公开(公告)号：US09103726B2

公开(公告)日：2015-08-11

申请号：US14002143

申请日：2012-03-02

Applicant: Yasuyuki Ozeki ,  Kazuyoshi Itoh ,  Keisuke Nose

Inventor： Yasuyuki Ozeki ,  Kazuyoshi Itoh ,  Keisuke Nose

IPC: G01J3/44 ,  G01N21/65 ,  G01J3/433 ,  H01S3/00 ,  H01S3/23

CPC classification number: G01J3/4412 ,  G01J3/433 ,  G01J3/44 ,  G01N21/65 ,  G01N2021/655 ,  H01S3/005 ,  H01S3/2391

Abstract: The stimulated Raman scattering detection apparatus includes first and second light pulse generators (1, 2) respectively generating first and second light pulses with first and second pulse periods, an optical system combining the first and second light pulses and focusing the combined light pulses onto a sample, and a detector (10) detecting the second light pulses intensity-modulated by stimulated Raman scattering generated by focusing of the combined light pulses onto the sample. The second light pulse generator divides each raw light pulse emitted with the second pulse period into two light pulses, delays one of the two light pulse with respect to the other thereof and combines the one light pulse divided from one raw light pulse and delayed, with the other light pulse divided from another raw light pulse emitted after the one raw light pulse, to generate the second light pulse.

Abstract translation: 被激发的拉曼散射检测装置包括分别产生具有第一和第二脉冲周期的第一和第二光脉冲的第一和第二光脉冲发生器（1,2），组合第一和第二光脉冲并将组合的光脉冲聚焦到 样品和检测器（10），检测通过将组合的光脉冲聚焦到样品上而产生的受激拉曼散射强度调制的第二光脉冲。 第二光脉冲发生器将以第二脉冲周期发射的每个原始光脉冲分成两个光脉冲，将两个光脉冲中的一个相对于另一个脉冲延迟，并将从一个原始光脉冲分离的一个光脉冲和延迟的一个光脉冲与 另一个光脉冲从在一个原始光脉冲之后发射的另一原始光脉冲中分离，以产生第二光脉冲。

公开(公告)号：US20150185154A1

公开(公告)日：2015-07-02

申请号：US14576699

申请日：2014-12-19

Applicant: Nuctech Company Limited

Inventor： Zhiqiang CHEN ,  Ziran ZHAO ,  Jianhong ZHANG ,  Hongqiu WANG ,  Yumin YI

IPC: G01N21/65

CPC classification number: G01N21/65 ,  G01J3/28 ,  G01J3/44 ,  G01J3/4412 ,  G01N2201/06113 ,  G01N2201/12

Abstract: An embodiment of the present invention provides a Raman spectroscopic detection method for detecting a sample in a vessel, comprising the steps of: (a) measuring a Raman spectrum of the vessel to obtain a first Raman spectroscopic signal; (b) measuring a Raman spectrum of the sample through the vessel to obtain a second Raman spectroscopic signal; (c) removing an interference caused by the Raman spectrum of the vessel from the second Raman spectroscopic signal on basis of the first Raman spectroscopic signal to obtain a third Raman spectroscopic signal of the sample itself; and (d) identifying the sample on basis of the third Raman spectroscopic signal. By means of the above method, the Raman spectrum of the sample in the vessel may be detected correctly so as to identify the sample to be detected efficiently.

