公开(公告)号：US11719920B2

公开(公告)日：2023-08-08

申请号：US17089818

申请日：2020-11-05

Applicant: LEICA MICROSYSTEMS (SCHWEIZ) AG

Inventor： Kyosuke Kamada ,  Yukie Tamura ,  Fumiya Takeuchi

IPC: G02B21/00 ,  G01J3/02 ,  G01J3/28 ,  G02B27/10 ,  G01N21/64 ,  G01J3/00

CPC classification number: G02B21/0012 ,  G01J3/0221 ,  G01J3/28 ,  G01N21/64 ,  G01N21/6458 ,  G02B21/0028 ,  G02B21/0076 ,  G02B27/10 ,  G01J2003/003

Abstract: Provided are an imaging unit 104 that uses a light emitted from a second beam splitter 202 of a microscope 2 that can use an exciting light and an observation light, which is a light including a wavelength other than that of the exciting light, as a light source by switching there between and is provided with the second beam splitter 202 to image images of the same observation region of the microscope 2 in situations where the exciting light and the observation light are used as the light source and an output unit 106 that overlaps, synthesizes, and outputs the images imaged by the imaging unit 104 respectively using the exciting light and the observation light as the light source.

公开(公告)号：US10024799B2

公开(公告)日：2018-07-17

申请号：US15122170

申请日：2015-02-13

Applicant: INDIAN INSTITUTE OF SCIENCE

Inventor： Siva Umapathy ,  Sanchita Sil ,  Gagan Dhal ,  Freek Ariese

IPC: G01J3/44 ,  G01N21/65 ,  G01B11/00 ,  G01J3/02

CPC classification number: G01N21/65 ,  G01B11/00 ,  G01J3/0221 ,  G01J3/027 ,  G01J3/0289 ,  G01J3/44 ,  G01J3/4412 ,  G01N21/4795 ,  G01N2201/0221 ,  G01N2201/06113 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: The invention provides a method for chemical signature resolved detection of a concealed object within a system. The method includes irradiating the system at a plurality of positions with aplurality of electromagnetic radiation of specific wavelength; capturing a certain component of the scattered electromagnetic radiation from the object at a plurality of locations along various 3D planes around the system; obtaining a plurality of profiles from the captured component of the scattered electromagnetic radiation; filtering the profiles to obtain a chemical signature specific to the object; and resolving the chemical signatures to detect the concealed object, wherein, the step of detection includes determination of the shape, size and location of the object.

公开(公告)号：US20180164218A1

公开(公告)日：2018-06-14

申请号：US15835608

申请日：2017-12-08

Applicant: The Board of Trustees of the Leland Stanford Junior University

Inventor： Cristina Zavaleta

IPC: G01N21/65 ,  G01J3/44 ,  A61B5/00 ,  G01J3/02 ,  A61B1/07

CPC classification number: G01N21/658 ,  A61B1/07 ,  A61B5/00 ,  A61B5/0075 ,  A61B5/0084 ,  B82Y15/00 ,  G01J3/02 ,  G01J3/0221 ,  G01J3/44 ,  G01J3/4406 ,  G01J3/4412 ,  G01N21/6456 ,  G01N21/65 ,  G01N2021/6439

Abstract: The present disclosure provides for a Raman probes and methods of imaging including a Raman probe. The Raman probes include a Raman detection system configured to illuminate an area of a subject or a sample with a light source and to receive Raman scattered light energy from the area. The Raman probe can include a proximity sensor system and a fluorescent imaging system. A method of imaging introduces a Raman probe to a subject. Fluorescent light is detected from an area of the subject, which guides the Raman probe to the area. The Raman probe is positioned at a target distance from the area using the proximity sensor system, and by exposing the area to a light beam from the Raman detection system. The light beam, Raman scattered light energy, is scattered by a Raman agent associated with the area. Raman scattered light is detected using the Raman imaging device.

公开(公告)号：US20180136043A1

公开(公告)日：2018-05-17

申请号：US15723103

申请日：2017-10-02

Applicant: UNIVERSITY OF MARYLAND BALTIMORE COUNTY

Inventor： BRADLEY ARNOLD ,  CHRISTOPHER COOPER ,  JOHN CATALDI

IPC: G01J3/44 ,  G01J3/18 ,  G02B5/18 ,  G01J3/06 ,  G01J3/28 ,  G02B6/32

CPC classification number: G01J3/44 ,  G01J3/0221 ,  G01J3/06 ,  G01J3/18 ,  G01J3/2803 ,  G01J3/36 ,  G02B5/1814 ,  G02B6/32

Abstract: The invention provides methods and apparatus comprising a multi-wavelength laser source that uses a single unfocused pulse of a low intensity but high power laser over a large sample area to collect Raman scattered collimated light, which is then Rayleigh filtered and focused using a singlet lens into a stacked fiber bundle connected to a customized spectrograph, which separates the individual spectra from the scattered wavelengths using a hybrid diffraction grating for collection onto spectra-specific sections of an array photodetector to measure spectral intensity and thereby identify one or more compounds in the sample.

