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公开(公告)号：US07298477B1
公开(公告)日：2007-11-20
申请号：US11506639
申请日：2006-08-18
Applicant: Brian T. Cunningham , Peter Y. Li , Frank DiFilippi
Inventor： Brian T. Cunningham , Peter Y. Li , Frank DiFilippi
IPC: G01J3/28
CPC classification number: G01N21/253 , B01L3/5085 , B01L2300/0645 , B01L2300/0654 , B01L2300/0829 , G01N21/4788 , G01N21/7743 , G01N33/54373 , G01N2201/0635 , G01N2201/08 , G01N2201/0833 , G01N2201/0846 , G01N2201/1248 , G02B5/1809 , G02B5/1814 , G02B21/06
Abstract: Method and apparatus for detecting biomolecular interactions. The use of labels is not required and the methods may be performed in a high-throughput manner. An apparatus for detecting biochemical interactions occurring on the surface of a biosensor includes a light source. A first optical fiber is coupled to the light source and illuminates the biosensor. A second optical fiber detects a wavelength reflected from the biosensor. A spectrometer determines spectra of a reflected signal from the biosensor.
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公开(公告)号：US20070041012A1
公开(公告)日：2007-02-22
申请号：US11404485
申请日：2006-04-13
Applicant: Brian Cunningham , Peter Li , Frank DeFilippi
Inventor： Brian Cunningham , Peter Li , Frank DeFilippi
IPC: G01J3/28
CPC classification number: G01N21/253 , B01L3/5085 , B01L2300/0645 , B01L2300/0654 , B01L2300/0829 , G01N21/4788 , G01N21/7743 , G01N33/54373 , G01N2201/0635 , G01N2201/08 , G01N2201/0833 , G01N2201/0846 , G01N2201/1248 , G02B5/1809 , G02B5/1814 , G02B21/06
Abstract: Method and apparatus for detecting biomolecular interactions. The use of labels is not required and the methods may be performed in a high-throughput manner. An apparatus for detecting biochemical interactions occurring on the surface of a biosensor includes a light source. A first optical fiber is coupled to the light source and illuminates the biosensor. A second optical fiber detects a wavelength reflected from the biosensor. A spectrometer determines spectra of a reflected signal from the biosensor.
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公开(公告)号：US07148964B2
公开(公告)日：2006-12-12
申请号：US11404162
申请日：2006-04-13
Applicant: Brian T. Cunningham , Peter Y. Li , Frank DiFilippi
Inventor： Brian T. Cunningham , Peter Y. Li , Frank DiFilippi
IPC: G01J3/28
CPC classification number: G01N21/253 , B01L3/5085 , B01L2300/0645 , B01L2300/0654 , B01L2300/0829 , G01N21/4788 , G01N21/7743 , G01N33/54373 , G01N2201/0635 , G01N2201/08 , G01N2201/0833 , G01N2201/0846 , G01N2201/1248 , G02B5/1809 , G02B5/1814 , G02B21/06
Abstract: Method and apparatus for detecting biomolecular interactions. The use of labels is not required and the methods may be performed in a high-throughput manner. An apparatus for detecting biochemical interactions occurring on the surface of a biosensor includes a light source. A first optical fiber is coupled to the light source and illuminates the biosensor. A second optical fiber detects a wavelength reflected from the biosensor. A spectrometer determines spectra of a reflected signal from the biosensor.
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公开(公告)号：US20060181704A1
公开(公告)日：2006-08-17
申请号：US11404162
申请日：2006-04-13
Applicant: Brian Cunningham , Peter Li , Frank DeFilippi
Inventor： Brian Cunningham , Peter Li , Frank DeFilippi
IPC: G01J3/28
CPC classification number: G01N21/253 , B01L3/5085 , B01L2300/0645 , B01L2300/0654 , B01L2300/0829 , G01N21/4788 , G01N21/7743 , G01N33/54373 , G01N2201/0635 , G01N2201/08 , G01N2201/0833 , G01N2201/0846 , G01N2201/1248 , G02B5/1809 , G02B5/1814 , G02B21/06
Abstract: Method and apparatus for detecting biomolecular interactions. The use of labels is not required and the methods may be performed in a high-throughput manner. An apparatus for detecting biochemical interactions occurring on the surface of a biosensor includes a light source. A first optical fiber is coupled to the light source and illuminates the biosensor. A second optical fiber detects a wavelength reflected from the biosensor. A spectrometer determines spectra of a reflected signal from the biosensor.
