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    SYSTEMS AND METHODS FOR SELECTIVE DETECTION AND IMAGING IN COHERENT RAMAN MICROSCOPY BY SPECTRAL-TEMPORAL EXCITATION SHAPING
    41.
    发明申请
    SYSTEMS AND METHODS FOR SELECTIVE DETECTION AND IMAGING IN COHERENT RAMAN MICROSCOPY BY SPECTRAL-TEMPORAL EXCITATION SHAPING 有权
    通过光谱激发成像在相干拉曼显微镜中选择性检测和成像的系统和方法

    公开(公告)号：US20100188496A1

    公开(公告)日：2010-07-29

    申请号：US12690579

    申请日：2010-01-20

    Applicant: Xiaoliang Sunney Xie ,  Christian Freudiger ,  Wei Min

    Inventor： Xiaoliang Sunney Xie ,  Christian Freudiger ,  Wei Min

    IPC: H04N7/18

    CPC classification number: G02B21/002 ,  G01J3/10 ,  G01J3/44 ,  G01J2003/1282 ,  G01N21/65 ,  G01N2021/653 ,  G01N2021/655 ,  G01N2201/0675 ,  G02B21/082

    Abstract: A microscopy imaging system is disclosed that includes a light source system, a spectral shaper, a modulator system, an optics system, an optical detector and a processor. The light source system is for providing a first train of pulses and a second train of pulses. The spectral shaper is for spectrally modifying an optical property of at least some frequency components of the broadband range of frequency components such that the broadband range of frequency components is shaped producing a shaped first train of pulses to specifically probe a spectral feature of interest from a sample, and to reduce information from features that are not of interest from the sample. The modulator system is for modulating a property of at least one of the shaped first train of pulses and the second train of pulses at a modulation frequency. The optical detector is for detecting an integrated intensity of substantially all optical frequency components of a train of pulses of interest transmitted or reflected through the common focal volume. The processor is for detecting a modulation at the modulation frequency of the integrated intensity of substantially all of the optical frequency components of the train of pulses of interest due to the non-linear interaction of the shaped first train of pulses with the second train of pulses as modulated in the common focal volume, and for providing an output signal for a pixel of an image for the microscopy imaging system.

    Abstract translation: 公开了一种显微镜成像系统，其包括光源系统，光谱整形器，调制器系统，光学系统，光学检测器和处理器。 光源系统用于提供第一脉冲串和第二脉冲串。 频谱整形器用于频谱修改频率分量的宽带范围的至少一些频率分量的光学特性，使得频率分量的宽带范围成形，产生成形的第一脉冲串，从而特别地探测来自 样本，并从样本中不感兴趣的特征中减少信息。 调制器系统用于以调制频率调制成形的第一脉冲序列和第二脉冲串中的至少一个的性质。 光学检测器用于检测通过公共焦点体积传输或反射的感兴趣的脉冲串的基本上所有的光学频率分量的积分强度。 处理器用于检测由于成形的第一脉冲序列与第二脉冲串的非线性相互作用而导致的感兴趣的脉冲串的基本上所有的光学频率分量的积分强度的调制频率的调制 在公共焦点体积中调制，并且为显微镜成像系统提供用于图像的像素的输出信号。

    Illumination Sources and Customizable Spectral Profiles
    44.
    发明申请
    Illumination Sources and Customizable Spectral Profiles 有权
    照明光源和可定制的光谱曲线

    公开(公告)号：US20100085563A1

    公开(公告)日：2010-04-08

    申请号：US12605103

    申请日：2009-10-23

    Applicant: Carl W. Dirk

    Inventor： Carl W. Dirk

    IPC: G01J3/00

    CPC classification number: G01J3/10 ,  G01J3/46 ,  G01J3/462 ,  G01J3/465 ,  G01J2001/0276 ,  G01J2003/1282 ,  G02B27/0012

