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公开(公告)号：US20180117175A1
公开(公告)日：2018-05-03
申请号：US15691340
申请日：2017-08-30
Applicant: Northwestern University
Inventor： Chad A. Mirkin , David A. Giljohann , Weston L. Daniel , Joshua I. Cutler , Ke Zhang , Dan Zheng
CPC classification number: A61K47/6923 , A61K47/6933 , A61K49/0002 , A61K49/0093 , A61K51/1251 , B82Y5/00 , B82Y15/00 , C12N15/88 , C12Q1/6876 , G01N33/588
Abstract: The present disclosure is directed to compositions comprising templated nanoconjugates and methods of their use.
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公开(公告)号：US20180059550A1
公开(公告)日：2018-03-01
申请号：US15693942
申请日：2017-09-01
Applicant: NORTHWESTERN UNIVERSITY
Inventor： Chad A. Mirkin , Xing Liao , Keith A. Brown , Guoliang Liu , Abrin L. Schmucke , Shu He , Wooyoung Shim , Daniel J. Eichelsdoerfer , Boris Rasin
CPC classification number: G03F7/7035 , B05D1/26 , B05D3/06 , B82Y40/00 , G02B13/143 , G03F7/0002 , G03F7/20 , G03F7/2049 , G03F7/70141 , G03F7/70325 , G03F7/70383 , G03F7/7045
Abstract: In accordance with an embodiment of the disclosure, a tip array can include an elastomeric tip substrate layer comprising a first surface and an oppositely disposed second surface, the tip substrate layer being formed from an elastomeric material; a plurality of tips fixed to the first surface, the tips each comprising a tip end disposed opposite the first surface, the tips having a radius of curvature of less than about 1 micron; and an array of heaters disposed on the second surface of the tip substrate layer and configured such that when the tip substrate layer is heated by a heater, a tip disposed in a location of a heated portion of tip substrate layer is lowered relative to a tip disposed in a location of an unheated portion of the tip substrate layer.
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公开(公告)号：US09757475B2
公开(公告)日：2017-09-12
申请号：US14865848
申请日：2015-09-25
Applicant: NORTHWESTERN UNIVERSITY
Inventor： Chad A. Mirkin , David A. Giljohann , Weston L. Daniel , Joshua I. Cutler , Ke Zhang , Dan Zheng
CPC classification number: A61K47/6923 , A61K47/6933 , A61K49/0002 , A61K49/0093 , A61K51/1251 , B82Y5/00 , B82Y15/00 , C12N15/88 , C12Q1/6876 , G01N33/588
Abstract: The present disclosure is directed to compositions comprising templated nanoconjugates and methods of their use.
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公开(公告)号：US20170232109A1
公开(公告)日：2017-08-17
申请号：US15502955
申请日：2015-08-19
Applicant: NORTHWESTERN UNIVERSITY
Inventor： Chad A. Mirkin , Jeffrey D. Brodin
IPC: A61K48/00 , C12N9/96 , C12N9/08 , C12N9/38 , A61K38/44 , C12P19/02 , C12P19/14 , A61K38/47 , C12P3/00 , A61K47/48 , A61K49/00
CPC classification number: C12Y111/01006 , A61K38/44 , A61K38/47 , A61K47/549 , A61K47/6921 , B82Y5/00 , C12N9/0065 , C12N9/2471 , C12N9/96 , C12P3/00 , C12P19/02 , C12P19/14 , C12Y302/01023 , Y02P20/582
Abstract: The present disclosure is directed to core-shell nanoparticles, compositions comprising core-shell nanoparticles, and methods of their use.
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公开(公告)号：US20170115558A1
公开(公告)日：2017-04-27
申请号：US15299565
申请日：2016-10-21
Applicant: NORTHWESTERN UNIVERSITY
Inventor： Chad A. Mirkin , Keith A. Brown , James L. Hedrick, III
CPC classification number: G03F7/0002 , C23C16/402
Abstract: Provided here are hard transparent polymer pen arrays, methods of printing indicia using the same, and methods of preparing the same.
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Patent Agency Ranking
公开(公告)号：US20170044544A1
公开(公告)日：2017-02-16
申请号：US15337674
申请日：2016-10-28
Applicant: NORTHWESTERN UNIVERSITY
Inventor： Chad A. Mirkin , David A. Giljohann
IPC: C12N15/113
CPC classification number: C12N15/113 , A61K47/6923 , B82Y5/00 , C07H1/00 , C07H21/00 , C12N2310/11 , C12N2310/351
Abstract: Disclosed are nanoparticles functionalized with an oligonucleotide and a domain, wherein the domain increases cellular uptake of the nanoparticles. The domain is a sequence of nucleobases or phosphate groups, such as a poly thymidine (polyT) sequence or a phosphate polymer (C3 residue) and may be located 5′ to the oligonucleotide 3′ to the oligonucleotide, within, or colinear with the oligonucleotide. Usage of the nanoparticles including modulating gene regulation is contemplated.