公开(公告)号：US20170059404A1

公开(公告)日：2017-03-02

申请号：US14840537

申请日：2015-08-31

Applicant: Mettler-Toledo AG

Inventor： Chun-Hung KUO ,  Robert KOVICH ,  Tomasz POL ,  Mario CREVATIN

IPC: G01J3/02 ,  G01J3/28

CPC classification number: G01J3/0229 ,  G01J3/0202 ,  G01J3/0218 ,  G01J3/0221 ,  G01J3/0291 ,  G01J3/04 ,  G01J3/18 ,  G01J3/2803

Abstract: A spectrograph as disclosed includes a housing, wherein a wall of the housing includes first, second and third openings, an entrance slit located at the first opening and configured to direct light along a first light path portion in the interior of the housing, a dispersive element located at the second opening and configured to receive light from the entrance slit along the first light path portion and direct light along a second light path portion in the interior of the housing, a detector located at the third opening and configured to receive light from the dispersive element along the second light path portion. The detector can include first and second groups of light-sensitive regions. A cover can be positioned to separate the first group of light-sensitive regions from the light path, the second group of light-sensitive regions being exposed to the light path.

Abstract translation: 所公开的光谱仪包括壳体，其中壳体的壁包括第一，第二和第三开口，位于第一开口处的入口狭缝，其构造成沿着壳体内部的第一光路部分引导光，分散 元件，其位于第二开口处，并被配置为沿着第一光路部分接收来自入口狭缝的光，并沿着壳体内部的第二光路部分引导光，位于第三开口处的被配置为接收来自 沿着第二光路部分的色散元件。 检测器可以包括第一和第二组光敏区域。 可以将盖定位成将第一组光敏区域与光路分开，第二组光敏区域暴露于光路。

公开(公告)号：US20150146201A1

公开(公告)日：2015-05-28

申请号：US13875671

申请日：2013-05-02

Applicant: Michael Burka ,  Stephen McLaughlin ,  Malcolm C. Smith ,  Jie Zhang

Inventor： Michael Burka ,  Stephen McLaughlin ,  Malcolm C. Smith ,  Jie Zhang

IPC: G01J3/02 ,  G01J3/44

CPC classification number: G01J3/0218 ,  G01J3/021 ,  G01J3/0221 ,  G01J3/44 ,  G01N21/65 ,  G02B6/262

Abstract: A side-looking optical probe for a Raman spectroscopy system is provided. The probe includes: a base for mounting the probe to an optical assembly of the system; and a prism mounted to the base, the prism configured for receiving signal light from a sample and providing the signal light to the system. A method of fabrication and a spectrometer are provided.

Abstract translation: 提供了一种用于拉曼光谱系统的侧视光学探针。 探头包括：用于将探针安装到系统的光学组件的基座; 以及安装在所述基座上的棱镜，所述棱镜被配置为接收来自样本的信号光并将信号光提供给所述系统。 提供了制造方法和光谱仪。

公开(公告)号：US20150103334A1

公开(公告)日：2015-04-16

申请号：US14514294

申请日：2014-10-14

Applicant: TSI, Incorporated

Inventor： Frederick Quant ,  Kenneth R. Farmer ,  Phillip V. Tan ,  Christopher B. Stipe ,  Steven G. Buckley ,  Erik Stockinger ,  Daniel Jensen

IPC: G01N21/71 ,  G01N21/33

CPC classification number: G01N21/718 ,  G01J3/0221 ,  G01J3/0272 ,  G01J3/0291 ,  G01J3/18 ,  G01J3/443 ,  G01J2003/1861 ,  G01N2201/0221 ,  G01N2201/0697

Abstract: A novel device, method and systems disclosed managing the thermal challenges of LIBS laser components and a spectrometer in a handheld structure as well the use of simplified light signal collection which includes a bare fiber optic to collect the emitted light in close proximity to (or in contact with) the test material. In one example embodiment of the handheld LIBS device, a burst pulse frequency is 4 kHz is used resulting in a time between pulses of about 250 μs which is a factor of 10 above that of other devices in the prior art. In a related embodiment, an active Q-switched laser module is used along with a compact spectrometer module using a transmission grating to improve LIBS measurement while substantially reducing the size of the handheld analyzer.