Abstract translation: 本发明的一个实施方案提供一种用于检测容器中的样品的拉曼光谱检测方法，包括以下步骤：（a）测量容器的拉曼光谱以获得第一拉曼光谱信号; （b）通过容器测量样品的拉曼光谱，以获得第二拉曼光谱信号; （c）基于所述第一拉曼光谱信号从所述第二拉曼光谱信号中除去由所述容器的拉曼光谱引起的干扰，以获得所述样品本身的第三拉曼光谱信号; 和（d）基于第三拉曼光谱信号鉴定样品。 通过上述方法，可以正确地检测容器中的样品的拉曼光谱，以便有效地鉴定要检测的样品。

公开(公告)号：US08994938B2

公开(公告)日：2015-03-31

申请号：US13486846

申请日：2012-06-01

Applicant: David R. Day ,  Malcolm C. Smith ,  Peidong Wang

Inventor： David R. Day ,  Malcolm C. Smith ,  Peidong Wang

IPC: G01J3/44 ,  G01J3/02 ,  G01J3/32

CPC classification number: G01J3/32 ,  G01J3/0229 ,  G01J3/0272 ,  G01J3/44 ,  G01J3/4412 ,  G01N21/65 ,  G01N2201/06113

Abstract: A Raman spectrometer including a laser excitation source, edge filters, and detection optics that direct light into a spectrograph. A spectrograph containing a dispersive element and optics that directs various wavelengths of light onto a segmented diffractive MEMS light modulator array. The MEMS array, depending on actuation state, directs light either to or away from a single detector. Control electronics drive the MEMS light modulator for either sequential wavelength measurement or multiplexed wavelength measurement (Hadamard for example).

公开(公告)号：US20140375990A1

公开(公告)日：2014-12-25

申请号：US14381009

申请日：2012-03-06

Applicant: R. Stanley Williams ,  Zhiyong Li

Inventor： R. Stanley Williams ,  Zhiyong Li

IPC: G01J3/02 ,  G01J3/44 ,  G01N21/65

CPC classification number: G01J3/0205 ,  G01J3/44 ,  G01J3/4412 ,  G01N21/658 ,  G01N2201/06113 ,  G01N2201/068

Abstract: A double-grating surface-enhanced Raman spectrometer. The spectrometer includes a substrate; a plurality of nanofingers carried by the substrate, the nanofingers arranged to define a first optical grating; a light source oriented to project a beam of light toward the first optical grating; a second optical grating oriented to receive a beam of light scattered from the first optical grating; and a detector oriented to receive a beam of light scattered from the second optical grating.

Abstract translation: 双光栅表面增强拉曼光谱仪。 光谱仪包括基片; 由衬底承载的多个纳米装置，所述纳米装置布置成限定第一光栅; 光源，其朝向所述第一光栅投影光束; 第二光栅，其被定向为接收从第一光栅散射的光束; 以及用于接收从第二光栅散射的光束的检测器。

公开(公告)号：US20140362374A1

公开(公告)日：2014-12-11

申请号：US14373417

申请日：2012-04-25

Applicant: Charles M. Santori ,  Marco Fiorentino ,  David A. Fattal ,  Zhen Peng ,  Raymond G. Beausoleil ,  Di Liang ,  Andrei Faraon

Inventor： Charles M. Santori ,  Marco Fiorentino ,  David A. Fattal ,  Zhen Peng ,  Raymond G. Beausoleil ,  Di Liang ,  Andrei Faraon

IPC: G01J3/44

CPC classification number: G02B6/2813 ,  G01J3/0227 ,  G01J3/0259 ,  G01J3/1895 ,  G01J3/2823 ,  G01J3/4412 ,  G01J3/45 ,  G02B2006/12152 ,  G02F2001/217

Abstract: Apparatuses and systems for analyzing light by mode interference are provided. An example of an apparatus for analyzing light by mode interference includes a number of waveguides to support in a multimode region two modes of the light of a particular polarization and a plurality of scattering objects offset from a center of at least one of the number of waveguides.