    Abstract: Methods for generating a customized spectral profile, which can be used to generate a corresponding filter, lamp or other type of illuminant. A trial spectrum can be generated. A reference spectrum can be determined or otherwise obtained. A SOURCE spectrum can be determined or otherwise obtained. One or more optical indices can be calculated using the trial spectrum and one or more of the optical indices are optimized by varying the trial spectrum to generate the customized spectral profile. A radiation force parameter can be used to minimize unsafe build-up of light in spectral regions. Adaptations of color rendering parameters can be used in the optimization process. Smoothing parameters can be used to enable easier design of filter structures. A reflectance camera can be used to measure reflectance data at one or more pixels of a digital representation of an object to be illuminated.

    Abstract translation: 用于产生可用于生成相应的过滤器，灯或其他类型的光源的定制光谱轮廓的方法。 可以生成试验光谱。 可以确定或以其他方式获得参考光谱。 可以确定或以其他方式获得SOURCE光谱。 可以使用试验光谱计算一个或多个光学折射率，并且通过改变试验光谱来优化一个或多个光学折射率以产生定制的光谱分布。 可以使用辐射力参数来最小化在光谱区域内的光的不安全积累。 显色参数的适应可以在优化过程中使用。 平滑参数可用于实现滤波器结构的简化设计。 可以使用反射相机来测量被照射物体的数字表示的一个或多个像素处的反射率数据。

    Optical instrument and parts thereof for optimally defining light pathways
    46.
    发明授权
    Optical instrument and parts thereof for optimally defining light pathways 失效
    光学仪器及其部件，用于最佳地定义光通路

    公开(公告)号：US07557925B2

    公开(公告)日：2009-07-07

    申请号：US11504187

    申请日：2006-08-15

    Applicant: Jon K. Nisper ,  Michael J. Mater ,  Bernard J. Berg

    Inventor： Jon K. Nisper ,  Michael J. Mater ,  Bernard J. Berg

    IPC: G01J3/51

    CPC classification number: G01J3/10 ,  G01J3/02 ,  G01J3/0213 ,  G01J3/0264 ,  G01J3/0272 ,  G01J3/0275 ,  G01J3/0289 ,  G01J3/0291 ,  G01J3/26 ,  G01J3/28 ,  G01J3/50 ,  G01J3/501 ,  G01J3/51 ,  G01J3/513 ,  G01J3/524 ,  G01J2003/1213 ,  G01J2003/1282 ,  G01J2003/2866 ,  G01J2003/467

    Abstract: An optical assembly is disclosed that includes an illumination source, a detection sensor, a monitor sensor, and an optical piece having a first side adapted to face a sample. The optical piece defines an illumination channel extending from the illumination source toward the first side, a detection channel extending from the first side toward the detection sensor, and a monitor channel extending from the illumination channel toward the monitor sensor. A spectrophotometer is also disclosed that includes a circuit board, illumination source and one or more sensors. The circuit board includes an optically transparent region, wherein the illumination source is mounted and situated relative to a first surface of the circuit board, so as to direct light through the optically transparent region. Each sensor is mounted and situated relative to a second surface of the circuit board opposite the first surface.

    Abstract translation: 公开了一种光学组件，其包括照明源，检测传感器，监视器传感器和具有适于面向样品的第一侧的光学片。 光学片限定从照明源向第一侧延伸的照明通道，从第一侧向检测传感器延伸的检测通道，以及从照明通道向监视传感器延伸的监视通道。 还公开了一种分光光度计，其包括电路板，照明源和一个或多个传感器。 电路板包括光学透明区域，其中相对于电路板的第一表面安装和定位照明源，以便将光引导通过光学透明区域。 每个传感器相对于与第一表面相对的电路板的第二表面安装和定位。

