公开(公告)号：US20190257980A1

公开(公告)日：2019-08-22

申请号：US16398607

申请日：2019-04-30

Applicant: Novartis AG

Inventor： Xinming Qian ,  Frank Chang ,  Yasuo Matsuzawa ,  Venkat Shankar

IPC: G02B1/04 ,  A61F2/14 ,  A61F2/16 ,  A61F9/007 ,  A61L12/04 ,  A61L27/18 ,  A61L27/34 ,  C08L83/04

Abstract: The invention is related to a medical device comprising a core material made of a crosslinkined silicone material and a hydrogel coating which is thermodynamically stable. The invention is also related to a method for producing such a medical device, especially a soft contact lens.

公开(公告)号：US10324233B2

公开(公告)日：2019-06-18

申请号：US15249577

申请日：2016-08-29

Applicant: Novartis AG

Inventor： Xinming Qian ,  Frank Chang ,  Yasuo Matsuzawa ,  Venkat Shankar

IPC: G02B1/04 ,  A61F2/14 ,  A61F2/16 ,  A61F9/007 ,  A61L12/04 ,  A61L27/18 ,  A61L27/34 ,  C08L83/04

Abstract: The invention is related to a medical device comprising a core material made of a crosslinked silicone material and a hydrogel coating which is thermodynamically stable. The invention is also related to a method for producing such a medical device, especially a soft contact lens.

公开(公告)号：US20190177460A1

公开(公告)日：2019-06-13

申请号：US16278304

申请日：2019-02-18

Applicant: Novartis AG

Inventor： Jinyu Huang ,  Frank Chang ,  Steve Yun Zhang ,  Feng Jing

IPC: C08F290/06 ,  C08G77/392 ,  C08G77/16 ,  G02B1/04 ,  C08G77/20

Abstract: The invention provides a hydrophilized polydiorganosiloxane vinylic crosslinker which comprises (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and hydrophilized siloxane units each having one methyl substituent and one monovalent C4-C40 organic radical substituent having two to six hydroxyl groups, wherein the molar ratio of the hydrophilized siloxane units to the dimethylsiloxane units is from about 0.035 to about 0.15, and (2) two terminal (meth)acryloyl groups. The hydrophilized polydiorganosiloxane vinylic crosslinker has a number average molecular weight of from about 3000 Daltons to about 80,000 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a hydrophilized polydiorganosiloxane vinylic crosslinker of the invention.

公开(公告)号：US10253112B2

公开(公告)日：2019-04-09

申请号：US15434101

申请日：2017-02-16

Applicant: Novartis AG

Inventor： Frank Chang ,  Troy Vernon Holland ,  Xinming Qian ,  Robert Scott ,  Joseph Michael Lindacher ,  Uwe Haken

IPC: C08F2/48 ,  A61F2/16 ,  G02B1/04

Abstract: The invention is related to a method for producing silicone medical devices, in particular, silicone contact lenses, having consistent mechanical properties in a cost-effective manner. The invention is also related to a silicone medical device, especially a soft silicone contact lens.

公开(公告)号：US20180346753A1

公开(公告)日：2018-12-06

申请号：US16057867

申请日：2018-08-08

Applicant: Novartis AG

Inventor： Troy Vernon Holland ,  Frank Chang ,  Yongxing Qiu ,  John Dallas Pruitt ,  Chung-Yuan Chiang ,  Venkat Shankar ,  Robert Scott ,  Yash Kapoor

IPC: C09D133/24 ,  C09D139/04 ,  C08F283/12 ,  C07D205/04 ,  C08F220/54 ,  C08F220/56 ,  C08F224/00 ,  C08F20/00 ,  C09D133/26 ,  C09D137/00 ,  B29D11/00 ,  C08F26/00 ,  C09D151/08

CPC classification number: C09D133/24 ,  B29D11/00865 ,  C07D205/04 ,  C08F20/00 ,  C08F26/00 ,  C08F220/54 ,  C08F220/56 ,  C08F224/00 ,  C08F283/124 ,  C08F2500/26 ,  C09D133/26 ,  C09D137/00 ,  C09D139/04 ,  C09D151/085

Abstract: The invention is related to azetidinium-containing copolymers and vinylic monomers and their uses in formation of non-silicone hydrogel coatings on silicone hydrogel contact lenses.

公开(公告)号：US20180113237A1

公开(公告)日：2018-04-26

申请号：US15792807

申请日：2017-10-25

Applicant: Novartis AG

Inventor： Frank Chang ,  Feng Jing ,  Fei Cheng ,  Ying Zheng

IPC: G02B1/04 ,  C08G77/20 ,  C08G77/28 ,  C08L83/08 ,  C08J3/075 ,  C08L25/06 ,  C08L33/10

CPC classification number: G02B1/043 ,  B29D11/00038 ,  B29D11/00134 ,  C08F283/122 ,  C08F285/00 ,  C08F290/142 ,  C08F299/08 ,  C08G77/20 ,  C08G77/28 ,  C08G2210/00 ,  C08J3/075 ,  C08J3/247 ,  C08J2383/08 ,  C08L25/06 ,  C08L33/10 ,  C08L83/08 ,  C08L2205/02 ,  C08L83/04 ,  C08F2222/108 ,  C08F2220/286 ,  C08F226/10

Abstract: The invention provides a class of amphiphilic branched polydiorganosiloxane macromers and the uses thereof. Such a macromer comprises a polydiorganosiloxane polymer chain and two terminal groups free of any ethylenically unsaturated group, wherein the polydiorganosiloxane polymer chain comprises (1) at least 5 dimethylsiloxane units in a consecutive sequence, (2) at least two first siloxane units each having methyl as one of the two substituents of each first siloxane unit and one first first organic radical having one sole (meth)acryloyl group as the other substituent, (3) at least one second siloxane unit having methyl as one of the two substituents of the second siloxane unit and one second organic radical, which is free of any ethylenically unsaturated group and comprises one or more hydrophilic groups or polymer chains, as the other substituent.