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公开(公告)号：US20060181703A1
公开(公告)日：2006-08-17
申请号：US11404158
申请日：2006-04-13
Applicant: Brian Cunningham , Peter Li , Frank DeFilippi
Inventor： Brian Cunningham , Peter Li , Frank DeFilippi
IPC: G01J3/28
CPC classification number: G01N21/253 , B01L3/5085 , B01L2300/0645 , B01L2300/0654 , B01L2300/0829 , G01N21/4788 , G01N21/7743 , G01N33/54373 , G01N2201/0635 , G01N2201/08 , G01N2201/0833 , G01N2201/0846 , G01N2201/1248 , G02B5/1809 , G02B5/1814 , G02B21/06
Abstract: Method and apparatus for detecting biomolecular interactions. The use of labels is not required and the methods may be performed in a high-throughput manner. An apparatus for detecting biochemical interactions occurring on the surface of a biosensor includes a light source. A first optical fiber is coupled to the light source and illuminates the biosensor. A second optical fiber detects a wavelength reflected from the biosensor. A spectrometer determines spectra of a reflected signal from the biosensor.
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Patent Agency Ranking
公开(公告)号：US20040263842A1
公开(公告)日：2004-12-30
申请号：US10480479
申请日：2004-08-17
Inventor： Gerwin Jan Puppels
IPC: G01J003/44
CPC classification number: G02B6/262 , G01N21/65 , G01N2021/656 , G01N2201/0846 , G02B2006/0325
Abstract: The spectrum of light, inelastically scattered by a sample (16) is measured. The light is guided through a capillary (12) from and to the sample, at least in one of these directions, through the channel no inelastic scattering of light occurs which can form an interfering background when measuring on the sample. By guiding the light through the channel, inelastic scattering of this light is prevented and it becomes possible to guide scattered light back through the channel to spectral analysis equipment (14) without problems with inelastic scattering during the guidance of the light. Preferably, the light is guided through the channel of the capillary in both directions.
Abstract translation: 测量由样品（16）非弹性散射的光谱。 通过通道，至少在这些方向中至少一个方向上，光从毛细管（12）引导到样品，不会发生光的非弹性散射，这可以在对样品进行测量时形成干扰背景。 通过引导光通过通道，防止该光的非弹性散射，并且可以在散射光的引导期间将散射光引导通过通道返回到光谱分析设备（14）而不存在非弹性散射的问题。 优选地，光在两个方向上被引导通过毛细管的通道。
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公开(公告)号：US06790672B2
公开(公告)日：2004-09-14
申请号：US10079635
申请日：2002-02-19
Applicant: Kenneth J. Balkus, Jr. , Paul Pantano , Claudia C. Meek , Decio H. Coutinho
Inventor： Kenneth J. Balkus, Jr. , Paul Pantano , Claudia C. Meek , Decio H. Coutinho
IPC: G01N2164
CPC classification number: G01N21/6452 , B01J2219/0045 , B01J2219/00466 , B01J2219/00502 , B01J2219/00545 , B01J2219/00576 , B01J2219/00648 , B01J2219/00702 , B01J2219/0072 , C40B60/14 , G01N21/6428 , G01N21/7703 , G01N2201/0846
Abstract: A molecular sieve particle-based analytic chemistry system is disclosed in which populations of encoded molecular sieve particles carrying different chemical functionalities are distributed into wells etched in an optical fiber bundle. The chemical functionalities are encoded on separate shaped molecular sieve particles using luminescent dyes and/or molecular sieve particle shapes and thus, a single sensor array may carry thousands of chemistries. Such encoded molecular sieve particles can provide at least a five-fold enhancement in tunable parameters for increasing the encoding possibilities of high throughput screening assays relative to the present dye-modified polymeric microsphere standard.