Abstract translation: 提供了通过模式干扰分析光的装置和系统。 用于通过模式干扰来分析光的装置的示例包括多个波导中的多个波导，所述波导在多模区域中支持特定偏振光的两种模式和从波导数的至少一个的中心偏移的多个散射物体 。

公开(公告)号：US08883094B2

公开(公告)日：2014-11-11

申请号：US12810876

申请日：2009-01-05

Applicant: Qun Huo ,  Xiong Liu ,  Qiu Dai

Inventor： Qun Huo ,  Xiong Liu ,  Qiu Dai

IPC: G01N21/47 ,  C40B60/12 ,  G01J3/44 ,  G01N33/542 ,  C12Q1/68 ,  G01N33/58 ,  G01N15/02 ,  G01N21/03

CPC classification number: G01N33/54346 ,  C12Q1/682 ,  C40B60/12 ,  G01J3/4412 ,  G01N15/0205 ,  G01N33/542 ,  G01N33/585 ,  C12Q2563/155 ,  C12Q2563/137

Abstract: Disclosed herein are systems and methods for detecting Chemical Species, Biomolecules and Biotargets (Analytes) using receptor functionalized metal nanoparticles and Dynamic Light Scattering.

Abstract translation: 本文公开了使用受体官能化金属纳米颗粒和动态光散射检测化学物种，生物分子和生物靶（分析物）的系统和方法。

公开(公告)号：US20140293280A1

公开(公告)日：2014-10-02

申请号：US14355655

申请日：2012-11-02

Applicant: CORNING INCORPORATION

Inventor： Glenn Eric Kohnke ,  Xinyuan Liu ,  Marcel Potuzak ,  Alranzo Boh Ruffin ,  Millicent Kaye Weldon Ruffin

IPC: G01J3/44

CPC classification number: G01J3/4412 ,  B82Y30/00 ,  G01N21/658

Abstract: Provided herein are substrates useful for surface-enhanced Raman spectroscopy (SERS), as well as methods of making substrates. The substrates comprise a support element; a nanoparticulate layer; a SERS-active layer in contact with said nanoparticulate layer; and optionally, an immobilizing layer disposed between said nanoparticulate layer and said support element; wherein if the optional immobilizing layer is not present, the nanoparticulate layer is thermally bonded to the support element; and if said optional immobilizing layer is present, said nanoparticulate layer thermally bonded to said immobilizing layer, and optionally, further thermally bonded to said support element. In addition, methods of making the substrates, along with methods of detecting and increasing a Raman signal using the substrates, are described herein.

Abstract translation: 本文提供了可用于表面增强拉曼光谱（SERS）的底物，以及制备底物的方法。 基板包括支撑元件; 纳米颗粒层; 与所述纳米颗粒层接触的SERS活性层; 并且可选地，设置在所述纳米颗粒层和所述支撑元件之间的固定层; 其中如果不存在任选的固定层，则纳米颗粒层热粘合到支撑元件上; 并且如果存在所述任选的固定层，则所述纳米颗粒层热粘合到所述固定层，并且任选地进一步热粘合到所述支撑元件。 此外，本文描述了制造衬底的方法以及使用衬底检测和增加拉曼信号的方法。

公开(公告)号：US20140211196A1

公开(公告)日：2014-07-31

申请号：US13750695

申请日：2013-01-25

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： Brian C. Samuels ,  Zhiyong Li

IPC: G01N1/28 ,  G01N21/01

CPC classification number: G01J3/4412 ,  G01J3/0205 ,  G01N21/658 ,  Y10T29/49155

Abstract: According to an example, an apparatus for performing spectroscopy includes a substrate on which a plurality of surface-enhanced spectroscopy (SES) elements are positioned substantially along a first plane. The apparatus also includes a first electrode positioned adjacent to the plurality of SES elements substantially along the first plane and a second electrode positioned adjacent to the plurality of SES elements substantially along the first plane and on a side of the plurality of SES elements that is opposite the first electrode. The first electrode and the second electrode are to generate an electric field around the plurality of SES elements when voltages are applied through the first electrode and the second electrode.