Abstract translation: 公开了用寡核苷酸和结构域功能化的纳米颗粒，其中该结构域增加纳米颗粒的细胞摄取。 该结构域是核碱基或磷酸基团的序列，例如多胸苷（polyT）序列或磷酸酯聚合物（C3残基），并且可以与寡核苷酸在寡核苷酸3'位置5'连接，或与寡核苷酸共线 。 预期使用纳米颗粒，包括调节基因调控。
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47.发明申请公开(公告)号：US20160159834A1
公开(公告)日：2016-06-09
申请号：US14785867
申请日：2014-04-22
Applicant: NORTHWESTERN UNIVERSITY
Inventor： Andrew Lee , Chad A. Mirkin , Colin Michael Calabrese , Natalia Chernyak , Evelyn Auyeung
IPC: C07F9/24 , C12N15/113 , C07H19/10
CPC classification number: C07F9/2408 , A61K9/14 , A61K9/5115 , C07F9/2412 , C07F9/2458 , C07F9/65586 , C07H19/073 , C07H19/10 , C07H21/00 , C07H21/04 , C12N15/111 , C12N15/113 , C12N15/87 , C12N2310/3515 , C12N2310/3519
Abstract: The present disclosure is directed to compositions comprising alkyne oligonucleotides, nanoconjugates prepared from the same, and methods of their use.
Abstract translation: 本公开涉及包含炔烃寡核苷酸，由其制备的纳结合物及其使用方法的组合物。
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48.发明授权公开(公告)号：US09216155B2
公开(公告)日：2015-12-22
申请号：US14215569
申请日：2014-03-17
Applicant: Northwestern University
Inventor： C. Shad Thaxton , Chad A. Mirkin , Kaylin M. McMahon , Sushant Tripathy , Raja Kannan Mutharasan , David M. Leander , Andrea Luthi
IPC: A61K9/127 , C12N15/113 , A61K31/7088 , A61K31/713 , A61K31/7105 , A61K47/48 , B82Y5/00 , C12N15/87 , A61K9/51 , C12N15/11
CPC classification number: A61K9/127 , A61K9/1271 , A61K9/5115 , A61K9/5123 , A61K31/7088 , A61K47/544 , A61K47/554 , A61K47/6917 , A61K47/6923 , B82Y5/00 , C12N15/111 , C12N15/87 , C12N2310/113 , C12N2310/3515 , C12N2320/32
Abstract: Articles, compositions, kits, and methods relating to nanostructures, including synthetic nanostructures, are provided. Certain embodiments described herein include structures having a core-shell type arrangement; for instance, a nanostructure core may be surrounded by a shell including a material, such as a lipid bilayer, and may include other components such as oligonucleotides. In some embodiments, the structures, when introduced into a subject, can be used to deliver nucleic acids and/or can regulate gene expression. Accordingly, the structures described herein may be used to diagnose, prevent, treat or manage certain diseases or bodily conditions. In some cases, the structures are both a therapeutic agent and a diagnostic agent.
Abstract translation: 提供了与纳米结构相关的制品，组合物，试剂盒和方法，包括合成纳米结构。 本文描述的某些实施例包括具有核 - 壳型布置的结构; 例如，纳米结构核心可以被包括诸如脂双层的材料的壳包围，并且可以包括其它成分如寡核苷酸。 在一些实施方案中，当引入受试者时，结构可用于递送核酸和/或可调节基因表达。 因此，本文所述的结构可用于诊断，预防，治疗或管理某些疾病或身体状况。 在一些情况下，结构既是治疗剂又是诊断剂。
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49.发明申请公开(公告)号：US20150259680A1
公开(公告)日：2015-09-17
申请号：US14614111
申请日：2015-02-04
Applicant: NORTHWESTERN UNIVERSITY
Inventor： Chad A. Mirkin , Nathaniel L. Rosi , C. Shad Thaxton , David A. Giljohann
IPC: C12N15/113 , A61K31/7088 , A61K47/48
CPC classification number: C12N15/113 , A61K9/5115 , A61K31/7088 , A61K47/6923 , A61K47/6929 , B82Y5/00 , C12N15/111 , C12N2310/11 , C12N2310/314 , C12N2310/315 , C12N2310/3181 , C12N2310/351 , C12N2320/32
Abstract: Materials and methods for regulating gene expression using nanoparticles functionalized with antisense oligonucleotides are provided.
Abstract translation: 提供了使用用反义寡核苷酸官能化的纳米粒子调节基因表达的材料和方法。
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公开(公告)号：US20150210868A1
公开(公告)日：2015-07-30
申请号：US14419360
申请日：2013-09-06
Applicant: NORTHWESTERN UNIVERSITY
Inventor： Chad A. Mirkin , Guoliang Liu , Daniel J. Eichelsdoerfer , Keith A. Brown
CPC classification number: C09D11/10 , B05D1/005 , B05D1/02 , B05D1/18 , B05D1/28 , B05D3/007 , B22F1/00 , B22F1/0018 , B22F9/20 , B81C1/00111 , B81C2201/0149 , B82Y40/00 , C08K3/22 , C09D11/037 , C09D11/52 , C23C18/06 , C23C18/08
Abstract: A method of forming a nanostructure on a substrate surface can include heating a substrate comprising a composition comprising a block copolymer and a nanostructure precursor to a temperature above the glass transition temperature of the block copolymer and below the decomposition temperature of the block copolymer to aggregate the nanostructure precursor to form a nanostructure precursor aggregated composition. The method can further include heating the nanostructure precursor aggregated composition to a temperature above the decomposition temperature of the nanostructure precursor to decompose the polymer and form the nanostructure.
Abstract translation: 在衬底表面上形成纳米结构的方法可以包括将包含嵌段共聚物和纳米结构前体的组合物的衬底加热至高于嵌段共聚物的玻璃化转变温度的温度并且低于嵌段共聚物的分解温度以聚集 纳米结构前体形成纳米结构前体聚集组合物。 该方法还可以包括将纳米结构前体凝集组合物加热至高于纳米结构前体分解温度的温度以分解聚合物并形成纳米结构。
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