolymer includes soft segments, hard segments, and end groups. The soft segments include a polyisobutylene diol residue. The hard segments include a diisocyanate residue. The end groups are bonded by urea bonds to a portion of the diisocyanate residue. The end groups include a residue of a mono-functional amine.

公开(公告)号：US11472911B2

公开(公告)日：2022-10-18

申请号：US16248498

申请日：2019-01-15

Applicant: Cardiac Pacemakers, Inc.

Inventor： Joseph T. Delaney, Jr. ,  Andrew J. Ro ,  David R. Wulfman ,  Niraj Gurung ,  Patrick Willoughby

IPC: C08G18/28 ,  C08G18/62 ,  C08G18/48 ,  A61L31/14 ,  C08G18/76 ,  A61L31/12 ,  C08G18/40 ,  C08G18/12 ,  A61L29/04 ,  C08G18/83 ,  A61L31/04 ,  A61L27/16

Abstract: A polymeric material includes a polyisobutylene-polyurethane block copolymer. The polyisobutylene-polyurethane block copolymer includes soft segments, hard segments, and end groups. The soft segments include a polyisobutylene diol residue. The hard segments include a diisocyanate residue. The end groups are bonded by urea bonds to a portion of the diisocyanate residue. The end groups include a residue of a mono-functional amine.

公开(公告)号：US10518004B2

公开(公告)日：2019-12-31

申请号：US15843673

申请日：2017-12-15

Applicant: Cardiac Pacemakers, Inc.

Inventor： Mary M. Byron ,  David R. Wulfman ,  Angelo Fruci ,  Adam McGraw ,  Danielle Frankson ,  Gregory J. Sherwood ,  Joseph T. Delaney, Jr. ,  Adeniyi O. Aremu

IPC: A61L31/16 ,  A61L31/14 ,  A61L31/04 ,  A61N1/05 ,  D01D5/00

Abstract: An implantable drug eluting medical device includes a polymer substrate having a surface, a first plurality of nanofibers, and at least one antimicrobial drug. Each of the first plurality of nanofibers includes a first portion interpenetrated with the surface of the substrate to mechanically fix the nanofiber to the substrate, and a second portion projecting from the surface. The at least one antimicrobial drug is disposed within or among the second portion of the first plurality of nanofibers.

公开(公告)号：US20190184158A1

公开(公告)日：2019-06-20

申请号：US16269845

申请日：2019-02-07

Applicant: Cardiac Pacemakers, Inc.

Inventor： Gregory J. Sherwood ,  Mary M. Byron ,  David R. Wulfman

IPC: A61N1/36 ,  A61L31/14 ,  A61M5/142 ,  A61L29/14 ,  A61L29/06 ,  A61L31/16 ,  A61N1/05 ,  A61N1/375 ,  A61N1/39 ,  A61N1/362 ,  A61L31/06 ,  A61L29/16

CPC classification number: A61N1/36 ,  A61L29/06 ,  A61L29/146 ,  A61L29/148 ,  A61L29/16 ,  A61L31/06 ,  A61L31/146 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/404 ,  A61L2300/604 ,  A61M5/14276 ,  A61N1/05 ,  A61N1/362 ,  A61N1/375 ,  A61N1/3968 ,  C08L67/04

Abstract: A method of preventing infection resulting from implanting a medical device. The method includes installing a polymer device at least substantially within a subcutaneous pocket formed to contain a housing of the medical device, and installing the medical device housing in the subcutaneous pocket. The polymer device includes a bioresorbable polymer structure and an antimicrobial agent configured to elute from the polymer structure. The polymer device covers less than about 20% of the surface area of the medical device housing.

公开(公告)号：US20190054204A1

公开(公告)日：2019-02-21

申请号：US16104069

申请日：2018-08-16

Applicant: Cardiac Pacemakers, Inc.