Abstract translation: 根据一个实例，用于执行光谱学的装置包括基本上沿着第一平面定位多个表面增强光谱（SES）元件的基板。 该装置还包括基本上沿着第一平面邻近多个SES元件定位的第一电极和基本沿着第一平面定位成与多个SES元件相邻的第二电极，并且在与多个SES元件相对的多个SES元件的一侧 第一个电极。 当通过第一电极和第二电极施加电压时，第一电极和第二电极将在多个SES元件周围产生电场。

公开(公告)号：US20140041217A1

公开(公告)日：2014-02-13

申请号：US13962583

申请日：2013-08-08

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Masashi ITO ,  Katsumi SHIBAYAMA ,  Takashi KASAHARA ,  Yoshihiro MARUYAMA

IPC: G01N21/65

CPC classification number: G01J3/0205 ,  G01J3/4412 ,  G01N21/658 ,  Y10T29/49155

Abstract: A method for making a surface enhanced Raman scattering device in accordance with one aspect of the present invention comprises a first step of forming a nanoimprint layer on a main surface of a wafer including a plurality of portions each corresponding to a substrate; a second step of transferring, by using a mold having a pattern corresponding to a fine structural part, the pattern to the nanoimprint layer after the first step, and thereby forming the formed layer including the fine structural part for each portion corresponding to the substrate; a third step of forming a conductor layer on the fine structural part after the second step; and a fourth step of cutting the wafer into each portion corresponding to the substrate after the second step.

Abstract translation: 根据本发明的一个方面的用于制造表面增强拉曼散射装置的方法包括在晶片的主表面上形成纳米压印层的第一步骤，该晶片的主表面包括各自对应于基板的多个部分; 在第一步骤之后，通过使用具有与精细结构部分相对应的图案的模具转移到纳米压印层的第二步骤，从而形成对应于基板的每个部分的包含精细结构部分的成形层; 在第二步骤之后，在精细结构部件上形成导体层的第三步骤; 以及在第二步骤之后将晶片切割成与基板相对应的每个部分的第四步骤。

公开(公告)号：US08629980B2

公开(公告)日：2014-01-14

申请号：US13375388

申请日：2010-06-02

Applicant: Yasuyuki Ozeki ,  Kazuyoshi Itoh ,  Fumihiro Dake ,  Kiichi Fukui ,  Shinichiro Kajiyama ,  Yuma Kitagawa ,  Norihiko Nishizawa ,  Kazuhiko Sumimura

Inventor： Yasuyuki Ozeki ,  Kazuyoshi Itoh ,  Fumihiro Dake ,  Kiichi Fukui ,  Shinichiro Kajiyama ,  Yuma Kitagawa ,  Norihiko Nishizawa ,  Kazuhiko Sumimura

IPC: G01J3/44

CPC classification number: G01J3/4412 ,  G01N21/65 ,  G02B21/06 ,  G02B21/365

Abstract: The invention provides an optical microscope that prevents an increase in the complexity of the light source system and is equipped with optics readily capable of adequate operation even when the modulation frequency is increased in order to reduce the impact of the intensity noise of the laser, etc. This optical microscope 100 irradiates a sample 6 with a first train of optical pulses having a first optical frequency, which is generated by a first light source, and a second train of optical pulses having a second optical frequency, which is temporally synchronized with the first train of optical pulses and is generated by a second light source, and detects light scattered from the sample 6. The repetition frequency of the train of optical pulses generated by the first light source is an integral sub-multiple of the repetition frequency of the train of optical pulses generated by the second light source.

Abstract translation: 本发明提供了一种光学显微镜，其防止光源系统的复杂性的增加，并且配备有即使当增加调制频率以便减少激光器的强度噪声的影响等时容易进行适当操作的光学器件 该光学显微镜100照射具有由第一光源产生的具有第一光学频率的第一列光脉冲的样品6和具有与第二光频同步的第二光学频率的第二光脉冲序列 第一光脉冲串，并由第二光源产生，并且检测从样品6散射的光。由第一光源产生的光脉冲序列的重复频率是该第一光源的重复频率的整数倍 由第二光源产生的光脉冲序列。