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    AMPHIPHILIC POLYSILOXANE PREPOLYMERS AND USES THEREOF
    44.
    发明申请
    AMPHIPHILIC POLYSILOXANE PREPOLYMERS AND USES THEREOF 有权
    聚硅氧烷聚合物预聚物及其用途

    公开(公告)号：US20150153482A1

    公开(公告)日：2015-06-04

    申请号：US14617310

    申请日：2015-02-09

    Applicant: Novartis AG

    Inventor： Frank Chang ,  Robert Scott ,  Jinyu Huang ,  Arturo N. Medina ,  Dawn A. Smith ,  Laura A. Sanders ,  John Dallas Pruitt

    IPC: G02B1/04 ,  C08G77/388

    CPC classification number: G02B1/043 ,  C08F290/068 ,  C08G77/388 ,  C08G77/458 ,  C08G2210/00 ,  C08L2205/02 ,  C08L83/04 ,  C08L51/085 ,  C08L101/14 ,  C08F220/56 ,  C08F220/28

    Abstract: The present invention provides an amphiphilic polysiloxane prepolymer which comprises hydrophilic monomeric units derived from at least one hydrophilic vinylic monomer, polysiloxane crosslinking units derived from at least one polysiloxane crosslinker having at least two terminal ethylenically-unsaturated groups, dangling polysiloxane chains each of which is terminated with one ethylenically unsaturated group, and chain-transfer units derived from a chain transfer agent other than a RAFT agent. A prepolymer of the invention is suitable for making hydrogel contact lenses. The present invention is also related to hydrogel contact lenses made from an amphiphilic polysiloxane prepolymer of the invention and to processes for preparing an amphiphilic polysiloxane prepolymer of the invention and for making silicone hydrogel contact lenses.

    Abstract translation: 本发明提供一种两亲性聚硅氧烷预聚物，其包含衍生自至少一种亲水乙烯基单体的亲水性单体单元，衍生自至少一种具有至少两个末端烯属不饱和基团的聚硅氧烷交联剂的聚硅氧烷交联单元，悬浮聚硅氧烷链各自被终止 具有一个烯键式不饱和基团，以及衍生自除RAFT试剂之外的链转移剂的链转移单元。 本发明的预聚物适用于制备水凝胶隐形眼镜。 本发明还涉及由本发明的两亲聚硅氧烷预聚物制成的水凝胶隐形眼镜以及制备本发明的两亲性聚硅氧烷预聚物和制备硅酮水凝胶隐形眼镜的方法。

    SILICONE HYDROGEL LENS WITH A CROSSLINKED HYDROPHILIC COATING
    45.
    发明申请
    SILICONE HYDROGEL LENS WITH A CROSSLINKED HYDROPHILIC COATING 有权
    硅胶水晶镜片，带有交联胶粘剂

    公开(公告)号：US20150099822A1

    公开(公告)日：2015-04-09

    申请号：US14571350

    申请日：2014-12-16

    Applicant: Novartis AG

    Inventor： Yongxing Qiu ,  Newton T. Samuel ,  John Dallas Pruitt ,  Chandana Kolluru ,  Arturo Norberto Medina ,  Lynn Cook Winterton ,  Daqing Wu ,  Xinming Qian ,  Jared Nelson

    IPC: G02B1/10 ,  G02B1/04

    CPC classification number: C09D177/06 ,  B29D11/00067 ,  C08G77/388 ,  C08J5/00 ,  C08J7/042 ,  C08J2383/04 ,  C08J2383/08 ,  C08J2433/02 ,  C08J2433/26 ,  C08J2487/00 ,  C08L83/04 ,  C09D5/1637 ,  C09D5/1681 ,  C09D133/02 ,  C09D133/14 ,  C09D133/26 ,  C09D171/02 ,  G02B1/043 ,  G02B1/10 ,  G02B1/18 ,  G02C7/049 ,  G02C2202/06 ,  G02C2202/16 ,  C08L101/14

    Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.

    Abstract translation: 本发明涉及制备其上具有交联亲水性涂层的硅氧水凝胶隐形眼镜的成本有效的方法。 本发明的方法涉及在具有带正电荷的氮杂环丁烷基团的水溶性，高度支化，热交联的亲水性聚合物材料存在下，在约40℃的温度下，在水溶液中加热硅酮水凝胶隐形眼镜 在约140℃下进行足够的时间以将可热交联的亲水聚合物材料共价连接到硅氧烷水凝胶隐形眼镜的表面上，通过共价连接，每个共价键在一个氮杂环丁烷基团和一个反应性官能团之间形成， 和/或靠近硅酮水凝胶隐形眼镜的表面，从而在硅氧水凝胶隐形眼镜上形成交联的亲水涂层。 这种方法可以有利地在高压釜中直接在密封的透镜包装中实现。

    METHOD FOR APPLYING A COATING ONTO A SILICONE HYDROGEL LENS
    46.
    发明申请
    METHOD FOR APPLYING A COATING ONTO A SILICONE HYDROGEL LENS 有权
    将涂层涂覆在硅胶水镜上的方法

    公开(公告)号：US20140174031A1

    公开(公告)日：2014-06-26

    申请号：US14101640

    申请日：2013-12-10

    Applicant: Novartis AG

    Inventor： Yongxing Qiu ,  Arturo Norberto Medina ,  John Dallas Pruitt

    IPC: G02C7/04 ,  B65B55/02

    CPC classification number: G02C7/04 ,  B29D11/00865 ,  B65B55/02 ,  G02B1/043 ,  C08L83/04 ,  C08L101/14

    Abstract: The present invention generally relates to a method for applying a coating of hydrophilic polymers onto silicone hydrogel contact lenses to improve hydrophilicity and lubricity. In particular, the present invention is directed to a method for forming a coating on a contact lens, preferably a silicone hydrogel contact lens, directly in the primary package and maintaining the coated contact lens within said primary package until insertion of the coated contact lens in the eye of the contact lens user. The resultant silicone hydrogel contact lens has a coating with good hydrophilicity, improved lubricity and good durability and also can be used directly from the lens package by a patient without washing and/or rising.

    Abstract translation: 本发明一般涉及将亲水性聚合物涂层涂覆在硅氧水凝胶隐形眼镜上以改善亲水性和润滑性的方法。 特别地，本发明涉及一种在初级包装中直接形成隐形眼镜，优选硅酮水凝胶隐形眼镜上的涂层的方法，并将涂覆的隐形眼镜保持在所述初级包装内，直到将涂覆的隐形眼镜插入 隐形眼镜用户的眼睛。 所得的硅酮水凝胶隐形眼镜具有亲水性好，润滑性好，耐久性好的涂层，也可以由患者直接从镜片包装中使用而无需洗涤和/或上升。

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