Inventor： Joseph T. Delaney, JR. ,  David R. Wulfman ,  Patrick Willoughby ,  Andrew J. Ro

IPC: A61L27/18 ,  C08J3/24 ,  C08G81/02

Abstract: A block copolymer including a plurality of polymeric chains and a plurality of cross-linking compound residues linking together the plurality of polymeric chains. The plurality of polymeric chains forms a plurality of hard domains and a plurality of soft domains. Each polymeric chain includes a plurality of soft segments and a plurality of hard segments. The plurality of soft segments includes a polyisobutylene diol or diamine residue. The plurality of soft segments forms the plurality of soft domains. The plurality of hard segments including a diisocyanate residue. The plurality of hard segments forms the plurality of hard domains. The cross-linking compound residues link together the hard segments of the plurality of polymeric chains.

公开(公告)号：US20180043056A1

公开(公告)日：2018-02-15

申请号：US15673274

申请日：2017-08-09

Applicant: Cardiac Pacemakers, Inc.

Inventor： Danielle Frankson ,  Joseph T. Delaney, JR. ,  David R. Wulfman ,  Adam McGraw ,  Sarah M. Gruba

IPC: A61L27/12 ,  A61L27/54 ,  A61L27/04

CPC classification number: A61L27/12 ,  A61F2/86 ,  A61L27/04 ,  A61L27/047 ,  A61L27/06 ,  A61L27/34 ,  A61L27/54 ,  A61L2300/102 ,  A61L2300/214 ,  A61L2300/404 ,  A61L2300/412 ,  C08L71/02

Abstract: A coating for a metal surface, the coating including poly(ethylene glycol) disposed on and covalently bonded directly to at least a portion of the metal surface, and a functional group grafted to at least a portion of the poly(ethylene glycol). The functional group is one of a bioactive functional group and an antimicrobial functional group.

公开(公告)号：US20170360987A1

公开(公告)日：2017-12-21

申请号：US15624102

申请日：2017-06-15

Applicant: Cardiac Pacemakers, Inc.

Inventor： Danielle Frankson ,  Joseph T. Delaney, JR. ,  Mary M. Byron ,  Adam McGraw ,  David R. Wulfman ,  Kylee M. Lersch

IPC: A61L27/34 ,  C09D5/16 ,  C09D123/06

CPC classification number: A61L27/34 ,  A61L27/04 ,  A61L27/06 ,  A61L31/022 ,  A61L31/10 ,  A61L2400/18 ,  A61L2420/02 ,  C09D5/1681 ,  C09D123/06 ,  C08L71/02

Abstract: A coating for a roughened metal surface of an implantable medical device includes a poly(ethylene glycol) disposed on at least a portion of the roughened metal surface, wherein the poly(ethylene glycol) is covalently bonded directly to the roughened metal surface.

公开(公告)号：US20160367800A1

公开(公告)日：2016-12-22

申请号：US15185398

申请日：2016-06-17

Applicant: Cardiac Pacemakers, Inc.

Inventor： Gregory J. Sherwood ,  Mary M. Byron ,  David R. Wulfman

IPC: A61N1/36 ,  A61N1/39 ,  A61L31/06 ,  A61N1/375 ,  A61L31/14 ,  A61L31/16 ,  A61N1/362 ,  A61M5/142

CPC classification number: A61N1/36 ,  A61L29/06 ,  A61L29/146 ,  A61L29/148 ,  A61L29/16 ,  A61L31/06 ,  A61L31/146 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/404 ,  A61L2300/604 ,  A61M5/14276 ,  A61N1/05 ,  A61N1/362 ,  A61N1/375 ,  A61N1/3968 ,  C08L67/04

Abstract: A polymer device configured to be implanted into a subcutaneous pocket to prevent infection, the pocket formed to contain an implantable medical device housing. The polymer device includes a structure made of a bioresorbable polymer, and an antimicrobial agent configured to elute from the structure. The polymer device is configured to cover less than about 20% of the surface area of the implantable medical device housing when implanted into the subcutaneous pocket.