    METHOD AND ARRANGEMENT FOR CHANGING THE SPECTRAL COMPOSITION AND/OR INTENSITY OF ILLUMINATION LIGHT AND/OR SPECIMEN LIGHT IN AN ADJUSTABLE MANNER
    49.
    发明申请
    METHOD AND ARRANGEMENT FOR CHANGING THE SPECTRAL COMPOSITION AND/OR INTENSITY OF ILLUMINATION LIGHT AND/OR SPECIMEN LIGHT IN AN ADJUSTABLE MANNER 有权
    改变荧光灯和/或样品光的光谱组成和/或强度的方法和装置

    公开(公告)号：US20080049221A1

    公开(公告)日：2008-02-28

    申请号：US11833761

    申请日：2007-08-03

    Applicant: RALF WOLLESCHENSKY

    Inventor： RALF WOLLESCHENSKY

    IPC: G02B21/06

    CPC classification number: G01N15/1434 ,  G01J3/02 ,  G01J3/0224 ,  G01J3/0229 ,  G01J3/10 ,  G01J3/4406 ,  G01J3/447 ,  G01J2003/1282 ,  G01J2003/1286 ,  G01N21/6445 ,  G01N21/6458 ,  G01N2015/0065 ,  G01N2015/149 ,  G01N2015/1493 ,  G02B21/002

    Abstract: Method and arrangement for changing the spectral composition and/or intensity of illumination light and/or specimen light in an adjustable manner, wherein a spatial separation into radiation components of different polarization is carried out with a first polarizing device, a spectral, spatial splitting of at least one radiation component is carried out with first dispersion device, the polarization state of at least one part of the spectrally spatially split radiation component is changed, and a spatial separation and/or combination of radiation components of different polarization are/is carried out by a second polarizing device, wherein a spatial combination of radiation components which are changed and not changed with respect to their polarization state is advantageously carried out by a second dispersion device.

    Abstract translation: 用于以可调节的方式改变照明光和/或标本光的光谱组成和/或强度的方法和装置，其中利用第一偏振装置，光谱，空间分裂进行不同偏振的辐射分量的空间分离 使用第一分散装置执行至少一个辐射分量，改变光谱空间分裂的辐射分量的至少一部分的偏振状态，并且执行不同极化的辐射分量的空间分离和/或组合 通过第二偏振装置，其中通过第二分散装置有利地进行相对于它们的偏振状态改变而不改变的辐射分量的空间组合。

    RGB primary color point identification system and method
    50.
    发明授权
    RGB primary color point identification system and method 有权

    公开(公告)号：US06992803B2

    公开(公告)日：2006-01-31

    申请号：US09851099

    申请日：2001-05-08

    Applicant: Chin Chang

    Inventor： Chin Chang

    IPC: H04N1/46

    CPC classification number: G01J1/32 ,  G01J3/10 ,  G01J3/465 ,  G01J3/506 ,  G01J3/51 ,  G01J3/513 ,  G01J2001/4252 ,  G01J2003/1282

    Abstract: A system and method for identifying primary color chromaticity coordinates of a red, green and blue light sources includes a tristimulus filter the receives the combined light generated by the light sources. The light sources are preferably a group of red, green and blue light emitting diodes. A processor is configured to generate a plurality of test control signals that sets a desired intensity value for each of the red, green and blue LEDs. Based on these test control signals, the system is configured to measure three sets of chromaticity coordinates corresponding to the combined light generated by these red, green and blue LEDs. The processor thereafter calculates the color chromaticity coordinates of the LEDs, based on the measured coordinates of the combined light, and the intensity values of the LEDs, and the intensity values of the combined light. This calculation in accordance with one embodiment of the invention is accomplished by solving a matrix equation. Once the color coordinates of the individual light sources is uniquely calculated, the system measures the intensity values of light for each of the light sources that is necessary to provide a combined light with a desired color chromaticity coordinates. These intensity values can be used in a feedback control circuit to maintain the desired combined light as the LEDs change their characteristics from batch to batch or over time.

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