公开(公告)号：US09950483B2

公开(公告)日：2018-04-24

申请号：US14289046

申请日：2014-05-28

Applicant: Novartis AG

Inventor： Xinming Qian ,  Frank Chang ,  Troy Vernon Holland ,  Yongxing Qiu ,  Venkat Shankar

IPC: G02B1/04 ,  C23C14/54 ,  C23C16/52 ,  B29D11/00

CPC classification number: B29D11/00865 ,  B29D11/00951 ,  G02B1/043 ,  C08L83/04 ,  C08L101/14 ,  C08L33/26

Abstract: The invention is related to a method for qualifying and quantifying carboxyl groups on the surfaces of a silicone hydrogel contact lens. The method of the invention comprises the steps of: (a) obtaining silicone hydrogel contact lenses each of which comprises a silicone hydrogel lens body (i.e., bulk material) and a coating thereon, wherein the silicone hydrogel lens body is obtained from a lens formulation free of any polymerizable component including one or more carboxyl groups, wherein the coating comprises a polymer having carboxyl groups; (b) immersing a given number of the silicone hydrogel contact lenses in a fixed volume of a C1-C4 alcohol solution of a positively-charged dye having acetate as counter anion at a given initial concentration for a time period sufficient to stain the silicone hydrogel contact lens; and (c) determining the concentration of carboxyl groups per each silicone hydrogel contact lens and/or the thickness of the coating on the silicone hydrogel contact lens.

公开(公告)号：US20180105619A1

公开(公告)日：2018-04-19

申请号：US15730780

申请日：2017-10-12

Applicant: Novartis AG

Inventor： Frank Chang ,  Troy Vernon Holland ,  Thomas M. Moy

IPC: C08F28/02 ,  C08F22/38 ,  C08F20/56

CPC classification number: C08F28/02 ,  C08F2/38 ,  C08F8/34 ,  C08F20/56 ,  C08F22/38 ,  C08F220/56 ,  C08F230/02 ,  C08F2810/20 ,  G02B1/04 ,  C08L43/02

Abstract: The invention is related to a class of hydrophilic polymers each comprising one sole thiol-containing terminal group. The hydrophilic polymers are highly reactive towards azetidinium groups of an azetidinium-containing polymer upon heating and can find particular use in for producing water-soluble highly-branched hydrophilic polymeric material useful for producing water gradient contact lenses.

公开(公告)号：US20170293050A1

公开(公告)日：2017-10-12

申请号：US15633999

申请日：2017-06-27

Applicant: Novartis AG

Inventor： Frank Chang ,  Troy Vernon Holland

IPC: G02B1/04 ,  C08G73/02 ,  C09D5/00 ,  C08G73/06 ,  C09D179/02 ,  G02C7/04 ,  C08J3/24

CPC classification number: G02B1/043 ,  A61L27/14 ,  A61L27/50 ,  A61L2430/16 ,  B05D5/00 ,  B29D11/00048 ,  B29D11/00125 ,  B29D11/00865 ,  C07D205/04 ,  C08G73/022 ,  C08G73/0226 ,  C08G73/0233 ,  C08G73/06 ,  C08J3/247 ,  C08J2379/02 ,  C09D5/00 ,  C09D179/02 ,  C09D179/04 ,  G02B1/10 ,  G02C7/049 ,  G02C2202/16 ,  C08L101/14 ,  C08L33/08 ,  C08L83/04

Abstract: The invention is related to poly(2-oxazoline-co-ethyleneimine)-epichlorohydrin copolymers and chemically-modified derivatives thereof as well as their uses in formation of non-silicone hydrogel coatings on silicone hydrogel contact lenses.

公开(公告)号：US20170254927A1

公开(公告)日：2017-09-07

申请号：US15598652

申请日：2017-05-18

Applicant: Novartis AG

Inventor： Jinyu Huang ,  Frank Chang

IPC: G02B1/04 ,  C07F9/09 ,  C08F230/08 ,  C08G77/38 ,  C08G77/388 ,  C08G77/392 ,  C08G77/395 ,  C08G77/50

CPC classification number: G02B1/043 ,  C07F7/1804 ,  C07F9/09 ,  C07F9/092 ,  C08F230/08 ,  C08F283/124 ,  C08G77/20 ,  C08G77/38 ,  C08G77/388 ,  C08G77/392 ,  C08G77/395 ,  C08G77/50 ,  C08L101/14 ,  C08L83/04 ,  C08L83/14 ,  C08L33/10

Abstract: The invention provides a hydrophilized carbosiloxane vinylic monomer which comprises (1) a poly(carbosiloxane) segment, (2) one sole ethylenically unsaturated group, and (3) at least one terminal or pendant group which is a hydrophilic group or hydrophilic polymer chain. The present invention is also related to a polymer, an actinically-crosslinkable silicone-containing prepolymer, a silicone hydrogel polymeric material, or a silicone hydrogel contact lens, which comprises monomeric units derived from a hydrophilized carbosiloxane vinylic monomer of the invention.