Abstract translation: 一种被配置成植入皮下袋以防止感染的聚合物装置，所述袋形成为容纳可植入医疗装置壳体。 聚合物装置包括由生物可再吸收聚合物制成的结构，以及被配置为从该结构洗脱的抗微生物剂。 聚合物装置被配置为当植入到皮下袋中时，覆盖可植入医疗装置壳体的表面积的小于约20％。

公开(公告)号：US20160311983A1

公开(公告)日：2016-10-27

申请号：US15097806

申请日：2016-04-13

Applicant: Cardiac Pacemakers, Inc.

Inventor： Joseph T. Delaney, JR. ,  David R. Wulfman ,  Adeniyi Aremu ,  Adegbola O. Adenusi

IPC: C08J3/09 ,  A61L31/10

CPC classification number: C08J3/09 ,  A61L27/34 ,  A61L29/085 ,  A61L31/10 ,  A61L2420/02 ,  A61L2420/06 ,  C08G18/4854 ,  C08J3/092 ,  C08J3/095 ,  C08J2323/22 ,  C08J2375/04 ,  C08J2375/08 ,  C09D123/22 ,  C09D175/08 ,  C08L23/22

Abstract: A method of making a solution including a block copolymer includes dissolving the block copolymer in a solvent mixture to form a solution, the solvent mixture including at least two solvent components. The solubility of the block copolymer in the solvent mixture is at least about 7 wt. % at about 64° C. The solvent mixture is non-reactive with the block copolymer. The solubility of the block copolymer in a single solvent solution consisting of any one of the at least two solvent components and the block copolymer is not greater than about 1 wt. % at about 64° C. The block copolymer includes polyisobutylene segments and polyurethane segments.

Abstract translation: 制备包含嵌段共聚物的溶液的方法包括将嵌段共聚物溶解在溶剂混合物中以形成溶液，溶剂混合物包括至少两种溶剂组分。 嵌段共聚物在溶剂混合物中的溶解度为至少约7wt。 ％，约64℃。溶剂混合物与嵌段共聚物不反应。 嵌段共聚物在由至少两种溶剂组分和嵌段共聚物中的任一种组成的单一溶剂溶液中的溶解度不大于约1wt。 ％。嵌段共聚物包括聚异丁烯链段和聚氨酯链段。

公开(公告)号：US20160158531A1

公开(公告)日：2016-06-09

申请号：US15043679

申请日：2016-02-15

Applicant: Cardiac Pacemakers, Inc.

Inventor： David R. Wulfman ,  Rahul K. Rajgarhia ,  David J. Smith ,  Tolga Tas ,  Daniel J. Cooke ,  Christopher R. Perrey

IPC: A61N1/05 ,  B29C59/02 ,  B29C47/02

CPC classification number: A61N1/05 ,  B29C47/025 ,  B29C59/02 ,  B29K2995/0005 ,  B29K2995/0007 ,  B29K2995/0072 ,  B29L2031/3462 ,  B29L2031/7546 ,  H01R43/16 ,  Y10T29/49174

Abstract: Described is a medical device lead including a lead body having a conductor lumen including an inner surface. The lead also includes a conductor assembly extending through the conductor lumen; the conductor assembly comprising a conductor member and an outer insulative layer; and an electrode coupled to the conductor cable. The outer insulative layer includes a textured external surface that reduces the coefficient of friction between the outer insulative layer and the inner surface of the conductor lumen through which the conductor assembly extends. Methods of forming the conductor assembly are also described.

Abstract translation: 描述了一种医疗装置引线，其包括具有包括内表面的导体内腔的引线本体。 引线还包括延伸穿过导体管腔的导体组件; 所述导体组件包括导体构件和外绝缘层; 以及耦合到导体电缆的电极。 外部绝缘层包括织构化的外表面，其减小了外部绝缘层与导体组件延伸通过的导体内腔的内表面之间的摩擦系数。 还描述了形成导体组件的方法。