Abstract translation: 公开了一种基于分子筛颗粒的分析化学系统，其中携带不同化学官能度的编码分子筛颗粒的群体分布在蚀刻在光纤束中的孔中。 化学功能性使用发光染料和/或分子筛颗粒形状在不同形状的分子筛颗粒上编码，因此，单个传感器阵列可带有数千种化学物质。 这样编码的分子筛颗粒可提供可调参数的至少五倍增强，以增加相对于本发明的染料改性聚合物微球体标准的高通量筛选测定的编码可能性。
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公开(公告)号：US06111653A
公开(公告)日：2000-08-29
申请号：US37163
申请日：1998-03-10
Applicant: Stephen Paul Bucknell , Nigel John Peter Winsey , Desmond Roy Gale
Inventor： Stephen Paul Bucknell , Nigel John Peter Winsey , Desmond Roy Gale
CPC classification number: G01N21/474 , G01N2021/4747 , G01N2021/4773 , G01N2201/062 , G01N2201/0833 , G01N2201/0846
Abstract: The translucency of a material is determined by illuminating the material and detecting the intensity of radiation leaving the material as a function of distance from the radiation source. The resulting measurements may be used to determine a "translucency gradient" for the material. In the case of materials in sheet form or having a defined thickness, the translucency can be measured in transmission mode or back scattering mode to measure "through translucency" or "surface translucency".
Abstract translation: 通过照射材料并检测离开材料的辐射强度作为距离辐射源的距离的函数来确定材料的半透明度。 所得到的测量可以用于确定材料的“半透明度梯度”。 在片材形式或具有规定厚度的材料的情况下，可以以透射模式或背散射模式测量半透明度以测量“通过半透明”或“表面半透明”。
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公开(公告)号：US5628311A
公开(公告)日：1997-05-13
申请号：US520428
申请日：1995-08-29
Applicant: Ganapati R. Mauze
Inventor： Ganapati R. Mauze
CPC classification number: G01N21/03 , G01N2021/036 , G01N2021/0378 , G01N2201/0225 , G01N2201/08 , G01N2201/0846
Abstract: A chemical sensor having a sheath, an optical fiber bundle, a mirror, and a mechanism associated with the optical fiber bundle for detecting light interaction, wherein the optical fiber means or the mirror is slidably disposed in the sheath, is provided. At least a portion of the sheath is permeable to a fluid suspected of containing a target chemical. The optical fiber bundle has a portion disposed in the sheath for emitting light to cause optical interaction with the target chemical surrounded by the sheath. The mirror is disposed in the sheath to reflect light emitted by the optical fiber bundle.
Abstract translation: 提供了一种具有鞘，光纤束，反射镜和与用于检测光相互作用的光纤束相关联的机构的化学传感器，其中光纤装置或镜可滑动地设置在护套中。 护套的至少一部分对于怀疑含有目标化学物质的流体是可渗透的。 光纤束具有设置在护套中用于发射光以使与被护套包围的目标化学物质发生光学相互作用的部分。 镜子设置在护套中以反射由光纤束发射的光。
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公开(公告)号：US11800981B2
公开(公告)日：2023-10-31
申请号：US16949466
申请日：2020-10-30
Applicant: Colgate-Palmolive Company
Inventor： Deborah Ann Peru , Hrebesh Molly Subhash
IPC: A61B5/00 , G01J3/02 , G02B6/04 , G01J3/06 , A61B5/145 , A61B5/1455 , G01J3/08 , G01J3/10 , G01N21/25 , G01J3/18 , G01J3/36 , G01N21/31 , G01J3/32
CPC classification number: A61B5/0075 , A61B5/0062 , A61B5/0088 , A61B5/14546 , A61B5/14551 , A61B5/4875 , G01J3/021 , G01J3/024 , G01J3/0205 , G01J3/027 , G01J3/0208 , G01J3/0218 , G01J3/0221 , G01J3/0229 , G01J3/0264 , G01J3/0291 , G01J3/06 , G01J3/08 , G01J3/10 , G01J3/18 , G01J3/32 , G01J3/36 , G01N21/255 , G01N21/31 , G02B6/04 , A61B5/441 , A61B5/4872 , A61B2562/0233 , G01J2003/061 , G01J2003/065 , G01J2003/066 , G01N2201/0826 , G01N2201/0833 , G01N2201/0846
Abstract: A spectroscopic system may include: a probe having a probe tip and an optical coupler, the optical coupler including an emitting fiber group and first and second receiving fiber groups, each fiber group having a first end and a second end, wherein the first ends of the fiber groups are formed into a bundle and optically exposed through the probe tip; a light source optically coupled to the second end of the emitting fiber group, the light source emitting light in at least a first waveband and a second waveband, the second waveband being different from the first waveband; a first spectrometer optically coupled to the second end of the first receiving fiber group and configured to process light in the first waveband; and a second spectrometer optically coupled to the second end of the second receiving fiber group and configured to process light in the second waveband.
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