Abstract translation: 公开了一种新颖的装置，方法和系统，其管理LIBS激光组件和光谱仪在手持式结构中的热挑战，以及使用简化的光信号采集，其包括裸光纤以收集靠近（或 接触）测试材料。 在手持式LIBS装置的一个示例性实施例中，突发脉冲频率为4kHz，导致约250μs的脉冲之间的时间，这是现有技术中其他装置的10倍之多。 在相关实施例中，使用有源Q开关激光模块以及使用传输光栅的紧凑型光谱仪模块来改善LIBS测量，同时显着减小手持式分析仪的尺寸。

公开(公告)号：US20140118722A1

公开(公告)日：2014-05-01

申请号：US13842098

申请日：2013-03-15

Applicant: Chemimage Corporation

Inventor： Patrick J. Treado ,  Matthew Nelson ,  Charles Gardner

IPC: G01N21/65 ,  G01N21/17

CPC classification number: G01N21/65 ,  G01J3/02 ,  G01J3/0221 ,  G01J3/0224 ,  G01J3/32 ,  G01J3/44 ,  G01N21/17 ,  G01N21/21 ,  G01N21/314 ,  G01N21/33 ,  G01N21/35 ,  G01N21/3581 ,  G01N21/359 ,  G02B21/0092 ,  G02B21/16 ,  G02B21/361

Abstract: A first location comprising an unknown material may be scanned using SWIR hyperspectral imaging in a dual polarization configuration. Surveying may also be applied to thereby determine whether or not a human is present. This surveying may be achieved my assessing LWIR data, data acquired from motion sensors, and combinations thereof. If no human is present, a second location may be interrogated using Raman spectroscopic techniques to thereby obtain a Raman data set representative of the region of interest. This Raman data set may be assessed to associate an unknown material with a known material. This assessment may be achieved by comparing the Raman data set to one or more reference data sets in a reference database, where each reference data set is associated with a known material.

公开(公告)号：US08131348B2

公开(公告)日：2012-03-06

申请号：US11803418

申请日：2007-05-14

Applicant: Vadim Backman ,  Hemant Roy ,  Brand Randall ,  Yang Liu ,  Jeremy Rogers ,  Vladimir Turzhitsky

Inventor： Vadim Backman ,  Hemant Roy ,  Brand Randall ,  Yang Liu ,  Jeremy Rogers ,  Vladimir Turzhitsky

IPC: A61B6/00 ,  G01J3/40

CPC classification number: G01J3/4412 ,  A61B1/00096 ,  A61B1/00179 ,  A61B1/00188 ,  A61B1/0051 ,  A61B1/018 ,  A61B1/0623 ,  A61B1/07 ,  A61B5/0084 ,  A61B5/7257 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0221 ,  G01J3/0224 ,  G01J3/10 ,  G01N21/21 ,  G01N21/474 ,  G01N2021/4709 ,  G01N2021/4745 ,  G01N2201/1293

Abstract: Systems, methods, and apparatuses of elastic light scattering spectroscopy and low-coherence enhanced backscattering spectroscopy are described here. An apparatus couple-able to a light source and a target object, to facilitate light transmission between the light source and the target object, the apparatus comprises: a probe to emit incident light that is partially coherent obtained from the light source onto the target object and to receive interacted light, the interacted light to be backscattered light from illumination of the incident light on the target object, the probe comprising: a delivery channel having at least one delivery optical fiber with a distal end portion couple-able to the light source and a proximal end portion suited to couple the incident light to the target object, a collection channel having a first collection optical fiber suited to collect substantially co-polarized backscattered light and a second collection optical fiber suited to collect substantially cross-polarized backscattered light.

Abstract translation: 这里描述弹性光散射光谱和低相干增强后向散射光谱的系统，方法和装置。 一种能够对光源和目标物体进行耦合的装置，以便于在光源和目标物体之间的光传输，所述装置包括：将从光源发射的部分相干的入射光发射到目标物体上的探测器 并且为了接收相互作用的光，所述相互作用的光从所述目标物体上的入射光的照射中反向散射光，所述探针包括：输送通道，其具有至少一个递送光纤，所述输送光纤具有可耦合到所述光源的远端部分 以及适于将入射光耦合到目标物体的近端部分，具有适于收集基本上共偏振的背散射光的第一收集光纤的收集通道和适于收集基本上交叉偏振的背散射光的第二收集光纤。

公开(公告)号：US20120045174A1

公开(公告)日：2012-02-23

申请号：US13213712

申请日：2011-08-19

Applicant: Manabu KOJIMA

Inventor： Manabu KOJIMA

IPC: G02B6/26

CPC classification number: G01J3/0221 ,  G01J3/0229 ,  G01J3/04

Abstract: A light guide may include a light stop part that is formed at a first end of an optical fiber, the light stop part stopping a light that is incident at a second end of the optical fiber and is transmitted through the optical fiber, and a slit part that is formed in the light stop part, the slit part being configured to pass the light that is incident at the second end of the optical fiber and is transmitted through the optical fiber.

Abstract translation: 光导可以包括形成在光纤的第一端的光停止部，所述光停止部停止入射在光纤的第二端并通过光纤的光，并且狭缝 形成在光停止部的部分，狭缝部被配置为使入射在光纤的第二端的光通过光纤。